In vivo dosimetry with thermoluminescent dosimeters in external photon beam radiotherapy
Proposal of a Brazilian accreditation program for personal dosimetry using OSL
Dosimetria usando luminecência opticamente estimulada: aplicações, propriedades físicas e caracterização de materiais dosimétricos; Dosimetry using optically stimulated luminescence: applications, physical properties and dosimeter detectors characterization
Estudo de parâmetros dosimétricos e dosimetria in vivo em radioterapia; Study of dosimetric parameters and in vivo dosimetry in Radiotherapy
Implementação de um sistema dosimétrico termoluminescente para utilização em dosimetria in vivo em teleterapia com feixes de fótons de energia alta; Implementation of a thermoluminescent dosimetric system for use in in vivo dosimetry on radiotherapy with external high energy photon beams
Utilização da dosimetria opticamente estimulada (OSL) na avaliação de parâmetros de qualidade de feixe em radioterapia; Utilization of optically stimulated dosimetry (OSL) to evaluate beam parameters of quality in radiotherapy
Síntese e caracterização de elemento sensor de matriz KAISi3O8, dopadas com Mn ou Gd, obtidos pela técnica sol-gel, visando a aplicação em dosimetria das radiações ionizantes por termoluminescência e luminescência opticamente estimulada.; Synthesis and caracterization of sensor element of kalSi3O8 matrix, doped with mn and gd, obtained by sol-gel method, for application in ionizing radiation dosimetry by thermoluminescence and optically stimulated luminescence.
Avaliação do dispositivo eletrônico de imagem portal "Portal Dosimetry" no controle de qualidade de radioterapia de intensidade modulada; Evaluation of electronic imaging device portal "Portal Dosimetry" in quality control in intensity modulated radiotherapy
Avaliação da resposta de detectores termoluminescentes na dosimetria de feixes clínicos utilizando diferentes objetos simuladores; Response evaluation of thermoluminescent detectors in clinical beams dosimetry using different phantoms
Estudo e validação da dosimetria em condições de não-referência; Estudy and validation of dosimetry in non-reference conditions
Desenvolvimento do dosímetro termoluminescente de CaSO4:Ce, Eu para a monitoração individual e a dosimetria clínica de fótons e elétrons; Development of CaSO4:Ce,Eu thermoluminescent dosimeters for individual monitoring for external exposures and clinical dosimetry
Dosimetria gel no controle de qualidade tridimensional para radioterapia de intensidade modulada (IMRT) de próstata; Gel dosimetry in three-dimensional quality control for Intensity Modulated Radiation Therapy (IMRT) for Prostate
Avaliação de parâmetros dosimétricos de fontes de braquiterapia utilizando simulação Monte Carlo e dosimetria gel polimérica; Evaluation of Dosimetric Parameters of Brachytherapy Sources Using Monte Carlo Simulation and Polymer Gel Dosimetry.
A theoretical evaluation of transmission dosimetry in 3D conformal radiotherapy.
The use of a treatment planning system to investigate the potential for transmission dosimetry in detecting patient breathing during breast 3D CRT
Development of a Novel Readout System for Radiochromic Film Dosimetry
Quantitative 3D Optical Imaging: Applications in Dosimetry and Biophysics
Optical-CT has been shown to be a potentially useful imaging tool for for the two very different spheres of biologists and radiation therapy physicists, but it has yet to live up to that potential. In radiation therapy, researchers have used optical-CT for the readout of 3D dosimeters, but it is yet to be a clinically relevant tool as the technology is too slow to be considered practical. Biologists have used the technique for structural imaging, but have struggled with emission tomography as the reality of photon attenuation for both excitation and emission have made the images quantitatively irrelevant.
Microbeam-Radiation-Therapy (MRT): Characterizing a Novel MRT Device Using High Resolution 3D Dosimetry
Purpose:
The feasibility of MRT has recently been demonstrated utilizing a new technology of Carbon-Nano-Tube (CNT) field emission x-ray sources. This approach can deliver very high dose (10's of Gy) in narrow stripes (sub-mm) of radiation, which enables the study of novel radiation treatment approaches. Here we investigate the application of high- resolution (50𝑢𝑚 isotropic) PRESAGE®/Optical-CT 3D dosimetry techniques to characterize the radiation delivered in this extremely dosimetrically challenging scenario.
Methods:
The CNT field emission x-ray source irradiator comprises of a linear cathode array and a novel collimating system. The device delivers small `stripe' beams of approximately X long and Y wide, at an energy of 160 kVp. To characterize the MRT beams, an ultra-high-resolution prototype 3D dosimetry system was constructed and optimized, consisting of two parts: a radiochromic 3D dosimetry material PRESAGE, and a high resolution small field-of-view optical-CT imaging system for dose-readout (DMicrOS - Duke Micro Optical-CT Scanner). Small PRESAGE cylindrical dosimeters (~2.2cm in height and ~2.5cm in diameter) were irradiated by CNT MRT delivering 3 stripes of radiation with a nominal entrance dose of 32 Gy (16Gy for the second batch). PRESGAE dosimeters (with same dimensions) were also irradiated with at 32 Gy entrance dose...
Clinical and Research Applications of 3D Dosimetry
Quality assurance (QA) is a critical component of radiation oncology medical physics for both effective treatment and patient safety, particularly as innovations in technology allow movement toward advanced treatment techniques that require increasingly higher accuracy in delivery. Comprehensive 3D dosimetry with PRESAGE® 3D dosimeters read out via optical CT has the potential to detect errors that would be missed by current systems of measurement, and thereby improve the rigor of current QA techniques through providing high-resolution, full 3D verification for a wide range of clinical applications. The broad objective of this dissertation research is to advance and strengthen the standards of QA for radiation therapy, both by driving the development and optimization of PRESAGE® 3D dosimeters for specific clinical and research applications and by applying the technique of high resolution 3D dosimetry toward addressing clinical needs in the current practice of radiation therapy. The specific applications that this dissertation focuses on address several topical concerns: (1) increasing the quality, consistency, and rigor of radiation therapy delivery through comprehensive 3D verification in remote credentialing evaluations, (2) investigating a reusable 3D dosimeter that could potentially facilitate wider implementation of 3D dosimetry through improving cost-effectiveness...
Toward Accurate Small Animal Dosimetry and Irradiator Quality Assurance
Purpose: To demonstrate specific methods of small animal dosimetry and quality assurance through (1) machine-specific quality assurance and (2) target-specific quality assurance (QA) protocols for different types of biological irradiators: (a) a large-field orthovoltage irradiator, (b) a small-field orthovoltage irradiator, and (c) a
Materials and Methods: (1) Machine-specific QA: (a) Large-field irradiator: Dose measurements were performed with an ion chamber and include: beam profile measurements at 50 cm SSD, linearity of output, in-air output for various irradiation settings, and light and radiation field coincidence measurement. A kVp meter was used to measure kVp and HVL for different irradiation settings. (b) Small-field irradiator: Dose measurements were completed using an ion chamber and MOSFET dosimeters. For the diagnostic mode measurements, the ion chamber was placed on the irradiation table and various diagnostic protocols were measured including table attenuation. MOSFETs were used to measure the backscatter factors (BSF) for various collimator sizes under therapy mode.
(2) Target-specific QA: (a) Large-field irradiator: A tissue-equivalent mouse phantom (2 cm diameter...