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Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome

LYRA, P.P.R.; DINIZ, E.M.A.; ABE-SANDES, K.; ANGELO, A.L.D.; MACHADO, T.M.B.; CARDEAL, M.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
46.68%
The etiology of respiratory distress syndrome (RDS) is multifactorial and multigenic. Studies have suggested that polymorphisms and mutations in the surfactant protein B (SP-B) gene are associated with the pathogenesis of RDS. The objectives of this study were to determine and compare the frequencies of SP-B gene polymorphisms in preterm babies with and without RDS. We studied 151 neonates: 79 preterm babies without RDS and 72 preterm newborns with RDS. The following four SP-B gene polymorphisms were analyzed: A/C at -18, C/T at 1580, A/G at 9306, and G/C at nucleotide 8714. The polymorphisms were detected by PCR amplification of genomic DNA and genotyping. The genotypes were determined using PCR-based converted restriction fragment length polymorphisms. The control group consisted of 42 (53%) girls and 37 (47%) boys. Weight ranged from 1170 to 3260 g and mean gestational age (GA) was 33.9 weeks (range: 29 to 35 weeks and 6 days). The RDS group consisted of 31 (43%) girls and 41 (57%) boys. Weight ranged from 614 to 2410 g and mean GA was 32 weeks (range: 26 to 35 weeks). The logistic regression model showed that GA was the variable that most contributed to the occurrence of RDS. The AG genotype of the A/G polymorphism at position 9306 of the SP-B gene was a protective factor in this population (OR = 0.1681; 95%CI = 0.0426-0.6629). We did not detect differences in the frequencies of the other polymorphisms between the two groups of newborns.

Aprendendo e ensinando sobre os cuidados com o filho prematuro: a vivência de mães em um programa de educação em saúde; Learning and teaching about the care to your preterm baby: the experience of mothers in a health educational program

Ferecini, Geovana Magalhães
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 25/01/2008 PT
Relevância na Pesquisa
46.93%
As práticas educativas dirigidas às mães de prematuros ainda ocorrem, em alguns hospitais, de maneira tradicional, ministradas por profissionais sem a participação ativa da clientela nesse processo. Num esforço para o preparo mais adequado de mães para a alta hospitalar de bebês prematuros, vislumbrando a possibilidade de construir com mães conhecimentos acerca dos cuidados com o filho, motivou-se realizar o presente estudo tendo como objetivos específicos: descrever o processo de desenvolvimento de um Programa de Educação em Saúde mediado pelo uso de uma cartilha educativa dirigida às mães de prematuros, utilizando a metodologia participativa; analisar a percepção destas mães sobre a vivência no Programa e avaliar a aquisição de conhecimentos cognitivos destas sobre os cuidados com seus filhos, proporcionados pela participação no Programa. Trata-se de pesquisa de intervenção educacional fundamentado no referencial da problematização de Paulo Freire e que utiliza as abordagens quantitativa e qualitativa. Participaram do estudo 38 mães de prematuros internados na unidade de cuidados intermediários neonatal de um hospital público universitário de Ribeirão Preto - SP. O Programa de Educação em Saúde consistiu em atividades educativas grupais mediadas pelo uso da cartilha educativa "Cuidados com o bebê prematuro: orientações para a família". As participantes receberam a cartilha educativa para leitura e...

Desenvolvimento e avaliação do objeto digital de aprendizagem sobre o aleitamento materno do prematuro; Development and evaluation of a digital learning object about breastfeeding of preterm babies

