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Lupus pleuritis: a relevant risk factor for pulmonary tuberculosis

PASOTO, S. G.; BORBA, E. F.; BONFA, E.; SHINJO, S. K.
Fonte: SAGE PUBLICATIONS LTD Publicador: SAGE PUBLICATIONS LTD
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
65.79%
The objective of the study was to evaluate risk factors for pulmonary tuberculosis in systemic lupus erythematosus (SLE). Clinical/laboratorial features of 1283 SLE patients (ACR criteria) followed at the Lupus Clinic were obtained from the electronic register database from 2001 to 2009. Pulmonary tuberculosis was diagnosed in 20 patients (1.6%) (TB+ group). As control group (TB-), 40 patients without tuberculosis matched for age, gender, ethnicity, age at SLE diagnosis, and disease duration were arbitrarily selected. All 20 patients of the TB+ group presented confirmed pulmonary tuberculosis from 1 to 23 years after SLE diagnosis (7.6 +/- 8.1 years). Frequencies of previous SLE involvements (cutaneous, articular, hematological, renal, pericarditis, pneumonitis, and central nervous system) were alike in TB+ and TB- groups (p > 0.05). In contrast, prior pleuritis was more frequent in the TB+ group (40% vs. 5%, p=0.001). In fact, pulmonary tuberculosis was diagnosed in 8/10 patients with previous pleuritis. Immunosuppressive and corticosteroid therapies at the moment of tuberculosis diagnosis were also similar in both groups (p > 0.05). We have identified pleuritis as a relevant risk factor for pulmonary tuberculosis, suggesting that previous pleural injury is a critical part of the complex interplay between altered immune system...

Análise dos fatores de risco para complicações pulmonares em pacientes laringectomizados : estudo retrospectivo do período de 1985 a 1996; Risk factors analysis to pulmonary complications in postoperative laryngeal cancer patients: restrospective study from 1985 to 1996

Melo, Giulianno Molina de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 22/11/2002 PT
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Os objetivos deste estudo foram identificar os fatores de risco para complicações pulmonares pós-operatórias em pacientes laringectomizados por carcinoma espinocelular de laringe, assim como os fatores de risco para apresentação de metástases pulmonares e os fatores de risco para apresentação de segundo tumores primários em pulmão destes pacientes no período de 1985 a 1996. O estudo consistiu em uma análise retrospectiva de 291 pacientes admitidos no Hospital do Câncer A. C. Camargo, no período de 1985 a 1996, portadores de carcinoma espinocelular de laringe, submetidos a tratamento cirúrgico com intenção curativa seguido ou não de radioterapia. Foram analisados as variáveis demográficas, as comorbidades, a localização do sítio primário, o estadiamento clínico, o tratamento do tumor primário e do pescoço, o tratamento radioterápico, a diferenciação celular, as margens cirúrgicas, as recidivas locais, as recidivas regionais, a presença de complicações maiores, de complicações menores, as metástases pulmonares e a presença de múltiplos tumores primários pulmonares. O teste de associação do qui-quadrado foi utilizado para análise univariada descritiva das diversas variáveis comparando-se os grupos com complicação pulmonar e sem complicação pulmonar. A análise multivariada através da regressão logística foi utilizada na determinação dos fatores de risco para apresentação de metástases pulmonares e múltiplos tumores primário pulmonares. A incidência de complicações pulmonares foi de 31...

Cyclin D1 gene polymorphism as a risk factor for squamous cell carcinoma of the upper aerodigestive system in non-alcoholics

Nishimoto, I. N.; Pinheiro, N. A.; Rogatto, Silvia Regina; Carvalho, A. L.; Simpson, A. J.; Caballero, O. L.; Kowalski, L. P.
Fonte: Elsevier B.V. Publicador: Elsevier B.V.
Tipo: Artigo de Revista Científica Formato: 604-610
ENG
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Squamous cell carcinoma of the upper aerodigestive tract (UADT) is associated with environmental factors, especially tobacco and alcohol consumption. Genetic factors, including cyclin D1 (CCND1) polymorphism have been suggested to play an important rote in tumorigenesis and progression of UADT cancer. To investigate the relationship between CCND1 polymorphism on susceptibility for UADT cancers, 147 cancer and 135 non-cancer subjects were included in this study. CCND1 genotype at codon 242(G870A) in exon 4 was undertaken using denaturing high performance liquid chromatography (DHPLC) and DNA sequencing. Significant odds ratio (OR) of the AA + GA genotypes [OR = 7.5 (95% Cl: 1.4-39.7)] was observed in non-drinkers but for non-smokers a non-significant [OR = 5.4 (95% Cl: 0.9-31.4)] was found in the adjusted model. These results suggest that allele A may be a risk factor for UADT cancer, especially in non-alcoholics. However, further epidemiological studies are needed to establish the exact role of CCND1 polymorphism and the development of UADT cancers. (C) 2004 Elsevier Ltd. All rights reserved.

