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The effect of naftidrofuryl oxalate on cerebral blood flow in elderly patients.

James, I M; Newbury, P; Woolard, M L
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /12/1978 EN
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27.990579%

Points from letters: Severe thrombophlebitis with naftidrofuryl oxalate

Gunaratnam, C W
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 18/06/1977 EN
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27.990579%

Severe thrombophlebitis with naftidrofuryl oxalate.

Gann, M
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 18/06/1977 EN
Relevância na Pesquisa
27.990579%

Thrombophlebitis with intravenous naftidrofuryl oxalate.

Standing, V F; Wiggins, P A; Pratt, D; Kester, R C
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 01/10/1977 EN
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27.990579%

Possible therapeutic effect of naftidrofuryl oxalate on brain energy metabolism after microsphere-induced cerebral embolism.

Miyake, K.; Tanonaka, K.; Minematsu, R.; Inoue, K.; Takeo, S.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /10/1989 EN
Relevância na Pesquisa
50.060977%
1. The present study was designed to determine whether naftidrofuryl oxalate exerts a possible therapeutic effect on brain energy metabolism impaired by microsphere-induced cerebral embolism in vitro. 2. Injection of microspheres into the right carotid canal resulted in a decrease in tissue high-energy phosphates both in the right and left hemispheres, and an increase in tissue lactate in the right hemisphere, on the 3rd and the 5th day after the embolism. The embolism also induced a marked reduction in mitochondrial oxidative phosphorylation ability and succinate dehydrogenase activity. The results suggest that severe ischaemia was induced in the brain by the microsphere administration. 3. Treatment of microsphere-injected rats with naftidrofuryl oxalate (15 mg kg-1) for 3 or 5 days elicited a significant recovery of tissue high-energy phosphate and lactate levels. The recovery was associated with a significant restoration of mitochondrial succinate dehydrogenase activity on the both days and of mitochondrial oxidative phosphorylation rate on the 5th day. 4. The results suggest that naftidrofuryl oxalate is beneficial in the recovery of cerebral energy metabolism impaired by microsphere-induced cerebral ischaemia, presumably through a mechanism involving its direct effect on the cerebral mitochondrial enzyme activities.

Effects of naftidrofuryl oxalate on microsphere embolism-induced decrease in regional blood flow of rat brain.

Miyake, K.; Takagi, N.; Takeo, S.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /05/1994 EN
Relevância na Pesquisa
49.926875%
1. The purpose of the present study was to determine whether naftidrofuryl oxalate (naftidrofuryl), a vasodilator, is capable of improving brain regional blood flow of animals in sustained ischaemia. 2. Cerebral ischaemia was induced by injecting 900 microspheres (48 microns in diameter) into the right internal carotid artery of rats. Cerebral blood flow of brain regions was measured by a hydrogen clearance method on the 3rd, 7th and 28th days after the onset of ischaemia. Ischaemic animals were treated with naftidrofuryl, 15 mg kg-1 day-1 i.p., from the first to 28th day. 3. Microsphere-embolism caused a sustained decrease in cortical and striatal blood flow over a period of 28 days, whereas hippocampal blood flow was decreased on the 3rd day but not on the 7th or 28th day. On the 3rd day, the striatal and hippocampal but not cortical blood flow of naftidrofuryl-treated, microsphere-embolized rats was higher than untreated rats. On the 7th and 28th days, the cortical and striatal blood flow of the treated and untreated animals did not differ. 4. Brain slices from microsphere-embolized rats contained areas, which were not stained with triphenyltetrazolium chloride (TTC), to a similar degree on the 3rd, 7th and 28th days, indicating the genesis of cerebral infarction. TTC-unstained areas of microsphere-embolized rats that had received naftidrofuryl treatment were smaller than those of untreated rats on the 3rd and 7th days...

