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Involvement of mitochondria in apoptosis of cancer cells induced by photodynamic therapy

Ribeiro,Joselito Nardy; Silva,André Romero da; Jorge,Renato Atilio
Fonte: Sociedade Brasileira de Patologia Clínica; Sociedade Brasileira de Patologia; Sociedade Brasileira de Citopatologia Publicador: Sociedade Brasileira de Patologia Clínica; Sociedade Brasileira de Patologia; Sociedade Brasileira de Citopatologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2004 EN
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Photodynamic therapy (PDT), a promising cancer treatment that employs a combination of a photosensitizing chemical, oxygen, and visible light, induces apoptosis in tumor cells. However, the precise mechanism of PDT-induced apoptosis is not well characterized. Many of the photosensitizers currently in clinical or pre-clinical studies of PDT are localized in or have a major influence on mitochondria. The treatment with PDT causes mitochondrial damage and induces apoptosis through the release of cytochrome c (cyt c), apoptosis-inducing factor (AIF), Smac/DIABLO and certain procaspases. Proapoptotic and antiapoptotic members of BcL-2 family regulate the release of these proteins from mitochondria. The purpose of this mini-review is to present some recent publications that focus on the involvement of the mitochondria in apoptosis of cancer cells induced by PDT.

The susceptibility of Streptococcus mutans to antibacterial photodynamic therapy: a comparison of two different photosensitizers and light sources

HAKIMIHA,Neda; KHOEI,Farzaneh; BAHADOR,Abbas; FEKRAZAD,Reza
Fonte: Faculdade De Odontologia De Bauru - USP Publicador: Faculdade De Odontologia De Bauru - USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2014 EN
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Streptococcus mutans is the main etiological agent for dental caries. Recently, photodynamic therapy (PDT) has been introduced as a new modality in bacterial decontamination. Objective: This in vitro study was carried out to evaluate the susceptibility of Streptococcus mutans to antibacterial PDT using two different photosensitizers and light sources. Material and Methods: Standard suspensions of S. mutans were exposed to laser light at 662 nm and Radachlorin® or LED 630 nm in combination with Toluidine blue O (TBO). Radiation-only groups, photosensitizer alone, and groups with no treatment were used as controls. Bacterial suspension from each treatment was subcultured onto the surface of Mueller-Hinton agar plates and bacterial growth was assessed. The results were analyzed by analysis of variance and Tukey test (p<0.05). Results: PDT with TBO and Radachlorin® significantly reduced S. mutans viability, whereas no difference was observed between two groups of PDT. In the groups treated just with the photosensitizer or irradiated alone, no significant reduction of S. mutans colonies was observed. Conclusion: S. mutans colonies were susceptible to either 662 nm laser or LED light in the presence of Radachlorin® and TBO respectively with no priority.

Influence of ceramide 2 on in vitro skin permeation and retention of 5-ALA and its ester derivatives, for Photodynamic Therapy

Pierre,Maria Bernadete Riemma; Lopez,Renata Fonseca Vianna; Bentley,Maria Vitória Lopes Badra
Fonte: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas Publicador: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2009 EN
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Photodynamic therapy (PDT) based on topical 5-aminolevulinic acid (5-ALA), an endogenous precursor of protoporphyrin, is an interesting approach for the treatment of skin cancer. However, 5-ALA is a hydrophilic molecule and such a characteristic limits its appropriate cutaneous penetration and retention. In this way, more lipophilic molecules, such as esterified 5-ALA derivatives, have been under investigation in order to improve the skin penetration of this molecule. Drug formulation can also alter 5-ALA skin penetration. Therefore, the aim of this work was to study the influence of ceramide 2 - the main lipid of the SC- on the cutaneous delivery of 5-ALA and its ester derivatives in vitro, using Franz diffusion cell. The skin permeation of all studied drugs was decreased in the presence of ceramide, representing a desirable characteristic in order to avoid the risk of systemic side effects. Nevertheless, the SC and [epidermis + dermis] retention after 16 h has also been decreased in the presence of ceramide, as compared to control. In conclusion, ceramide was not a good adjuvant, meaning that research of other vehicles could be useful to improve cutaneous delivery of 5-ALA.

