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Surdocegueira e deficiência múltipla sensorial: análise do Programa Atendimento Domiciliar & Famílias Apoiadas; Deafblindness and Multiple Sensory Impairment: analysis of the Home Visit & Supported Families Program

Souza, Marcia Maurilio
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 14/04/2010 PT
Relevância na Pesquisa
96.23%
O objetivo desta dissertação foi o de identificar as orientações e estratégias, utilizadas com as famílias no atendimento em ambiente domiciliar, que ajudaram seus filhos com surdocegueira ou com deficiência múltipla sensorial a alcançarem habilidades em atividades de vida autônoma e social (Avas). A fundamentação teórica refere-se à caracterização da pessoa com surdocegueira e deficiência múltipla sensorial, suas dificuldades de comunicação e participação; às metodologias que orientam a avaliação e organização de programas educacionais; à caracterização e necessidades das famílias; à programas baseados em Avas. Os participantes da pesquisa foram dois alunos e suas mães atendidos no Programa de Atendimento Domiciliar e Famílias Apoiadas (Programa AD & FA), da Ahimsa. Os critérios de seleção dos sujeitos foram: semelhanças nas características devidas à etiologia da deficiência, Síndrome da Rubéola Congênita (SRC) e alterações de comportamentos causados pelas manifestações tardias da (SRC); similaridade da faixa etária, jovens entre 22 e 23 anos. Para a coleta de dados foram realizadas dez visitas domiciliares para cada família no período de fevereiro a setembro de 2009, nas quais foram desenvolvidas atividades em Avas e elaborados relatórios das observações; foram realizadas no final dos atendimentos entrevistas semi-estruturadas com as mães. Foram elencadas as estratégias que efetivaram a participação do aluno e os fatores que constituíram auxílio ou dificuldade para as mães efetivarem ou não as estratégias...

Processos de estabelecimento da atenção conjunta em um bebê vidente e em outro com deficiência visual severa; Establishment of joint attention in a seer baby and in a severe visual impairment baby

Colus, Katia Miguel
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 26/10/2012 PT
Relevância na Pesquisa
35.94%
A atenção conjunta é considerada, na literatura específica, como sendo uma habilidade fundamental do bebê para que este possa, a partir dela, estabelecer um conjunto de dimensões básicas no seu desenvolvimento cognitivo, social e afetivo. A atenção conjunta se refere a comportamentos como olhar na direção do olhar do outro, observar a face, a intenção e os interesses do outro, mostrar e compartilhar interativamente objetos com outros. Episódios de atenção conjunta, portanto, podem quase ser denominados de episódios de atenção visual conjunta. Esta capacidade, como dado eminentemente visual, tem sido considerada como crucialmente importante para o desenvolvimento da capacidade interativa do bebê, sendo indispensável para que este se socialize. Entretanto, ao se pensar estes processos em crianças cegas ou com deficiência visual severa, depara-se com a pouca quantidade de informação disponível em dados de pesquisas. Assim, a meta desta pesquisa foi investigar se ocorreu e como ocorreu a construção, o estabelecimento e a manutenção do processo de atenção conjunta em um bebê vidente e um bebê com deficiência visual severa, ambos em interação com os parceiros em seu entorno. Para tal, partiu-se da verificação de quais pistas sensoriais o bebê ou os parceiros circundantes se utilizam nas interações (se pistas visuais...

