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Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity

JONES, David S.; BRUSCHI, Marcos Luciano; FREITAS, Osvaldo de; GREMIAO, Maria Palmira Daflon; LARA, Elza Helena Guimaraes; ANDREWS, Gavin P.
Fonte: ELSEVIER SCIENCE BV Publicador: ELSEVIER SCIENCE BV
Tipo: Artigo de Revista Científica
ENG
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67.556987%
This study described the formulation and characterisation of the viscoelastic, mechanical and mucoadhesive properties of thermoresponsive, binary polymeric systems composed of poloxamer (P407) and poly(acrylic acid, C974P) that were designed for use as a drug delivery platform within the oral cavity. Monopolymeric and binary polymeric formulations were prepared containing 10, 15 and 20% (w/w) poloxamer (407) and 0.10-0.25% (w/w) poly(acrylic acid, 934P). The flow theological and viscoelastic properties of the formulations were determined using controlled stress and oscillatory rheometry, respectively, the latter as a function of temperature. The mechanical and mucoadhesive properties (namely the force required to break the bond between the formulation and a pre-hydrated mucin disc) were determined using compression and tensile analysis, respectively. Binary systems composed of 10% (w/w) P407 and C934P were elastoviscous, were easily deformed under stress and did not exhibit mucoadhesion. Formulations containing 15 or 20% (w/w) Pluronic P407 and C934P exhibited a sol-gel temperature T(sol/gel), were viscoelastic and offered high elasticity and resistance to deformation at 37 degrees C. Conversely these formulations were elastoviscous and easily deformed at temperatures below the sol-gel transition temperature. The sol-gel transition temperatures of systems containing 15% (w/w) P407 were unaffected by the presence of C934P; however...

Oral cavity is not a reservoir for Helicobacter pylori in infected patients with functional dyspepsia

ROSSI-AGUIAR, V. P. Silva; NAVARRO-RODRIGUEZ, T.; MATTAR, R.; PERES, M. P. Siqueira de Melo; BARBUTI, R. Correa; SILVA, F. M.; CARRILHO, F. J.; EISIG, J. N.
Fonte: WILEY-BLACKWELL PUBLISHING, INC Publicador: WILEY-BLACKWELL PUBLISHING, INC
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
67.71547%
Helicobacter pylori infection is very prevalent in Brazil, infecting almost 65% of the population. The aim of this study was to evaluate the presence of this bacterium in the oral cavity of patients with functional dyspepsia (epigastric pain syndrome), establish the main sites of infection in the mouth, and assess the frequency of cagA and vacA genotypes of oral H. pylori. All 43 outpatients with epigastric pain syndrome, who entered the study, were submitted to upper gastrointestinal endoscopy to rule out organic diseases. Helicobacter pylori infection in the stomach was confirmed by a rapid urease test and urea breath tests. Samples of saliva, the tongue dorsum and supragingival dental plaque were collected from the oral cavity of each subject and subgingival dental plaque samples were collected from the patients with periodontitis; H. pylori infection was verified by polymerase chain reaction using primers that amplify the DNA sequence of a species-specific antigen present in all H. pylori strains; primers that amplify a region of urease gene, and primers for cagA and vacA (m1, m2, s1a, s1b, s2) genotyping. Thirty patients harbored H. pylori in the stomach, but it was not possible to detect H. pylori in any oral samples using P1/P2 and Urease A/B. The genotype cagA was also negative in all samples and vacA genotype could not be characterized (s-m-). The oral cavity may not be a reservoir for H. pylori in patients with epigastric pain syndrome...