Current Status of Photodynamic Therapy for Bile Duct Cancer

Lee, Tae Yoon; Cheon, Young Koog; Shim, Chan Sup
Fonte: The Korean Society of Gastrointestinal Endoscopy Publicador: The Korean Society of Gastrointestinal Endoscopy
Tipo: Artigo de Revista Científica
EN
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The most common form in bile duct cancers is a highly desmoplastic cancer with a growth pattern characterized by periductal extension and infiltration. The prognosis of bile duct cancers, especially hilar cholangiocarcinoma, is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Although biliary endoprosthesis improves occlusion rates and reduces the number of therapeutic interventions, median survival time is not ameliorated. Photodynamic therapy (PDT) is a local photochemical tumor treatment that consists of a photosensitizing agent in combination with laser irradiation of a distinct wavelength. Tumor ablation with PDT combined with biliary stenting reduces cholestasis and significantly improves median survival time in selected patients with bile duct cancers.

Current evidence and applications of photodynamic therapy in dermatology

Wan, Marilyn T; Lin, Jennifer Y
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Artigo de Revista Científica
EN_US
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In photodynamic therapy (PDT) a photosensitizer – a molecule that is activated by light – is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered to the skin, it should come as no surprise that PDT is an increasingly utilized therapeutic in dermatology. PDT is used commonly to treat precancerous cells, sun-damaged skin, and acne. It has reportedly also been used to treat other conditions including inflammatory disorders and cutaneous infections. This review discusses the principles behind how PDT is used in dermatology, as well as evidence for current applications of PDT.

Bioluminescence-Activated Deep-Tissue Photodynamic Therapy of Cancer

Kim, Yi Rang; Kim, Seonghoon; Choi, Jin Woo; Choi, Sung Yong; Lee, Sang-Hee; Kim, Homin; Hahn, Sei Kwang; Koh, Gou Young; Yun, Seok Hyun
Fonte: Ivyspring International Publisher Publicador: Ivyspring International Publisher
Tipo: Artigo de Revista Científica
EN_US
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Optical energy can trigger a variety of photochemical processes useful for therapies. Owing to the shallow penetration of light in tissues, however, the clinical applications of light-activated therapies have been limited. Bioluminescence resonant energy transfer (BRET) may provide a new way of inducing photochemical activation. Here, we show that efficient bioluminescence energy-induced photodynamic therapy (PDT) of macroscopic tumors and metastases in deep tissue. For monolayer cell culture in vitro incubated with Chlorin e6, BRET energy of about 1 nJ per cell generated as strong cytotoxicity as red laser light irradiation at 2.2 mW/cm2 for 180 s. Regional delivery of bioluminescence agents via draining lymphatic vessels killed tumor cells spread to the sentinel and secondary lymph nodes, reduced distant metastases in the lung and improved animal survival. Our results show the promising potential of novel bioluminescence-activated PDT.

Die Pigmentepithelabhebung als Form der altersabhängigen Makuladegeneration - Ein Vergleich der Behandlungsmethoden: Photodynamische Therapie und Makulatranslokation; Retinal pigment epithelium detachment in age-related macular degeneration - comparison of treatment with photodynamic therapy and macula translocation

Völker, Michael
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
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Die altersabhängige Makuladegeneration (AMD) ist die Hauptursache eines fortschreitenden Visusverlustes bei Erwachsenen höheren Alters. Pigmentepithelabhebungen treten als Sekundärkomplikation im Rahmen verschiedener Pathologien der AMD auf. Die vorliegende Arbeit vergleicht die Effektivität der Photodynamischen Therapie und der Makulatranslokation bei der Behandlung dieses Krankheitsbildes.; Exsudative age-related macular degeneration (AMD) is the major cause of severe visual loss in older adults. Various changes secondary to AMD may result in elevation or detachment of the retinal pigment epithelium. The present study compares the effectiveness of verteporfin photodynamic therapy and macular translocation.