Pediatric multiple sclerosis in Venezuela

Peña,Joaquín A.; Ravelo,María Elena; Rubio,Evelio; Pirela,Dulce; Soto,Arnoldo; Nava,Cecilia Montiel
Fonte: Academia Brasileira de Neurologia - ABNEURO Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2012 EN
Relevância na Pesquisa
35.8%
OBJECTIVE: To describe the epidemiological and clinical characteristics of Venezuelan pediatric patients with multiple sclerosis (MS). METHODS: Database records from the National Program for MS were searched for patients with an established diagnosis of MS whose first symptoms appeared before age 18. RESULTS: The national database held records of 1.710 patients; 3.8% had onset of the first symptoms before age 18. 46.7% were boys, yielding an F:M ratio of 1.13:1. Many children had a disease onset characterized by motor impairment (30.7%), brainstem/cerebellum and spinal cord affectation (27.6%), headache (26%). Less frequent symptoms were sensory symptoms (8%) and optic neuritis (7%). DISCUSSION: Pediatric MS patients in Venezuela represent a significant proportion of all MS cases. The clinical pattern is characterized by motor symptoms at onset, and predominantly monosymptomatic presentation with a relapsing-remitting pattern. This is the first systematic attempt to estimate the prevalence of pediatric MS in Venezuela.

Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord

Zackowski, Kathleen M.; Smith, Seth A.; Reich, Daniel S.; Gordon-Lipkin, Eliza; Chodkowski, BettyAnn A.; Sambandan, Divya R.; Shteyman, Michael; Bastian, Amy J.; van Zijl, Peter C.; Calabresi, Peter A.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
25.94%
The human spinal cord contains segregated sensory and motor pathways that have been difficult to quantify using conventional magnetic resonance imaging (MRI) techniques. Multiple sclerosis is characterized by both focal and spatially diffuse spinal cord lesions with heterogeneous pathologies that have limited attempts at linking MRI and behaviour. We used a novel magnetization-transfer-weighted imaging approach to quantify damage to spinal white matter columns and tested its association with sensorimotor impairment. We studied 42 participants with multiple sclerosis who each underwent MRI at 3 Tesla and quantitative tests of sensorimotor function. We measured cerebrospinal-fluid-normalized magnetization-transfer signals in the dorsal and lateral columns and grey matter of the cervical cord. We also measured brain lesion volume, cervical spinal cord lesion number and cross-sectional area, vibration sensation, strength, walking velocity and standing balance. We used linear regression to assess the relationship between sensorimotor impairment and MRI abnormalities. We found that the dorsal column cerebrospinal-fluid-normalized magnetization-transfer signal specifically correlated with vibration sensation (R = 0.58, P < 0.001) and the lateral column signal with strength (R = −0.45...

Multiple Sensory Impairment and Quality of Life

Fischer, Mary E; Cruickshanks, Karen J; Klein, Barbara E K; Klein, Ronald; Schubert, Carla R; Wiley, Terry L
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em //2009 EN
Relevância na Pesquisa
35.7%

Clinical efficacy issues in the treatment of multiple sclerosis: update of natalizumab

Patti, Francesco; Pappalardo, Angelo
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Artigo de Revista Científica
Publicado em 21/08/2009 EN
Relevância na Pesquisa
35.77%
Multiple sclerosis is a frequent neurologic disease, which causes sensory impairment, fatigue, cognitive deficits, imbalance, loss of mobility, spasticity, and bladder and bowel dysfunction. Several new therapies have been introduced in the past decade, but additional drugs are needed to slow disease progression and reduce disability. Natalizumab (NA) is an α4 integrin antagonist, effective in decreasing the development of brain lesions in experimental models and in several studies of patients with MS. Six randomized controlled trials of NA in MS have been published in the last 10 years. Overall, 2,688 relapsing-remitting MS subjects have been enrolled in these studies. Hence, there are already sufficient data to draw some conclusions about the effectiveness of NA in the treatment of MS, although for definitive considerations it would be reasonable to wait for the observational phase IV studies of clinical practice to complete. Moreover, the medical community is concerned with the safety of NA, particularly with the risk of developing progressive multifocal leukoencephalopathy while on NA therapy. From the analyses of the six cases, it seems that the overall risk is around 1/1,000 and could increase with the number of NA infusions.

