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Construção de um espectrógrafo de projeção e sua utilização em demonstrações de espectroscopia óptica; Construction of a projection spectrograph and its use in optical spectroscopy classrooms demonstrations

AZEVEDO, Eduardo Ribeiro de; NUNES, Luiz Antônio de Oliveira
Fonte: Sociedade Brasileira de Química Publicador: Sociedade Brasileira de Química
Tipo: Artigo de Revista Científica
POR
Relevância na Pesquisa
674.1419%
This article describes a projection spectrograph for use in optical spectroscopy classrooms demonstrations. The apparatus is based on an overhead projector and permits the visualization of several phenomena such as, light dispersion by diffraction gratings, diffraction order, optical fluorescence, continuous and discrete optical emission spectra, and light absorption by liquids and solids. A historical survey about the optical spectroscopy development is also presented.

Noninvasive Evaluation of Oral Lesions Using Depth-sensitive Optical Spectroscopy

SCHWARZ, Richard A.; GAO, Wen; WEBER, Crystal Redden; KURACHI, Cristina; LEE, J. Jack; EL-NAGGAR, Adel K.; RICHARDS-KORTUM, Rebecca; GILLENWATER, Ann M.
Fonte: JOHN WILEY & SONS INC Publicador: JOHN WILEY & SONS INC
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
575.4231%
BACKGROUND: Optical spectroscopy is a noninvasive technique with potential applications for diagnosis of oral dysplasia and early cancer. In this study, we evaluated the diagnostic performance of a depth-sensitive optical spectroscopy (DSOS) system for distinguishing dysplasia and carcinoma from non-neoplastic oral mucosa. METHODS: Patients with oral lesions and volunteers without any oral abnormalities were recruited to participate. Autofluorescence and diffuse reflectance spectra of selected oral sites were measured using the DSOS system. A total of 424 oral sites in 124 subjects were measured and analyzed, including 154 sites in 60 patients with oral lesions and 270 sites in 64 normal volunteers. Measured optical spectra were used to develop computer-based algorithms to identify the presence of dysplasia or cancer. Sensitivity and specificity were calculated using a gold standard of histopathology for patient sites and clinical impression for normal volunteer sites. RESULTS: Differences in oral spectra were observed in: (1) neoplastic versus nonneoplastic sites, (2) keratinized versus nonkeratinized tissue, and (3) shallow versus deep depths within oral tissue. Algorithms based on spectra from 310 nonkeratinized anatomic sites (buccal...

USE OF THE LINEAR LIGHT SENSOR ILX554 IN OPTICAL SPECTROSCOPY

Assirati, Lucas; Terra, Idelma A. A.; Nunes, Luiz A. O.
Fonte: SOC BRASILEIRA QUIMICA; SAO PAULO Publicador: SOC BRASILEIRA QUIMICA; SAO PAULO
Tipo: Artigo de Revista Científica
POR
Relevância na Pesquisa
566.2226%
USE OF THE LINEAR LIGHT SENSOR ILX554 IN OPTICAL SPECTROSCOPY. This technical note describes the construction of a low-cost optical detector. This device is composed by a high-sensitive linear light sensor (model ILX554) and a microcontroller. The performance or the detector was demonstrated by the detection of emission and Raman spectra of the several atomic systems and the results reproduce those found in the literature.

Espectroscopia de íons de Eu+3 como impureza em GdAlO3; Optical spectroscopy of Eu+3 dopped GdAlO3