Ferecini, Geovana Magalhães
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 27/01/2012 PT
Relevância na Pesquisa
56.78%
Em um esforço para auxiliar mães e famílias na prática e manutenção do aleitamento materno de bebês prematuros, motivamo-nos a realizar o presente estudo, visualizando a possibilidade de construir um instrumento educativo a fim de auxiliá-los neste cuidado com seus filhos prematuros. Neste sentido, os objetivos do presente estudo são: desenvolver um objeto digital de aprendizagem, um website sobre o aleitamento materno do prematuro, dirigido à família, e avaliar este objeto digital de aprendizagem junto a profissionais de enfermagem e informática. Trata-se de uma pesquisa descritiva, cujo referencial teórico para o desenvolvimento do objeto digital está fundamentado em Paulo Freire e na CAI (Computer Assisted Instruction - Instrução Assistida por Computador). Como modelo de desenvolvimento de website, utilizamos o User-Centered Design (projeto centrado no usuário) cujas fases foram: escolha do tema e fatores motivacionais do projeto, avaliação e análise das necessidades de saúde junto à profissionais (por meio de chats e ligações telefônicas com um comitê de especialistas, utilizando-se de temas geradores); identificação de soluções, articulação dos objetivos e análises dos questionamentos; e desenvolvimento e prototipagem com avaliação junto aos usuários. A amostra intencional constituiu-se de 29 enfermeiros e cinco profissionais da área da informática. O instrumento de avaliação utilizado baseou-se em princípios estabelecidos pela Norma ISO 9241 (divididos em sete grupos) e de Usabilidade. Para a análise dos dados utilizou-se a estatística descritiva. O projeto foi aprovado por Comitê de Ética em Pesquisa. Com base nos temas sugeridos pelo comitê de especialistas...

Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome

Lyra,P.P.R.; Diniz,E.M.A.; Abe-Sandes,K.; Angelo,A.L.D.; Machado,T.M.B.; Cardeal,M.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2011 EN
Relevância na Pesquisa
46.68%
The etiology of respiratory distress syndrome (RDS) is multifactorial and multigenic. Studies have suggested that polymorphisms and mutations in the surfactant protein B (SP-B) gene are associated with the pathogenesis of RDS. The objectives of this study were to determine and compare the frequencies of SP-B gene polymorphisms in preterm babies with and without RDS. We studied 151 neonates: 79 preterm babies without RDS and 72 preterm newborns with RDS. The following four SP-B gene polymorphisms were analyzed: A/C at -18, C/T at 1580, A/G at 9306, and G/C at nucleotide 8714. The polymorphisms were detected by PCR amplification of genomic DNA and genotyping. The genotypes were determined using PCR-based converted restriction fragment length polymorphisms. The control group consisted of 42 (53%) girls and 37 (47%) boys. Weight ranged from 1170 to 3260 g and mean gestational age (GA) was 33.9 weeks (range: 29 to 35 weeks and 6 days). The RDS group consisted of 31 (43%) girls and 41 (57%) boys. Weight ranged from 614 to 2410 g and mean GA was 32 weeks (range: 26 to 35 weeks). The logistic regression model showed that GA was the variable that most contributed to the occurrence of RDS. The AG genotype of the A/G polymorphism at position 9306 of the SP-B gene was a protective factor in this population (OR = 0.1681; 95%CI = 0.0426-0.6629). We did not detect differences in the frequencies of the other polymorphisms between the two groups of newborns.

Phagocytosis and killing ability of Candida albicans by blood leucocytes of healthy term and preterm babies.

Xanthou, M; Valassi-Adam, E; Kintsonidou, E; Matsaniotis, N
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/1975 EN
Relevância na Pesquisa
46.81%
The phagocytosis and killing ability of leucocytes of 24 term and 22 preterm babies against Candida albicans were studies during the first 20 days of life because of the increased incidence of monilia infection at this time. The leucocytes of 14 adults aged 20 to 30 years served as controls. The phagocytosis ability of the leucocytes in adults, term, and preterm babies was not significantly different, mean values being respectively 66-7%, 57%, and 56-9%. The killing ability of the leycocytes in term and preterm babies was lower when compared with that of adult leucocytes (P less than 0-001 for term and P less than 0-01 for preterm infants). The mean value in adults was 27-5%, in term infants 9-7%, and in preterm infants 9-5%. It is suggested that as the addition of adult serum did not improve the candidacidal ability of newborn leucocytes, the killing defect should be sought in the leucocyte itself and not in serum factors.

Providing warmth for preterm babies by a heated, water filled mattress.

Sarman, I; Tunell, R
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/1989 EN
Relevância na Pesquisa
46.63%
Seventeen healthy preterm babies had extra warmth provided in their cots by thermocontrolled, heated, water filled mattresses. As controls 17 babies of the same weight were nursed in air heated incubators. Both groups were studied for three weeks. No differences were found in minimal oxygen consumption (measured by indirect calorimetry), rectal and mean skin temperatures, or in daily weight gain. The babies were kept just as warm on the heated, water filled mattresses as in air heated incubators but the mattresses had the advantage of giving the mothers easy access to their babies.

