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Escafoldes para implantes ósseos em alumina/hidroxiapatita/biovidro: análises mecânica e in vitro ; Scaffolds in alumina, hydroxyapatite and bio-glass for bone implants: mechanical tests and in vitro analysis
Obtenção e utilização de microesferas de parafina para confecção de arcabouços teciduais baseados em cimento de α-fosfato tricálcico; Production and use of paraffin microspheres for tissue scaffolds based on α-tricalcium phosphate cement
Porous titanium scaffolds produced by powder metallurgy for biomedical applications
Effect of flow perfusion on the osteogenic differentiation of bone marrow stromal cells cultured on starch-based three dimensional scaffolds
Morphology, mechanical characterization and in vivo neo-vascularization of chitosan particle aggregated scaffolds architectures
Novel hydroxyapatite/carboxymethylchitosan composite scaffolds prepared through an innovative ‘‘autocatalytic’’ electroless coprecipitation route
Novel 3D scaffolds of chitosan-PLLA blends for tissue engineering applications : preparation and characterization
Cartilage regeneration approach based on squid chitosan scaffolds : in-vitro assessment
Novel approach to create hybrid and hierarchical scaffolds aimed for tissue regeneration
Gellan gum-based hydrogel bilayered scaffolds for osteochondral tissue engineering
Avaliação de "engineering scaffolds" de hidroxiapatite e fosfato tricálcico para crescimento ósseo.
Fiber Scaffolds of Poly (glycerol-dodecanedioate) and its Derivative via Electrospinning for Neural Tissue Engineering
Synthesis of spirocyclic scaffolds by aminoallylation/RCM sequence and approach toward the total synthesis of the Macrolide Dictyostatin; Synthese spiroverknüpfter Scaffolds durch eine Aminoallylierung/Ringschluss Metathese Sequenz und ein Zugang zur Totalsynthese des Macrolids Dictyostatin
Development of biocomposite scaffolds and injectable biocement for bone regeneration.
Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks
Composite polymer-bioceramic scaffolds with drug delivery capability for bone tissue engineering
Control of Crosslinking for Tailoring Collagen-based Scaffolds Stability and Mechanics
Optimisation of UV Irradiation as a Binding Site Conserving Method for Crosslinking Collagen-based Scaffolds
Biomimetic Composite Scaffolds for the Functional Tissue Engineering of Articular Cartilage
Articular cartilage is the connective tissue that lines the ends of long bones in diarthrodial joints, providing a low-friction load-bearing surface that can withstand a lifetime of loading cycles under normal conditions. Despite these unique and advantageous properties, the tissue possesses a limited capacity for self-repair due to its lack of vasculature and innervation. Total joint replacement is a well-established treatment for degenerative joint disease; however, the materials used in these procedures have a limited lifespan in vivo and will likely fail over time, requiring additional - and increasingly complicated - revision surgeries. For younger or more active patients, this risk is unacceptable. Unfortunately, alternative surgical options are not currently available, leaving pain management as the only viable treatment. In seeking to discover a new therapeutic strategy, the goal of this dissertation was to develop a functional tissue-engineered cartilage construct that may be used to resurface an entire diseased or damaged joint.
A three-dimensional (3-D) woven textile structure, produced on a custom-built miniature weaving loom, was utilized as the basis for producing novel composite scaffolds and cartilage tissue constructs that exhibited initial properties similar to those of native articular cartilage. Using polyglycolic acid (PGA) fibers combined with chondrocyte-loaded agarose or fibrin hydrogels...
Development of Cartilage-Derived Matrix Scaffolds via Crosslinking, Decellularization, and Ice-Templating
Articular cartilage is a connective tissue that lines the surfaces of diarthrodial joints; and functions to support and distribute loads as wells as facilitate smooth joint articulation. Unfortunately, cartilage possesses a limited capacity to self-repair. Once damaged, cartilage continues to degenerate until widespread cartilage loss results in the debilitating and painful disease of osteoarthritis. Current treatment options are limited to palliative interventions that seek to mitigate pain, and fail to recapitulate the native function. Cartilage tissue engineering offers a novel treatment option for the repair of focal defects as well as the complete resurfacing of osteoarthritic joints. Tissue engineering combines cells, growth factors, and biomaterials in order to synthesize new cartilage tissue that recapitulates the native structure, mechanical properties, and function of the native tissue. In this endeavor, there has been a growing interest in the use of scaffolds derived from the native extracellular matrix of cartilage. These cartilage-derived matrix (CDM) scaffolds have been show to recapitulate the native epitopes for cell-matrix interactions as well as provide entrapped growth factors; and have been shown to stimulate chondrogenic differentiation of a variety of cell types. Despite the potent chondroinductive properties of CDM scaffolds...