Últimos itens adicionados do Acervo: Universidade Européia

Universidade privada em Madrid, Espanha

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Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes

Emanuele, Enzo; Bertona, Marco; Sanchís-Gomar, Fabián; Pareja Galeano, Helios; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Trehalose, a naturally occurring non-reducing disaccharide, is known to act as a major protein stabilizer that can reduce ultraviolet B (UVB)-induced corneal damage when topically applied to the eye. However, due to the low skin permeability of trehalose, which makes the development of topical formulations difficult, its use as a skin photoprotective agent has been limited. Previous findings demonstrated that liposomes may significantly improve the intracellular delivery of trehalose. Therefore, the present study aimed to assess the protective effects of trehalose-loaded liposomes against UVB-induced photodamage using the immortalized human keratinocyte cell line, HaCaT. The effects were also compared to those of the common skin photoprotective compounds, including L-carnosine, L-(+)-ergothioneine, L-ascorbic acid and DL-α-tocopherol. The levels of cyclobutane pyrimidine dimers, 8-hydroxy-2'-deoxyguanosine and protein carbonylation in HaCaT cells were used as biological markers of UVB-induced damage. Compared to other compounds, trehalose-loaded liposomes showed the highest efficacy in reducing the levels of the three markers following UVB irradiation of HaCaT cells (all P<0.001 when compared to each of the four other photoprotective compounds). Therefore...

Analysis of the response speed of musculature of the knee in professional male and female volleyball players

Rodríguez Ruiz, David; Díez Vega, Ignacio; Rodríguez Matoso, Darío; Fernández del Valle, María; Sagastume Fernández, Rafael; Molina Martín, Juan José
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
The aim of this study was to evaluate the normalized response speed (Vrn) of the knee musculature (flexor and extensor) in high competitive level volleyball players using tensiomyography (TMG) and to analyze the muscular response of the vastus medialis (VM), rectus femoris (RF), vastus lateralis (VL), and biceps femoris (BF) in accordance with the specific position they play in their teams. One hundred and sixty-six players (83 women and 83 men) were evaluated. They belonged to eight teams in the Spanish women's superleague and eight in the Spanish men's superleague.The use of Vrn allows avoiding possible sample imbalances due to anatomical and functional differences and demands. We found differences between Vrn in each of the muscles responsible for extension (VM, RF, and VL) and flexion (BF) regardless of the sex. Normalized response speed differences seem to be larger in setters, middle blockers, and outside players compared to liberos and larger in males when compared to females. These results of Vrn might respond to the differences in the physical and technical demands of each specific position, showing an improved balance response of the knee extensor and flexor musculature in male professional volleyball players.

Culture and immigration in context: an ethnography with Romanian migrant workers in London

Briggs, Daniel; Dobre, Dorina
Fonte: Palgrave MacMillan Publicador: Palgrave MacMillan
Tipo: Livro
ENG
In recent years, increased political attention has been drawn to the issue of immigration to the UK. For some, their motives to be in the UK are associated with 'organised crime' networks, begging and claiming various welfare benefits. In contrast to the belief that migrants are a 'risk' to British society and have put significant pressure on the British health and social system, Briggs and Dobre debunk these thin accusations to provide a more humane and realistic account of Romanian economic migrants and their life in the UK. Their focus is to place immigration in its historical and political economic context by examining the cultural and structural barriers which the Romanian labour force face when they come to work in London. Culture and Immigration in Context acts as a critique to the dominant, economic-modelled field of migrant studies by offering an ethnographic lens which is social, political and subjective in its vista to reveal the lived experience of Romanian migrant workers in Britain who have left the debt and corruption of their home life in the hope of finding something better in Britain.