Comparison between computed tomography and clinical evaluation in tumour/node stage and follow-up of oral cavity and oropharyngeal cancer

FIGUEIREDO, P. T.; LEITE, A. F.; FREITAS, A. C.; NASCIMENTO, L. A.; CAVALCANTI, M. G.; MELO, N. S.; GUERRA, E. N.
Fonte: BRITISH INST RADIOLOGY Publicador: BRITISH INST RADIOLOGY
Tipo: Artigo de Revista Científica
ENG
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67.69252%
Objectives: The aim was to verify the concordance of CT evaluation among four radiologists (two oral and maxillofacial and two medical radiologists) at the TN (tumour/node) stage and in the follow-up of oral cavity and oropharyngeal cancer patients. The study also compared differences between clinical and CT examinations in determining the TN stage. Methods: The following clinical and tomographic findings of 15 non-treated oral cavity and oropharyngeal cancer patients were compared: tumour size, bone invasion and lymph node metastases. In another 15 patients, who had previously been treated, a clinical and tomographic analysis comparison for the presence of tumoural recurrence, post-therapeutic changes in muscles and lymph node metastases was performed. The concordances of tomographic evaluation between the radiologists were analysed using the kappa index. Results: Significant agreement was verified between all radiologists for the T stage, but not for the N stage. In the group of treated patients, CT disclosed post-therapeutic changes in muscles, tumour recurrence and lymph node metastases, but no concordance for the detection of lymph node metastases was found between radiologists. In the first group, for all radiologists, no concordance was demonstrated between clinical and tomographic staging. CT was effective for delimitating advanced lesions and for detecting lymph node involvement in N0 stage patients. CT revealed two cases of bone invasion not clinically detected. Conclusions: Interprofessional relationships must be stimulated to improve diagnoses...

Polimorfismo PRO198LEU no gene para a enzima antioxidante dependente de selênio glutationa peroxidase 1 e risco de câncer epidermóide da cavidade oral e orofaringe; PRO198LEU polymorphism in the gene for the selenium-dependent antioxidant enzyme glutathione peroxidase 1 and risk of oral cavity and oropharyngeal squamous cell cancer

Nishimura, Luciana Sigueta
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 09/09/2010 PT
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O selênio é um micronutriente essencial que apresenta ação antioxidante por meio de selenoproteínas, como a glutationa peroxidase 1 (GPX1). O polimorfismo PRO198LEU no gene em questão tem sido relacionado ao aumento do risco para alguns tipos de câncer, como o de mama e pulmão. Atualmente, o câncer de cabeça e pescoço é um importante problema de saúde pública no mundo e, inclusive, no Brasil. O objetivo do presente estudo foi avaliar eventual associação entre o polimorfismo GPX1 PRO198LEU e risco de câncer epidermóide da cavidade oral e orofaringe, bem como possível interação com utilização de tabaco e ingestão de álcool. O genótipo para o polimorfismo GPX1 PRO198LEU foi determinado pela técnica de PCR-RFLP (Reação em cadeia da polimerase - Polimorfismo no comprimento do fragmento de restrição) e seqüenciamento do DNA em 175 pacientes com câncer epidermóide da cavidade oral e orofaringe (grupo caso) integrantes de parte da casuística do Projeto Genoma Clínico do Câncer de Cabeça e Pescoço, e em 203 indivíduos sem a doença, internados nas enfermarias do Hospital Heliópolis (grupo controle). A freqüência do alelo de referência e do polimórfico foi de 0,72 e 0,28, respectivamente, em ambos os grupos. A freqüência dos genótipos encontrou-se em equilíbrio de Hardy-Weinberg nos grupos caso e controle. Não houve diferença estatisticamente significante (p>0...

Valor prognóstico da correlação do Ki-67 e p53 em carcinomas epidermoides da cavidade oral e língua; Ki-67 and p53 correlation prognostic value in squamous cell carcinomas of the oral cavity and tongue

