Últimos itens adicionados do Acervo: Universidade Européia

Universidade privada em Madrid, Espanha

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Gestión emocional y hábito reflexivo en la relación de ayuda para el cuidado holístico del paciente paliativo

Blas Gómez, Irene de; Rodríguez García, Marta; Alburquerque Medina, Eulalia
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
SPA
Para cuidar a pacientes paliativos es fundamental que el profesional desarrolle competencias emocionales. Ello implica adquirir el hábito de la reflexión de sentimientos propios y ajenos para ser capaces de identificar emociones personales, de pacientes, familia y equipo. La reflexión entraña un esfuerzo continuo para razonar sobre los aspectos relativos a la práctica profesional, sobre todo en temas tan complejos como el sufrimiento y la muerte. Tanto el razonamiento reflexivo como la gestión emocional son vitales en la Relación de Ayuda. Para los profesionales de enfermería cuidar a nivel emocional significa tomar conciencia de los sentimientos propios y ajenos, llegar a comprenderlos y aceptarlos para poderlosgestionar adecuadamente. La actividad enfermera implica cualidades de competencia social, empatía, sensibilidad, habilidades comunicativas, honestidad, flexibilidad y capacidad de adaptación a las necesidades individuales de las personas cuidadas. En el contexto del cuidado de los pacientes paliativos y sus familias todos estos aspectos son fundamentales y forman parte de la filosofía de los mismos. La educación emocional en nuestra profesión sigue siendo un reto en la formación inicial y en la formación continua.

Prolonged intense exercise training increases life expectancy without damaging the heart

Pareja Galeano, Helios; Fiuza Luces, María del Carmen; Garatachea, Nuria
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG

The hMTH1 paradox: antioxidants recommended in cancer?

Sanchís-Gomar, Fabián; Pareja Galeano, Helios; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG

Serum irisin levels, precocious myocardial infarction, and healthy exceptional longevity

Emanuele, Enzo; Minoretti, Piercarlo; Pareja Galeano, Helios; Sanchís-Gomar, Fabián; Garatachea, Nuria; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Skeletal muscles produce irisin. Growing controversy exists on the association between this myokine and chronic disease risk. On the basis of the potential protective effects that irisin could exert on both vascular function and skeletal muscle mass, we hypothesized that an elevated level of this molecule may contribute to successful aging.

Anti-gout drugs as potential therapy for atrial fibrillation

Sanchís-Gomar, Fabián; Pérez-Quilis, Carmen; Cervellin, Gianfranco; Lucía Mulas, Alejandro; Lippi, Giuseppe
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG

Cardiorespiratory fitness, physical activity, and quality of life in patients with McArdle disease

Munguía-Izquierdo, Diego; Santalla Hernández, Alfredo; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
METHODS: Eighty-one adult patients with McArdle disease underwent aerobic capacity testing to determine peak oxygen uptake (V˙O2peak), among other variables. HRQoL (Short Form 36-Item Health Survey questionnaire version 2 (SF-36 version 2)) and PA (International Physical Activity Questionnaire) questionnaires were completed by 45 of the patients. HRQoL and V˙O2peak data were compared with published normative data. RESULTS: Positive correlations were observed between V˙O2peak and leisure time PA versus the physical component summary score and scores for several domains of the SF-36 questionnaire after adjusting for age, body mass index, and disease severity (R values, 0.42-0.68; all P < 0.01). In a regression analysis, the physical component summary score was directly linked to V˙O2peak (B = 1.28; 95% confidence interval, 0.78-1.78; P < 0.001; R = 0.422). The mean V˙O2peak recorded for patients with McArdle disease was 57% lower than the normative value (17.1 ± 5.3 vs 40.0 ± 9.5 mL·kg·min, respectively; P < 0.001). All patients showed a CRF below their age-/sex-matched normality value and scored clinically lower in the physical component summary and in most SF-36 domains compared with the Spanish general population. CONCLUSIONS: Patients showed a consistent link between higher physical HRQoL scores and higher CRF. Patients fulfilling leisure time PA recommendations showed higher CRF and physical HRQoL scores than those not meeting guideline recommendations. According to normative data for healthy subjects...