Padua, Sebastiao Jose Nascimento de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 11/08/1988 PT
Relevância na Pesquisa
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Espectros de absorção, fluorescência e excitação do íon Eu+3 em GdAlO3 na região do visível são mostrados neste trabalho. Todos os níveis 7Fj (j= 0, 1, 2 e 4) e 5Dj (j= 0 a 2) foram medidos e quase todas as transições do íon, na região do visível, foram identificadas nos espectros. A abertura dos níveis de energia verificada está de acordo com a simetria C5 do campo cristalino. Medidas de absorção polarizada foram feitas com o intuito de verificar a natureza das transições de dipolo e para determinar as representações irredutíveis dos níveis de energia 7F0, 7F1 e 5Dj (j= 0 a 2). Linhas da impureza Er+3 (não intencional) foram identificadas no espectro de absorção e sua presença no cristal foi verificada através dos valores conhecidos dos níveis de energia do íon Er+3 em GdAlO3 [III-4]. Além disso, medidas dos níveis de energia 7F2 do íon Eu+3 através da técnica espectroscópica não linear CARS, foram tentadas. Medidas preliminares destes níveis e dos níveis vibracionais do benzeno e da calcita são mostrados no final da dissertação.; Absorption, fluorescence and excitation of the Eu+3 íon in GdAlO3 in the visible region are presented in this work. All of the 7Fj (j= 0, 1, 2 and 4) and 5Dj (j= 0 to 2) energy levels were measured and almost all of the transitions in the visible region of the ion were seen in the spectra. The splitting of energy levels verified is according to the C5 symmetry of the crystal field. Polarized absorption techniques are used to check the nature of the dipole transitions and to determine the irreducible representations of the 7F0...

On observation of the downconversion mechanism in Er3+/Yb3+ co-doped tellurite glass using thermal and optical parameters

Figueiredo, M. S.; Santos, F. A.; Yukimitu, K.; Moraes, J. C. S.; Nunes, L. A. O.; Andrade, L. H. C.; Lima, S. M.
Fonte: Elsevier B.V. Publicador: Elsevier B.V.
Tipo: Artigo de Revista Científica Formato: 365-370
ENG
Relevância na Pesquisa
568.89508%
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Processo FAPESP: 140459/2011-1; Processo FAPESP: 305063/2012-0; Processo FAPESP: 307943/2012-7; Processo FAPESP: 306970/2011-2; Processo FAPESP: 306950/2011-1; In this work we report the observed downconversion (DC) mechanism in Er3+/Yb3+-codoped tellurite glasses (in mol%, 80TeO(2)-10Li(2)O-10TiO(2)). The samples were synthesized by the conventional melt-quenching method and then studied using optical spectroscopy and thermal lens spectroscopy (TLS). These characterizations enabled investigation of the radiative and nonradiative processes involved in energy transfer from erbium to ytterbium. The visible Er3+ fluorescence intensities decreased as a function of the Yb3+ concentration, and there was a corresponding increase in the ytterbium emission at around 980 nm. Simultaneously, there was a reduction in the heat-generated due nonradiative decays (similar to 21%) when ytterbium was added. This temperature change was measured by TLS measurements and the results corroborate with the indicated by spectroscopic interpretation. (C) 2014 Elsevier B.V. All rights reserved.

Utilização da fase para estimativa das propriedades ópticas absolutas do tecido biológico com espectroscopia óptica de difusão; Using the phase to estimate the absolute optical properties of biological tissue with diffuse optical spectroscopy

Reember Cano Rodriguez
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 10/11/2014 PT
Relevância na Pesquisa
675.03766%
A capacidade de observar a fisiologia funcional do tecido humano tem crescido rapidamente nos últimos anos. Entre outras técnicas, destaca-se a espectroscopia óptica de difusão (DOS), uma técnica emergente que utiliza os princípios da difusão de fótons e permite o monitoramento do tecido biológico de forma continua e portátil. A partir da luz (~ 700 - 900 nm) espalhada pelo tecido é possível determinar variações relativas do seu coeficiente de absorção, que estão relacionadas com as concentrações de oxi-hemoglobina (HbO2) e deoxi-hemoglobina (HbR) presentes no sangue. Neste trabalho, utilizamos a técnica de DOS no domínio da frequência, e a informação da defasagem da onda espalhada (em relação _a onda incidida) para determinação das propriedades ópticas absolutas do tecido biológico e, consequentemente, da sua fisiologia. Em particular, comparamos diferentes modelos de propagação da luz no tecido (semi-infinito e duas camadas) e as propriedades ópticas derivadas destes modelos. Além disso, investigamos métodos de calibração do sinal óptico no tecido, do ponto de vista teórico e experimental, mostrando sua aplicabilidade em experimentos com humanos, no estado de repouso e em intervenções cirúrgicas; The ability to observe the functional physiology of human tissue has grown rapidly in recent years. Among other techniques...

