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Spring-mediated skull expansion: overall effects in sutural and parasutural areas. An experimental study in rabbits; Expansão craniana com molas: efeitos globais nas áreas suturais e parassuturais. Estudo experimental em coelhos

Dornelles, Rodrigo de Faria Valle; Cardim, Vera Lúcia Nocchi; Martins, Marília Trierveiler; Pinto, Ana Carolina Brandão de Campos Fonseca; Alonso, Nivaldo
Fonte: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia - SOBRADPEC; São Paulo Publicador: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia - SOBRADPEC; São Paulo
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
16.85%
OBJETIVO: O uso de molas na expansão craniana tem provado ser efetivo no tratamento da craniossinostoses. A expansão com molas tem sido estudada nas regiões sagital e parassagital, especialmente nas escafocefalias. Um modelo com coelho foi usado no presente estudo para analizar os efeitos das molas sobre a calota craniana e suturas. MÉTODOS: Treze coelhos Nova Zelândia, com quarto semanas de vida, foram divididos em quatro grupos: no grupo I, somente marcadores de amálgama foram implantados como controle; no grupo II, marcadores de amálgama foram implantados e foi retirada a sutura sagital; no grupo III, marcadores de amálgama foram implantados, foi retirada a sutura sagital e foi colocada uma mola expansora na região interparietal e no grupo IV, marcadores de amálgamas foram implantados, uma craniectomia linear parassagital foi realizada e foi colocada uma mola expansora. Os animais foram sacrificados com 2, 4, 8 e 12 semanas. Foi realizado controle radiológico e histológico nas áreas de implantação das molas. RESULTADOS: Nos grupos que utilizaram molas a distração das margens ósseas de craniectomia foi maior do que nos grupos que não utilizaram molas. Neoformação óssea foi observada em todos os grupos, tendo sido mais rápida no grupo II. O crescimento ósseo teve início a partir das margens e da profundidade. A regeneração óssea apresentou padrões histológicos similares nos grupos com o uso de molas na região sagital e parassagital. CONCLUSÕES: O modelo experimental com coelho provou ser adequado para a análise proposta pelo estudo. O uso das molas nos grupos com osteotomia sagital e parassagital promoveu uma distração similar dos marcadores de amálgamas e ambos os grupos tiveram padrão histológico de ossificação similar; PURPOSE: The use of springs in cranial expansion has proven to be effective in the treatment of craniosynostosis. Spring-mediated expansion has been studied both in the sagittal and in parasagittal regions...

Skull Base Cephalometric Changes in Cranial Expansion by Springs

DORNELLES, Rodrigo de Faria Valle; CARDIM, Vera Lucia Nocchi; PINTO, Ana Carolina Brandao de Campos Fonseca; ALONSO, Nivaldo
Fonte: LIPPINCOTT WILLIAMS & WILKINS Publicador: LIPPINCOTT WILLIAMS & WILKINS
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
16.85%
Background: The use of springs in cranial expansion has demonstrated to be effective for craniosynostosis treatment. The spring-exerted expansile action has been observed when springs are placed both in the sagittal and parasagittal regions, mainly in scaphocephaly. In this study, a variation in cephalometric measurements under expansible spring action on the skull base was analyzed. Methods: Thirteen 4-week-old New Zealand white rabbits were divided into 4 groups: group 1, in which only amalgam markers were used (control); group 2, in which amalgam markers were used, and a sagittal suturectomy was performed; group 3, in which amalgam markers were used, and a sagittal suturectomy was performed with placement of expansible springs in the interparietal region; and group 4, in which markers were used, and a linear parasagittal craniectomy was performed with spring placement. All animals were killed at weeks 2, 4, 8, and 12. Radiologic control with cephalometric study was performed. Results: Distraction of amalgam markers in the groups with springs was greater than in those without springs. A proportional change in the angles measured through craniometry was observed in these groups. Conclusions: The experimental rabbit model was shown to be adequate to the analysis proposed by the study. Under the action of springs...