Quality-Adjusted Life Years Lost to Road Crash Injury: Updating the Injury Impairment Index

Spicer, Rebecca S.; Miller, Ted R.; Hendrie, Delia; Blincoe, Lawrence J.
Fonte: Association for the Advancement of Automotive Medicine Publicador: Association for the Advancement of Automotive Medicine
Tipo: Artigo de Revista Científica
Publicado em /10/2011 EN
Relevância na Pesquisa
25.89%
The Injury Impairment Index (III) has long been used internationally to estimate the quality-adjusted life year (QALY) losses associated with crash injuries. The III has major limitations, notably its lack of detailed validation, but it is widely used and estimates from it are regularly published. It is based on physician estimates of typical impairment on 6 dimensions of functioning (cognitive, mobility, bending/grasping/lifting, sensory, pain and cosmetic), supplemented with data on work-related disability. This paper reports on a literature synthesis used to update the III scoring algorithm that converts impairment levels by dimension into a combined QALY loss score. An extensive international literature search identified 13 health status scales, some of them with multiple scorings. From the scorings, we extracted utility scores for each level of each dimension of the III. We also searched for direct utility estimates for III dimension endpoints (e.g., blindness, deafness). Median and inter-quartile ranges were computed by scale point to represent the uncertainty range of preference weights within each III dimension and level. Average QALY losses per injury by MAIS were computed using the updated preference weight ranges applied to 2000–2006 U.S. crash data. The updated QALY loss estimates are lower than those computed with the QALY weights developed in 1990. This paper’s tables of estimated average QALY losses by MAIS...

Cochlear implantation in multi-handicapped patients: the merf experience

Kameshwaran, Mohan; Kumar, Anand; Natarajan, Kiran; Raghavan, Dilip; Aram, Jawahar Nagasund; Jacob, Jeeth Isaac
Fonte: Springer India Publicador: Springer India
Tipo: Artigo de Revista Científica
Publicado em /04/2006 EN
Relevância na Pesquisa
25.89%
Hearing loss is the most common form of sensory impairment in humans. When hearing impairment is present from birth or is acquired in early childhood, it can be devastating for normal development. Early childhood deafness also has implications for cognitive, emotional and social development. In the majority of cases of early childhood hearing impairment, deafness is an isolated disorder. However, in a substantial number of cases, early childhood hearing impairment is not isolated, but forms part of a genetic syndrome with associated handicaps, or is acquired through pre-, perior postnatal causes, possibly with associated deficits. This means that more demands are made on the child’s family, the teachers and medical professionals to help these children cope with their rehabilitation, needs and demands. The presence of an additional handicap can pose special problems with regard to surgery, anesthesia or rehabilitation. Cochlear implantation is effective and aids in the effective rehabilitation of other additional handicaps. However, careful patient selection is required and thorough parental counseling regarding expectations must be given. In our Cochlear Implant Clinic a large proportion of implantees are in the paediatric age group. Of these...

Nicotine, Auditory Sensory Memory, and sustained Attention in a Human Ketamine Model of Schizophrenia: Moderating Influence of a Hallucinatory Trait

Knott, Verner; Shah, Dhrasti; Millar, Anne; McIntosh, Judy; Fisher, Derek; Blais, Crystal; Ilivitsky, Vadim
Fonte: Frontiers Research Foundation Publicador: Frontiers Research Foundation
Tipo: Artigo de Revista Científica
Publicado em 28/09/2012 EN
Relevância na Pesquisa
25.89%
Background: The procognitive actions of the nicotinic acetylcholine receptor (nAChR) agonist nicotine are believed, in part, to motivate the excessive cigarette smoking in schizophrenia, a disorder associated with deficits in multiple cognitive domains, including low-level auditory sensory processes and higher-order attention-dependent operations. Objectives: As N-methyl-d-aspartate receptor (NMDAR) hypofunction has been shown to contribute to these cognitive impairments, the primary aims of this healthy volunteer study were to: (a) to shed light on the separate and interactive roles of nAChR and NMDAR systems in the modulation of auditory sensory memory (and sustained attention), as indexed by the auditory event-related brain potential – mismatch negativity (MMN), and (b) to examine how these effects are moderated by a predisposition to auditory hallucinations/delusions (HD). Methods: In a randomized, double-blind, placebo-controlled design involving a low intravenous dose of ketamine (0.04 mg/kg) and a 4 mg dose of nicotine gum, MMN, and performance on a rapid visual information processing (RVIP) task of sustained attention were examined in 24 healthy controls psychometrically stratified as being lower (L-HD, n = 12) or higher (H-HD) for HD propensity. Results: Ketamine significantly slowed MMN...