Season of birth as a risk factor for multiple sclerosis in Brazil

Becker, Jefferson; Callegaro, Dagoberto; Lana-Peixoto, Marco Aurélio; Ferreira, Maria Lúcia B.; Melo, Ailton; Diniz Da Gama, Paulo; Souza, Doralina G.B.; Teixeira, Carlos A.C.; Kaimen-Maciel, Damacio Ramón; Gonçalves, Marcus Vinícius; Matta, André P
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 6-10
ENG
Relevância na Pesquisa
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Risk factors for development of multiple sclerosis (MS) are still a matter of debate. Latitude gradient, vitamin D deficiency and season of birth are among the most investigated environmental factors associated with the disease. Several international studies suggest that birth in spring is a substantial risk factor for MS. We investigated the season of birth as a potential risk for MS in different geographical regions of Brazil. We conducted a cross-sectional retrospective study with 2257 clinically definite MS patients enrolled in 13 Brazilian MS clinics in the south, southeast, and northeast regions of Brazil. Demographic and clinical data relating to date of birth and clinical features of the disease were collected and analysed, and subsequently compared with birth date among the general Brazilian population. The distribution of date of birth of MS patients showed an increase in spring and a decrease in autumn, with no difference being observed in the other seasons. In conclusion, season of birth is a probable risk factor for MS in most parts of Brazil. These findings may be related to the role that vitamin D plays in MS pathogenesis. © 2013 Elsevier B.V. All rights reserved.

Q192R polymorphism of the paraoxonase-1 gene as a risk factor for obesity in Portuguese women

Veiga, Luísa; Silva-Nunes, José; Melão, Alice; Oliveira, Ana; Duarte, Leone; Brito, Miguel
Fonte: European Society of Endocrinology Publicador: European Society of Endocrinology
Tipo: Artigo de Revista Científica
Publicado em /02/2011 ENG
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Introduction - Obesity became a major public health problem as a result of its increasing prevalence worldwide. Paraoxonase-1 (PON1) is an esterase able to protect membranes and lipoproteins from oxidative modifications. At the PON1 gene, several polymorphisms in the promoter and coding regions have been identified. The aims of this study were i) to assess PON1 L55M and Q192R polymorphisms as a risk factor for obesity in women; ii) to compare PON1 activity according to the expression of each allele in L55M and Q192R polymorphisms; iii) to compare PON1 activity between obese and normal-weight women. Materials and methods - We studied 75 healthy (35.9±8.2 years) and 81 obese women (34.3±8.2 years). Inclusion criteria for obese subjects were body mass index ≥30 kg/m2 and absence of inflammatory/neoplasic conditions or kidney/hepatic dysfunction. The two PON1 polymorphisms were assessed by real-time PCR with TaqMan probes. PON1 enzymatic activity was assessed by spectrophotometric methods, using paraoxon as a substrate. Results - No significant differences were found for PON1 activity between normal and obese women. Nevertheless, PON1 activity was greater (P<0.01) for the RR genotype (in Q192R polymorphism) and for the LL genotype (in L55M polymorphism). The frequency of allele R of Q192R polymorphism was significantly higher in obese women (P<0.05) and was associated with an increased risk of obesity (odds ratio=2.0 – 95% confidence interval (1.04; 3.87)). Conclusion - 55M and Q192R polymorphisms influence PON1 activity. The allele R of the Q192R polymorphism is associated with an increased risk for development of obesity among Portuguese Caucasian premenopausal women.