Expansão craniana com molas: estudo experimental em coelhos; Spring-mediated skull expansion: experimental study in rabbits

Dornelles, Rodrigo de Faria Valle
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 28/04/2010 PT
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A expansão craniana com o uso de molas tem demonstrado eficácia no tratamento das anormalidades craniofaciais, tais como as craniossinostoses. A ação expansora exercida pelas molas tem sido observada tanto quando colocadas entre as margens parietais dos ossos do crânio, como quando lateralmente à sutura sagital, principalmente nas escafocefalias. No presente estudo foi criado um modelo experimental com coelhos, e feita uma avaliação descritiva do comportamento da calota craniana e das suturas sob ação de molas. Foram utilizados 13 coelhos Nova Zelândia com quatro semanas de vida, divididos em quatro grupos: grupo I, foram implantados no crânio marcadores de amálgama para controle; no grupo II, marcadores de amálgama e osteotomia da sutura sagital; no grupo III, marcadores de amálgama, osteotomia da sutura sagital e colocação de uma mola expansora na região interparietal e, no grupo IV, marcadores de amálgama, craniotomia parassagital linear com colocação da mola. Os animais foram sacrificados com duas, quatro, oito e doze semanas. Foi realizado controle radiológico com avaliação do afastamento dos marcadores de amálgama, da variação dos ângulos cefalométricos e das medidas da base do crânio, bem como um estudo histopatológico da região de colocação das molas. Nos grupos com o uso de molas a separação dos bordos da craniotomia foi maior do que naqueles sem a utilização de mola. Houve ossificação em todos os grupos...

Spring-mediated skull expansion: overall effects in sutural and parasutural areas. An experimental study in rabbits

Dornelles,Rodrigo de Faria Valle; Cardim,Vera Lúcia Nocchi; Martins,Marília Trierveiler; Pinto,Ana Carolina Brandão de Campos Fonseca; Alonso,Nivaldo
Fonte: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Publicador: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2010 EN
Relevância na Pesquisa
16.85%
PURPOSE: The use of springs in cranial expansion has proven to be effective in the treatment of craniosynostosis. Spring-mediated expansion has been studied both in the sagittal and in parasagittal regions, especially in scaphocephaly. A rabbit model was used in the present study to analyze the effects of springs on the cranial vault and sutures. METHODS: Thirteen 4-week-old New Zealand rabbits were divided into 4 groups: in group I, only amalgam markers were used as control; in group II, amalgam markers were used and sagittal suturectomy was performed; in group III, amalgam markers were used, a sagittal suturectomy was performed and an expansible spring was fitted in the interparietal region and in group IV, markers were used and linear parasagittal craniectomy was carried out with springs. Animals were sacrificed after 2, 4, 8 and 12 weeks. Radiological control and histological analysis were performed in the area of spring implantation. RESULTS: In the groups using springs distraction of the craniectomy borders was greater than in those that did not use springs. New bone formation was observed in all groups, and was faster in group II. Bone growth started from the borders and depth. Bone regeneration presented a similar histological pattern in the groups with spring in the sagittal and parasagittal region. CONCLUSION: The rabbit model proved to be adequate for the analysis proposed by the study. The use of springs in the groups with sagittal and parasagittal osteotomy led to a similar distraction of amalgam markers and both groups had similar ossification histological pattern.

Scaphocephaly, bilateral aniridia, and bilateral anterior polar cataract with posterior dislocation of the lens.

