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The degradation behaviour of nanoscale HA/PLGA and ?-TCP/PLGA composites

Ege, Duygu; Best, Serena; Cameron, Ruth
Fonte: ICE Publishing Publicador: ICE Publishing
Tipo: Article; published version
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This is the final published article and will be under embargo until the 11th of January 2015. It was originally published by Bioinspired, Biomimetics and Nanobiomaterials (http://www.icevirtuallibrary.com/content/journals). Permission is granted by ICE Publishing to print one copy for personal use. Any other use of these PDF files is subject to reprint fees.; The aim of this work was to prepare and analyze the degradation properties of pure PLGA, homogeneous ?-tricalcium phosphate (?-TCP)/PLGA and hydroxyapatite (HA)/PLGA composites for potential bone replacement applications. ?-TCP and HA powders were prepared in-house and 25 nominal wt% of calcium phosphate (CaP) powder was incorporated into commercially available PLGA pellets by twin screw extrusion. The degradation studies showed that pure PLGA had the fastest degradation rate followed by HA/PLGA and $\alpha$-TCP/PLGA. Overall, it was found that ?-TCP acted as a better buffering agent than HA, resulting in reduced acid group autocatalysis and hence a slower degradation rate.; Other