Página 2 dos resultados de 124249 itens digitais encontrados em 0.195 segundos

Reinnervation of original synaptic sites on muscle fiber basement membrane after disruption of the muscle cells.

Marshall, L M; Sanes, J R; McMahan, U J
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /07/1977 EN
Relevância na Pesquisa
36.068096%
Regenerating axons form new synapses precisely at sites of original synapses in denervated skeletal muscle. To determine what role the muscle cell plays in this phenomenon, we studied reinnervation of frog muscle at intervals after crushing the nerve and damaging the muscle fibers. Damaged muscle fibers degenerate and are phagocytized, but their basement membrane persists and acts as a scaffold for regenerating muscle cells. Specializations of the basement membrane serve to mark original synaptic sites after nerve and muscle have degenerated. Regenerating axons enter the region of damage and form functional synapses with regenerating myofibers. The new nerve terminals are found almost exclusively at the original synaptic sites, demonstrating that the integrity of the original postsynaptic cell is not necessary for topographically precise reinnervation of denervated muscle.

Induction of compression in the re-established visual projections on to a rotated tectal reimplant that retains its original topographic polarity within the halved optic tectum of adult goldfish.

Yoon, M G
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/1977 EN
Relevância na Pesquisa
36.068096%
1. The topographic pattern of re-established retinotectal projections following various surgical manipulations of the optic tectum was studied in adult goldfish with neurophysiological mapping methods. 2. Immediately following excision of the caudal half of the tectum, a piece of the tectal tissue was dissected from the remaining rostral half-tectum, and then reimplanted to the same half-tectum after either 180 or 90 degrees anticlockwise rotation around the dorsoventral axis in the first experimental group. 3. A majority (twenty-one out of twenty-three) of these operated fish, in which the reimplanted tectal tissue degenerated, showed no sign of a field compression: only the nasal half of the visual field (with a localized partial scotoma corresponding to the area of the degenerated reimplant) projected on to the remaining intact area of the rostral half-tectum. 4. In seven fish, the re-established visual projections on to the 180 or 90 degrees rotated reimplants showed a corresponding localized 180 or 90 degrees rotation with reference to the other projections on to the surrounding intact area of the same half-tectum. Only one of these seven fish showed also a compression in the re-established projections from the entire visual field on to the operated half-tectum with the 90 degrees rotated reimplant. 5. When a field compression was induced first in the intact rostral half-tectum following excision of the caudal half...

Cadmium necrosis in transplanted testicles as evidence for persistence of original vessels in the graft.

Záhor, Z.; Povýsil, C.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /11/1979 EN
Relevância na Pesquisa
36.029258%
The testicles of newborn rats were transplanted subcutaneously to the external ears of mature male rats. Four and 8 weeks later the hosts received a subtoxic dose of cadmium chloride. Forty-eight hours thereafter focal, but evidently cadmium-induced necroses occurred in the grafts. As is the generally acknowledged, the tissue selectively sensitive to cadmium is the original endothelium of testicular vessels. Therefore the results of the study can be summarized as follows: 1) In the transplanted testicles the original vessels and their endothelium survive for at least 8 weeks. 2) Under the experimental conditions used here, the original vasculature of the graft joins with the vascular system of the host.

DISQUISITIONS ON ORIGINAL ANTIGENIC SIN : II. PROOF IN LOWER CREATURES

de St.Groth, S. Fazekas; Webster, R. G.
Fonte: The Rockefeller University Press Publicador: The Rockefeller University Press
Tipo: Artigo de Revista Científica
Publicado em 01/09/1966 EN
Relevância na Pesquisa
36.029258%
Experiments in rabbits were designed to test the two unproven assumptions of the hypothesis proposed in the companion paper (1): that Original Antigenic Sin is fundamentally a restricted anamnestic response, and that there exists a trapping mechanism capable of deflecting antigen from one kind of cell and guiding it to another. It is shown that whole-body X-irradiation, sufficient to abolish primary but not secondary production of antibodies, leaves all manifestations of the Original Antigenic Sin untouched. This proves the first assumption. Primary immune animals challenged with very large doses of a related antigen produce an immediate response of cross-reactive antibodies, followed by a standard primary response to the challenging antigen. When boosted with an appropriate mixture of both antigens, the response is of standard secondary type to the homologous antigen, followed by a standard primary response to the crossreacting antigen. When animals are primarily vaccinated with a mixture of two related antigens, small booster doses of either will stimulate a standard secondary response only. When such animals are given very large booster doses of either antigen, the response is a compound of a homologous secondary and of an Original Antigenic Sin-type against the related antigen. Each of these findings demonstrates a corollary of the second assumption. The results are discussed in terms of the limitations they impose on theories concerned with the production of antibodies.