Risk factors for Toxoplasma gondii infection in women of childbearing age

Avelino,Mariza Martins; Campos Júnior,Dioclécio; Parada,Josetti Barbosa de; Castro,Ana Maria de
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2004 EN
Relevância na Pesquisa
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OBJECTIVES: Determine the risk factors involved in toxoplasmosis transmission and determine whether pregnancy is a risk factor for toxoplasmosis infection. STUDY DESIGN: Cross-sectional study carried out on 2,242 women at childbearing age. An indirect immunofluorescence reaction was used to identify immunity to Toxoplasma gondii. Previous gestations were also analyzed as a possible risk factor. The results were analyzed by chi2 and OR tests, and by variance analysis. The sample was statistically balanced according to social-economic risk factors. RESULTS: Previously pregnant women were 1.74 times more frequently infected with toxoplasmosis, regardless of environmental conditions. Pregnant women living under unfavorable environmental conditions had an approximately two times increased risk of being infected for each risk factor (contact with host animals, presence of vehicles of oocyst transmission). Previous pregnancy was the risk factor that had the strongest influence on acquiring toxoplasmosis (variance analysis and statistical balancing). DISCUSSION: The prevalence of this zoonosis is high in Goiânia-GO, Brazil (65.8%). Inadequate environmental sanitation was not significantly correlated with toxoplasmosis infection, except when associated with previous pregnancy...

Risk Profiles for Aortic Dissection and Ruptured or Surgically Treated Aneurysms: A Prospective Cohort Study

Landenhed, Maya; Engström, Gunnar; Gottsäter, Anders; Caulfield, Michael P.; Hedblad, Bo; Newton‐Cheh, Christopher; Melander, Olle; Smith, J. Gustav
Fonte: Blackwell Publishing Ltd Publicador: Blackwell Publishing Ltd
Tipo: Artigo de Revista Científica
EN_US
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55.9%
Background: Community screening to guide preventive interventions for acute aortic disease has been recommended in high‐risk individuals. We sought to prospectively assess risk factors in the general population for aortic dissection (AD) and severe aneurysmal disease in the thoracic and abdominal aorta. Methods and Results: We studied the incidence of AD and ruptured or surgically treated aneurysms in the abdominal (AAA) or thoracic aorta (TAA) in 30 412 individuals without diagnosis of aortic disease at baseline from a contemporary, prospective cohort of middle‐aged individuals, the Malmö Diet and Cancer study. During up to 20 years of follow‐up (median 16 years), the incidence rate per 100 000 patient‐years at risk was 15 (95% CI 11.7 to 18.9) for AD, 27 (95% CI 22.5 to 32.1) for AAA, and 9 (95% CI 6.8 to 12.6) for TAA. The acute and in‐hospital mortality was 39% for AD, 34% for ruptured AAA, and 41% for ruptured TAA. Hypertension was present in 86% of individuals who subsequently developed AD, was strongly associated with incident AD (hazard ratio [HR] 2.64, 95% CI 1.33 to 5.25), and conferred a population‐attributable risk of 54%. Hypertension was also a risk factor for AAA with a smaller effect. Smoking (HR 5.07, 95% CI 3.52 to 7.29) and high apolipoprotein B/A1 ratio (HR 2.48...

The use of chronic disease risk factor surveillance systems for evidence-based decision-making: physical activity and nutrition as examples

Taylor, A.; Campostrini, S.; Gill, T.; Carter, P.; DalGrande, E.; Herriot, M.
Fonte: Birkhauser Verlag Ag Publicador: Birkhauser Verlag Ag
Tipo: Artigo de Revista Científica
Publicado em //2010 EN
Relevância na Pesquisa
65.86%
Objective To highlight the value of continuous risk factor surveillance systems in providing evidence of the impact of, and to inform health promotion interventions. Method An ongoing risk factor surveillance system involving telephone interviews with approximately n = 600 randomly selected South Australians each month. Trend analysis on physical activity (PA) levels and daily consumption of fruit and vegetables was undertaken. Results An apparent seasonal trend for fruit consumption and PA was found, with less activity and fruit consumption undertaken in winter months. Overweight/obese adults exercised less than those with normal BMI, and females less than males, although PA rates for both females and overweight/obese adults are rising. There was an increase in vegetable consumption following a major media campaign. Although reported prevalence of the consumption of five or more serves of vegetables daily and the mean number of serves consumed daily has decreased, it is still above pre-campaign rates. Conclusion Additional information obtained from a risk factor surveillance system, when compared to an annual or point-in-time survey, provides valuable evidence for health professionals interested in measuring and assessing the effectiveness of health promotion interventions.; Anne W. Taylor...

