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Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region

Suzkuki, Kazuo; Juelich, Torsten; Lim, Heidi; Ishida, Takaomi; Watanebe, Toshiki; Cooper, David A; Rao, Sudha; Kelleher, Anthony D
Fonte: American Society for Biochemistry and Molecular Biology Inc Publicador: American Society for Biochemistry and Molecular Biology Inc
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
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In some mammalian systems small interfering RNAs (siRNA) targeting homologous sequences in promoter regions of genes induce transcriptional gene silencing (TGS). We have previously reported the induction of TGS by an siRNA (prom-A siRNA) targeting the tan