Dexamethasone and infection in preterm babies: a controlled study.

Ng, P C; Thomson, M A; Dear, P R
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /01/1990 EN
Relevância na Pesquisa
46.68%
To find out if the use of steroids affected the incidence of infection in babies who were nursed in the neonatal intensive care unit for nine weeks or more, 24 preterm babies who had received a three weeks course of dexamethasone (0.6 mg/kg/day, reducing to 0.3 mg/kg/day after a week, and 0.15 mg/kg/day after two weeks) were compared with 18 preterm babies who had not been so treated. No differences were found in the incidence or pattern of septicaemia or other bacteriologically proved infections between the groups. Of 57 episodes of septicaemia, 44 (77%) were caused by coagulase negative staphylococci.

Gastroduodenal perforation in preterm babies treated with dexamethasone for bronchopulmonary dysplasia.

Ng, P C; Brownlee, K G; Dear, P R
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /10/1991 EN
Relevância na Pesquisa
46.62%
Three cases of gastroduodenal perforation and one case of ulceration and extreme thinning of the gastric wall occurred in preterm babies treated with dexamethasone for bronchopulmonary dysplasia. This complication of treatment with steroids has not to our knowledge previously been described in preterm infants. Urgent abdominal paracentesis was an essential part of the resuscitation in these cases, and this potentially serious side effect should be considered in all babies treated with steroids.

Asymptomatic bacteriuria in healthy preterm babies.

Moncrieff, M; Bamford, M; Benson, J; Bodden, J
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /09/1980 EN
Relevância na Pesquisa
46.86%
Urine was cultured from 51 healthy preterm babies. If the initial bag specimen grew more than 50 000 organisms/ml, a second bag specimen was cultured. After two positive bag specimens a suprapubic urine was cultured. Significant bacteriuria was excluded on the basis of one or two bag specimens in 90% of the babies. Suprapubic urine was sterile in a further 11 babies. Four babies with positive bag specimens were unfortunately not completely investigated: 2 had mixed growths and 2 had pure growths of 100 000 organisms/ml. As we and others consider that bacteriuria can only be diagnosed on a suprapubic sample of urine the incidence of proved infection in our series was zero. If both the babies with a pure growth of 100 000 organisms/ml had true bacteriuria, the incidence would rise to 1.3%. In view of the difficulties in obtaining clean urine samples in preterm babies and as the incidence of bacteriuria is so low, we do not recommend that healthy preterm babies be screened for bacteriuria.

Safety and effectiveness of BCG vaccination in preterm babies

Thayyil-Sudhan, S.; Kumar, A.; Singh, M.; Paul, V. K.; Deorari, A. K.
Fonte: BMJ Group Publicador: BMJ Group
Tipo: Artigo de Revista Científica
Publicado em /07/1999 EN
Relevância na Pesquisa
46.79%
AIM—To assess the cell mediated immune response to BCG vaccine in preterm babies.
METHODS—Sixty two consecutive preterm babies born at < 35 weeks of gestation were randomly allocated into two groups. Babies in group A were vaccinated early at 34-35 weeks and group B were vaccinated late at 38-40 weeks of postconceptional age. The two groups were similar in terms of: gestational age (mean (SD) 33.1 (1.1) and 33 (1.2) weeks, respectively); birthweight 1583 (204) and 1546(218) g; neonatal problems; socioeconomic status; and postnatal weight gain. The cell mediated immune response to BCG was assessed using the Mantoux test and the lymphocyte migration inhibition test (LMIT) 6-8 weeks after BCG vaccination. Induration of >5 mm after the Mantoux test was taken as a positive response.
RESULTS—There was no significant difference in the tuberculin conversion rates (80% and 80.7%, respectively), positive LMIT (86.6% and 90.3%, respectively), or BCG scar (90.0% and 87.1%, respectively) among the two groups.
CONCLUSIONS—Prematurity seems to be an unlikely cause for poor vaccine uptake. Preterm babies can be effectively vaccinated with BCG at 34-35 weeks of postconceptional age, the normal time of discharge in a developing country.