Systematische in vitro Charakterisierung des Photosensibilisators Hypericin für die Photodynamische Therapie von malignen Gliomen; Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines

Wein, Hannah Teresa
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
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Gliome imponieren morphologisch durch Heterogenität und diffus-infiltrierendes Wachstum. Die Prognose ist bei einer mittleren Überlebenszeit von weniger als 6 Monaten erschreckend. Somit ist eine exakte nicht nur präoperative, sondern vor allem intraoperative Tumoridentifizierung und -lokalisierung für einen radikalen chirurgischen Eingriff erforderlich. Weiterhin sind suffizientere adjuvante Therapieformen zur Verlängerung der Überlebenszeit, und auch für eine humane palliative Verbesserung der Lebensqualität gefragt. Die photodynamische Therapie ist ein hierfür geeignetes Verfahren in der Tumortherapie, welches Tumorgewebe selektiv zu schädigen vermag. Als Fluoreszenzmarker und auch als Photosensibilisator ist die Substanz Hypericin optimal für eine intraoperative wie auch adjuvante photodynamische Anwendung bei malignen Gliomen. Diese These konnte im Rahmen dieser Arbeit mittels einer standardisierten in-vitro-Charakterisierung von Hypericin unter Anwendung quantitativer (FACS) und qualitativer Messverfahren (Fluoreszenzmikroskopie) bestätigt werden. Bei der Evaluation der optimalen Inkubationskonzentration für alle weiteren Experimente erwiesen sich 2.5 microM Hypericin unter dem Aspekt einer geringen Zytotoxizität am optimalsten. Die zytotoxischen Effekte von Hypericin erwiesen sich bei allen Experimenten als äußerst gering und waren allenfalls bei ansteigenden Inkubationskonzentrationen (> 5 microM) oder längeren Inkubationszeiten (24 Stunden) zu beobachten. Die Zellvitalität betrug hierbei jedoch für sämtliche Versuche und alle Zelllinien nie weniger als 87...

Einsatz von Hypericin zur in-vitro photodynamischen Therapie von kindlichen Lebertumoren; In vitro photodynamic therapy in pediatric epithelial liver tumors promoted by hypericin

Krause, Renita Bianca
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
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Beim Hepatoblastom und kindlichem Hepatozellulären Karzinom handelt es sich um epitheliale Lebertumore, die über 90% aller kindlichen hepatischen Malignome darstellen. Den wichtigsten prognostischen Faktor für das Überleben dieser Patienten stellt die vollständige chirurgische Resektion des Tumors dar. Für die Therapie von multifokalen Tumoren bestehen noch ungelöste Probleme, so dass der Erforschung alternativer Therapiestrategien besondere Bedeutung zukommt. Einen neuen Ansatz könnte die Photodynamische Therapie (PDT) mit photoaktiviertem Hypericin darstellen. Hypericin wird aus Johanneskraut (Hypericum perforatum) gewonnen. Es wurde bereits in mehreren Studien bei den verschiedensten Tumorarten erfolgreich als kurative Therapieoption eingesetzt. Aufgrund dieser Erfahrungen ist die Möglichkeit der PDT auch für die Behandlung von kindlichen Lebertumoren von potentiellem Interesse. Der Grundgedanke dieser Studie war die Entwicklung der wissenschaftlichen Grundlagen für eine photodynamische Behandlung mit Hypericin bei kindlichen Lebertumoren, mit dem Ziel die Prognose zu verbessern, den chirurgischen Eingriff zu vereinfachen und eine R0 – Resektionen zu ermöglichen. Zielsetzung der vorliegenden Arbeit ist daher zum einen die Untersuchung...

Superficial radially resolved fluorescence and 3D photochemical time-dependent model for photodynamic therapy

Salas García, Irene; Fanjul Vélez, Félix; Arce Diego, José Luis
Fonte: The Optical Society (OSA) Publicador: The Optical Society (OSA)
Tipo: info:eu-repo/semantics/article; publishedVersion
ENG
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Photodynamic therapy (PDT) dosimetric tools are crucial for treatment planning and noninvasive monitoring by means of fluorescence. Present approaches consider usually a 1D problem, a simple photochemical process, or a spatially homogeneous photosensitizer. In this work, a radially resolved superficial photosensitizer fluorescence and 3D photochemical time-dependent PDT model are presented. The model provides a time-dependent estimation of tissue fluorescence and the photosensitizer and singlet oxygen 3D concentrations. The model is applied to a basal cell carcinoma treated by Metvix topical photosensitizer protocol. The analysis shows the potentiality in treatment planning and monitoring. The fluorescence results are in agreement with previous measurements.