Mohan, H; Sen, D K; Gupta, D K
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /09/1971 EN
Relevância na Pesquisa
16.85%

Familial scaphocephaly syndrome caused by a novel mutation in the FGFR2 tyrosine kinase domain

McGillivray, G; Savarirayan, R; Cox, T; Stojkoski, C; McNeil, R; Bankier, A; Bateman, J; Roscioli, T; Gardner, R; Lamande, S
Fonte: BMJ Group Publicador: BMJ Group
Tipo: Artigo de Revista Científica
Publicado em /08/2005 EN
Relevância na Pesquisa
16.85%

Scaphocephaly, Oxycephaly and Hypertelorism: With Reports of Cases

Ogilvie, A. G.; Posel, M. M.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em //1927 EN
Relevância na Pesquisa
16.85%

Atypical Craniosynostosis with Torticollis and Neurological Symptoms: A Rhombencephalosynapsis Sequence

Koljonen, Virve; Leikola, Junnu; Valanne, Leena; Hukki, Jyri
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.85%
Purpose. We describe a case of 3-year-old girl with rhombencephalosynapsis, a rare cerebellar anomaly. Patient. A 3-year-old girl was admitted to our hospital due to congenital torticollis and asymmetry of face, skull and trunk. Craniosynostosis was suspected due to abnormal head shape. 3D-CT revealed closure of the sagittal suture without scaphocephalic skull. Due to atypical craniosynostosis with neurological symptoms, brain-MRI was performed revealing rhombencephalosynapsis. Results. Our patient presented with atypical craniosynostosis and balance problems, not typical for scaphocephaly. Operative treatment for craniosynotosis was not carried out because the cause of the problems was the cerebellum instead of the brain. Conclusions. Therefore, we conclude that patients with atypical craniosynostosis should be examined with brain-MRI to exclude the intracranial malformations, which 3D-CT does not reveal. Without brain-MRI, decision (not) to perform surgery could have been different.

New insights into the relationship between suture closure and craniofacial dysmorphology in sagittal nonsyndromic craniosynostosis

Heuzé, Yann; Boyadjiev, Simeon A; Marsh, Jeffrey L; Kane, Alex A; Cherkez, Elijah; Boggan, James E; Richtsmeier, Joan T
Fonte: Blackwell Science Inc Publicador: Blackwell Science Inc
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
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Premature closure of the sagittal suture occurs as an isolated (nonsyndromic) birth defect or as a syndromic anomaly in combination with other congenital dysmorphologies. The genetic causes of sagittal nonsyndromic craniosynostosis (NSC) remain unknown. Although variation of the dysmorphic (scaphocephaly) skull shape of sagittal NSC cases has been acknowledged, this variation has not been quantitatively studied three-dimensionally (3D). We have analyzed the computed tomography skull images of 43 infants (aged 0.9–9 months) with sagittal NSC using anatomical landmarks and semilandmarks to quantify and characterize the within-sample phenotypic variation. Suture closure patterns were defined by dividing the sagittal suture into three sections (anterior, central, posterior) and coding each section as ‘closed’ or ‘fused’. Principal components analysis of the Procrustes shape coordinates representing the skull shape of 43 cases of NSC did not separate individuals by sex, chronological age, or dental stages of the deciduous maxillary first molar. However, analysis of suture closure pattern allowed separation of these data. The central section of the sagittal suture appears to be the first to fuse. Then, at least two different developmental paths towards complete fusion of the sagittal suture exist; either the anterior section or the posterior section is the second to fuse. Results indicate that according to the sequence of sagittal suture closure patterns...

Immediate Spontaneous Shape Correction Using Expantile Zigzag Craniectomy in Infantile Scaphocephaly -Is There an Improvement in the Developmental Quotient Following Surgery?-

Kim, Sang-Dae; Oi, Shizuo
Fonte: The Korean Neurosurgical Society Publicador: The Korean Neurosurgical Society
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.54%
There is still debate over which method of the surgery is the most appropriate for the treatment of scaphocephalic infants. In addition, change in psychomotor development following these procedures is a very complex issue that has not yet been resolved. In this paper, the authors describe a surgical technique for immediate spontaneous shape correction of infantile scaphocephaly. There were significant differences between pre- and postoperative cephalic index. We also describe an improvement in the developmental quotient following surgery. Therefore, this expantile zigzag craniectomy should be recommended to correct for isolated sagittal craniosynostosis in infants.