Optimum oxygen therapy in preterm babies

Tin, W; Gupta, S
Fonte: BMJ Group Publicador: BMJ Group
Tipo: Artigo de Revista Científica
Publicado em /03/2007 EN
Relevância na Pesquisa
46.68%
Oxygen is the most commonly used therapy in neonatal nurseries as an integral part of respiratory support. The goal of oxygen therapy is to achieve adequate delivery of oxygen to the tissue without creating oxygen toxicity. Oxygen must have been given to newborn preterm babies more than any other medicinal product in the past 60 years. Despite this, we still know very little about how much oxygen these babies actually need, or how much oxygen is safe to give, especially in the first few weeks of life. Recent observational studies have raised concerns that giving oxygen to target the saturation at “physiological” levels in newborn preterm babies may do more harm than good, but to date, clinicians have not been able to resolve the uncertainties surrounding optimum oxygen therapy.

Working to improve survival and health for babies born very preterm: The WISH project protocol

Crowther, C.; Middleton, P.; Bain, E.; Ashwood, P.; Bubner, T.; Flenady, V.; Morris, J.; McIntyre, S.
Fonte: BioMed Central Ltd. Publicador: BioMed Central Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
46.89%
Background: Babies born very preterm (before 30 weeks gestation) are at high risk of dying in their first weeks of life, and those who survive are at risk of developing cerebral palsy in childhood. Recent high-quality evidence has shown that giving women magnesium sulphate immediately prior to very early birth can significantly increase the chances of their babies surviving free of cerebral palsy. In 2010 Australian and New Zealand clinical practice guidelines recommended this therapy. The WISH (Working to Improve Survival and Health for babies born very preterm) Project aims to bi-nationally improve and monitor the use of this therapy to reduce the risk of very preterm babies dying or having cerebral palsy. Methods/Design: The WISH Project is a prospective cohort study. The 25 Australian and New Zealand tertiary level maternity hospitals will be provided with a package of active implementation strategies to guide the introduction and local adaptation of guideline recommendations. Surveys will be conducted at individual hospitals to evaluate outcomes related to local implementation progress and the use and value of the WISH implementation strategies. For the hospitals participating in the ‘WISH audit of uptake and health outcomes data collection’...

Insufficient early weight gain in preterm babies and influence on weight at 12 months.

Davies, D P; Kennedy, J D
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /08/1985 EN
Relevância na Pesquisa
46.62%
Relations between the amount and duration of insufficient early gain in weight and later catch up and absolute weight at 1 year of corrected age were investigated in 30 preterm babies of greater than 32 weeks' gestation. There were no significant correlations to suggest that insufficient early weight gain affected later patterns of weight despite individual weights at 1 year generally being distributed in lower centile channels. These findings have important clinical implications for the feeding of preterm babies.

Water loss from the skin of term and preterm babies.

Rutter, N; Hull, D
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /11/1979 EN
Relevância na Pesquisa
46.93%
Water loss from the skin of term and preterm babies, nursed naked in incubators under neutral thermal conditions, was measured by a method based on estimating the water vapour pressure gradient close to the skin surface. 199 sets of measurements were made on 78 babies whose gestational ages ranged from 26 to 41 weeks, during the first 4 weeks of life. Babies of 34 to 41 weeks' gestation had high water losses in the first 4 hours after birth, which then fell to low levels averaging 6 g/m2 per hour. Babies of 30 to 33 weeks' gestation had high water losses in the first week which then fell to levels similar to those of mature babies. Babies less than 30 weeks' gestation had strikingly high losses, averaging 32 g/m2 per hour in the first 4 days of life. At 2 weeks, levels were still higher than those of mature babies. Light-for-dates babies had skin water losses appropriate for their gestations. The high water losses in extremely preterm babies are probably transepidermal and the result of a thin, poorly keratinised stratum corneum. Water loss from the palms and soles was high in term babies and although low in preterm babies it rose steadily in the first 4 weeks of life. This is thought to represent the onset of emotional sweating. In terms of actual heat and water lost...

Neonatal risk factors for cerebral palsy in very preterm babies: case-control study.