Re-Creation of Historical Chrysotile-Containing Joint Compounds

Brorby, G. P.; Sheehan, P. J.; Berman, D. W.; Greene, J. F.; Holm, S. E.
Fonte: Informa Healthcare Publicador: Informa Healthcare
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.068096%
Chrysotile-containing joint compound was commonly used in construction of residential and commercial buildings through the mid 1970s; however, these products have not been manufactured in the United States for more than 30 years. Little is known about actual human exposures to chrysotile fibers that may have resulted from use of chrysotile-containing joint compounds, because few exposure and no health-effects studies have been conducted specifically with these products. Because limited amounts of historical joint compounds are available (and the stability or representativeness of aged products is suspect), it is currently impossible to conduct meaningful studies to better understand the nature and magnitude of potential exposures to chrysotile that may have been associated with historical use of these products. Therefore, to support specific exposure and toxicology research activities, two types of chrysotile-containing joint compounds were produced according to original formulations from the late 1960s. To the extent possible, ingredients were the same as those used originally, with many obtained from the original suppliers. The chrysotile used historically in these products was primarily Grade 7RF9 from the Philip Carey mine. Because this mine is closed...

Predictive value of seven preoperative prognostic scoring systems for spinal metastases

Leithner, Andreas; Radl, Roman; Gruber, Gerald; Hochegger, Markus; Leithner, Katharina; Welkerling, Heike; Rehak, Peter; Windhager, Reinhard
Fonte: Springer-Verlag Publicador: Springer-Verlag
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.029258%
Predicting prognosis is the key factor in selecting the proper treatment modality for patients with spinal metastases. Therefore, various assessment systems have been designed in order to provide a basis for deciding the course of treatment. Such systems have been proposed by Tokuhashi, Sioutos, Tomita, Van der Linden, and Bauer. The scores differ greatly in the kind of parameters assessed. The aim of this study was to evaluate the prognostic value of each score. Eight parameters were assessed for 69 patients (37 male, 32 female): location, general condition, number of extraspinal bone metastases, number of spinal metastases, visceral metastases, primary tumour, severity of spinal cord palsy, and pathological fracture. Scores according to Tokuhashi (original and revised), Sioutos, Tomita, Van der Linden, and Bauer were assessed as well as a modified Bauer score without scoring for pathologic fracture. Nineteen patients were still alive as of September 2006 with a minimum follow-up of 12 months. All other patients died after a mean period of 17 months after operation. The mean overall survival period was only 3 months for lung cancer, followed by prostate (7 months), kidney (23 months), breast (35 months), and multiple myeloma (51 months). At univariate survival analysis...

Predictive ability of a modified Örebro Musculoskeletal Pain Questionnaire in an acute/subacute low back pain working population

Gabel, Charles Philip; Melloh, Markus; Yelland, Michael; Burkett, Brendan; Roiko, Anne
Fonte: Springer-Verlag Publicador: Springer-Verlag
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.068096%
The original ‘Örebro Musculoskeletal Pain Questionnaire’ (original-ÖMPQ) has been shown to have limitations in practicality, factor structure, face and content validity. This study addressed these concerns by modifying its content producing the ‘Örebro Musculoskeletal Screening Questionnaire’ (ÖMSQ). The ÖMSQ and original-ÖMPQ were tested concurrently in acute/subacute low back pain working populations (pilot n = 44, main n = 106). The ÖMSQ showed improved face and content validity, which broadened potential application, and improved practicality with two-thirds less missing responses. High reliability (0.975, p < 0.05, ICC: 2.1), criterion validity (Spearman’s r = 0.97) and internal consistency (α = 0.84) were achieved, as were predictive ability cut-off scores from ROC curves (112–120 ÖMSQ-points), statistically different ÖMSQ scores (p < 0.001) for each outcome trait, and a strong correlation with recovery time (Spearman’s, r = 0.71). The six-component factor structure reflected the constructs originally proposed. The ÖMSQ can be substituted for the original-ÖMPQ in this population. Further research will assess its applicability in broader populations.