Actual concepts in scaphocephaly : (an experience of 98 cases)

Ciurea, AV; Toader, C; Mihalache, C
Fonte: Carol Davila University Press Publicador: Carol Davila University Press
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.91%
Craniosynostoses are recognized as a group of birth defects that impair the skull structures by early closure of one or more sutures, causing an abnormal cranial shape. Among the "simple" craniosynostoses, (a single closed suture) the most common is scaphocephaly. The 3D CT scan is the most relevant and rapid diagnostic test. The authors present the personal experience of 98 scaphocephaly cases diagnosed and surgically treated in the Neurosurgical Department of "Bagdasar-Arseni" Emergency Hospital during a period of 10 years (2000 – 2009). The procedure of choice was the Stein & Schut (1977) extensive craniotomy that removes the early closed suture. There were no post-operatory death cases and no abnormally closed sutures. The routine use of the craniotome facilitates the lateral osteotomy that allows a normal brain growth and a normal symmetrical skull shape development. The authors advocate for early surgery during the first 6 months of life.

Isolated Sagittal Synostosis in a Boy with Craniofrontonasal Dysplasia and a Novel EFNB1 Mutation

Chauhan, Bharesh K.; Hoover, Jacqueline M.; Scanga, Hannah; Medsinge, Anagha; Arnold, Georgianne L.; Nischal, Ken K.
Fonte: Wolters Kluwer Health Publicador: Wolters Kluwer Health
Tipo: Artigo de Revista Científica
Publicado em 08/07/2015 EN
Relevância na Pesquisa
16.85%
Craniofrontonasal syndrome (CFNS) is a rare X-linked disorder that shows greater severity in females and is largely attributed to mutations in EFNB1. A 7-year-old boy presented with hypertelorism, broad nasal root, midfacial hypoplasia, mandibular prognathia, ptosis, and scaphocephaly was clinically diagnosed with CFNS. Three-dimensional computed tomographic scans confirmed the isolated sagittal synostosis. His mother also showed clinical features of CFNS, but less severe. Genetic tests uncovered a novel C to T mutation at nucleotide 466 (c.466C>T) in exon 1 of EFNB1 for both. To the best of our knowledge, this is the only reported incident of CFNS in a male child exhibiting isolated sagittal synostosis.

Étude rétrospective des malocclusions dento-squelettiques associées à la scaphocéphalie

Lebuis, Ariane
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
FR
Relevância na Pesquisa
27.91%
Introduction : La scaphocéphalie est la craniosynostose monosuturaire la plus commune (1/2000). Celle-ci est causée par la fusion prématurée de la suture sagittale. Une chirurgie corrective de la voûte crânienne peut être effectuée dans la première année de vie de l’enfant. Il n’existe actuellement aucune donnée précise dans la littérature scientifique étudiant l’occlusion chez les patients scaphocéphales, ainsi que les impacts potentiels de la chirurgie de la voûte crânienne sur celle-ci. Objectifs : L’objectif primaire de cette étude est de décrire et comparer la malocclusion dento-squelettique d’un groupe de patients scaphocéphales à une population pédiatrique normale. L’objectif secondaire est d’évaluer la différence au niveau de l’occlusion entre un sous-groupe de patients scaphocéphales ayant eu une chirurgie corrective de la voûte crânienne et un sous-groupe ne l’ayant pas eu. Méthodologie : Quatre-vingt-onze patients scaphocéphales (2-11 ans; 71 garçons) de la banque de données de la Clinique de Craniofacial du CHU Ste-Justine ont formé le groupe expérimental. Tous les patients ont eu un examen orthodontique complet et ont été suivis. Parmi ceux-ci, quarante-quatre avaient eu une chirurgie corrective de la voûte crânienne et quarante-sept n’en avaient pas eu...