Effect of weight reduction and cardiometabolic risk factor management on symptom burden and severity in patients with atrial fibrillation a randomized clinical trial

Abed, H.; Wittert, G.; Leong, D.; Shirazi, M.; Bahrami, B.; Middeldorp, M.; Lorimer, M.; Lau, D.; Antic, N.; Brooks, A.; Abhayaratna, W.; Kalman, J.; Sanders, P.
Fonte: Amer Medical Assoc Publicador: Amer Medical Assoc
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
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IMPORTANCE: Obesity is a risk factor for atrial fibrillation. Whether weight reduction and cardiometabolic risk factor management can reduce the burden of atrial fibrillation is not known. OBJECTIVE: To determine the effect of weight reduction and management of cardiometabolic risk factors on atrial fibrillation burden and cardiac structure. DESIGN, SETTING, AND PATIENTS: Single-center, partially blinded, randomized controlled study conducted between June 2010 and December 2011 in Adelaide, Australia, among overweight and obese ambulatory patients (N = 150) with symptomatic atrial fibrillation. Patients underwent a median of 15 months of follow-up. INTERVENTIONS: Patients were randomized to weight management (intervention) or general lifestyle advice (control). Both groups underwent intensive management of cardiometabolic risk factors. MAIN OUTCOMES AND MEASURES: The primary outcomes were Atrial Fibrillation Severity Scale scores: symptom burden and symptom severity. Scores were measured every 3 months from baseline to 15 months. Secondary outcomes performed at baseline and 12 months were total atrial fibrillation episodes and cumulative duration measured by 7-day Holter, echocardiographic left atrial area, and interventricular septal thickness. RESULTS: Of 248 patients screened...

Multiple risk factor intervention and progression of coronary atherosclerosis in patients with type 2 diabetes mellitus

Kataoka, Y.; Shao, M.; Wolski, K.; Uno, K.; Puri, R.; Tuzcu, E.; Nissen, S.; Nicholls, S.
Fonte: Sage Publications Ltd Publicador: Sage Publications Ltd
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
65.85%
BACKGROUND: Diabetic patients with coronary artery disease (CAD) demonstrate accelerated progression of coronary atherosclerosis. The impact of multiple risk factor intervention on disease progression has not been investigated. DESIGN: We investigated 448 diabetic patients with angiographic CAD who underwent serial intravascular ultrasound imaging to monitor the change in atheroma burden in seven clinical trials. METHODS: Disease progression was compared in patients stratified according to whether they achieved increasing numbers of treatment goals of individual risk factors (HbA1c <7.0%, LDL cholesterol <2.5 mmol/l, triglyceride <1.7 mmol/l, systolic blood pressure <130 mmHg, high sensitivity C-reactive protein <2.0 mg/l). RESULTS: A high rate of established medical therapies was used in all patients (89% statins, 94% aspirin, 76% β-blockers, 66% ACE inhibitors, 66% metformin, 62% thiazolidinediones, 17% insulin). No differences were observed with regard to percentage atheroma volume (PAV) and total atheroma volume (TAV) at baseline. On serial evaluation, slowing of progression of PAV (p = 0.01) and TAV (p  < 0.001) was observed with increasing numbers of risk factors achieving treatment goals. On multivariate analysis adjusting for baseline risk factors...

World alliance for risk factor surveillance white paper on surveillance and health promotion

Campostrini, S.; McQueen, D.; Taylor, A.W.; Daly, A.
Fonte: AIMS Press Publicador: AIMS Press
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
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This is not a research paper on risk factor surveillance. It is an effort by a key group of researchers and practitioners of risk factor surveillance to define the current state of the art and to identify the key issues involved in the current practice of behavioral risk factor surveillance. Those of us who are the principal authors have worked and carried out research in this area for some three decades. As a result of a series of global meetings beginning in 1999 and continuing every two years since then, a collective working group of the International Union of Health Promotion and Education (IUHPE) was formed under the name World Alliance of Risk Factor Surveillance (WARFS). Under this banner the organization sought to write a comprehensive statement on the importance of surveillance to health promotion and public health. This paper, which has been revised and reviewed by established peers in the field, is the result. It provides the reader with a clear summary of the major issues that need to be considered by any and all seeking to carry out behavioral risk factor surveillance.; Stefano Campostrini, David McQueen, Anne Taylor, and Alison Daly

Prevalence and risk factor analysis of lower extremity abnormal alignment characteristics among rice farmers