Motta, Rafael da Ros; Zettler, Claudio Galleano; Cambruzzi, Eduardo; Jotz, Geraldo Pereira; Berni, Renata Brutti
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf
POR
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67.666484%
O carcinoma epidermoide representa 90% a 95% das neoplasias malignas da cavidade oral, responsável por 13.470 casos/ano. Objetivos: Correlacionar a expressão do p53 e Ki-67 nos carcinomas epidermoides de cavidade oral e lín¬gua com o estado linfonodal, sexo, grau histológico, volume tumoral e estadiamento patológico. Materiais e Métodos: Foi realizado estudo retrospectivo de 28 casos de carcino¬mas epidermoides da cavidade oral e língua. Estes foram submetidos à técnica de imunoistoquímica para verificar a expressão dos anticorpos p53 e Ki-67 e compará-los estatis¬ticamente quanto ao status linfonodal, sexo, grau histológico, volume tumoral e estadiamento patológico. Resultados: O p53 analisado individualmente mostrou significância esta¬tística (p<0,05) quando comparado com o volume tumoral (p=0,029). Apesar de uma forte tendência, a relação de p53 com estado linfonodal não foi significativa. Quando o p53 + Ki67 foram analisados, o volume tumoral mostrou p < 0,05 (p = 0,029). Discussão: A literatura mostra que a ex¬pressão dos marcadores p53 e Ki-67 está relacionada com presença de metástases para linfonodos e pior prognóstico. Conclusão: Nos carcinomas epidermoides da cavidade oral e língua o p53 e o Ki-67 estão relacionados a tumores de maior volume...

Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity

Jones, David S.; Bruschi, Marcos Luciano; de Freitas, Osvaldo; Daflon Gremiao, Maria Palmira; Guimaraes Lara, Elza Helena; Andrews, Gavin P.
Fonte: Elsevier B.V. Publicador: Elsevier B.V.
Tipo: Artigo de Revista Científica Formato: 49-58
ENG
Relevância na Pesquisa
67.556987%
This study described the formulation and characterisation of the viscoelastic, mechanical and mucoadhesive properties of thermoresponsive, binary polymeric systems composed of poloxamer (P407) and poly(acrylic acid, C974P) that were designed for use as a drug delivery platform within the oral cavity. Monopolymeric and binary polymeric formulations were prepared containing 10, 15 and 20% (w/w) poloxamer (407) and 0.10-0.25% (w/w) poly(acrylic acid, 934P). The flow theological and viscoelastic properties of the formulations were determined using controlled stress and oscillatory rheometry, respectively, the latter as a function of temperature. The mechanical and mucoadhesive properties (namely the force required to break the bond between the formulation and a pre-hydrated mucin disc) were determined using compression and tensile analysis, respectively. Binary systems composed of 10% (w/w) P407 and C934P were elastoviscous, were easily deformed under stress and did not exhibit mucoadhesion. Formulations containing 15 or 20% (w/w) Pluronic P407 and C934P exhibited a sol-gel temperature T(sol/gel), were viscoelastic and offered high elasticity and resistance to deformation at 37 degrees C. Conversely these formulations were elastoviscous and easily deformed at temperatures below the sol-gel transition temperature. The sol-gel transition temperatures of systems containing 15% (w/w) P407 were unaffected by the presence of C934P; however...

Presence of Staphylococcus spp. and Candida spp. in the human oral cavity

Martins, Clélia Aparecida; Koga-Ito, Cristiane Yumi; Jorge, Antonio Olavo Cardoso
Fonte: Sociedade Brasileira de Microbiologia Publicador: Sociedade Brasileira de Microbiologia
Tipo: Artigo de Revista Científica Formato: 236-240
ENG
Relevância na Pesquisa
67.595767%
A presença de leveduras do gênero Candida e Staphylococcus na cavidade bucal humana é de extrema importância, pois podem atuar como microbiota suplementar e em determinadas situações causar doença bucal ou sistêmica. O objetivo do presente trabalho foi estudar a prevalência de Candida spp. e Staphylococcus spp. na cavidade bucal humana. Enxagüe bucal foi coletado de 68 indivíduos segundo a técnica proposta por Samaranayake e MacFarlane e a seguir semeados em ágar Sabouraud dextrose com cloranfenicol e ágar Baird-Parker. Após crescimento, os microrganismos foram isolados e identificados através de provas bioquímicas. Os dados foram analisados através de análise de variância (ANOVA). Leveduras do gênero Candida foram encontradas em 61,76% dos indivíduos examinados, sendo C. albicans a mais frequentemente isolada. Staphylococcus spp. foram isolados em 95,60% das cavidades bucais, sendo 41 cepas (63%) coagulase-negativas. Das cepas coagulase-positivas, nove eram S. aureus, 11 S. hyicus, e quatro S. schleiferi subespécie coagulans. Não foi observada correlação entre as contagens (UFC) de Candida spp. e Staphylococcus spp. encontradas nos enxagües bucais dos indivíduos examinados.; The presence of yeasts and staphylococci in the oral cavity is important because they can act as supplementary microbiota and in certain situations can cause oral or systemic diseases. The aim of this work was to study the prevalence of Candida spp. and Staphylococcus spp. in the human oral cavity. Oral rinses were collected from sixty-eight individuals according to the technique described by Samaranayake and MacFarlane and then cultured on Sabouraud medium supplemented with chloramphenicol and Baird-Parker agar. After the incubation period...

