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Fluorescent chemosensors for exploring zinc metalloneurochemistry and detecting mercury in aqueous solution

Nolan, Elizabeth M. (Elizabeth Marie), 1978-
Fonte: Massachusetts Institute of Technology Publicador: Massachusetts Institute of Technology
Tipo: Tese de Doutorado Formato: 523 p.
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Chapter 1. An Introduction to Zinc Metalloneurochemistry and Zinc Detection in Biology. This chapter presents an overview of zinc neurophysiology and pathology, which provides motivation for the design of new tools and tactics for zinc detection in vivo. A historical account of biological zinc detection is also given, followed by a summary of recent progress in the development and use of fluorescent Zn(II) sensors for in vivo studies. A summary of project goals and thesis organization is also included. Chapter 2. Zinc Sensors Based on Monosubstituted Fluorescein Platforms I: Routes to Electronic Variation, Syntheses and Spectroscopic Characterization. In this work, a convergent synthetic approach for the assembly of fluorescent zinc sensors from aniline-derivatized ligands and a fluroescein carboxaldehyde platform is presented. These sensors are based on the previously reported ZP4 motif and incorporate a di(2-picolyl)amine moiety in the aniline-based ligand framework. The effects of electronic variation, achieved by halogenation of either the zinc-binding unit or the fluorophore platform, on the fluorescence properties and aniline nitrogen atom pKa values are considered.; (cont.) Chapter 3. Spectroscopic Characterization and Biological Applications of Halogenated Zinpyr Sensors. In this chapter...