Uses of Complementary and Alternative Medicine in Multiple Sclerosis

Namjooyan, Foroogh; Ghanavati, Rahil; Majdinasab, Nastaran; Jokari, Shiva; Janbozorgi, Mohammad
Fonte: Medknow Publications & Media Pvt Ltd Publicador: Medknow Publications & Media Pvt Ltd
Tipo: Artigo de Revista Científica
Publicado em //2014 EN
Relevância na Pesquisa
25.87%
Multiple sclerosis (MS) is a chronic, disabling, recurrent demyelination of the central nervous system (CNS). It could affect different regions in the brain and spinal cord, and according to the domain which is affected, it could cause different symptoms such as motor, sensory, or visual impairment; fatigue; bowel, bladder, and sexual dysfunction; cognitive impairment; and depression. MS patients also face reduced quality of life. Drugs that are used in MS are not fully efficient and patients suffer from many symptoms and adverse effects. Today there is an increasing trend of using complementary and alternative medicine (CAM). People are more likely to use this type of treatment. Using appropriate lifestyle and CAM therapy can subside some of the symptoms and could improve the quality of life in these patients. Many people with MS explore CAM therapies for their symptoms. This review is aimed to introduce CAM therapies that could be used in MS patients.

Targeting Dynamic Balance in Falls-Prevention Interventions in Multiple Sclerosis: Recommendations from the International MS Falls Prevention Research Network

Cattaneo, Davide; Jonsdottir, Johanna; Coote, Susan
Fonte: The Consortium of Multiple Sclerosis Centers Publicador: The Consortium of Multiple Sclerosis Centers
Tipo: Artigo de Revista Científica
Publicado em //2014 EN
Relevância na Pesquisa
35.8%
Balance deficits are common in people with multiple sclerosis (MS) and are associated with past and future falls. People with MS tend to fall during activities of daily living and recreation that involve transitions between body positions and during walking and turning. The evident deficits in dynamic balance may be partly due to impairment in the collection or integration of sensory inputs or the execution of appropriate movements in moments of distraction. There is growing evidence that dynamic balance is modifiable and that improvements in dynamic balance are associated with reduction in falls. Consequently, it is imperative that balance measures be appropriate to capture changes in components of dynamic balance. There are numerous ways to measure dynamic balance. When selecting the appropriate dynamic balance measure for an MS falls-prevention trial, the inclusion criteria and content of intervention will inform the choice of measure. The International MS Falls Prevention Research Network (IMSFPRN) suggests that measures of dynamic balance be included as an outcome measure for use in falls-prevention trials.

Sensory electrical stimulation improves foot placement during targeted stepping post-stroke

Walker, Eric R.; Hyngstrom, Allison S.; Schmit, Brian D.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
35.86%
Proper foot placement is vital for maintaining balance during walking, requiring the integration of multiple sensory signals with motor commands. Disruption of brain structures post-stroke likely alters the processing of sensory information by motor centers, interfering with precision control of foot placement and walking function for stroke survivors. In this study, we examined whether somatosensory stimulation, which improves functional movements of the paretic hand, could be used to improve foot placement of the paretic limb. Foot placement was evaluated before, during, and after application of somatosensory electrical stimulation to the paretic foot during a targeted stepping task. Starting from standing, twelve chronic stroke participants initiated movement with the non-paretic limb and stepped to one of five target locations projected onto the floor with distances normalized to the paretic stride length. Targeting error and lower extremity kinematics were used to assess changes in foot placement and limb control due to somatosensory stimulation. Significant reductions in placement error in the medial–lateral direction (p = 0.008) were observed during the stimulation and post-stimulation blocks. Seven participants, presenting with a hip circumduction walking pattern...