Deviance, risk and the holiday: an ethnographic study of British tourists in Ibiza

Briggs, Daniel
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Livro
ENG
This book represents the first attempt to step inside the holiday experience of young British tourists. Using ethnographic methods such as observation, open-ended interviewing and focus groups in San Antonio, Ibiza, this book reveals the ugly truth about 'how' and 'why' young Brits get involved in deviance and risk-taking when they go abroad, exploring vivid accounts of drug use, drug dealing, violence, prostitution, and injury. In contrast to existing knowledge and populist depictions, Briggs argues that the root of these behaviours is not pathological but rather it is more about how this social group have come to self validate what is expected of them in their leisure time and, as a consequence, how their attitudes are subtly guided and endorsed by the commodified social context of resorts which are only interested in making money at their expense. Exploring issues of youth culture, political economy, tourism and identity, this book will appeal to scholars in sociology, criminology, cultural studies, tourism and youth studies.

Running-specific, periodized strength training attenuates loss of stride length during intense endurance running

Esteve Lanao, Jonathan; Rhea, Matthew R.; Fleck, Steven J.; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
The purpose of this study was to determine the effects of a running-specific, periodized strength training program (performed over the specific period [8 weeks] of a 16-week macrocycle) on endurance-trained runners' capacity to maintain stride length during running bouts at competitive speeds. Eighteen well-trained middle-distance runners completed the study (personal bests for 1500 and 5000 m of 3 minutes 57 seconds +/- 12 seconds and 15 minutes 24 seconds +/- 36 seconds). They were randomly assigned to each of the following groups (6 per group): periodized strength group, performing a periodized strength training program over the 8-week specific (intervention) period (2 sessions per week); nonperiodized strength group, performing the same strength training exercises as the periodized group over the specific period but with no week-to-week variations; and a control group, performing no strength training at all during the specific period. The percentage of loss in the stride length (cm)/speed (m.s) (SLS) ratio was measured by comparing the mean SLS during the first and third (last) group of the total repetitions, respectively, included in each of the interval training sessions performed at race speeds during the competition period that followed the specific period. Significant differences (p < 0.05) were found in mean percentage of SLS loss between the 3 study groups...

Reanalysis of Eysenck's, Gray's, and Zuckerman's structural trait models based on a new measure: The Zuckerman-Kuhlman-Aluja Personality Questionnaire (ZKA-PQ)

Aluja, Antón; Escorial, Sergio; García, Luis F.; García López, Óscar; Blanch, Ángel; Zuckerman, Marvin
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG

McArdle disease: what do neurologists need to know?

Lucía Mulas, Alejandro; Nogales-Gadea, Gisela; Pérez Ruiz, Margarita; Martín, Miguel Ángel; Andreu, Antoni L.; Arenas, Joaquín
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
McArdle disease (also known as glycogen storage disease type V) is a pure myopathy caused by an inherited deficit of myophosphorylase, the skeletal muscle isoform of the enzyme glycogen phosphorylase. The disease exhibits clinical heterogeneity, but patients typically experience exercise intolerance, that is, reversible, acute crises (early fatigue and contractures, sometimes with rhabdomyolysis and myoglobinuria) triggered by static muscle contractions (e.g. lifting weights) or dynamic exercise (e.g. climbing stairs or running). In this Review, we discuss the main features of McArdle disease, with the aim of providing neurologists with up-to-date, useful information to assist their patients. The topics covered include diagnostic tools-for example, molecular genetic diagnosis, the classic ischemic forearm test and the so-called 'second wind' phenomenon-and current therapeutic options-for example, a carbohydrate-rich diet and carbohydrate ingestion shortly before strenuous exercise, in combination with medically supervised aerobic training of low to moderate intensity.