Murphy, D. J.; Hope, P. L.; Johnson, A.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 08/02/1997 EN
Relevância na Pesquisa
46.68%
OBJECTIVE: To identify neonatal risk factors for cerebral palsy among very preterm babies and in particular the associations independent of the coexistence of antenatal and intrapartum factors. DESIGN: Case-control study. SETTING: Oxford health region. SUBJECTS: Singleton babies born between 1984 and 1990 at less than 32 weeks' gestation who survived to discharge from hospital: 59 with cerebral palsy and 234 randomly selected controls without cerebral palsy. MAIN OUTCOME MEASURES: Adverse neonatal factors expressed as odds ratios and 95% confidence intervals. RESULTS: Factors associated with an increased risk of cerebral palsy after adjustment for gestational age and the presence of previously identified antenatal and intrapartum risk factors were patent ductus arteriosus (odds ratio 2.3; 95% confidence interval 1.2 to 4.5), hypotension (2.3; 1.3 to 4.7), blood transfusion (4.8; 2.5 to 9.3), prolonged ventilation (4.8; 2.5 to 9.0), pneumothorax (3.5; 1.6 to 7.6), sepsis (3.6; 1.8 to 7.4), hyponatraemia (7.9; 2.1 to 29.6) and total parenteral nutrition (5.5; 2.8 to 10.5). Seizures were associated with an increased risk of cerebral palsy (10.0; 4.1 to 24.7), as were parenchymal damage (32; 12.4 to 84.4) and appreciable ventricular dilatation (5.4; 3.0 to 9.8) detected by cerebral ultrasound. CONCLUSION: A reduction in the rate of cerebral palsy in very preterm babies requires an integrated approach to management throughout the antenatal...

An Exploratory Investigation of Some Statistical Summaries of Oximeter Oxygen Saturation Data from Preterm Babies

Lee, Dominic S.; Zahari, Marina; Russell, Glynn; Darlow, Brian A.; Scarrott, Carl J.; Reale, Marco
Fonte: International Scholarly Research Network Publicador: International Scholarly Research Network
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
46.88%
Aim. To explore the potential usefulness of the mean, standard deviation (SD), and coefficient of variation (CV = SD/mean) of oximeter oxygen saturations in the clinical care of preterm babies. Methods. This was an exploratory investigation involving 31 preterm babies at 36 weeks postmenstrual age. All babies were healthy, but two were considered to be clinically unstable and required greater attention. Each baby's oxygen saturations were recorded using an oximeter and summarized by the mean, SD, and CV. The potential usefulness of each measure was assessed by its ability to distinguish the two unstable babies from the others. This was achieved using box plots and hierarchical clustering together with the Calinski-Harabasz (CH) index to quantify clustering performance (higher CH index indicates stronger clustering outcome). Results. The box plots flagged both unstable babies as outliers and none of the other babies. Successful clustering of the stable and unstable babies was achieved using the CV (CH = 72.8) and SD (CH = 63.3) but not with the mean. Conclusion. Taking the box plots and clustering results together, it seems plausible that variability might be more effective than mean level for detecting instability in oxygen saturation in preterm babies and that the combination of variability and level through the CV might be even better.

Type I collagenases in bronchoalveolar lavage fluid from preterm babies at risk of developing chronic lung disease

Sweet, D; McMahon, K; Curley, A; O'Connor, C; Halliday, H
Fonte: BMJ Group Publicador: BMJ Group
Tipo: Artigo de Revista Científica
Publicado em /05/2001 EN
Relevância na Pesquisa
46.68%
OBJECTIVE—To assess whether increased collagenolysis precedes severe chronic lung disease (CLD).
METHODS—Matrix metalloproteinase-1 (MMP-1) and MMP-8 (enzymes that degrade type I collagen, the main structural protein of lung extracellular matrix) were measured by enzyme linked immunosorbent assay in 100 bronchoalveolar lavage samples taken during the first 6 postnatal days from 45 ventilated preterm babies < 33 weeks gestation. The median value for each baby was calculated. CLD was defined as an oxygen requirement after the 36th week after conception.
RESULTS—MMP-8 levels in bronchoalveolar lavage fluid were higher (median 13 ng/ml) in 20 babies who developed CLD than in 25 without CLD (median 2 ng/ml). No MMP-1 was detected in any sample.
CONCLUSIONS—MMP-8 can be detected in bronchoalveolar lavage fluid from preterm babies, and higher levels are found in those who later develop CLD. MMP-8 may contribute to lung injury that occurs as a prelude to CLD.