Intersections between disability, type of impairment, gender and socio-economic disadvantage in a nationally representative sample of 33,101 working-aged Australians

Kavanagh, A.M.; Krnjacki, L.; Aitken, Z.; LaMontagne, A.D.; Beer, A.; Baker, E.; Bentley, R.
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
Publicado em //2015 EN
Relevância na Pesquisa
35.95%
BACKGROUND: People with disabilities are socio-economically disadvantaged and have poorer health than people without disabilities; however, little is known about the way in which disadvantage is patterned by gender and type of impairment. OBJECTIVES: 1. To describe whether socio-economic circumstances vary according to type of impairment (sensory and speech, intellectual, physical, psychological and acquired brain injury). 2. To compare levels of socio-economic disadvantage for women and men with the same impairment type. METHODS: We used a large population-based disability-focused survey of Australians, analyzing data from 33,101 participants aged 25-64. Indicators of socio-economic disadvantage included education, income, employment, housing vulnerability, and multiple disadvantage. Stratified by impairment type, we estimated: the population weighted prevalence of socio-economic disadvantage; the relative odds of disadvantage compared to people without disabilities; and the relative odds of disadvantage between women and men. RESULTS: With few exceptions, people with disabilities fared worse for every indicator compared to people without disability; those with intellectual and psychological impairments and acquired brain injuries were most disadvantaged. While overall women with disabilities were more disadvantaged than men...

Prevalence of dual sensory impairment and its association with traumatic brain injury and blast exposure in OEF/OIF Veterans

Lew, Henry L.; Pogoda, Terri K.; Baker, Errol; Stolzmann, Kelly L.; Meterko, Mark; Cifu, David X.; Amara, Jomana; Hendricks, Ann M.
Fonte: Escola de Pós-Graduação Naval Publicador: Escola de Pós-Graduação Naval
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
46.1%
Background: Many service members deployed to the Afghanistan and Iraq theatre of operations are returning with multiple injuries, including traumatic brain injury (TBI) and sensory impairment. Studies of sensory impairment among patients with TBI have focused either on the auditory or visual modality. However, their co-prevalence, termed dual sensory impairment (DSI), is not well-documented. We examined self-reported rates of auditory and visual impairment in Afghanistan and Iraq war Veterans receiving TBI evaluations.

Hanseníase forma neural pura: aspectos clínicos e eletroneuromiográficos dos pacientes avaliados no serviço de doenças neuromusculares do HCRP da USP no período de março de 2001 a março de 2013; Pure neural leprosy: clinical and electrophysiologic features of patients evaluated in a Brazilian tertiary centre of neuromuscular deseases between March 2001 and March 2013

Tomaselli, Pedro José
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 23/05/2014 PT
Relevância na Pesquisa
25.93%
Introdução: A hanseníase é a principal causa infecciosa de neuropatia periférica e consequentes incapacidades em todo o mundo. Seu diagnóstico, na maioria das vezes é simples, especialmente quando as clássicas lesões cutâneas estão presentes. No entanto, alguns pacientes apresentam apenas envolvimento neural (forma neural pura - PNL) transformando o seu diagnóstico em um grande desafio. Nesses casos, mesmo quando essa possibilidade é aventada, sua confirmação pode ser extremamente difícil e muitos pacientes só serão corretamente diagnosticados tardiamente, quando uma neuropatia grave e irreversível já está estabelecida. Objetivos: Analisar as características de uma série de pacientes com diagnóstico definitivo ou provável de PNL seguidos no setor de doenças neuromusculares e dermatologia no HCRP em um período de 12 anos e reconhecer o padrão de apresentação mais frequente, suas manifestações clínicas e o padrão eletroneuromiográfico. Métodos: Estudo retrospectivo, observacional, cujos critérios de inclusão foram: evidência clínica de comprometimento de nervos periféricos na ausência de lesões de pele. O diagnóstico definitivo foi estabelecido quando o Mycobacterium leprae foi identificado na biópsia de nervo...