Plasmacytoma in the oral cavity: a case report

Barros, Tarley Eloy Pessoa de; Sevilha, Fábio Moschetto; Amantea, Daniela Vieira; Campolongo, Gabriel Denser; Borelli Neto, Laurindo; Alves, Nilton; Oliveira, Reinaldo José de
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 115-118
ENG
Relevância na Pesquisa
67.595767%
The plasma cell neoplasms may present in soft tissue as extramedullary plasmacytoma (EMP), in bone as a solitary plasmacytoma of bone (SPB), or as part of the multifocal disseminated disease multiple myeloma (MM). The EMP is rare, comprising around 3% of all plasma cell neoplasm. The majority (80%) occurs in the head and neck region. In this study we report a case of a man, 70 years old, melanoderm, with a lesion of the oral cavity. Upon physical examination, a lesion was found that extended throughout the posterior upper alveolar ridge, as far as the maxillary tuber on the left side, extending towards the palate. Radiographic examination, complementary laboratory exams were performed. Based on the conclusive symptoms of plasmacytoma, the patient was referred to the hematology service for treatment with local radiotherapy. The patient responded satisfactorily to the treatment, and after 15 months, all clinical symptoms of the lesion in the oral cavity had disappeared.; La neoplasia de células plasmáticas se presenta en los tejidos blandos como plasmocitoma extramedular (EMP), en el hueso como plasmocitoma solitario (SPB), o como parte de una enfermedad diseminada, el mieloma múltiple (MM). El EMP es poco frecuente, manifestandose en alrededor de un 3%. Se presentan generalmente (80%) en las regiones de cabeza y cuello. En este reporte de caso...

The Effect of Tannins on Mediterranean Ruminant Ingestive Behavior: The Role of the Oral Cavity

Lamy, Elsa; Rawel, Harshadrai; Schweigert, Florian J.; Capela e Silva, Fernando; Ferreira, Ana; Costa, Ana Rodrigues; Antunes, Célia; Almeida, André Martinho; Coelho, Ana Varela; Sales-Baptista, Elvira
Fonte: Universidade de Évora Publicador: Universidade de Évora
Tipo: Artigo de Revista Científica
POR
Relevância na Pesquisa
67.50329%
Abstract: Sheep, cattle and goat are domestic ruminants of significant economic interest in the Mediterranean region. Although sharing the same pasture ranges, they ingest different plants and plant parts and, consequently different levels of tannins. This suggests an ability to detect and adapt ingestion according to animal physiological limits of tolerance for plant secondary metabolites. This review will detail the effects of dietary tannins on feeding behavior, and the role of the oral cavity in this process, with focus on such ruminant species. The role of salivary protein profile in tannin perception in the oral cavity, and as a defense mechanism, will be discussed.