Exercise as the master polypill of the 21st century for the prevention of cardiovascular disease

Sanchís-Gomar, Fabián; Fiuza Luces, María del Carmen; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG

Physical activity and depression: type of exercise matters

Pareja Galeano, Helios; Sanchís-Gomar, Fabián; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Letter to the editor

Can enhanced autophagy be associated with human longevity? Serum levels of the autophagy biomarker beclin-1 are increased in healthy centenarians

Emanuele, Enzo; Minoretti, Piercarlo; Sanchís-Gomar, Fabián; Pareja Galeano, Helios; Yilmaz, Yusuf; Garatachea, Nuria; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Autophagy is a major clearance mechanism that degrades organelles and large protein aggregates to maintain cell survival and protein homeostasis. Although induction of autophagy can promote longevity in experimental models, the question as to whether increased basal levels of autophagy can be associated with human longevity remains open. In this pilot study, we investigated the association between serum concentrations of beclin-1, a key regulator of autophagy, and human exceptional longevity (EL). Serum beclin-1 was measured in three study groups: 79 healthy centenarians (39 males, aged 100-104 years); 178 non-diabetic patients who had experienced an acute myocardial infarction at a young age (101 males, 28-39 years); and 180 age- and sex-matched healthy young volunteers (103 males, 27-39 years) using an enzyme-linked immunosorbent assay.

Exercise attenuates the major hallmarks of aging

Garatachea, Nuria; Pareja Galeano, Helios; Sanchís-Gomar, Fabián; Santos-Lozano, Alejandro; Fiuza Luces, María del Carmen; Emanuele, Enzo; Joyner, Michael J.; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Regular exercise has multi-system anti-aging effects. Here we summarize how exercise impacts the major hallmarks of aging. We propose that, besides searching for novel pharmaceutical targets of the aging process, more research efforts should be devoted to gaining insights into the molecular mediators of the benefits of exercise and to implement effective exercise interventions for elderly people.

FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

Sanchís-Gomar, Fabián; Garatachea, Nuria; Zi-Hong, He; Pareja Galeano, Helios; Fuku, Noriyuki; Tian, Ye; Arai, Yasumichi; Abe, Yukiko; Murakami, Haruka; Miyachi, Motohiko; Yvert, Thomas; Santiago Dorrego, Catalina; Venturini, Letizia; Fiuza Luces, Marí
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Irisin might play an important role in reducing the risk of obesity, insulin resistance, or several related diseases, and high irisin levels may contribute to successful aging. Thus, the irisin precursor (FNDC5) gene is a candidate to influence exceptional longevity (EL), i.e., being a centenarian. It has been recently shown that two single-nucleotide polymorphisms (SNPs) in the FNDC5 gene, rs16835198 and rs726344, are associated with in vivo insulin sensitivity in adults. We determined luciferase gene reporter activity in the two above-mentioned SNPs and studied genotype distributions among centenarians (n = 175, 144 women) and healthy controls (n = 347, 142 women) from Spain. We also studied an Italian [79 healthy centenarians (40 women) and 316 healthy controls (156 women)] and a Japanese cohort [742 centenarians (623 women) and 499 healthy controls (356 women)]. The rs726344 SNP had functional significance, as shown by differences in luciferase activity between the constructs of this SNP (all P ≤ 0.05), with the variant A-allele having higher luciferase activity compared with the G-allele (P = 0.04). For the rs16835198 SNP, the variant T-allele tended to show higher luciferase activity compared with the G-allele (P = 0.07). However...

Methodological considerations to determine the effect of exercise on brain-derived neurotrophic factor levels

Pareja Galeano, Helios; Alis, Rafael; Sanchís-Gomar, Fabián; Cabo, Helena; Cortell-Ballester, José; Gomez-Cabrera, Mari Carmen; Lucía Mulas, Alejandro; Viña, José
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Physical exercise up-regulates brain-derived neurotrophic factor (BDNF) in the brain and blood. However, there is yet no consensus about the adequate blood processing conditions to standardize its assessment. We aimed to find a reliable blood sample processing method to determine changes in BDNF due to exercise.