Propriedades ótica e estrutural de pontos quânticos de InP embebidos em InGaP; Optical and structural properties of InP quantum dots embedded in InGaP

André Luís Gazoto
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 31/03/2004 PT
Relevância na Pesquisa
568.0225%
Neste trabalho realizamos um estudo sobre a influência da espessura nominal do poço quântico de InP nas propriedades ótica e estrutural de pontos quânticos de InP crescidos sobre InGaP. Foram utilizadas técnicas de espectroscopia ótica como fotoluminescência (PL), microfotoluminescência (?-PL) e fotoluminescência de excitação (PLE), assim como técnicas de caracterização estrutural Reflection High Energy Electron Diffraction (RHEED) e Atomic Force Microscopy (AFM). As questões envolvidas na evolução de um crescimento bidimensional para um tridimensional são investigadas em amostras crescidas pela técnica de Chemical Beam Epitaxy (CBE), utilizando-se o método Stranski-Krastanov de crescimento. Os resultados dessa investigação mostraram que as propriedades ótica e estrutural são fortemente correlacionadas e dependentes da espessura nominal do poço quântico de InP. Por AFM foi possível observar a formação de pontos quânticos a partir da rugosidade superficial do InP. Com o incremento na espessura nominal do poço quântico de InP o sistema evolui para uma configuração bimodal de ilhas pseudomórficas e com forma de tronco de pirâmide, formando assim duas famílias. A transição entre estas famílias se dá com o facetamento das ilhas pseudomórficas a partir de um volume crítico VC de cada ilha. O ponto em que essa transição ocorre pode ser determinado com o aparecimento de estruturas tipo chevron no padrão de difração do RHEED. Ficou claro que a transição de um crescimento bi para tridimensional não é abrupta...

Clinical research device for ovarian cancer detection by optical spectroscopy in the ultraviolet C-visible

George, Ronie; Chandrasekaran, Archana; Brewer, Molly A.; Hatch, Kenneth D.; Utzinger, Urs
Fonte: Society of Photo-Optical Instrumentation Engineers Publicador: Society of Photo-Optical Instrumentation Engineers
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
565.94195%
Early detection of ovarian cancer could greatly increase the likelihood of successful treatment. However, present detection techniques are not very effective, and symptoms are more commonly seen in later stage disease. Amino acids, structural proteins, and enzymatic cofactors have endogenous optical properties influenced by precancerous changes and tumor growth. We present the technical details of an optical spectroscopy system used to quantify these properties. A fiber optic probe excites the surface epithelium (origin of 90% of cases) over 270 to 580 nm and collects fluorescence and reflectance at 300 to 800 nm with four or greater orders of magnitude instrument to background suppression. Up to four sites per ovary are investigated on patients giving consent to oophorectomy and the system’s in vivo optical evaluation. Data acquisition is completed within 20 s per site. We illustrate design, selection, and development of the components used in the system. Concerns relating to clinical use, performance, calibration, and quality control are addressed. In the future, spectroscopic data will be compared with histological biopsies from the corresponding tissue sites. If proven effective, this technique can be useful in screening women at high risk of developing ovarian cancer to determine whether oophorectomy is necessary.