Oral cavity eumycetoma

Nai,Gisele Alborghetti; Stuani,Maria Luiza de Toledo; Stuani,Luís Antonio Sasso
Fonte: Instituto de Medicina Tropical Publicador: Instituto de Medicina Tropical
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2011 EN
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67.424023%
Mycetoma is a pathological process in which eumycotic (fungal) or actinomycotic causative agents from exogenous source produce grains. It is a localized chronic and deforming infectious disease of subcutaneous tissue, skin and bones. We report the first case of eumycetoma of the oral cavity in world literature. CASE REPORT: A 43-year-old male patient, complaining of swelling and fistula in the hard palate. On examination, swelling of the anterior and middle hard palate, with fistula draining a dark liquid was observed. The panoramic radiograph showed extensive radiolucent area involving the region of teeth 21-26 and the computerized tomography showed communication with the nasal cavity, suggesting the diagnosis of periapical cyst. Surgery was performed to remove the lesion. Histopathological examination revealed purulent material with characteristic grain. Gram staining for bacteria was negative and Grocott-Gomori staining for the detection of fungi was positive, concluding the diagnosis of eumycetoma. The patient was treated with ketoconazole for nine months, and was considered cured at the end of treatment. CONCLUSION: Histopathological examination, using histochemical staining, and direct microscopic grains examination can provide the distinction between eumycetoma and actinomycetoma accurately.

Oral cavity lymphoma as secondary AIDS-defining neoplasm in a patient on HAART with immune reconstitution

Corti,Marcelo; Solari,Rubén; Cangelosi,Diana; De Carolis,Luis; Schtirbu,Ricardo; Lewi,Daniel
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2007 EN
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Lymphomas of the oral cavity are a rare complication of advanced HIV/AIDS disease. The clinical appearance of these neoplasms includes masses or ulcerative lesions that involve the oral soft tissue and the jaw as the predominant manifestation. We report the case of a patient with AIDS who developed diffuse large B-cell non-Hodgkin’s lymphoma of the oral cavity during highly active antiretroviral therapy, with undetectable plasma viral load and immune reconstitution.

Presence of Staphylococcus spp. and Candida spp. in the human oral cavity

Martins,Clélia Aparecida de Paiva; Koga-Ito,Cristiane Yumi; Jorge,Antonio Olavo Cardoso
Fonte: Sociedade Brasileira de Microbiologia Publicador: Sociedade Brasileira de Microbiologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2002 EN
Relevância na Pesquisa
67.595767%
The presence of yeasts and staphylococci in the oral cavity is important because they can act as supplementary microbiota and in certain situations can cause oral or systemic diseases. The aim of this work was to study the prevalence of Candida spp. and Staphylococcus spp. in the human oral cavity. Oral rinses were collected from sixty-eight individuals according to the technique described by Samaranayake and MacFarlane and then cultured on Sabouraud medium supplemented with chloramphenicol and Baird-Parker agar. After the incubation period, the microorganisms were isolated and identified through biochemical tests. The data obtained were statistically analysed by ANOVA. Candida spp. were isolated from 61.76% of the examined individuals and C. albicans was the more frequently isolated specie. Staphylococcus spp. were isolated from 95.60% of the individuals and 41 strains were coagulase negative (63%). Among the coagulase positive strains, nine were S. aureus, 11 S. hyicus and 4 S. schleiferi subspecie coagulans. No correlation was observed between the counts (cfu) of the isolated Candida spp. and Staphylococcus spp.

Ki-67 and p53 correlation prognostic value in squamous cell carcinomas of the oral cavity and tongue

Motta,Rafael Da Ros; Zettler,Claudio Galeano; Cambruzzi,Eduardo; Jotz,Geraldo Pereira; Berni,Renata Brutti
Fonte: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial Publicador: Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2009 EN
Relevância na Pesquisa
67.50329%
Epidermoid carcinomas represent from 90% to 95% of oral cavity malignant neoplasias, making up 13,470 cases/year. AIMS: To correlate p53 and Ki-67 expressions in mouth and tongue carcinomas with lymph node status, gender, histological grade, tumor volume and pathological stage. MATERIALS AND METHODS: We carried out a retrospective study of 28 cases of mouth and tongue epidermoid carcinomas. They were submitted to immunohistochemical study in order to check the expression of p53 and Ki-67 antibodies and statistically compare them in terms of lymph node status, gender, histological grade, tumor volume and pathological staging. RESULTS: The individually analyzed p53 proved to have statistical significance (p<0.05) when compared to tumor volume (p=0.029). Despite a strong tendency, the p53/tumor volume relation was not significant. When p53 + Ki67 were analyzed, tumor volume had p < 0.05 (p = 0.029). DISCUSSION: Literature shows that the expression of p53 and Ki-67 is related to the presence of metastasis to lymph nodes and a worse prognosis. CONCLUSION: In oral cavity and tongue epidermoid carcinomas, p53 and Ki-67 are related to larger tumors, metastasis to lymph nodes and very likely to a worse prognosis.

