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TiO2 nanoparticles as carries of 225Ac/213Bi in vivo generator

Fonte: Oak Ridge National Laboratory Publicador: Oak Ridge National Laboratory
Tipo: Contributions to Conferences Formato: Printed
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Alpha particle emitting isotopes are in considerable interest for radionuclide therapy because of their high cytotoxicity and short path length. Unfortunately, all available emitters have serious disadvantages: 211At forms weak bond with carbon atoms in the biomolecule and in the case of 212Bi and 213Bi short half-life often limits the application of these nuclides. However, the short half-life of 212Bi and 213Bi could be effectively lengthened by binding the parent radionuclide 212Pb (t1/2 = 10.6 h) or 225Ac (t1/2 = 10 d) to the biomolecule, thereby effectively extending the use of short half-life 212Bi and 213Bi. In addition, in vivo generator delivers much greater dose per unit of administered activity compared to 212Bi and 213Bi alone. In our studies we investigated the use of TiO2 nanoparticles as potential carriers for 225Ac/213Bi in vivo generator. The TiO2 nanoparticles have unique properties like: high specific surface, high affinity for multivalent cations and simple way of synthesis, which are useful in the process of labelling. Commercially available (e.g. P-25 Degussa) and synthesised in our laboratory nanoparticles were used in experiments. The nanoparticles were characterized by TEM, SEM, DLS and NanoSight techniques. In our experiments we tested two different methods of labelling. The first one was based on the possibility of formation strong bonds with certain cations on the surface of the nanopraticles. In the second one...