Effects of probe geometry on transscleral diffuse optical spectroscopy

Svenmarker, Pontus; Xu, Can T.; Andersson-Engels, Stefan; Krohn, Jørgen
Fonte: Optical Society of America Publicador: Optical Society of America
Tipo: Artigo de Revista Científica
Publicado em 07/10/2011 EN
Relevância na Pesquisa
566.2226%
The purpose of this study was to investigate how the geometry of a fiber optic probe affects the transmission and reflection of light through the scleral eye wall. Two geometrical parameters of the fiber probe were investigated: the source-detector distance and the fiber protrusion, i.e. the length of the fiber extending from the flat surface of the fiber probe. For optimization of the fiber optic probe geometry, fluorescence stained choroidal tumor phantoms in ex vivo porcine eyes were measured with both diffuse reflectance- and laser-induced fluorescence spectroscopy. The strength of the fluorescence signal compared to the excitation signal was used as a measure for optimization. Intraocular pressure (IOP) and temperature were monitored to assess the impact of the probe on the eye. For visualizing any possible damage caused by the probe, the scleral surface was imaged with scanning electron microscopy after completion of the spectroscopic measurements. A source-detector distance of 5 mm with zero fiber protrusion was considered optimal in terms of spectroscopic contrast, however, a slight fiber protrusion of 0.5 mm is argued to be advantageous for clinical measurements. The study further indicates that transscleral spectroscopy can be safely performed in human eyes under in vivo conditions...

Accuracy of optical spectroscopy for the detection of cervical intraepithelial neoplasia without colposcopic tissue information; a step toward automation for low resource settings

Yamal, Jose-Miguel; Zewdie, Getie A.; Cox, Dennis D.; Neely Atkinson, E.; Cantor, Scott B.; MacAulay, Calum; Davies, Kalatu; Adewole, Isaac; Buys, Timon P. H.; Follen, Michele
Fonte: Society of Photo-Optical Instrumentation Engineers Publicador: Society of Photo-Optical Instrumentation Engineers
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
574.43453%
Optical spectroscopy has been proposed as an accurate and low-cost alternative for detection of cervical intraepithelial neoplasia. We previously published an algorithm using optical spectroscopy as an adjunct to colposcopy and found good accuracy (sensitivity=1.00 [95% confidence interval (CI)=0.92 to 1.00], specificity=0.71 [95% CI=0.62 to 0.79]). Those results used measurements taken by expert colposcopists as well as the colposcopy diagnosis. In this study, we trained and tested an algorithm for the detection of cervical intraepithelial neoplasia (i.e., identifying those patients who had histology reading CIN 2 or worse) that did not include the colposcopic diagnosis. Furthermore, we explored the interaction between spectroscopy and colposcopy, examining the importance of probe placement expertise. The colposcopic diagnosis-independent spectroscopy algorithm had a sensitivity of 0.98 (95% CI=0.89 to 1.00) and a specificity of 0.62 (95% CI=0.52 to 0.71). The difference in the partial area under the ROC curves between spectroscopy with and without the colposcopic diagnosis was statistically significant at the patient level (p=0.05) but not the site level (p=0.13). The results suggest that the device has high accuracy over a wide range of provider accuracy and hence could plausibly be implemented by providers with limited training.

Performance of a lookup table-based approach for measuring tissue optical properties with diffuse optical spectroscopy

Nichols, Brandon S.; Rajaram, Narasimhan; Tunnell, James W.
Fonte: Society of Photo-Optical Instrumentation Engineers Publicador: Society of Photo-Optical Instrumentation Engineers
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
567.1267%
Diffuse optical spectroscopy (DOS) provides a powerful tool for fast and noninvasive disease diagnosis. The ability to leverage DOS to accurately quantify tissue optical parameters hinges on the model used to estimate light-tissue interaction. We describe the accuracy of a lookup table (LUT)-based inverse model for measuring optical properties under different conditions relevant to biological tissue. The LUT is a matrix of reflectance values acquired experimentally from calibration standards of varying scattering and absorption properties. Because it is based on experimental values, the LUT inherently accounts for system response and probe geometry. We tested our approach in tissue phantoms containing multiple absorbers, different sizes of scatterers, and varying oxygen saturation of hemoglobin. The LUT-based model was able to extract scattering and absorption properties under most conditions with errors of less than 5 percent. We demonstrate the validity of the lookup table over a range of source-detector separations from 0.25 to 1.48 mm. Finally, we describe the rapid fabrication of a lookup table using only six calibration standards. This optimized LUT was able to extract scattering and absorption properties with average RMS errors of 2.5 and 4 percent...

Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy

Mastanduno, Michael A.; Jiang, Shudong; DiFlorio-Alexander, Roberta; Pogue, Brian W.; Paulsen, Keith D.
Fonte: Optical Society of America Publicador: Optical Society of America
Tipo: Artigo de Revista Científica
Publicado em 31/08/2012 EN
Relevância na Pesquisa
565.94195%
The design and testing of a new, fully automated, calibration approach is described. The process was used to calibrate an image-guided diffuse optical spectroscopy system with 16 photomultiplier tubes (PMTs), but can be extended to any large array of optical detectors and associated imaging geometry. The design goals were accomplished by developing a routine for robust automated calibration of the multi-detector array within 45 minutes. Our process was able to characterize individual detectors to a median norm of the residuals of 0.03 V for amplitude and 4.4 degrees in phase and achieved less than 5% variation between all the detectors at the 95% confidence interval for equivalent measurements. Repeatability of the calibrated data from the imaging system was found to be within 0.05 V for amplitude and 0.2 degrees for phase, and was used to evaluate tissue-simulating phantoms in two separate imaging geometries. Spectroscopic imaging of total hemoglobin concentration was recovered to within 5% of the true value in both cases. Future work will focus on streamlining the technology for use in a clinical setting with expectations of achieving accurate quantification of suspicious lesions in the breast.

Characterizing human pancreatic cancer precursor using quantitative tissue optical spectroscopy

Lee, Seung Yup; Lloyd, William R.; Chandra, Malavika; Wilson, Robert H.; McKenna, Barbara; Simeone, Diane; Scheiman, James; Mycek, Mary-Ann
Fonte: Optical Society of America Publicador: Optical Society of America
Tipo: Artigo de Revista Científica
Publicado em 14/11/2013 EN
Relevância na Pesquisa
568.6442%
In a pilot study, multimodal optical spectroscopy coupled with quantitative tissue-optics models distinguished intraductal papillary mucinous neoplasm (IPMN), a common precursor to pancreatic cancer, from normal tissues in freshly excised human pancreas. A photon-tissue interaction (PTI) model extracted parameters associated with cellular nuclear size and refractive index (from reflectance spectra) and extracellular collagen content (from fluorescence spectra). The results suggest that tissue optical spectroscopy has the potential to characterize pre-cancerous neoplasms in human pancreatic tissues.

In vivo optical spectroscopy for improved detection of pancreatic adenocarcinoma: a feasibility study

Lloyd, William R.; Wilson, Robert H.; Lee, Seung Yup; Chandra, Malavika; McKenna, Barbara; Simeone, Diane; Scheiman, James; Mycek, Mary-Ann
Fonte: Optical Society of America Publicador: Optical Society of America
Tipo: Artigo de Revista Científica
Publicado em 02/12/2013 EN
Relevância na Pesquisa
568.6442%
Pancreatic adenocarcinoma has a five-year survival rate of less than 6%. This low survival rate is attributed to the lack of accurate detection methods, which limits diagnosis to late-stage disease. Here, an in vivo pilot study assesses the feasibility of optical spectroscopy to improve clinical detection of pancreatic adenocarcinoma. During surgery on 6 patients, we collected spectrally-resolved reflectance and fluorescence in vivo. Site-matched in vivo and ex vivo data agreed qualitatively and quantitatively. Quantified differences between adenocarcinoma and normal tissues in vivo were consistent with previous results from a large ex vivo data set. Thus, optical spectroscopy is a promising method for the improved diagnosis of pancreatic cancer in vivo.

Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue

Valdes, Claudia P.; Varma, Hari M.; Kristoffersen, Anna K.; Dragojevic, Tanja; Culver, Joseph P.; Durduran, Turgut
Fonte: Optical Society of America Publicador: Optical Society of America
Tipo: Artigo de Revista Científica
Publicado em 23/07/2014 EN
Relevância na Pesquisa
565.94195%
We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep tissue blood flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using liquid phantoms which demonstrate that SCOS is capable of measuring the dynamic properties of turbid media non-invasively. We further present an in vivo measurement in a human forearm muscle using SCOS in two modalities: one with the dependence of the speckle contrast on the source-detector separation and another on the exposure time. In doing so, we also introduce crucial corrections to the speckle contrast that account for the variance of the shot and sensor dark noises.