Isolamento, identifica????o e suscetibilidade in vitro de leveduras isoladas da cavidade oral de f??meas caninas; Isolation, identification and in vitro susceptibility test of yeasts from oral cavity of female canine

SANTIN, Rosema
Fonte: Universidade Federal de Pelotas; Veterin??ria; Programa de P??s-Gradua????o em Veterin??ria; UFPel; BR Publicador: Universidade Federal de Pelotas; Veterin??ria; Programa de P??s-Gradua????o em Veterin??ria; UFPel; BR
Tipo: Dissertação Formato: application/pdf
POR
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The aims of this study was the oral cavity evaluation of females stray dogs from Pelotas-RS, as well as yeast isolation and identification from three different areas of this cavity, comparison of two technique of sample collection (swabs and curettes) and test the in vitro susceptibility of isolated yeasts against common oral antiseptics used in pets. Fifty-nine randomized animals were included in the study. All of them were SRD, without age defined and from Pelotas-RS. They were divided in three groups of ages by the evaluation of dental arc, and were examined to determine the cranial morphology, presence of dental plaque, tooth fractures, malocclusion, halitosis and gingival bleeding. Measure of periodontal groove depth was also done. Samples were collected from three areas, gingival mucosa, dental biofilm and periodontal grooves, with different collection techniques: swab, curettes, millimeter periodontal probe and cellulose polymers membranes. In vitro susceptibility tests by microdilution methods was done with 15 of those yeasts against A product (0,12% chlorhexidine gluconate, 0,12% benzalkonium chloride and 0,10% chlorophila extract) and B product (0,2% benzalkonium chloride, 1% propolis and 0,5% peppermint arome). It was also evaluated chemical principles of products in separated...

Langzeitresultate der Behandlung von Tumorerkrankungen im Bereich von Mundhöhle und Oropharynx; Long-term results in the treatment of tumor diseases in the area of oral cavity and oropharynx

Spengler, Krischan Robert
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
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67.50329%
Zur Untersuchung der Langzeitergebnisse wurden alle Patienten mit einer malignen Tumorerkrankung im Bereich der Mundhöhle und des Oropharynx erfasst, die zwischen 1982 und 1991 an der HNO-Klinik in Tübingen therapiert worden sind. Insgesamt sind 609 Patienten in die Auswertung eingeflossen. Getrennt nach vier Tumorregionen wurden die 5-Jahres-Überlebensraten ermittelt und zur Erstdiagnose und zu den verschiedenen Therapieschemata in Beziehung gebracht. Bei den untersuchten Tumorerkrankungen kann insgesamt von einer Inzidenzzunahme ausgegangen werden. Es zeigt sich tendenziell eine Vorverlagerung des Diagnosezeitpunktes; bezüglich der Ausdehnung der Primärtumoren lassen sich zwischen älteren und jüngeren Patienten keine bedeutsamen Unterschiede feststellen. Das männliche Geschlecht stellt einen positiven Vorhersagewert für das Auftreten von Plattenepithelkarzinomen sowie für eine Verschlechterung der Überlebenswahrscheinlichkeit dar. Dabei spielen schädigende Noxen wie Alkohol und Rauchen eine bedeutende Rolle. Die Überlebensraten sind weitgehend geschlechts- und altersunabhängig. Bezüglich einer niederen histologischen Differenzierung kann kein negativer Vorhersagewert abgeleitet werden, allerdings zeigt sich eine prognostische Bedeutung des Lymphknotenbefalls bei Erstdiagnose. Außerdem ist die Überlebensrate mit zunehmender Tumorausbreitung reduziert; es ließ sich aber kein signifikanter Unterschied zwischen den einzelnen T-Stadien nachweisen. Eine verminderte Überlebensrate kann somit nicht alleine dem verwendeten Therapiemodus zugeschrieben werden. Die deutlich schlechtere Prognose von ausgedehnteren Tumoren hängt direkt mit dem Risiko für die Entwicklung von Fernmetastasen zusammen. Bei vor allem lymphogenem Metastasierungsweg ist deshalb die Durchführung einer Neck Dissection nicht nur ein therapeutischer sondern auch ein wichtiger prognostischer Faktor. Auf die häufig radikalen chirurgischen Maßnahmen kann in den vergangenen Jahren zunehmend – zu Gunsten eines funktionserhaltenden Eingriffs –verzichtet werden. Im Gegensatz zu den Patienten mit Karzinom im Bereich des Oropharynx und der Mundhöhle zeigte sich bei Behandlung der Mundboden-Karzinom-Patienten ein signifikanter Unterschied bezüglich der registrierten Überlebenszeiten...