Novel mutations in patients with McArdle disease by analysis of skeletal muscle mRNA

García-Consuegra, Inés; Rubio, Juan Carlos; Nogales-Gadea, Gisela; Bautista, José M.; Jiménez Sáiz, Sergio Lorenzo; Cabello Sánchez, Ana Belén; Lucía Mulas, Alejandro; Andreu, Antoni L.; Arenas, Joaquín; Martín, Miguel Ángel
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Objective: Methods: Results: Conclusions: To identify pathogenic mutant alleles of the PYGM gene in "genetic manifesting heterozygous" patients with McArdle disease-that is, those in whom we could only find a sole mutant allele by genomic DNA analysis.We studied four unrelated patients. PCR-RFLP, gene sequencing, and muscle cDNA analysis were performed to search for mutations in the PYGM gene. The effects of the mutations were evaluated by in silico analysis, and gene expression was assessed by real-time polymerase chain reaction (PCR).Patient 1 was a compound heterozygous for the p.G205S missense mutation and for a novel "in frame" mutation, p.Q176_M177insVQ, resulting from a retention of six nucleotides from the 3'-end sequence of intron 4. Patient 2 was heterozygous for the common nonsense mutation p.R50X, and for a 1094 bp, c.1969+214_2177+369del mutation, spanning from intron 16 to intron 17 sequences. Furthermore, mRNA expression level was dramatically reduced consistent with nonsense mediated decay. Patient 3 was heterozygous for the p.R50X substitution, and patient 4 was heterozygous for the relatively common private Spanish mutation p.W798R. These two patients harboured a heterozygous exonic synonymous variant, p.K215K. Quantification of gene transcripts in patient 3 revealed a drastic decrease in the relative expression of the gene...

Effects of Hypoxic Living and Training on Gene Expression in an Obese Rat Model

He, Zi-Hong; Feng, Lianshi; Zhang, Li; Lu, Yingli; Xu, Jianfang; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Effects of Hypoxic Living and Training on Gene Expression in an Obese Rat Model. Med. Sci. Sports Exerc., Vol. 44, No. 6, pp. 1013-1020, 2012. Purpose: The study's purpose was to determine in a rat obesity model the effects of nom-toxic training, sedentary hypoxic living, or hypoxic living plus training on the skeletal muscle messenger RNA (mRNA) levels of 14 genes involved in oxygen sensing (hypoxia-inducible factor 1 alpha, vascular endothelial growth factor, myoglobin), glucose metabolism (glucose transporter 4, muscle phosphofructokinase), mitochondrial biogenesis (peroxisome proliferator activated receptor gamma coactivator 1-alpha, nuclear respiratory factor 1) and function (citrate synthase, mitochondrial-encoded cytochrome oxidase subunit I), pH regulation (monocarboxylate transporter 1, carbonic anhydrase 3), and antioxidant defense (manganese superoxide dismutase, copper/zinc superoxide dismutase, glutathione S-transferase pi). Methods: One hundred thirty male 3-wk-old Sprague Dawley rats were fed a high-fat diet (4100 kcal.kg(-1)) for 3 months (all reaching a final weight >415 g) and then randomly assigned to the following groups (n = 10 per group): C (control, 2 d of sedentary living in normoxic conditions), TN1-TN4 (1-4 wk of normoxic treadmill training)...

Feasibility of resistance training in adult McArdle patients: clinical outcomes and muscle strength and mass benefits

Santalla Hernández, Alfredo; Munguía-Izquierdo, Diego; Brea Alejo, Lidia; Pagola Aldazabal, Itziar; Díez Bermejo, Jorge; Fleck, Steven J.; Ara, Ignacio; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
We analyzed the effects of a 4-month resistance (weight lifting) training program followed by a 2-month detraining period in 7 adult McArdle patients (5 female) on: muscle mass (assessed by DXA), strength, serum creatine kinase (CK) activity and clinical severity. Adherence to training was ≥84% in all patients and no major contraindication or side effect was noted during the training or strength assessment sessions. The training program had a significant impact on total and lower extremities' lean mass (P < 0.05 for the time effect), with mean values increasing with training by +855 g (95% confidence interval (CI): 30, 1679) and +547 g (95%CI: 116, 978), respectively, and significantly decreasing with detraining.