In Vivo Tissue Diagnosis for Myocardial Infarction Using Optical Spectroscopy with Novel Spectral Interpretation Algorithms

Chen, Po-Ching
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
Relevância na Pesquisa
574.43453%
In recent decades, the rapid development of optical spectroscopy for tissue diagnosis has been indicative of its high clinical value. The goal of this research is to prove the feasibility of using diffuse reflectance spectroscopy and fluorescence spectroscopy to assess myocardial infarction (MI) in vivo. The proposed optical technique was designed to be an intra-operative guidance tool that can provide useful information about the condition of an infarct for surgeons and researchers. In order to gain insight into the pathophysiological characteristics of an infarct, two novel spectral analysis algorithms were developed to interpret diffuse reflectance spectra. The algorithms were developed based on the unique absorption properties of hemoglobin for the purpose of retrieving regional hemoglobin oxygenation saturation and concentration data in tissue from diffuse reflectance spectra. The algorithms were evaluated and validated using simulated data and actual experimental data. Finally, the hypothesis of the study was validated using a rabbit model of MI. The mechanism by which the MI was induced was the ligation of a major coronary artery of the left ventricle. Three to four weeks after the MI was induced, the extent of myocardial tissue injury and the evolution of the wound healing process were investigated using the proposed spectroscopic methodology as well as histology. The correlations between spectral alterations and histopathological features of the MI were analyzed statistically. The results of this PhD study demonstrate the applicability of the proposed optical methodology for assessing myocardial tissue damage induced by MI in vivo. The results of the spectral analysis suggest that connective tissue proliferation induced by MI significantly alter the characteristics of diffuse reflectance and fluorescence spectra. The magnitudes of the alterations could be quantitatively related to the severity and extensiveness of connective tissue proliferation.

In Vivo characterization of Epileptic Tissue with Optical Spectroscopy

Yadav, Nitin
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
Relevância na Pesquisa
675.4231%
For children with intractable seizures, surgical removal of epileptic foci, if identifiable and feasible, can be an effective way to reduce or eliminate seizures. The success of this type of surgery strongly hinges upon the ability to identify and demarcate those epileptic foci. The ultimate goal of this research project is to develop an effective technology for detection of unique in vivo pathophysiological characteristics of epileptic cortex and, subsequently, to use this technology to guide epilepsy surgery intraoperatively. In this PhD dissertation the feasibility of using optical spectroscopy to identify unique in vivo pathophysiological characteristics of epileptic cortex was evaluated and proven using the data collected from children undergoing epilepsy surgery. In this first in vivo human study, static diffuse reflectance and fluorescence spectra were measured from the epileptic cortex, defined by intraoperative ECoG, and its surrounding tissue from pediatric patients undergoing epilepsy surgery. When feasible, biopsy samples were taken from the investigated sites for the subsequent histological analysis. Using the histological data as the gold standard, spectral data was analyzed with statistical tools. The results of the analysis show that static diffuse reflectance spectroscopy and its combination with static fluorescence spectroscopy can be used to effectively differentiate between epileptic cortex with histopathological abnormalities and normal cortex in vivo with a high degree of accuracy. To maximize the efficiency of optical spectroscopy in detecting and localizing epileptic cortex intraoperatively...