Esclerosis múltiple recurrente remitente en el sector público de salud de Chile. Descripción clínica de 314 pacientes

Nogales-Gaete, Jorge; Aracena, Rodrigo; Cepeda-Zumaeta, Sergio; Eloiza, Claudio; Agurto, Paula; Díaz, Vannia; Labbé, Silvia; Martínez, Séfora; Flores, Jazmín; Araya, Casandra
Fonte: Sociedad Médica de Santiago Publicador: Sociedad Médica de Santiago
Tipo: Artigo de Revista Científica
ES
Relevância na Pesquisa
35.84%
Background: Immunomodulatory drugs (IMD), Interferon β1a, β1b and glatiramer acetate are available in the Chilean public health system since June 2008 for patients with relapsing-remitting multiple sclerosis (RR-MS). Diagnostic confirmation and programmed follow up of these patients is carried out at a public national reference center. Aim: To describe the epidemiological and clinical features of 314 patients evaluated in this center between 2008 and 2012. Patients and Methods: Review of clinical records, to obtain information about demographic background, medical history, expanded disability status scale of Kurtzke (EDSS), multiple sclerosis functional composite (MSFC), intensity fatigue scale of Krupp, Rao’s Brief Repeatable Battery of Neuropsychological Tests (BNR-R) and anxious-depressive manifestations using Hamilton and Beck questionnaires. Results: The ages of patients ranged from 12 to 63 years and 67% were women. The initial symptoms were sensory disturbances in 20%, motor alterations in 18% and optical neuritis in 16%. In 9% of patients, the disease began with several manifestations. The EDSS was 4 or less in 73% of patients and cognitive impairment was observed in 34%. Treatment failure during the first and second years...

Pain in multiple sclerosis: characterization of a Portuguese population of 85 patients.; Dor na esclerose múltipla: caracterização de uma população Portuguesa de 85 doentes.

Seixas, Daniela; Instituto de Histologia e Embriologia, Universidade do Porto, Porto.; Galhardo, Vasco; Sá, Maria José; Guimarães, Joana; Lima, Deolinda
Fonte: Ordem dos Médicos Publicador: Ordem dos Médicos
Tipo: info:eu-repo/semantics/article; article; article; info:eu-repo/semantics/publishedVersion Formato: application/pdf
Publicado em 30/06/2009 POR
Relevância na Pesquisa
26.09%
Multiple sclerosis (MS) is a frequent neurological disease, with an estimated prevalence in Portugal of 60/100.000. It is a disease of the young adult, whose first symptoms are commonly of sensory type. The pathological process is of inflammatory nature, involving the central nervous system. The typical histopathological lesion is an area of demyelination. Initial descriptive studies affirmed that pain was an uncommon symptom in MS. However, it soon became evident that the majority of MS patients experience pain in the course of their disease. In MS it is possible to find any kind of pain syndrome, being the most common central neuropathic pain. A sample of 85 MS patients of the Outpatient Clinic of Demyelinating Diseases of the Neurology Department of São João Hospital, Oporto, Portugal, was studied. The presence of pain, demographic characteristics, disease duration, year of diagnosis, MS subtype, treatments and Expanded Disability Status Scale (EDSS) score were investigated. The group of MS patients with pain completed the short versions of the pain questionnaires The Brief Pain Inventory (BPI) and The McGill Pain Questionnaire (MPQ), for more detailed pain characterization. The prevalence of pain found was 34%. We have not established an association between the existence of pain and disease duration or functional impairment. However...