Familial scaphocephaly syndrome caused by a novel mutation in the FGFR2 tyrosine kinase domain

McGillivray, George; Savarirayan, Ravi; Cox, Timothy Chilton; Stojkoski, Cvetan; McNeil, R.; Bankier, Agnes; Bateman, John Francis; Roscioli, T.; McKinlay Gardner, R. J.; Lamade, S. R.
Fonte: BMJ Publishing Group Ltd. Publicador: BMJ Publishing Group Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2005 EN
Relevância na Pesquisa
16.85%
G McGillivray, R Savarirayan, T C Cox, C Stojkoski, R McNeil, A Bankier, J F Bateman, T Roscioli, R J M Gardner, S R Lamandé; Copyright © 2005 by the BMJ Publishing Group Ltd.

Management of cranial deformity following ventricular shunting

Doorenbosch, X.; Molloy, C.; David, D.; Santoreneos, S.; Anderson, P.
Fonte: Springer-Verlag Publicador: Springer-Verlag
Tipo: Artigo de Revista Científica
Publicado em //2009 EN
Relevância na Pesquisa
16.85%
Purpose: Ventricular shunt-induced craniosynostosis is a widely recognised cause of secondary craniosynostosis. We reviewed the management and long-term outcome of the cases of cranial deformity post cerebrospinal fluid shunting in our unit and compared these with previously published series. Methods: The Australian Craniofacial Unit and Department of Neurosurgery database was searched to identify cases of ventricular shunt-induced cranial deformity and a case note review was undertaken. Results: Eight cases were identified, and all were shunted within 6 months of birth. Our patients required shunting with a low pressure valve for hydrocephalus secondary to either aqueduct stenosis or intraventricular haemorrhage. The diagnosis was made following computed tomography (CT) three-dimensional surface reconstruction of the skull. Two cases of confirmed suture fusion were treated with cranial vault remodelling and programmable shunt insertion. In six cases, the sutures were not completely fused on the CT images despite a scaphocephalic head shape. These patients were managed conservatively with close monitoring. Conclusion: Cranial vault remodelling together with insertion of programmable shunt valve is indicated in CT confirmed cases of secondary craniosynostosis.; X. Doorenbosch...

Comparative outcomes of craniectomy versus cranial remodelling in the human infant with isolated sagittal synostosis.

Thwin, May
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2015
Relevância na Pesquisa
16.85%
BACKGROUND Craniosynostosis is a congenital condition characterised by the premature closure of one or more cranial sutures. The sagittal suture is the most common site, comprising 40-60% of cases. Premature fusion of this suture can cause scaphocephaly, seen morphologically as a narrow elongated skull with a decreased cephalic index. Diagnosis is made clinically and/or radiologically. The goals of surgical correction and the techniques used have evolved over time. Whilst there has been a general move from limited craniectomy to calvarial remodelling, in recent times there has been a return towards less invasive methods. OBJECTIVES The objectives were to identify and synthesize the best available evidence on the morphological, functional and neurological outcomes of craniectomy compared to cranial vault remodelling and compare this to existing results. METHODS A systematic review of the literature was conducted using the Joanna Briggs Institute methodology. The review considered studies of infants with primary isolated sagittal synostosis operated on before a mean of two years of age. The intervention of interest was sagittal craniectomy; this was compared to cranial vault remodelling. Morphological, functional and neurological outcomes were included. Mortality...

Value of high-resolution ultrasound in the differential diagnosis of scaphocephaly and occipital plagiocephaly

Krimmel, Michael; Kluba, Susanne; Reinert, Siegmar; Schuhmann, Martin Ulrich; Will, Bernd; Wolff, Markus; Haas-Lude, Karin; Schäfer, Jürgen Frank
Fonte: Churchill Livingstone Publicador: Churchill Livingstone
Tipo: Artikel
EN
Relevância na Pesquisa
16.85%

Alterações antropométricas na base do crânio em crianças com craniostenose sagital submetidas à correção cirúrgica; Anthropometric changes in the skull base in children with sagittal craniosynostosis submitted to surgical correction