Karukunchit, U.; Puntumetakul, R.; Swangnetr, M.; Boucaut, R.
Fonte: Dove Press Publicador: Dove Press
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
Relevância na Pesquisa
55.9%
BACKGROUND: Rice farming activities involve prolonged manual work and human-machine interaction. Prolonged farming risk-exposure may result in lower limb malalignment. This malalignment may increase the risk of lower extremity injury and physical disabilities. However, the prevalence and factors associated with lower extremity malalignment have not yet been reported. This study aimed to investigate the prevalence and risk factors of lower extremity malalignment among rice farmers. METHODS: A cross-sectional survey was conducted with 249 rice farmers. Lower extremity alignment assessment included: pelvic tilt angle, limb length equality, femoral torsion, quadriceps (Q) angle, tibiofemoral angle, genu recurvatum, rearfoot angle, and medial longitudinal arch angle. Descriptive statistics were used to analyze participant characteristics and prevalence of lower extremity malalignment. Logistic regression analysis was used to identify risk factors. RESULTS: The highest prevalence of lower extremity malalignment was foot pronation (36.14%), followed by the abnormal Q angle (34.94%), tibiofemoral angle (31.73%), pelvic tilt angle (30.52%), femoral antetorsion (28.11%), limb length inequality (22.49%), tibial torsion (21.29%), and genu recurvatum (11.24%). In females...

Risikofaktoren für das Auftreten einer Anastomoseninsuffizienz nach konventioneller Operation wegen eines Kolonkarzinoms in den Jahren 2000 - 2004; Risk factors for anastomotic leakage after conventional resection of a colonic carcinoma in the years 2000 - 2004

Oswald, Jochen
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
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Einleitung: Eine postoperative Anastomoseninsuffizienz ist eine gefürchtete Komplikation in der kolorektalen Chirurgie, da sie ist mit einer hohen Morbidität und Letalität behaftet ist. Ziel dieser retrospektiven Arbeit war zu untersuchen, welche Faktoren das Auftreten einer Anastomoseninsuffizienz nach Eingriff am Kolon erhöhten. Material und Methodik: Um eine möglichst homogene Patientengruppe zu erhalten, wurden nur Patienten ausgewählt, die in den Jahren 2000 - 2004 in der Klinik für Allgemeine Chirurgie am Universitätsklinikum Tübingen wegen eines Kolonkarzinoms offen operiert wurden. Patienten, die wegen anderer Ursachen am Dickdarm oder wegen eines Rektumkarzinoms operiert wurden, sind ausgeschlossen worden. Die demographischen, operativen und postoperativen Daten sowie relevante Begleitkrankheiten wurden retrospektiv anhand der Krankenakten erhoben. Zunächst erfolgte die Auswertung des gesamten Patientengutes. Danach folgte eine getrennte Auswertung der Patienten mit und ohne Anastomoseninsuffizienz in Abhängigkeit des untersuchten Risikofaktors, um den Einfluss des einzelnen Faktors zu bestimmen. Ergebnisse: Von den insgesamt 399 operierten Patienten (230 Männer und 169 Frauen) entwickelten 27 eine Anastomoseninsuffizienz (6.8%). Die Patienten mit einer Insuffizienz hatten alle eine signifikant längere Verweildauer mit einer Klinikliegezeit von durchschnittlich 33.3 Tagen (p<0.001). Als signifikante Risikofaktoren für das Entstehen einer Anastomoseninsuffizienz konnten ein hoher Body-Mass-Index (p=0.02)...

Das Hepatozelluläre Karzinom im chirurgischen Krankengut : eine retrospektive Analyse der Risikofaktoren; The hepatocellular carcinoma in surgically treated patients : a retrospective risk factor analysis