McArdle disease: a unique study model in sports medicine

Santalla Hernández, Alfredo; Nogales-Gadea, Gisela; Ortenblad, Niels; Brull, Astrid; Luna, Noemí de; Pinós, Tomàs; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
McArdle disease is arguably the paradigm of exercise intolerance in humans. This disorder is caused by inherited deficiency of myophosphorylase, the enzyme isoform that initiates glycogen breakdown in skeletal muscles. Because patients are unable to obtain energy from their muscle glycogen stores, this disease provides an interesting model of study for exercise physiologists, allowing insight to be gained into the understanding of glycogen-dependent muscle functions. Of special interest in the field of muscle physiology and sports medicine are also some specific (if not unique) characteristics of this disorder, such as the so-called 'second wind' phenomenon, the frequent exercise-induced rhabdomyolysis and myoglobinuria episodes suffered by patients (with muscle damage also occurring under basal conditions), or the early appearance of fatigue and contractures, among others. In this article we review the main pathophysiological features of this disorder leading to exercise intolerance as well as the currently available therapeutic possibilities.

Resistance training does not have an effect on cognition or related serum biomarkers in nonagenarians: a randomized controlled trial

Ruiz, Jonatan R.; Gil Bea, Francisco; Bustamante-Ara, Natalia; Rodríguez Romo, Gabriel; Fiuza Luces, María del Carmen; Serra-Rexach, José A.; Cedazo-Mínguez, Ángel; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
The aim of this randomized controlled trial was to determine the effects of 8-week exercise-intervention on cognition and related serum biochemical markers in nonagenarians. We also studied the effects of a 4-week training cessation ('detraining') period on our study variables. Participants were randomly allocated to a standard-care (control) or intervention (exercise) group [n=20 (16 women)/group]. The intervention focused on supervised, light-to-moderate-intensity aerobic and resistance exercises (mainly leg press), and included 3 weekly sessions. Cognitive status was determined by the mini-mental state examination and geriatric depression scale. We analysed proteins with reported relation with mechanisms behind cognition changes such as serum levels of angiotensin converting enzyme, amyloid-precursor protein, epidermal growth factor, brain-derived neural factor and tumor necrosis factor. No significant change (P>0.05) in any of the variables studied was found following the exercise intervention compared with the standard-care group. Similarly, no significant changes (P>0.05) were observed following the detraining period compared with the standard-care group.

The ApoE gene is related with exceptional longevity: a systematic review and meta-analysis

Garatachea, Nuria; Marín, Pedro J.; Santos-Lozano, Alejandro; Sanchís-Gomar, Fabián; Emanuele, Enzo; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
The objective of this meta-analysis was to determine the association of the apolipoprotein E (ApoE) gene with exceptional longevity (EL) (i.e., reaching 100+ years) by identifying possible unequal distribution of alleles/genotypes in the common variants ε2, ε3, and ε4 among centenarians and younger population. The association of ApoE with EL was analyzed in a total of 2776 centenarians (cases) and 11,941 younger controls (from 13 case-control studies) using the chi-squared test with the Yates correction. We conducted combined and separate analyses for all ethnic groups studied in the literature (Caucasian and Asian). The present meta-analysis confirms that, besides its previously documented influence on Alzheimer's and cardiovascular disease risk, the ApoE gene is associated with the likelihood of reaching EL.

New insights on nucleoside 2'-deoxyribosyltransferases: a versatile biocatalyst for one-pot one-step synthesis of nucleoside analogs

Fresco-Taboada, Alba; Mata Riesco, Isabel de la; Arroyo Sánchez, Miguel; Fernández Lucas, Jesús
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG

Incorporación de nuevas rúbricas y protocolos en la evaluación de Proyectos Fin de Grado en el Área Industrial