Photochemical model of Photodynamic Therapy applied to skin diseases by a topical photosensitizer

Fanjul Vélez, Félix; Salas García, Irene; Fernández Fernández, Luis Alberto; López-Escobar García-Prendes, María; Buelta Carrillo, Luis; Ortega Quijano, Noé; Arce Diego, José Luis
Fonte: The Optical Society (OSA)-; SPIE Society of Photo-Optical Instrumentation Engineers Publicador: The Optical Society (OSA)-; SPIE Society of Photo-Optical Instrumentation Engineers
Tipo: info:eu-repo/semantics/conferenceObject; publishedVersion
ENG
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Photodynamic Therapy (PDT) provides a non-invasive, efficient and safe treatment for skin diseases with good cosmetic results. These characteristics make this technique more advantageous than radiotherapy or chemotherapy, which present limitations in a big number of lesions, are painful in many cases and produce non-satisfactory cosmetic results. We present the clinical results obtained at present by this optical technique and a photochemical model of the PDT process applied to the skin by means of a topical photosensitizer, in order to find the optimal PDT parameters. Optical propagation inside the tissue is calculated by means of the three dimensional Beer-Lambert law, due to its facility to be integrated in the differential equations system used to model the photochemical processes involved. With this information it is possible to obtain an initial estimation about the optimal drug dose and the optical power required.

Photodynamic therapy with topical methyl aminolaevulinate for 'difficult-to-treat' basal cell carcinoma

Vinciullo, C.; Elliott, T.; Francis, D.; Gebauer, F.; Spelman, L.; Nguyen, R.; Weightman, W.; Sheridan, A.; Reid, C.; Czarnecki, D.; Murrell, D.
Fonte: Blackwell Science Ltd Publicador: Blackwell Science Ltd
Tipo: Artigo de Revista Científica
Publicado em //2005 EN
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Background: Basal cell carcinoma (BCC) may be difficult to treat by conventional means, particularly if the lesions are large or located in the mid-face (H-zone). Photodynamic therapy (PDT) using topical methyl aminolaevulinate (MAL) may be a good noninvasive option for these patients. Objectives: To investigate the efficacy and safety of PDT using MAL for BCCs defined as ‘difficult to treat’, i.e. large lesions, in the H-zone, or in patients at high risk of surgical complications. Methods: This was a prospective, multicentre, noncomparative study. Patients were assessed 3, 12 and 24 months after the last PDT treatment. One hundred and two patients with ‘difficult-to-treat’ BCC were treated with MAL PDT, using 160 mg g−1 cream and 75 J cm−2 red light (570–670 nm), after lesion preparation and 3 h of cream exposure. Results: Ninety-five patients with 148 lesions were included in the per protocol analysis. The histologically confirmed lesion complete response rate at 3 months was 89% (131 of 148). At 12 months, 10 lesions had reappeared, and therefore the cumulative treatment failure rate was 18% (27 of 148). At 24 months, an additional nine lesions had reappeared, resulting in a cumulative treatment failure rate of 24% (36 of 148). The estimated sustained lesion complete response rate (assessed using a time-to-event approach) was 90% at 3 months...

Singlet oxygen quantum yields from halogenated chlorins: potential new photodynamic therapy agents

Pineiro, Marta; Pereira, Mariette M.; Rocha Gonsalves, A. M. d'A.; Arnaut, Luis G.; Formosinho, Sebastião J.
Fonte: Universidade de Coimbra Publicador: Universidade de Coimbra
Tipo: Artigo de Revista Científica Formato: aplication/PDF
ENG
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Flash photolysis and photoacoustic calorimetry were used to measure the energy-transfer rates and singlet oxygen quantum yields originated by the triplet states of halogenated tetrakisphenylporphyrins and related chlorins in aerated toluene. The chlorins ([lambda]max[approximate]660 nm, [var epsilon][approximate]3×104 M-1 cm-1) have long-lived triplet states (>12 [mu]s) in the absence of molecular oxygen, and in its presence the singlet oxygen production quantum yields of the 2-chloro and 2,6-dichlorophenyl derivatives are 0.89±0.05 and 0.98±0.02, respectively. The high absorptivity in the red, the photostability and the efficiency of these chlorins in producing singlet oxygen suggests a ground for the development of better sensitisers for photodynamic therapy.; http://www.sciencedirect.com/science/article/B6TGY-41YG70D-7/1/de6fc7896eaf9c58239551fa798e3e7b

Photodynamic Therapy for Barrett's Esophagus and Esophageal Carcinoma

Qumseya, Bashar J.; David, Waseem; Wolfsen, Herbert C.
Fonte: The Korean Society of Gastrointestinal Endoscopy Publicador: The Korean Society of Gastrointestinal Endoscopy
Tipo: Artigo de Revista Científica
EN
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This paper reviews the use of photodynamic therapy (PDT) in patients with Barrett's esophagus and esophageal carcinoma. We describe the history of PDT, mechanics, photosensitizers for PDT in patients with esophageal disease. Finally, we discuss its utility and limitations in this setting.