Lucio, José Erasmo Dal'Col
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 07/04/2011 PT
Relevância na Pesquisa
28.28%
Craniostenose é o fechamento precoce de uma ou mais suturas cranianas, levando ao redirecionamento do crescimento craniofacial e à deformidade do crânio. Estudos têm pesquisado o impacto da fusão da sutura sagital na base do crânio, focalizando a morfologia da base do crânio na presença de craniostenose sagital isolada (escafocefalia), enquanto outros têm avaliado o crescimento da base do crânio, antes e após a cirurgia. Este estudo teve como objetivo realizar as medidas antropométricas da base do crânio em crianças com escafocefalia, avaliar a influência da correção cirúrgica no remodelamento da base do crânio e nas medidas antropométricas. Foram operadas 21 crianças com diagnóstico clínico e radiológico de escafocefalia, entre abril de 2007 e outubro de 2008, sendo realizadas medidas antropométricas na base do crânio, antes e após 1 ano do tratamento cirúrgico. As medidas foram o índice craniano (IC), distância entre a crista galli e o tubérculo selar (CG-TS), distância entre a crista galli e o meato acústico interno (CG-MAI), distância entre os forames ovais (FO-FO), distância entre os meatos Acústicos internos (MAI-MAI), o ângulo da base do crânio Â1) e o ângulo entre o násio, centro selar e básio (Â2). Houve normalização do IC em todas as crianças...

Surgical treatment of isolated and syndromic craniosynostosis: Results and complications in 283 consecutive cases

Esparza,J.; Hinojosa,J.; García-Recuero,I.; Romance,A.; Pascual,B.; Martínez de Aragón,A.
Fonte: Neurocirugía Publicador: Neurocirugía
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/12/2008 ENG
Relevância na Pesquisa
18.13%
Objective. To review the results and complications of the surgical treatment of craniosynostosis in 283 consecutive patients treated between 1999 and 2007. Patients and methods. Our series consisted of 330 procedures performed in 283 patients diagnosed with scaphocephaly (n=155), trigonocephaly (n=50), anterior plagiocephaly (n=28), occipital plagiocephaly (n=1), non-syndromic multi-suture synostosis (n=20), and with diverse craniofacial syndromes (n=32; 11 Crouzon, 11 Apert, 7 Pfeiffer, 2 Saethre-Chotzen, and 2 clover-leaf skull). We used the classification of Whitaker et al. to evaluate the surgical results. Complications of each technique and time of patients'hospitalization were also recorded. The surgeries were classified in 12 different types according to the techniques used. Type I comprised endoscopic assisted osteotomies for sagittal synostosis (42 cases). Type II included sagittal suturectomy and expanding osteotomies (46 cases). Type III encompassed procedures similar to type II but that included frontal dismantling or frontal osteotomies in scaphocephaly (59 cases). Type IV referred to complete cranial vault remodelling (holocranial dismantling) in scaphocephaly (13 cases). Type V belonged to fronto-orbital remodelling without fronto-orbital bandeau in trigonocephaly (50 cases). Type VI included fronto-orbital remodelling without fronto-orbital bandeau in plagiocephaly (14 cases). In Type VII cases of plagiocephaly with frontoorbital remodelling and fronto-orbital bandeau were comprised (14 cases). Type VIII consisted of occipital advancement in posterior plagiocephaly (1 case). Type IX included standard bilateral fronto-orbital advancement with expanding osteotomies (30 cases). Type X was used in multi-suture craniosynostosis (15 cases) and consisted of holocranial dismantling (complete cranial vault remodelling). Type XI included occipital and suboccipital craniectomies in multiple suture craniosynostosis (10 cases) and Type XII instances of fronto-orbital distraction (26 cases). Results. The mortality rate of the series was 2 out of 283 cases (0.7%). These 2 patients died one year after surgery. All complications were resolved without permanent deficit. Mean age at surgery was 6.75 months. According to Whitaker et al's classification...