Egido García, Verónica; Peña Martínez, Beatriz
Fonte: Universidad Europea de Madrid Publicador: Universidad Europea de Madrid
Tipo: Conferência ou Objeto de Conferência
SPA
En este artículo se muestra el trabajo realizado en el área industrial orientado a la evaluación de los proyectos fin de grado. Con la experiencia acumulada de años anteriores en los llamados proyectos fin de carrera y las nuevas directrices marcadas por el Espacio Europeo de Educación Superior, se intentó mejorar tanto la planificación, como la forma de evaluación realizada hasta el momento. Se pretende con estos cambios un doble objetivo: 'mejorar la coordinación entre los profesores que dirigen proyectos fin de grado y los tribunales de evaluación, y conseguir una mayor objetividad en la evaluación de los proyectos. A pesar de que el título indica el concepto proyecto fin de grado, la metodología se aplicó tanto a los proyectos de titulaciones Pre-Bolonia como a las titulaciones enmarcadas en el EEES.

Utility of the Actiheart Accelerometer for Estimating Exercise Energy Expenditure in Female Adolescent Runners

Nichols, Jeanne F.; Aralis, Hilary; García Merino, Sonia; Barrack, Michelle T.; Stalker-Fader, Lindsay; Rauh, Mitchell J.
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
There is a growing need to accurately assess exercise energy expenditure (EEE) in athletic populations that may be at risk for health disorders because of an imbalance between energy intake and energy expenditure. The Actiheart combines heart rate and uniaxial accelerometry to estimate energy expenditure above rest. The authors' purpose was to determine the utility of the Actiheart for predicting EEE in female adolescent runners (N = 39, age 15.7 +/- 1.1 yr). EEE was measured by indirect calorimetry and predicted by the Actiheart during three 8-min stages of treadmill running at individualized velocities corresponding to each runner's training, including recovery, tempo, and 5-km-race pace. Repeated-measures ANOVA with Bonferroni post hoc comparisons across the 3 running stages indicated that the Actiheart was sensitive to changes in intensity (p < .01), but accelerometer output tended to plateau at race pace. Pairwise comparisons of the mean difference between Actiheart- and criterion-measured EEE yielded values of 0.0436, 0.0539, and 0.0753 kcal . kg(-1) min(-1) during recovery, tempo, and race pace, respectively (p < .0001). Bland Altman plots indicated that the Actiheart consistently underestimated EEE except in 1 runner's recovery bout. A linear mixed-model regression analysis with height as a covariate provided an improved EEE prediction model...

ACTN3 genotype in Spanish elite swimmers: no “heterozygous advantage”

Ruiz, Jonatan R.; Santiago Dorrego, Catalina; Yvert, Thomas; Muniesa Ferrero, Carlos Alberto; Díaz Ureña, Germán; Bekendam Blanco, Nora; Fiuza Luces, María del Carmen; Gómez Gallego, Félix; Femia Marzo, Pedro; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
The aim of the present case-control study was to examine the association of the ACTN3 R577X genotype with elite swimming status. We compared a group of Spanish (Caucasian) elite swimmers (n = 88) with other cohorts of the same ethnic origin, i.e., nonathletic controls (n = 343) and other types of athletes who are in both end-points of the sports performance continuum, i.e., world-class power (n = 119) and endurance male athletes (n = 154). Swimmers had a lower odds ratio (OR) of having the RX genotype [1.815, 95% confidence intervals (CI): 0.899-3.664] compared with nonathletic controls, yet the association did not reach statistical significance (P = 0.096). Endurance athletes had greater OR of having the XX genotype (OR: 2.88, 95% CI: 1.162-7.135, P = 0.022), or the RX+XX genotype (OR: 1.903, 95% CI: 1.015-3.567, P = 0.045) compared with swimmers. No other association was found. In summary, we did not observe an association between the ACTN3 R577X polymorphism and elite swimmer's status, suggesting that any influence of this polymorphism is not of sufficient magnitude as to significantly influence elite swimming performance, at least in Spanish athletes.