Discussion and revision of the mathematical modeling tool described in the previously published article “Modeling HIV Transmission risk among Mozambicans prior to their initiating highly active antiretroviral therapy”

Cassels, Susan; Pearson, Cynthia R.; Kurth, Ann E.; Martin, Diane P.; Simoni, Jane M.; Matediana, Eduardo; Gloyd, Stephen
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /07/2009 EN
Relevância na Pesquisa
36.0569%
Mathematical models are increasingly used in social and behavioral studies of HIV transmission; however, model structures must be chosen carefully to best answer the question at hand and conclusions must be interpreted cautiously. In Pearson et al. (2007), we presented a simple analytically tractable deterministic model to estimate the number of secondary HIV infections stemming from a population of HIV-positive Mozambicans and to evaluate how the estimate would change under different treatment and behavioral scenarios. In a subsequent application of the model with a different data set, we observed that the model produced an unduly conservative estimate of the number of new HIV-1 infections. In this brief report, our first aim is to describe a revision of the model to correct for this underestimation. Specifically, we recommend adjusting the population-level sexually transmitted infection (STI) parameters to be applicable to the individual-level model specification by accounting for the proportion of individuals uninfected with an STI. In applying the revised model to the original data, we noted an estimated 40 infections/1000 HIV-positive persons per year (versus the original 23 infections/1000 HIV-positive persons per year). In addition...

Direct and indirect interactions of the dopamine D3 receptor with glutamate pathways: implications for the treatment of schizophrenia

Sokoloff, Pierre; Leriche, Ludovic; Diaz, Jorge; Louvel, Jacques; Pumain, René
Fonte: Springer-Verlag Publicador: Springer-Verlag
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.0569%
This article, based on original data as well as on previously reported preclinical and clinical data that are reviewed, describes direct and indirect interactions of the D3 receptor with N-methyl-d-aspartate receptor (NMDA) signaling and their functional consequences and therapeutic implications for schizophrenia. D3 receptor immunoreactivity at ultrastructural level with electron microscopy was identified at presumably glutamatergic, asymmetric synapses of the medium-sized spiny neurons of the nucleus accumbens. This finding supports the existence of a direct interaction of the D3 receptor with glutamate, in line with previously described interactions with NMDA signaling involving Ca2+/calmodulin-dependent protein kinase II at post-synaptic densities (Liu et al. 2009). Indirect interactions of the D3 receptor with glutamate could involve a negative control exerted by the D3 receptor on mesocortical dopamine neurons and the complex regulation of the glutamatergic pyramidal cells by dopamine in the prefrontal cortex. This could be exemplified here by the regulation of pyramidal cell activity in conditions of chronic NMDA receptor blockade with dizocilpine (MK-801). BP897, a D3 receptor-selective partial agonist, reversed the dysregulation of cortical c-fos mRNA expression and pyramidal cell hyperexcitability...

Recalled Aspects of Original Encoding Strategies Influence Episodic Feeling of Knowing

Hertzog, Christopher; Fulton, Erika K.; Sinclair, Starlette M.; Dunlosky, John
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/2014 EN
Relevância na Pesquisa
36.068096%
We tested the hypothesis that feeling of knowing (FOK) after a failed recall attempt is influenced by recalling aspects of the original encoding strategy. Individuals were instructed to use interactive imagery to encode unrelated word pairs. We manipulated item concreteness (abstract versus concrete) and item repetition at study (1 versus 3). Participants orally described the mediator produced immediately after studying each item, if any. After a delay they were given cued recall, made FOK ratings, and attempted to recall their original mediator. Concreteness and item repetition enhanced strategy recall, which had a large effect on FOKs. Controlling on strategy recall reduced the predictive validity of FOKs for recognition memory, indicating that access to original aspects of encoding influenced FOK accuracy. Confidence judgments (CJs) for correctly recognized items covaried with FOKs, but FOKs did not fully track strategy recall associations with CJs, suggesting emergent effects of strategy cues elicited by recognition tests not accessed at the time of the FOK judgment. In summary, cue-generated access to aspects of the original encoding strategy strongly influenced episodic FOK, although other influences are also implicated.