Collagen type I expression in squamous cell carcinoma of the oral cavity; Expressão do colágeno I em carcinomas epidermóides da cavidade oral

Martins, Gabriela Botelho; Reis, Sílvia Regina de Almeida; Silva, Tânia Maria Correia
Fonte: Universidade de São Paulo. Faculdade de Odontologia Publicador: Universidade de São Paulo. Faculdade de Odontologia
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Artigo Avaliado pelos Pares Formato: application/pdf
Publicado em 01/03/2003 POR
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An analysis of the extracellular matrix at the invasive front of squamous cell carcinoma of the oral cavity may improve the understanding of tumour cell matrix interactions during malignancy growth. Alterations in collagen I expression may influence cellular invasion and metastasis. In this work, 23 cases of squamous cell carcinoma were submitted to the Anneroth's malignancy grading system¹. H. E. and sirius red staining were used. Immunohistochemical expression of collagen type I protein was observed in different malignancy scores. As a result, it was observed that the extracellular matrix in squamous cell carcinoma of the oral cavity shows different patterns of collagen I expression in low and high scores of malignancy.; A matriz extracelular no carcinoma epidermóide da cavidade oral sofre modificações qualitativas e quantitativas durante a sua progressão. Estas alterações parecem possibilitar os processos de invasão e metástase que caracterizam as neoplasias malignas e são mais evidentes na interface tumor-hospedeiro. No nosso estudo, 23 biópsias incisionais de carcinomas epidermóides de diversas localizações da cavidade oral foram classificadas segundo o sistema de graduação histológica preconizado por Anneroth et al.¹ (1987). Foram utilizadas as colorações pela H. E. e a do tipo picrosirius...

Eumicetoma da cavidade bucal; Oral cavity eumycetoma

Nai, Gisele Alborghetti; Stuani, Maria Luiza de Toledo; Stuani, Luís Antonio Sasso
Fonte: Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo Publicador: Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; Formato: application/pdf
Publicado em 01/06/2011 ENG
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Micetoma é um processo patológico no qual agentes eumicóticos (fungos) ou actinomicóticos de origem exógena podem causar formação de grãos. É uma doença infecciosa localizada, crônica e deformante do tecido subcutâneo, pele e ossos. Relatamos o primeiro caso de eumicetoma da cavidade bucal da literatura mundial. RELATO DE CASO: Paciente masculino, de 43 anos, com queixa de edema e fístula no palato duro. Ao exame clínico, observava-se edema da região anterior e média de palato duro, com fístula drenando líquido escuro. A radiografia panorâmica mostrou área radiolúcida extensa, envolvendo a região dos dentes 21 ao 26 e a Tomografia computadorizada evidenciou comunicação com a cavidade nasal, sugerindo o diagnóstico de cisto periapical. Foi realizada cirurgia para remoção da lesão. O exame histopatológico revelou material purulento com grãos característicos. A coloração de Gram para pesquisa de bactérias foi negativa e a coloração de Gomori-Grocott para pesquisa de fungos foi positiva, concluindo o diagnóstico de eumicetoma. O paciente foi tratado com Cetoconazol durante nove meses, obtendo cura ao final do tratamento. CONCLUSÃO: O exame histopatológico, usando colorações histoquímicas, e o exame dos grãos por microscopia direta podem proporcionar adequada distinção entre eumicetoma e actinomicetoma.; Mycetoma is a pathological process in which eumycotic (fungal) or actinomycotic causative agents from exogenous source produce grains. It is a localized chronic and deforming infectious disease of subcutaneous tissue...