Mecanismos de muerte y supervivencia celular por terapia fotodinámica basada en ácido 5-aminolevúlico; Mechanisms of cell death and survival after photodynamic therapy with aminolevulinic acid

Teijo, María Julieta
Fonte: Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires Publicador: Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires
Tipo: info:eu-repo/semantics/doctoralThesis; tesis doctoral; info:eu-repo/semantics/publishedVersion Formato: application/pdf
Publicado em //2012 SPA
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La Terapia Fotodinámica (TFD) es utilizada para el tratamiento del cáncer y otras patologías no malignas. Se basa en la administración un compuesto fotosensibilizante (FS) que se acumula selectivamente en el tejido maligno y al recibir luz de longitud de onda adecuada, éste interactúa con el O2 produciendo especies reactivas del oxígeno (ROS), que son altamente tóxicas y desencadenan la muerte celular. La administración exógena del ácido 5-aminolevúlico (ALA), precursor biológico de la síntesis de los tetrapirroles, induce la acumulación de protoporfirina IX (PpIX), el único FS endógeno. En la erradicación de tumores mediante TFD intervienen diferentes procesos de muerte celular, los que incluyen apoptosis, necrosis, y autofagia. En el presente trabajo se estudiaron los mecanismos que llevan a la muerte celular por TFD basada en ALA en células de adenocarcinoma de pulmón humanas (A549) cultivadas de modo convencional -en monocapa- o en esferoides multicelulares (EMCs, agregados celulares compactos que desarrollan gradientes de nutrientes y oxígeno), y en una variante resistente derivada mediante sucesivos ciclos de tratamiento fotodinámico y recuperación. La acumulación de PpIX a partir de ALA aumentó con el tiempo de incubación y la concentración de ALA hasta alcanzar un plateau con 1 mM tanto en monocapas como en EMCs. Estudios de microscopía confocal indicaron que las mitocondrias son el principal sitio de localización de PpIX endógena pero no de PpIX administrada exógenamente...

Potentiation of photodynamic therapy of cancer by complement: the effect of gamma-inulin

Korbelik, M; Cooper, Peter
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
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Host response elicited by photodynamic therapy (PDT) of cancerous lesions is a critical contributor to the clinical outcome, and complement system has emerged as its important element. Amplification of complement action was shown to improve tumour PDT res

Animal models for photodynamic therapy (PDT)

Silva, Zenildo Santos; Bussadori, Sandra Kalil; Fernandes, Kristianne Porta Santos; Huang, Ying-Ying; Hamblin, Michael R.
Fonte: Portland Press Ltd. Publicador: Portland Press Ltd.
Tipo: Artigo de Revista Científica
EN_US
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Photodynamic therapy (PDT) employs non-toxic dyes called photosensitizers (PSs), which absorb visible light to give the excited singlet state, followed by the long-lived triplet state that can undergo photochemistry. In the presence of ambient oxygen, reactive oxygen species (ROS), such as singlet oxygen and hydroxyl radicals are formed that are able to kill cancer cells, inactivate microbial pathogens and destroy unwanted tissue. Although there are already several clinically approved PSs for various disease indications, many studies around the world are using animal models to investigate the further utility of PDT. The present review will cover the main groups of animal models that have been described in the literature. Cancer comprises the single biggest group of models including syngeneic mouse/rat tumours that can either be subcutaneous or orthotopic and allow the study of anti-tumour immune response; human tumours that need to be implanted in immunosuppressed hosts; carcinogen-induced tumours; and mice that have been genetically engineered to develop cancer (often by pathways similar to those in patients). Infections are the second biggest class of animal models and the anatomical sites include wounds, burns, oral cavity, ears...