New molecular targets and lifestyle interventions to delay aging sarcopenia

Sanchís-Gomar, Fabián; Pareja Galeano, Helios; Mayero, Sara; Pérez-Quilis, Carmen; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG

Physical inactivity and low fitness deserve more attention to alter cancer risk and prognosis

Sanchís-Gomar, Fabián; Lucía Mulas, Alejandro; Yvert, Thomas; Ruiz-Casado, Ana; Pareja Galeano, Helios; Santos-Lozano, Alejandro; Fiuza Luces, María del Carmen; Garatachea, Nuria; Lippi, Giuseppe; Bouchard, Claude; Berger, Nathan A.
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Sedentary lifestyle is associated with elevated cancer risk whereas regular physical activity (PA) and high cardiorespiratory fitness (CRF) have the opposite effect, with several biologic mechanisms mediating such associations. There is a need for lifestyle interventions aimed at increasing the PA levels and CRF of the general population and particularly cancer survivors. Furthermore, provocative data suggest a dose-dependent benefit of increasing levels of PA and/or CRF against cancer risk or mortality. Thus, current PA guidelines (≥150 min/wk of moderate-to-vigorous PA) may not be sufficiently rigorous for preventing cancer nor for extending cancer survivorship. Research targeting this issue is urgently needed. Promoting regular PA along with monitoring indicators of CRF and adiposity may provide powerful strategies to prevent cancer in populations, help patients with cancer more effectively deal with their disease and enhance secondary prevention programs in those who are affected by cancer.

Where are supercentenarians located? A worldwide demographic study

Santos-Lozano, Alejandro; Sanchís-Gomar, Fabián; Pareja Galeano, Helios; Fiuza Luces, María del Carmen; Emanuele, Enzo; Lucía Mulas, Alejandro; Garatachea, Nuria
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
The world population is continuously aging, and centenarians may be considered to be the most successfully aged individuals. Among people who reach extreme longevity (EL; i.e., >95 years), supercentenarians (SCs; aged ≥110 years) represent a subgroup of great scientific interest. Unfortunately, data on the worldwide distribution of SCs remain scarce. Therefore, this study was designed to investigate this issue. Current available data indicate that Japan is the country with the highest number of currently alive SCs. Interestingly, Puerto Rico would show the highest prevalence of SCs among people who reach EL (approximately one SC per 10,000 inhabitants aged ≥95 years), although data on this country must be intrepreted with caution owing to potential methodological limitations, mainly related to its small population. Our findings highlight the need to investigate in greater detail the genetic and lifestyle background of SCs, with the ultimate goal of unraveling new potential mechanisms underlying human EL.

PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study

Garatachea, Nuria; Fuku, Noriyuki; He, Zi-Hong; Tian, Ye; Arai, Yasumichi; Abe, Yukiko; Miyachi, Motohiko; Yvert, Thomas; Venturini, Letizia; Santiago Dorrego, Catalina; Santos-Lozano, Alejandro; Rodríguez Romo, Gabriel; Ricevuti, Giovanni; Hirose, Nobuy
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Focal adhesion is critical for cell survival. The focal adhesion kinase (FAK, or PTK2) is an important component of the human interactome and thus is a potential longevity-related protein. Here we studied the association between two PTK2 gene single-nucleotide polymorphisms (SNPs) (rs7843014, rs7460) and exceptional longevity (EL). In addition to gaining insight into their functionality by determining luciferase gene reporter activity, we studied the genotype/allele frequency of these two SNPs among three different cohorts: (1) Spanish centenarians (n=175, 100-111 years, 144 women) and healthy controls (n=355, 20-50 years, 284 women); (2) Italian centenarians (n=79, 100-104 years, 40 women) and controls (n=316, 29-50 years, 156 women); and (3) Japanese centenarians (n=742, 100-116 years, 623 women) and healthy controls (n=499, 23-59 years, 356 women). Both SNPs had functional significance, with the A allele up-regulating luciferase activity compared to the other allele (rs7460 T allele and rs7843014 C allele, respectively).

Long-term strenuous endurance exercise and the right ventricle: Is it a real matter of concern?