Accuracy of optical spectroscopy for the detection of cervical intraepithelial neoplasia without colposcopic tissue information; a step toward automation for low resource settings

Yamal, Jose-Miguel; Zewdie, Getie A.; Cox, Dennis D.; Atkinson, E. Neely; Cantor, Scott B.; MacAulay, Calum; Davies, Kalatu; Adewole, Isaac; Buys, Timon P. H.; Follen, Michele
Fonte: Universidade Rice Publicador: Universidade Rice
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
574.43453%
Optical spectroscopy has been proposed as an accurate and low-cost alternative for detection of cervical intraepithelial neoplasia. We previously published an algorithm using optical spectroscopy as an adjunct to colposcopy and found good accuracy (sensitivity ¼ 1.00 [95% confidence interval ðCIÞ ¼ 0.92 to 1.00], specificity ¼ 0.71 [95% CI ¼ 0.62 to 0.79]). Those results used measurements taken by expert colposcopists as well as the colposcopy diagnosis. In this study, we trained and tested an algorithm for the detection of cervical intraepithelial neoplasia (i.e., identifying those patients who had histology reading CIN 2 or worse) that did not include the colposcopic diagnosis. Furthermore, we explored the interaction between spectroscopy and colposcopy, examining the importance of probe placement expertise. The colposcopic diagnosis-independent spectroscopy algorithm had a sensitivity of 0.98 (95% CI ¼ 0.89 to 1.00) and a specificity of 0.62 (95% CI ¼ 0.52 to 0.71). The difference in the partial area under the ROC curves between spectroscopy with and without the colposcopic diagnosis was statistically significant at the patient level (p ¼ 0.05) but not the site level (p ¼ 0.13). The results suggest that the device has high accuracy over a wide range of provider accuracy and hence could plausibly be implemented by providers with limited training.

Hyperspectral imaging for diagnosis and quality control in agri-food and industrial sectors

García Allende, Pilar Beatriz; Conde Portilla, Olga María; Mirapeix Serrano, Jesús María; Cobo García, Adolfo; López Higuera, José Miguel
Fonte: SPIE Society of Photo-Optical Instrumentation Engineers Publicador: SPIE Society of Photo-Optical Instrumentation Engineers
Tipo: info:eu-repo/semantics/conferenceObject; publishedVersion
ENG
Relevância na Pesquisa
572.9571%
Optical spectroscopy has been utilized in various fields of science, industry and medicine, since each substance is discernible from all others by its spectral properties. However, optical spectroscopy traditionally generates information on the bulk properties of the whole sample, and mainly in the agri-food industry some product properties result from the heterogeneity in its composition. This monitoring is considerably more challenging and can be successfully achieved by the so-called hyperspectral imaging technology, which allows the simultaneous determination of the optical spectrum and the spatial location of an object in a surface. In addition, it is a nonintrusive and non-contact technique which gives rise to a great potential for industrial applications and it does not require any particular preparation of the samples, which is a primary concern in food monitoring. This work illustrates an overview of approaches based on this technology to address different problems in agri-food and industrial sectors. The hyperspectral system was originally designed and tested for raw material on-line discrimination, which is a key factor in the input stages of many industrial sectors. The combination of the acquisition of the spectral information across transversal lines while materials are being transported on a conveyor belt...

Spectroscopic Polymer Optical Fiber sensor for orbital arc-welding on-line monitoring

Cobo García, Adolfo; Mirapeix Serrano, Jesús María; Valdiande Gutiérrez, José Julián; García Allende, Pilar Beatriz; Conde Portilla, Olga María; López Higuera, José Miguel
Fonte: Universidade de Cantabria Publicador: Universidade de Cantabria
Tipo: info:eu-repo/semantics/conferenceObject; publishedVersion
ENG
Relevância na Pesquisa
568.7236%
Plasma optical spectroscopy has proved to be a promising solution for the on-line monitoring of both laser and arc-welding processes, where quality assurance plays a mayor role, especially in some particular industrial scenarios like aeronautics. Despite the robustness provided by these spectroscopic analysis techniques, the implementation of an efficient and non-invasive optical sensor system is not always feasible. Input optics based on optical collimators are commonly employed, but when complex shapes are to be welded, or specific welding processes are being considered, a different approach must be designed. In this paper we propose an optical sensor based on the use of a Polymer Optical Fiber (POF) as the input optics. The external protection of the POF is removed, providing an acquisition of the plasma radiation from the fiber cladding. Experimental welding tests will show the feasibility of the proposed POF sensor.