Influence of ceramide 2 on in vitro skin permeation and retention of 5-ALA and its ester derivatives, for Photodynamic Therapy

Pierre, Maria Bernadete Riemma; Lopez, Renata Fonseca Vianna; Bentley, Maria Vitória Lopes Badra
Fonte: Universidade de São Paulo. Faculdade de Ciências Farmacêuticas Publicador: Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/03/2009 ENG
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A Terapia Fotodinâmica (TFD) tópica com um precursor das porfirinas endógenas, o ácido 5-aminolevulínico (5-ALA), constitui uma nova modalidade para o tratamento do câncer de pele. Entretanto, o 5-ALA é uma molécula hidrofílica, o que limita sua penetração e retenção cutânea apropriadas. Moléculas mais lipofílicas, tais como derivados esterificados do 5-ALA, estão sob intensa investigação para melhorar a penetração cutânea desta molécula. A formulação que contém o fármaco também pode alterar a penetração cutânea do 5-ALA. Desta forma, o objetivo deste trabalho foi estudar a influência da ceramida 2 - o principal lipídeo do EC- sobre a penetração cutânea de 5-ALA e seus derivados esterificados usando células de difusão de Franz. A permeação de todas as drogas estudadas através da pele foi diminuída na presença de ceramida, o que é desejável, evitando riscos de efeitos colaterais sistêmicos. Entretanto, a retenção no EC e [epiderme + derme] também foi diminuída na presença da ceramida, após 16 horas, comparado ao controle. Concluindo, a ceramida não foi um bom adjuvante, sendo necessária a pesquisa de outros veículos para melhorar a liberação cutânea do 5-ALA.; Photodynamic therapy (PDT) based on topical 5-aminolevulinic acid (5-ALA)...

Chlorins in Photodynamic Therapy – Synthesis and applications; Clorinas em Terapia Fotodinâmica – Síntese e Aplicações

Mário José F. Calvete; Universidade de Aveiro; Ana Teresa P. C. Gomes; Universidade de Aveiro; Nuno M. M. Moura; Universidade de Aveiro
Fonte: Revista Virtual de Química Publicador: Revista Virtual de Química
Tipo: ; Formato: binary/octet-stream
Publicado em 08/05/2009 PT
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Porphyrins have already demonstrated its potentiality in several scientific areas, with emphasis to medicinal applications, like Photodynamic Therapy (PDT). Over the last years, the efforts to develop methods able to convert porphyrins in new derivatives with adequate structural and spectroscopic characteristics to become efficient PDT photosensitizers have been outstanding. In this work we review chlorins role in PDT as well as synthesis of these derivatives, always taking into account its potential to be therapeutically used as agents against cancer. DOI: 10.5935/1984-6835.20090012; As porfirinas já demonstraram grandes potencialidades em vários campos científicos, com principal destaque para aplicações medicinais como a Terapia Fotodinâmica (TFD). Nos últimos anos vários esforços para o desenvolvimento de novos métodos capazes de converter porfirinas em derivados com características estruturais e espectroscópicas adequadas para uma potencial aplicação tem sido realizados. Neste trabalho, é apresentada uma pequena revisão do papel das clorinas em TFD, bem como sua síntese e potencial aplicação destes agentes na terapia do câncer. DOI: 10.5935/1984-6835.20090012

Treatment of oral lichen planus with photodynamic therapy mediated methylene blue: A case report

Aghahosseini,Farzane; Arbabi-Kalati,Fateme; Fashtami,Leila Ataie; Fateh,Mohsen; Djavid,Gholamreza Esmaeeli
Fonte: Medicina Oral, Patología Oral y Cirugía Bucal (Internet) Publicador: Medicina Oral, Patología Oral y Cirugía Bucal (Internet)
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/04/2006 ENG
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Oral lichen planus (OLP) is a common chronic disease of uncertain origin. Many patients with OLP are refractory to all available therapies. The photodynamic therapy (PDT) was used as a possible alternative method in the treatment of lichen planus. Two patients with five oral lichen planus lesions were treated using topical PDT mediated by methylene blue (MB-PDT). The patients were followed up on sessions 3, 7, 15 days and 1 to 9 months after PDT. Clinical improvement was achieved in four lesions. Two lesions showed complete remission, and another two lesions had about 50% clinically improvement 3-9 months after a single session of PDT. No response detected in one lesion. MB-PDT blue seems to be an effective alternative treatment for control of OLP. In our opinion, this preliminary result warrant further studies in order to show the efficacy of MB-PDT in control of OLP for a longer period of time.