Sanchís-Gomar, Fabián; Pareja Galeano, Helios; Santos-Lozano, Alejandro; Fiuza Luces, María del Carmen; Garatachea, Nuria; Lucía Mulas, Alejandro
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Letters to the Editor

Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795 and ACSL1 rs6552828

Fuku, Noriyuki; He, Zi-Hong; Sanchís-Gomar, Fabián; Pareja Galeano, Helios; Tian, Ye; Arai, Yasumichi; Abe, Yukiko; Murakami, Haruka; Miyachi, Motohiko; Zempo, Hirofumi; Naito, Hisashi; Yvert, Thomas; Verde Rello, Zoraida; Venturini, Letizia; Fiuza Luce
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
There are several gene variants that are candidates to influence functional capacity in long-lived individuals. As such, their potential association with exceptional longevity (EL, i.e., reaching 100+ years) deserves analysis. Among them are rs7832552 in the thyrotropin-releasing hormone receptor (TRHR) gene, rs1800795 in the interleukin-6 (IL6) gene and rs6552828 in the coenzyme A synthetase long-chain 1 (ACSL1) gene. To gain insight into their functionality (which is yet unknown), here we determined for the first time luciferase gene reporter activity at the muscle tissue level in rs7832552 and rs6552828. We then compared allele/genotype frequencies of the 3 abovementioned variants among centenarians [n = 138, age range 100-111 years (114 women)] and healthy controls [n = 334, 20-50 years (141 women)] of the same ethnic and geographic origin (Spain). We also studied healthy centenarians [n = 79, 100-104 years (40 women)] and controls [n = 316, 27-81 years (156 women)] from Italy, and centenarians [n = 742, 100-116 years (623 women)] and healthy controls [n = 499, 23-59 years (356 women)] from Japan.

A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging

Sanchís-Gomar, Fabián; Pareja Galeano, Helios; Santos-Lozano, Alejandro; Garatachea, Nuria; Fiuza Luces, María del Carmen; Venturini, Letizia; Ricevuti, Giovanni; Lucía Mulas, Alejandro; Emanuele, Enzo
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
Although the number of centenarians is growing worldwide, the potential factors influencing the aging process remain only partially elucidated. Researchers are increasingly focusing toward biomarkers as tools to shed more light on the pathophysiology of complex phenotypes, including the ability to reach successful aging, i.e., free of major chronic diseases. We therefore conducted a case-control study examining the potential associations of multiple candidate biomarkers in healthy centenarians and sex-matched healthy elderly controls. Using a case-control study of 81 centenarians (aged ≥ 100 years) selected based on the fact that they were disease-free and 46 healthy elderly controls (aged 70-80 years), serum levels of 15 different candidate biomarkers involved in the regulation of metabolism, angiogenesis, inflammation, and bone formation were measured. Of the 15 biomarkers tested, four molecules (chemerin, fetuin-A, and fibroblast growth factors [FGF] 19 and 21) were found to be independently associated with successful aging regardless of sex. Logistic regression analysis confirmed that chemerin, fetuin-A, FGF19, and FGF21 were independently associated with successful aging [predicted probability (PP) = 1 / [1 + 1 / exp (11.832 - 0.027 × (chemerin) - 0.009 × (fetuin-A) + 0.014 × (FGF19) - 0.007 × (FGF21)]. The area under the curve (AUC) of predicted probability values for the four-biomarker panel revealed that it can discriminate between centenarians and elderly controls with excellent accuracy (AUC > 0.94...

Clinical significance of conduction disturbances after aortic valve intervention: current evidence

Martínez Sellés Oliveria Soares, Manuel; Bramlage, P.; Thoenes, M.; Schymik, Gerhard
Fonte: Universidade Européia Publicador: Universidade Européia
Tipo: Artigo de Revista Científica
ENG
The occurrence of new conduction abnormalities that lead to the requirement for new permanent pacemaker implantation (PPI) has been reported to be the most frequent complication following transcatheter aortic valve implantation (TAVI). However, the reasons and clinical significance of TAVI-induced conduction disturbances and PPI are yet to be fully delineated. This review aims to evaluate the procedure- and patient-related factors that may contribute to the development of aberrant atrioventricular conduction following TAVI as well as its clinical consequences.