Feelings and expectations of mothers of preterm babies at discharge

Rabelo,Maria Zuleide da Silva; Chaves,Edna Maria Camelo; Cardoso,Maria Vera Lúcia Moreira Leitão; Sherlock,Maria do Socorro Mendonça
Fonte: Escola Paulista de Enfermagem, Universidade Federal de São Paulo Publicador: Escola Paulista de Enfermagem, Universidade Federal de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2007 EN
Relevância na Pesquisa
46.74%
OBJECTIVE: To investigate the feelings and expectations of mothers of preterm babies at discharge. METHODS: This descriptive study used Bardin's framework to collect data among 11 mothers of preterm babies from a Neonatal Intensive Care Unit. Data were collected through interviews from December 2004 to January 2005. RESULTS: Four categories emerged: the moment of the discharge; mothers' knowledge and questions; mothers' preparation and orientation for discharge; and, mothers' desired orientation. CONCLUSION: Although mothers' experienced excitement and happiness at discharge, many reported being anxious and insecure on how to take care of their preterm babies.

A AMAMENTAÇÃO DE BEBÊS PRÉ-TERMO: UM CAMINHO POSSÍVEL PARA A CONSTRUÇÃO DA COMUNICAÇÃO; THE PRETERM BABY’S BREAST-FEEDING: A POSSIBLE PATHWAY FOR THE COMMUNICATION CONSTRUCTION

Delgado, Susana E.; Zorzetto, Marileuza
Fonte: Universidade de São Paulo. Faculdade de Saúde Pública Publicador: Universidade de São Paulo. Faculdade de Saúde Pública
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; Formato: application/pdf
Publicado em 19/06/2003 POR
Relevância na Pesquisa
56.74%
O objetivo do presente trabalho foi verificar o conhecimento que as mães de filhos prétermo têm à respeito do aleitamento materno e da importância deste como forma de comunicação,descrevendo os sinais de vínculo e comportamentos comunicativos da díade mãe-bebê durante amamentação. Foram realizadas entrevistas com as mães e observação da amamentação. A amostra foi composta de 15 mães, com idades entre 20 – 25 anos, e seus bebês pré-termo, internados na UTINeonatal. Os resultados quanto ao conhecimento das mães em relação ao aleitamento mostraram que a maioria tinha informações adequadas sobre o mesmo, sendo que as formas de comunicação mais observadas foram a expressão facial, o contato visual e o contato físico. Concluiu-se que a maioria das díades, apesar das dificuldades iniciais, consegue, por meio da amamentação, desencadear a experiência da comunicação e da vinculação mãe-bebê.; The objective of the present work was to verify the knowledge that mothers of preterm babies have about maternal breast-feeding and the importance of this as a form of communication,describing the bond signs and the communicative behaviors of the mother-baby dyad during breastfeeding. Data were collected by means of interviews carried out with the mothers and one observation of breast-feeding. The sample was composed of 15 mothers...

The ProVIDe study: the impact of protein intravenous nutrition on development in extremely low birthweight babies

Bloomfield, F.H.; Crowther, C.A.; Harding, J.E.; Conlon, C.A.; Jiang, Y.; Cormack, B.E.
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
Relevância na Pesquisa
46.76%
BACKGROUND: Preterm birth and very small size at birth have long-term effects on neurodevelopment and growth. A relatively small percentage of extremely low birthweight babies suffer from severe neurological disability; however, up to 50% experience some neurodevelopmental or learning disability in childhood. Current international consensus is that increased protein intake in the neonatal period improves both neurodevelopment and growth, but the quantum of protein required is not known. This trial aims to assess whether providing an extra 1 to 2 g.kg(-1).d(-1) protein in the first 5 days after birth will improve neurodevelopmental outcomes and growth in extremely low birthweight babies. METHODS/DESIGN: The ProVIDe study is a multicentre, two-arm, double-blind, parallel, randomised, controlled trial. In addition to standard intravenous nutrition, 430 babies with a birthweight of less than 1000 g who have an umbilical arterial line in situ will be randomised in 1:1 ratio to receive either an amino acid solution (TrophAmine®) or placebo (saline) administered through the umbilical arterial catheter for the first 5 days. Exclusion criteria are admission to neonatal intensive care more than 24 h after birth; multiple births of more than 2 babies; known chromosomal or genetic abnormality...