Oral leiomyoma in retromolar trigone: A case report

Luaces Rey,Ramón; Lorenzo Franco,Fernanda; Gómez Oliveira,Guillermo; Patiño Seijas,Beatriz; Guitián,Dolores; López-Cedrún Cembranos,José Luis
Fonte: Medicina Oral, Patología Oral y Cirugía Bucal (Internet) Publicador: Medicina Oral, Patología Oral y Cirugía Bucal (Internet)
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/01/2007 ENG
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Leiomyomas are bening tumours originated on smooth muscle. The most frequent site of appearance are uterine myometrium, gastrointestinal tract and skin. The highest incidence ocurs between 40 and 49 years of age. Its presentation is unusual in children or in older patients. Leiomyomas are unfrequent in the oral cavity, but in this location are usually localized on tongue, lips and palate. Leiomyomas use to appear as well-defined masses, with slow growth and totally asymptomatic. Pain is present just in rare cases. The treatment is surgical escision. Recurrences are extremely unfrequent. The diagnosis is mainly determined by histological studies due to its unspecific clinical appearance. Histopathologicaly proliferation of smooth muscle cells is observad without necrotic areas. A low number of mitotic figures can be seen. We present the case report of a 25-year old male patient, with a leiomioma on his right retromolar trigone.The low incidence of this pathology, the age of the patient and the inusual location, make the report of the case worthy.

A boy with oral hair: Case report

Agha-Hosseini,Farzaneh; Etesam,Farideh; Rohani,Bita
Fonte: Medicina Oral, Patología Oral y Cirugía Bucal (Internet) Publicador: Medicina Oral, Patología Oral y Cirugía Bucal (Internet)
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/09/2007 ENG
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In personal communication we have never seen or heard of hair being detected in the oral cavity. Even Julia Pastrana, the famous "Bearded Lady" of the 1800’s, had no record of oral hair, although her entire body was covered with hair. Extensive records of her oral condition, including plaster models of her teeth have been preserved in the Odontological Museum of the Royal College of Surgeons in London city. She suffered from excessive gingival hyperplasia, but apparently no hair existed within the mouth. Some rodents have oral hair as a normal occurrence, but the condition is apparently limited in the animal kingdom. A case of hair occurring naturally in the mouth has been reported only twice previously. A third case of this rare anomaly is reported here. In this case, multiple hairs were found at the gingival sulcus in the labial, buccal, lingual and palatal tooth surfaces in an 11-year-old boy.

Classic Kaposi’s sarcoma presenting in the oral cavity of two HIV-negative Quechua patients

Mohanna,Salim; Bravo,Francisco; Ferrufino,Juan Carlos; Sanchez,Juvenal; Gotuzzo,Eduardo
Fonte: Medicina Oral, Patología Oral y Cirugía Bucal (Internet) Publicador: Medicina Oral, Patología Oral y Cirugía Bucal (Internet)
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/09/2007 ENG
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Traditionally, classic KS lesions have a general distribution, often involving the skin of the feet and legs, and to a lesser extent, that of the hands, arms, and trunk. Oral involvement is a rare manifestation. Initial oral involvement is an even rarer occurrence. We report two unusual cases of classic KS presenting in the oral cavity of two patients from indigenous origin; the first patient with primary oral KS lesion on the hard palate, with no other signs of the condition in any other region of the body; the second patient with generalized dermal KS lesions with lymph node and lower lip involvement. In conclusion, clinicians and pathologists should be aware of the typical clinical, gross, and histologic features of KS. Moreover, we would like to emphasize that oral KS may affect patients without AIDS or exposure to immunosuppression. The awareness of oral classic KS as a diagnostic possibility is important in the work-up of vascular lesions in the oral cavity of non-immunosuppressed individuals.