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Comparison of the efficacy of Rose Bengal and erythrosin in photodynamic therapy against Enterobacteriaceae

Rossoni, Rodnei D.; Junqueira, Juliana Campos; Santos, Evelyn Luzia S.; Costa, Anna Carolina B.; Jorge, Antonio Olavo C.
Fonte: Springer London Ltd Publicador: Springer London Ltd
Tipo: Artigo de Revista Científica Formato: 581-586
ENG
Relevância na Pesquisa
68.07911%
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Processo FAPESP: 07/54442-3; The aim of this study was to evaluate the effects of the photosensitizers Rose Bengal and erythrosin combined with a light-emitting diode (LED) on Enterobacteriaceae. Twelve Enterobacteriaceae strains isolated from the oral cavities of patients undergoing prolonged antibiotic therapy, including three Escherichia coli, three Enterobacter cloacae, three Klebsiella oxytoca and three Klebsiella pneumoniae, were studied. An Enterobacteriaceae suspension (10(6) cells/ml) was prepared from each clinical strain isolated from the human oral cavity and subjected to the following treatments: LED and Rose Bengal, LED and erythrosin, LED and physiological solution, and physiological solution only as control. A blue LED unit (460 nm), and Rose Bengal and erythrosin at a concentration of 50 A mu mol/l were used. After incubation at 37A degrees C for 48 h, the number of colony-forming units (CFU) was calculated and subjected to analysis of variance (ANOVA). The Enterobacterial strains were sensitive to photodynamic therapy with Rose Bengal. There was a reduction of approximately 7.14 log10 for Enterobacter cloacae, 7.73 log10 for Escherichia coli, 6.76 log10 for Klebsiella pneumoniae and 7.21 log10 for Klebsiella oxytoca. However...

Photodynamic therapy for the treatment of buccal candidiasis in rats

Junqueira, Juliana Campos; Martins, Joyce da Silva; Faria, Raquel Lourdes; Dias Colombo, Carlos Eduardo; Cardoso Jorge, Antonio Olavo
Fonte: Springer London Ltd Publicador: Springer London Ltd
Tipo: Artigo de Revista Científica Formato: 877-884
ENG
Relevância na Pesquisa
68.045464%
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Processo FAPESP: 05/55084-8; The study objective was to evaluate the effects of photodynamic therapy on buccal candidiasis in rats. After experimental candidiasis had been induced on the tongue dorsum, 72 rats were distributed into four groups according to treatment: treated with laser and methylene blue photosensitizer (L+P+); treated only with laser (L+P-); treated only with photosensitizer (L--P+); not treated with laser or photosensitizer (L-P-). The rats were killed immediately, 1 day, or 5 days after treatment, for microscopic analysis of the tongue dorsum. Observation verified that the photodynamic therapy group (L+P+) exhibited fewer epithelial alterations and a lower chronic inflammatory response than the L-P- group. The group L+P- presented more intense epithelial alterations and chronic inflammatory response than the remaining groups. The L-P+ group showed tissue lesions similar to those of the L-P- group. In conclusion, rats treated with photodynamic therapy developed more discrete candidiasis lesions than did the remaining groups.