Polygenic determinants of white matter volume derived from GWAS lack reproducibility in a replicate sample

Papiol, S; Mitjans, M; Assogna, F; Piras, F; Hammer, C; Caltagirone, C; Arias, B; Ehrenreich, H; Spalletta, G
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.068096%
A recent publication reported an exciting polygenic effect of schizophrenia (SCZ) risk variants, identified by a large genome-wide association study (GWAS), on total brain and white matter volumes in schizophrenic patients and, even more prominently, in healthy subjects. The aim of the present work was to replicate and then potentially extend these findings. According to the original publication, polygenic risk scores—using single nucleotide polymorphism (SNP) information of SCZ GWAS—(polygenic SCZ risk scores; PSS) were calculated in 122 healthy subjects, enrolled in a structural magnetic resonance imaging (MRI) study. These scores were computed based on P-values and odds ratios available through the Psychiatric GWAS Consortium. In addition, polygenic white matter scores (PWM) were calculated, using the respective SNP subset in the original publication. None of the polygenic scores, either PSS or PWM, were found to be associated with total brain, white matter or gray matter volume in our replicate sample. Minor differences between the original and the present study that might have contributed to lack of reproducibility (but unlikely explain it fully), are number of subjects, ethnicity, age distribution, array technology, SNP imputation quality and MRI scanner type. In contrast to the original publication...

Understanding Original Antigenic Sin in Influenza with a Dynamical System

Pan, Keyao
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 29/08/2011 EN
Relevância na Pesquisa
36.096147%
Original antigenic sin is the phenomenon in which prior exposure to an antigen leads to a subsequent suboptimal immune response to a related antigen. Immune memory normally allows for an improved and rapid response to antigens previously seen and is the mechanism by which vaccination works. I here develop a dynamical system model of the mechanism of original antigenic sin in influenza, clarifying and explaining the detailed spin-glass treatment of original antigenic sin. The dynamical system describes the viral load, the quantities of healthy and infected epithelial cells, the concentrations of naïve and memory antibodies, and the affinities of naïve and memory antibodies. I give explicit correspondences between the microscopic variables of the spin-glass model and those of the present dynamical system model. The dynamical system model reproduces the phenomenon of original antigenic sin and describes how a competition between different types of B cells compromises the overall effect of immune response. I illustrate the competition between the naïve and the memory antibodies as a function of the antigenic distance between the initial and subsequent antigens. The suboptimal immune response caused by original antigenic sin is observed when the host is exposed to an antigen which has intermediate antigenic distance to a second antigen previously recognized by the host's immune system.

Commercialized non-Camellia tea: traditional function and molecular identification

Long, Ping; Cui, Zhanhu; Wang, Yingli; Zhang, Chunhong; Zhang, Na; Li, Minhui; Xiao, Peigen
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.068096%
Non-Camellia tea is a part of the colorful Chinese tea culture, and is also widely used as beverage and medicine in folk for disease prevention and treatment. In this study, 37 samples were collected, including 33 kinds of non-Camellia teas and 4 kinds of teas (Camellia). Traditional functions of non-Camellia teas were investigated. Furthermore, non-Camellia teas of original plants were characterized and identified by molecular methods. Four candidate regions (rbcL, matK, ITS2, psbA-trnH) were amplified by polymerase chain reaction. In addition, DNA barcodes were used for the first time to discriminate the commercial non-Camellia tea and their adulterants, and to evaluate their safety. This study showed that BLASTN and the relevant phylogenetic tree are efficient tools for identification of the commercial non-Camellia tea and their adulterants. However, some sequences from original plants have not been found and there is a limitation of sequence number of original plants in GenBank. Submitting more original plant sequences to the GenBank will be helpful for evaluating the safety of non-Camellia teas.

CONTRIBUTION OF KAUTILYA ARTHASASHTRA TOWARDS DRAVYAGUNA, RASASASTRA AND BHAISHAJYAKALPANA BRANCHES OF AYURVEDIC MEDICINE

Prasad, Goli Penchala; Bhuyan, G. C.; Nagalakshmi, V.; Babu, G.; Swamy, G. K.; Sasty, Uttama Vaidya Shri Pammi Satyanarayana
Fonte: Medknow Publications & Media Pvt Ltd Publicador: Medknow Publications & Media Pvt Ltd
Tipo: Artigo de Revista Científica
Publicado em //2006 EN
Relevância na Pesquisa
36.0569%
It is believed Kautilya, whose name was Vishnugupta and is popular as Chanakya (The son of Chanaka) wrote Arthasastra. This article is mainly based on Kautilya's Arthasastra, translated by R. Shamasastry. In the preface of 1st to 5th edition of this text, the translator Dr. R. Shamasastry tried to clarify the uncertainty regarding the name of the author and the time of the text. Kamandaka and Dandi quotation support the time of this treatise somewhere between 321 and 300 B.C. These quotations also support the authorship of Vishnugupta. According to Kadambari, the author of Arthasastra was Kautilya and according to Manu and Dharmasastras, Chanakya had written this Arthasastra. Though there are some controversies regarding the name of the author and time of this text, translator R. Shamasastry tried his level best in providing proper support for naming this text as Kautilya's Arthasastra as the original available manuscript contains the name of Kautilya at the end of each of the hundred and fifty chapters of the work. Still there is controversy regarding the exact time of this text. If views of many scholars is considered, time of the text can be placed between 3rd century B.C. to 3rd century A.D. This translated original text contains 15 books (Basic discussions of the text)...