Natural History of Multiple Sclerosis Symptoms

Kister, Ilya; Bacon, Tamar E.; Chamot, Eric; Salter, Amber R.; Cutter, Gary R.; Kalina, Jennifer T.; Herbert, Joseph
Fonte: The Consortium of Multiple Sclerosis Centers Publicador: The Consortium of Multiple Sclerosis Centers
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
36.01%
The North American Research Committee on Multiple Sclerosis (NARCOMS) Registry is a database that contains information from over 35,000 patient volunteers on symptom severity in 11 domains commonly affected in multiple sclerosis (MS): mobility, hand function, vision, fatigue, cognition, bowel/bladder function, sensory, spasticity, pain, depression, and tremor/coordination. The Registry affords a unique opportunity to study the frequency and severity of domain-specific impairment in a contemporary, mostly treated MS cohort over the course of the disease. The objective of this work was to calculate symptom prevalence in each of the 11 domains for years 0 to 30 from symptom onset. The resulting “symptom prevalence tables” demonstrate that a majority of participants perceive at least some degree of impairment in most domains as early as the first year of disease. The severity of impairment increases with disease duration across all domains, but the patterns of disability accumulation differ. The symptom prevalence tables illustrate the magnitude of perceived impact of the disease and highlight the extent of unmet need in symptomatic management. The tables are easy to use and allow MS patients and their clinicians to compare an individual's own impairment in any of the 11 domains to that of NARCOMS participants with the same disease duration.

Interactions of Attention, Stimulus Conflict, and Multisensory Processing

Donohue, Sarah Elizabeth
Fonte: Universidade Duke Publicador: Universidade Duke
Tipo: Dissertação
Publicado em //2012
Relevância na Pesquisa
25.87%

At every moment in life we are receiving input from multiple sensory modalities. We are limited, however, in the amount of information we can selectively attend to and fully process at any one time. The ability to integrate the relevant corresponding multisensory inputs together and to segregate other sensory information that is conflicting or distracting is therefore fundamental to our ability to successfully navigate through our complex environment. Such multisensory integration and segregation is done on the basis of temporal, spatial, and semantic cues, often aided by selective attention to particular inputs from one or multiple modalities. The precise nature of how attention interacts with multisensory perception, and how this ramifies behaviorally and neurally, has been largely underexplored. Here, in a series of six cognitive experiments in humans using auditory and visual stimuli, along with electroencephalography (EEG) measures of brain activity and behavioral measures of task performance, I examine the interactions between attention, stimulus conflict, and multisensory processing. I demonstrate that attention can spread across modalities in a pattern that closely follows the temporal linking of multisensory stimuli...

Esclerosis múltiple recurrente remitente en el sector público de salud de Chile: Descripción clínica de 314 pacientes

Nogales-Gaete,Jorge; Aracena,Rodrigo; Cepeda-Zumaeta,Sergio; Eloiza,Claudio; Agurto,Paula; Díaz,Vannia; Labbé,Silvia; Martínez,Séfora; Flores,Jazmín; Araya,Casandra
Fonte: Sociedad Médica de Santiago Publicador: Sociedad Médica de Santiago
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/05/2014 ES
Relevância na Pesquisa
35.82%
Background: Immunomodulatory drugs (IMD), Interferon β1a, β1 b and glatiramer acetate are available in the Chilean public health system since June 2008 for patients with relapsing-remitting multiple sclerosis (RR-MS). Diagnostic confirmation and programmed follow up of these patients is carried out at a public national reference center. Aim: To describe the epidemiological and clinical features of 314 patients evaluated in this center between 2008 and 2012. Patients and Methods: Review of clinical records, to obtain information about demographic background, medical history, expanded disability status scale of Kurtzke (EDSS), multiple sclerosis functional composite (MSfic), intensity fatigue scale of Krupp, Rao’s Brief Repeatable Battery of Neuropsychological Tests (BNR-R) and anxious-depressive manifestations using Hamilton and Beck questionnaires. Results: The ages of patients ranged from 12 to 63 years and 67% were women. The initial symptoms were sensory disturbances in 20%, motor alterations in 18% and optical neuritis in 16%. In 9% of patients, the disease began with several manifestations. The EDSS was 4 or less in 73% of patients and cognitive impairment was observed in 34%. Treatment failure during the first and second years...