Schwetlick, Regina
Fonte: Universität Tübingen Publicador: Universität Tübingen
Tipo: Dissertation; info:eu-repo/semantics/doctoralThesis
DE_DE
Relevância na Pesquisa
65.76%
In dieser Studie wurden retrospektiv die Angaben aus Krankenakten von 224 ambulanten bzw. stationären Patienten erfasst, die sich im Zeitraum von 1989 bis 1999 in der Chirurgischen Universitätsklinik Tübingen wegen eines gesicherten Hepatozellulären Karzinoms in Behandlung befanden. Ziel der Studie war es, bei dem Patientengut eine Analyse der Risikofaktoren unter besonderer Berücksichtigung des TNM-Stadiums bei Erstdiagnose vorzunehmen, die Erhöhung des Tumormarkers Alphafetoprotein bei Erstdiagnose zu erfassen und diese Ergebnisse mit den Angaben in der Literatur zu vergleichen. Das Durchschnittsalter der Patienten dieser Studie beträgt 59,9 Jahre, 82,5% der Patienten waren bei Erstdiagnose zwischen 50 und 74 Jahre alt. Abweichend von den Angaben in der Literatur waren die weiblichen Patienten mit einem Altersdurchschnitt von 58,5 Jahren zum Zeitpunkt der Diagnosestellung jünger als die männlichen Patienten mit einem Altersdurchschnitt von 60,2 Jahren. Den überwiegenden Anteil des Patientenkollektivs bilden - wie in vergleichbaren Studien - männliche Patienten beim Verhältnis 5,2:1. Bei 45,1% der Patienten war anamnestisch erhöhter Alkoholkonsum erfassbar, was den Ergebnissen in der Literatur weitgehend entspricht; vergleichsweise gering (62...

Predicting the unpredictable: identifying risk factors in homicide victimization an offending

Joudo, Jacqueline
Fonte: Universidade Nacional da Austrália Publicador: Universidade Nacional da Austrália
Tipo: Relatório
Relevância na Pesquisa
55.92%
Incident Characteristics • A total of 4112 homicide incidents were recorded by police between 1 July 1989 and 30 June 2002. • The incidence of homicide in Australia has remained relatively stable, with an average of 316 incidents per year. • Residential premises accounted for over half of all homicide locations, with the victim's home accounting for approximately 47 per cent of incidents. • Almost half of all homicide incidents occurred on Friday, Saturday, Sunday and 63 per cent of incidents occured between 6pm and 6am. Gender as a risk factor • There were a total of 4501 offenders identified by police. • Males accounted for at least 80 per cent of offenders in each of the thirteen years reviewed. • The highest rates of offending are found in the Northern Territory; 19.3 per 100, 000 population for males and 3.1 per 100,000 population for females. • There were a total of 4421 victims of homicide. • The highest rates of victimisation are found in the Northern Territory; 11.86 per 100,000 population for males and 7.75 per 100,000 population for females. • Domestic arguments are the most commonly cited motive for homicide incidents involving females. Age as a risk factor • For males, the 18 to 24 year age group consistently recorded the highest rates of offending...

Urinary tract infection in full-term newborn infants: risk factor analysis

Falcão,Mário Cícero; Leone,Cléa Rodrigues; D'Andrea,Renata A. P.; Berardi,Roberta; Ono,Nilce A.; Vaz,Flávio Adolfo Costa
Fonte: Faculdade de Medicina / Universidade de São Paulo - FM/USP Publicador: Faculdade de Medicina / Universidade de São Paulo - FM/USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2000 EN
Relevância na Pesquisa
65.85%
OBJECTIVE: To analyze the correlation of risk factors to the occurrence of urinary tract infection in full-term newborn infants. PATIENTS AND METHODS: Retrospective study (1997) including full-term infants having a positive urine culture by bag specimen. Urine collection was based on: fever, weight loss > 10% of birth weight, nonspecific symptoms (feeding intolerance, failure to thrive, hypoactivity, debilitate suction, irritability), or renal and urinary tract malformations. In these cases, another urine culture by suprapubic bladder aspiration was collected to confirm the diagnosis. To compare and validate the risk factors in each group, the selected cases were divided into two groups: Group I - positive urine culture by bag specimen collection and negative urine culture by suprapubic aspiration, and Group II - positive urine culture by bag specimen collection and positive urine culture by suprapubic aspiration . RESULTS: Sixty one infants were studied, Group I, n = 42 (68.9%) and Group II, n = 19 (31.1%). The selected risk factors (associated infectious diseases, use of broad-spectrum antibiotics, renal and urinary tract malformations, mechanical ventilation, parenteral nutrition and intravascular catheter) were more frequent in Group II (p<0.05). Through relative risk analysis...