Original Antigenic Sin Responses to Influenza Viruses1

Kim, Jin Hyang; Skountzou, Ioanna; Compans, Richard; Jacob, Joshy
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.096147%
Most immune responses follow Burnet's rule in that Ag recruits specific lymphocytes from a large repertoire and induces them to proliferate and differentiate into effector cells. However, the phenomenon of “original antigenic sin” stands out as a paradox to Burnet's rule of B cell engagement. Humans, upon infection with a novel influenza strain, produce Abs against older viral strains at the expense of responses to novel, protective antigenic determinants. This exacerbates the severity of the current infection. This blind spot of the immune system and the redirection of responses to the “original Ag” rather than to novel epitopes were described fifty years ago. Recent reports have questioned the existence of this phenomenon. Hence, we revisited this issue to determine the extent to which original antigenic sin is induced by variant influenza viruses. Using two related strains of influenza A virus, we show that original antigenic sin leads to a significant decrease in development of protective immunity and recall responses to the second virus. In addition, we show that sequential infection of mice with two live influenza virus strains leads to almost exclusive Ab responses to the first viral strain, suggesting that original antigenic sin could be a potential strategy by which variant influenza viruses subvert the immune system.

Quality of abstracts of original research articles in CMAJ in 1989.

Narine, L; Yee, D S; Einarson, T R; Ilersich, A L
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 15/02/1991 EN
Relevância na Pesquisa
36.0569%
PURPOSE: To evaluate the quality of abstracts of original research articles. DESIGN: Blind, criterion-based survey. SAMPLE: Systematic sample of 33 abstracts of original research articles published in CMAJ in 1989. MEASUREMENT: The quality of abstracts was measured against a checklist of evaluation criteria, which were divided into eight categories. A score for each abstract was obtained by dividing the number of criteria present by the number applicable. The overall mean score was also determined. RESULTS: The overall mean score of abstract quality was 0.63 (standard deviation 0.13) out of 1. Of the abstracts reporting study design 56% did not include specific technical descriptors. About 52% did not explicitly describe the study variables. In describing subject selection 79% failed to use specific technical terms. Of the abstracts reporting results 66% did not provide appropriate supporting data. Of those that gave conclusions 86% did not address study limitations and 93% made no recommendations for future study. CONCLUSION: Most of the abstracts provided some information pertaining to each evaluation criterion but did not provide detail sufficient to enhance the reader's understanding of the article. On the basis of the study sample the abstracts need improvement in description of research design...

Construct Validity of the Holistic Complementary and Alternative Medicines Questionnaire (HCAMQ)—An Investigation Using Modern Psychometric Approaches

Kersten, Paula; White, P. J.; Tennant, A.
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.0569%
The scientific basis of efficacy studies of complementary medicine requires the availability of validated measures. The Holistic Complementary and Alternative Medicine Questionnaire (HCAMQ) is one such measure. This article aimed to examine its construct validity, using a modern psychometric approach. The HCAMQ was completed by 221 patients (mean age 66.8, SD 8.29, 58% females) with chronic stable pain predominantly from a single joint (hip or knee) of mechanical origin, waiting for a hip (40%) or knee (60%) joint replacement, on enrolment in a study investigating the effects of acupuncture and placebo controls. The HCAMQ contains a Holistic Health (HH) Subscale (five items) and a CAM subscale (six items). Validity of the subscales was tested using Cronbach alpha's, factor analysis, Mokken scaling and Rasch analysis, which did not support the original two-factor structure of the scale. A five-item HH subscale and a four-item CAM subscale (worded in a negative direction) fitted the Rasch model and were unidimensional (χ2 = 8.44, P = 0.39, PSI = 0.69 versus χ2 = 17.33, P = 0.03, PSI = 0.77). Two CAM items (worded in the positive direction) had significant misfit. In conclusion, we have shown that the original two-factor structure of the HCAMQ could not be supported but that two valid shortened subscales can be used...