Benefits of combining inspiratory muscle with 'whole muscle' training in children with cystic fibrosis: a randomised controlled trial

Santana Sosa, Elena; González-Sáiz, Laura; Groeneveld, Iris F.; Villa‐Asensi, José R.; Barrio Gómez de Aguero, María I.; Fleck, Steven J.; López Mojares, Luis Miguel; Pérez Ruiz, Margarita; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
BACKGROUND: The purpose of this study (randomised controlled trial) was to assess the effects of an 8-week combined 'whole muscle' (resistance+aerobic) and inspiratory muscle training (IMT) on lung volume, inspiratory muscle strength (PImax) and cardiorespiratory fitness (VO2 peak) (primary outcomes), and dynamic muscle strength, body composition and quality of life in paediatric outpatients with CF (cystic fibrosis, secondary outcomes). We also determined the effects of a detraining period. METHODS: Participants were randomly allocated with a block on gender to a control (standard therapy) or intervention group (initial n=10 (6 boys) in each group; age 10±1 and 11±1 years). The latter group performed a combined programme (IMT (2 sessions/day) and aerobic+strength exercises (3 days/week, in-hospital)) that was followed by a 4-week detraining period. All participants were evaluated at baseline, post-training and detraining. RESULTS: Adherence to the training programme averaged 97.5%±1.7%. There was a significant interaction (group×time) effect for PImax, VO2peak and five-repetition maximum strength (leg-press, bench-press, seated-row) (all (p<0.001), and also for %fat (p<0.023) and %fat-free mass (p=0.001), with training exerting a significant beneficial effect only in the intervention group...

The K153R polymorphism in the myostatin gene and muscle power phenotypes in young, non-athletic men

Santiago Dorrego, Catalina; Ruiz, Jonatan R.; Rodríguez Romo, Gabriel; Fiuza Luces, María del Carmen; Yvert, Thomas; González-Freire, Marta; Gómez Gallego, Félix; Morán, María; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
The Lys(K)153Arg(R) polymorphism in exon 2 (rs1805086, 2379 A>G replacement) of the myostatin (MSTN) gene is a candidate to influence skeletal muscle phenotypes. We examined the association between the MSTN K153R polymorphism and 'explosive' leg power, assessed during sprint (30 m) and stationary jumping tests [squat (SJ) and counter-movement jumps (CMJ)] in non-athletic young adults (University students) [n = 281 (214 men); age: 21-32 years]. We also genotyped the MSTN exonic variants E164K (rs35781413), I225T, and P198A, yet no subject carried any of these variant MSTN alleles. As for the K153R polymorphism, we found only one woman with the KR genotype; thus, we presented the results only for men. The results of a one-way ANCOVA (with age, weight and height entered as covariates) showed that men with the KR genotype (n = 15) had a worse performance in vertical jumps compared with those with the KK genotype [SJ: vertical displacement of center of gravity (CG) of 35.17 ± 1.42 vs. 39.06 ± 0.39 cm, respectively, P = 0.009; CMJ: vertical displacement of CG of 36.44 ± 1.50 vs. 40.63 ± 0.41 cm, respectively, P = 0.008]. The results persisted after adjusting for multiple comparisons according to Bonferroni. Performance in 30 m sprint tests did however not differ by K153R genotypes. In summary...

Integrating Internet of Things and Cloud Computing for Health Services Provisioning: The Virtual Cloud Carer Project

Gachet Páez, Diego; De Buenaga Rodríguez, Manuel; Aparicio Galisteo, Fernando; Padrón Nápoles, Víctor Manuel
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Conferência ou Objeto de Conferência
ENG
The demographic and social changes are causing a gradual increase of the population in situation of dependency. The main concern of the elder people is their health and its consequences in terms of dependence and also is the primary cause of suffering and self-rated ill health. Since elder people have different health problems that the rest of the population, we need a deep change in national's health policy to get adapted to population aging. This paper describes the preliminary advances of "Virtual Cloud Carer" (VCC), a Spanish national R&D project, whose primary purpose is the creation of new health services for dependents and chronics elder lies, using technologies associated with internet of things and cloud computing.