Spectrophotometric, Spectrofluorimetric and Voltammetric Analyses of Naftidrofuryl Oxalate in its Tablets

Sabry, Suzy M.; Belal, Tarek S.; Barary, Magda H.; Ibrahim, Mohammed E. A.
Fonte: Master Publishing Group Publicador: Master Publishing Group
Tipo: Artigo de Revista Científica
Publicado em /09/2009 EN
Relevância na Pesquisa
49.112046%
This work deals with several direct and indirect spectrophotometric, spectrofluorimetric and voltammetric analyses of the vasodilator drug: naftidrofuryl oxalate (NF). For the derivative spectrophotometric measurement, NF was determined by measuring the peak to peak amplitude of 1D263–299 and 2D282–311 or the absolute peak height of 1D237 and 2D241, while its reaction product with concentrated sulfuric acid was determined by measuring the peak to peak amplitude of 2D248–263 or the absolute peak height of 1D275. For the spectrofluorimetric measurement, native NF fluorescence was measured in Britton-Robinson buffer (pH 5) at λem = 331 nm (λex = 277 nm), while the reaction product was measured in aqueous solution at λem = 385 nm (λex = 258 nm). All factors affecting these analyses were studied and optimized. This work also describes a differential pulse cathodic voltammetric determination of the NF reaction product with concentrated sulfuric acid at the hanging mercury drop electrode (HMDE) where the experimental conditions affecting analysis including buffer pH, pulse amplitude and scan rate were examined and optimized. The chemical structure of the reaction product with concentrated sulfuric acid was investigated using several spectroscopic methods. All the developed procedures were validated and satisfactorily applied for the determination of NF in its pharmaceutical tablets.

Effects of vasodilator drugs, alkaline phosphatase, and cyclic AMP-dependent protein kinase on the 45calcium uptake of sarcolemmal microsomes from human umbilical arteries.

Kreye, V. A.; Schlicker, E.
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
Publicado em /12/1980 EN
Relevância na Pesquisa
17.990579%
1 A microsomal fraction was prepared from human umbilical arteries by differential centrifugation. The preparation was capable of an oxalate-stimulated Ca2+ uptake at a mean rate of 0.74 nmol Ca2+ mg-1 protein min-1 which could be inhibited by a Ca2+ ionophore, A 23 187, and by Tween 80. 2 The rate of Ca2+ uptake in the fraction obtained by density gradient fractionation paralleled 5'-nucleotidase activity suggesting that vesicles of predominantly sarcolemmal origin were responsible for the microsomal Ca2+ uptake. 3 Cyclic adenosine 3',5'-monophosphate-dependent protein kinase enhanced membrane phosphorylation but did not affect Ca2+ uptake. Preincubation with alkaline phosphatase reduced membrane phosphorylation to a greater extent than Ca2+ uptake. These data are not in favour of a close correlation between Ca2+ uptake and phosphorylation. 4 None of 15 vasodilator drugs (bencyclane, carbocromen, diazoxide, dilazep, hydralazine, indapamide, isosorbide dinitrate, methyl-isobutyl-xanthine, minoxidil, naftidrofuryl, nitroglycerine, prenylamine, sodium nitroprusside, tetracaine, and verapamil) had any effect on Ca2+ uptake at 10(-5) M. This suggests that vasodilator drugs do not act by a direct influence on the Ca2+ pumps of vascular smooth muscle cells.

Application of Membrane-Selective Electrodes for the Determination of Naftidrofuryl Oxalate in the Presence of Its Alkaline Degradant in Tablets and Plasma

Abbas,Samah S.; Zaazaa,Hala E.; El-Ghobashy,Mohamed R.; Fayez,Yasmin M.; Fattah,Soheir A.
Fonte: Sociedade Portuguesa de Electroquímica Publicador: Sociedade Portuguesa de Electroquímica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/05/2012 EN
Relevância na Pesquisa
69.69948%
Membrane selective electrodes were used to determine Naftidrofuryl Oxalate (NFL) in presence of its alkaline degradate (I). The membrane selective electrodes include construction of water insoluble ion-association complexes. These are NFL-tetraphenyl borate (NFL-TPB), NFL-reinikate (NFL-R). These complexes are used as electroactive materials, in poly-vinyl chloride (PVC) matrix membrane sensors, for the determination of NFL. The performance characteristics of these sensors, evaluated according to IUPAC recommendations, reveal fast, stable and linear response for NFL. The sensors are used for determination of NFL in plasma. The suggested method was used to determine NFL in synthetic mixtures and in commercial tablets. The obtained results were statistically compared with official HPLC method, showing no significant difference with respect to accuracy and precision.