The Earnings/Price Risk Factor in Capital Asset Pricing Models

Noda,Rafael Falcão; Martelanc,Roy; Kayo,Eduardo Kazuo
Fonte: Universidade de São Paulo, Faculdade de Economia, Administração e Contabilidade, Departamento de Contabilidade e Atuária Publicador: Universidade de São Paulo, Faculdade de Economia, Administração e Contabilidade, Departamento de Contabilidade e Atuária
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2015 EN
Relevância na Pesquisa
55.91%
This article integrates the ideas from two major lines of research on cost of equity and asset pricing: multi-factor models and ex ante accounting models. The earnings/price ratio is used as a proxy for the ex ante cost of equity, in order to explain realized returns of Brazilian companies within the period from 1995 to 2013. The initial finding was that stocks with high (low) earnings/price ratios have higher (lower) risk-adjusted realized returns, already controlled by the capital asset pricing model's beta. The results show that selecting stocks based on high earnings/price ratios has led to significantly higher risk-adjusted returns in the Brazilian market, with average abnormal returns close to 1.3% per month. We design asset pricing models including an earnings/price risk factor, i.e. high earnings minus low earnings, based on the Fama and French three-factor model. We conclude that such a risk factor is significant to explain returns on portfolios, even when controlled by size and market/book ratios. Models including the high earnings minus low earnings risk factor were better to explain stock returns in Brazil when compared to the capital asset pricing model and to the Fama and French three-factor model, having the lowest number of significant intercepts. These findings may be due to the impact of historically high inflation rates...

History of depression as a risk factor for dementia: An updated review

Jorm, Anthony F
Fonte: SAGE Publications Publicador: SAGE Publications
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
65.79%
Objective: This review updates an earlier meta-analysis of the data on history of depression as a risk factor for dementia. It also considers the available evidence on the hypotheses proposed to explain the association between history of depression and de

Blood pressure and control of cardiovascular risk

Whitworth, Judith
Fonte: Dove Medical Press Ltd Publicador: Dove Medical Press Ltd
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
55.86%
Two key early 20th century notions, the first the primacy of diastolic pressure in determining risk, and the second that hypertension is a discrete disorder, have proved to be incorrect. We now recognize the primacy of systolic pressure as a risk factor for cardiovascular disease and that hypertension is an arbitrary definition. In the early 21st century, we are moving away from a dichotomous approach to risk classification, and away from notions of hypertension and normotension towards an appreciation that blood pressure-related risk is continuous. In parallel, there has been a paradigm shift from a single risk factor approach to comprehensive cardiovascular disease risk prevention. Accordingly, prevention of cardiovascular disease requires a focus on lowering of blood pressure and modification of associated risk factors rather than simply treatment of hypertension. This emphasis is reflected in the World Health Organization (WHO)-International Society of Hypertension (ISH) 2003 statement on management of hypertension.

Idade materna como fator de risco: estudo com primigestas na faixa etária igual ou superior a 28 anos; La edad materna como un factor de riesgo: estudio com primigestas en la facha etaria igual o superior a 28 años; Maternal age as a risk factor: a study on first time pregnant women with age equal or higher than 28 years old

Parada, Cristina Maria Garcia de Lima; Pelá, Nilza Teresa Rotter
Fonte: Universidade de São Paulo. Escola de Enfermagem de Ribeirão Preto Publicador: Universidade de São Paulo. Escola de Enfermagem de Ribeirão Preto
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Formato: application/pdf
Publicado em 01/10/1999 POR
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55.94%
Trata-se de estudo transversal, cujo objetivo foi analisar a idade materna como fator de risco ou não, através da verificação de intercorrências na gestação, parto e puerpério de primigestas com idade igual ou superior a 28 anos e das condições de nascimento e alta de seus recém-nascidos, comparando-as com o grupo de primigestas na faixa etária de 20 a 27 anos. Foi realizado em Botucatu/S.P., no período de janeiro de 1990 a junho de 1995. A análise estatística, discutida ao nível de 5% de significância, foi realizada através da prova de Mann-Whitney, teste de Goodman e avaliação do risco relativo e risco relativo corrigido, através da técnica de Mantel-Haenszel. Concluiu-se que a idade materna igual ou superior a 28 anos não constituiu fator de risco gestacional, puerperal e intra-parto mas, por outro lado, foi fator de risco, mesmo após controlado o tipo de parto, para as seguintes intercorrências perinatais: taquipnéia transitória do recém-nascido, cianose generalizada ao nascer e infecção neonatal.; Es un estudio que tiene por objetivo analizar la edad materna como factor de riesgo o no, a través de la verificación de complicaciones en la gestación, parto y puerperio de primigestantes con edad igual o superior a 28 años...