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Engineering biomolecular microenvironments for cell instructive biomaterials

Custódio, Catarina Almeida; Reis, R. L.; Mano, J. F.
Fonte: Universidade do Minho Publicador: Universidade do Minho
Tipo: Artigo de Revista Científica
Publicado em /01/2014 ENG
Relevância na Pesquisa
36.88%
Engineered cell instructive microenvironments with the ability to stimulate specific cellular responses is a topic of high interest in the fabrication and development of biomaterials for application in tissue engineering. Cells are inherently sensitive to the in vivo microenvironment that is often designed as the cell “niche”. The cell “niche” comprising the extracellular matrix and adjacent cells, influences not only cell architecture and mechanics, but also cell polarity and function. Extensive research has been performed to establish new tools to fabricate biomimetic advanced materials for tissue engineering that incorporate structural, mechanical and biochemical signals that interact with cells in a controlled manner and to recapitulate the in vivo dynamic microenvironment. Bioactive tunable microenvironments using micro and nanofabrication have been successfully developed and proven to be extremely powerful to control intracellular signaling and cell function. This review is focused in the assortment of biochemical signals that have been explored to fabricate bioactive cell microenvironments and the main technologies and chemical strategies to encode them in engineered biomaterials with biological information.

The intersection between chemical and biomedical engineering: green technologies towards the development of enhanced biomaterials

Duarte, Ana Rita C.; Reis, R. L.
Fonte: Universidade do Minho Publicador: Universidade do Minho
Tipo: Conferência ou Objeto de Conferência
Publicado em /09/2015 ENG
Relevância na Pesquisa
36.88%
Despite the advances on biomaterials development and polymer processing technologies, this remains still one of the major scientific challenges that tissue engineering and regenerative medicine (TERM) faces to go from benchtop to bedside. Ideal scaffolds should be biocompatible, biodegradable and promote cellular interactions and tissue development and possess proper mechanical and physical properties. The preparation of 3D matrices must result, hereafter in structures with adequate porosity, interconnectivity, pore size distribution and compression properties which make then suitable for the tissue to be engineered. A wide range of biomaterials has been proposed for biomedical applications, from metals to ceramics and polymers. Due to their versatility, polymers are the straightforward choice. These must comply with different requirements such as hydrophilicity, biocompatibility, degradation rate, citotoxicity, among others. The use of natural based polymers in tissue engineering and regenerative medicine applications has long been proposed, precisely due to their chemical/biological versatility. Nonetheless, its processing using supercritical fluids only recently has started to received more attention from researchers. Supercritical fluids appear as an interesting alternative to the conventional methods for processing biopolymers as they do not require the use of large amounts of organic solvents and the processes can be conducted at mild temperatures. Different processing methods based on the use of supercritical carbon dioxide have been proposed for the creation of novel architectures able to fulfill the particular needs of each tissue to be regenerated and these will be unleashed in this presentation.