Os jardins da residência Moreira Salles. O projeto original de Burle Marx e a restauração de Isabel Duprat;

Santos, Eloisa
Fonte: Universidade de São Paulo. Faculdade de Arquitetura e Urbanismo Publicador: Universidade de São Paulo. Faculdade de Arquitetura e Urbanismo
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Formato: application/pdf
Publicado em 31/12/2007 POR
Relevância na Pesquisa
36.068096%
This article consists of a morfologic analysis of the projected landscape of the residence of Moreira Salles, the current cultural center of the Institute of Moreira Salles, located in the neighborhood of Gávea, in Rio de Janeiro, designed in 1950 by architect Olavo Redig de Campos. By a comparative study between the project of landscape designer Roberto Burle Marx, conceived one year later, and the restoration, elaborated by the landscape designer Isabel Duprat and concluded in 1999, we can identify the influences revealed by the original project, the relation of the gardens of Burle Marx with a building representative of Modern Architecture, and the changes that have occurred in this space over close to a half a century.; Esse artigo se propõe a uma análise morfológica com base nas linhas projetuais paisagísticas para a residência Moreira Salles, atual centro cultural Instituto Moreira Salles, localizada no bairro da Gávea, no Rio de Janeiro, e projetada em 1950 pelo arquiteto Olavo Redig de Campos. Através do estudo comparativo entre o projeto do paisagista Roberto Burle Marx, concebido um ano depois, e o de restauração, elaborado pela paisagista Isabel Duprat e concluído em 1999, podemos identificar as influências reveladas pelo projeto original...

Liberalism and the view from the end of History; Economia Política e as raízes da posição original em Rawls

Pontin, Fabricio; Southern Illinois University
Fonte: UFPR Publicador: UFPR
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 27/05/2013 POR
Relevância na Pesquisa
36.068096%
The impact and relevance of economic theory to the development of “A Theory of Justice” are often left aside in the immense literature regarding the works of John Rawls. And yet, understanding the elements of political economy in Rawls’work is fundamental for the comprehension of why Rawls will abandons a utilitarian approach to political philosophy and, consequentially, for our understanding of the main issues that motivate the notion of Justice as Fairness.  This article has two mains goals: First, to describe the influence of John Stuart Mill, Kenneth Arrow and Vilfredo Pareto in the methodological turn found in the idea of the Original Position; and second, to describe the historical elements that are presupposed for the conceivability of Rawls’ ideals. I conclude the present paper with some remarks suggesting a historicist and phenomenological complement to the ideal descriptions found in political liberalism as understood by Rawls.; O impacto e a relevância da teoria econômica para o desenvolvimento de A Theory of Justice são, frequentemente, deixados de lado na imensa literatura a respeito das obras de John Rawls. Ainda assim, entender os elementos de economia política na obra de Rawls é fundamental para a compreensão dos motivos pelos quais ele abandonará uma abordagem utilitarista para a filosofia política e...

Economia Política e as raízes da posição original em Rawls (English version); Political Economy and the roots of Rawls’ original position

Pontin, Fabrício; Universidade Federal do Paraná, Curitiba, PR
Fonte: UFPR Publicador: UFPR
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; Formato: application/pdf
Publicado em 09/06/2013 ENG
Relevância na Pesquisa
36.068096%
O impacto e a relevância da teoria econômica para o desenvolvimento de A Theory of Justice são, frequentemente, deixados de lado na imensa literatura a respeito das obras de John Rawls. Ainda assim, entender os elementos de economia política na obra de Rawls é fundamental para a compreensão dos motivos pelos quais ele abandonará uma abordagem utilitarista para a filosofia política e, consequentemente , par a noss o entendimento das principais questões que dão origem à noção de justiça como equidade. Este artigo tem dois objetivos principais: primeiramente, descrever a influência de John Stuart Mill, Kenneth Arrow e Vilfredo Pareto na virada metodológica encontrada na ideia de posição original; segundo, descrever os elementos históricos pressupostos para a compreensibilidade dos ideais rawlsianos. Concluirei com algumas observações que sugerem um complemento historicista e fenomenológico para as descrições ideais encontradas no liberalismo político tal como é entendido por Rawls.; The impact and relevance of economic theory to the development of “A Theory of Justice” are often left aside in the immense literature regarding the works of John Rawls. And yet, understanding the elements of political economy in Rawls’ work is fundamental for the comprehension of why Rawls’ will abandons a utilitarian approach to political philosophy and...