- PERGAMON-ELSEVIER SCIENCE LTD
- Biblioteca Digitais de Teses e Dissertações da USP
- The National Academy of Sciences
- Cold Spring Harbor Laboratory Press
- American Physiological Society
- National Academy of Sciences
- Frontiers Research Foundation
- Frontiers Media S.A.
- Oxford University Press
- Public Library of Science
- Hindawi Publishing Corporation
- Université de Montréal
- Quens University
- Universidade Duke
- Nature Preceedings
- Mais Publicadores...
Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in the hippocampal-prefrontal cortex pathway of rats in vivo: A possible involvement of monoaminergic systems
Plasticidade sináptica no córtex pré-frontal induzida por estimulação do tálamo mediodorsal de ratos in vivo: efeitos da modulação colinérgica muscarínica e nicotínica; Prefrontal cortical synaptic plasticity induced by stimulation of the rat mediodorsal thalamus in vivo: effects of cholinergic muscarinic and nicotinic modulation
Dynamical model of long-term synaptic plasticity
Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment
Layer 2/3 Synapses in Monocular and Binocular Regions of Tree Shrew Visual Cortex Express mAChR-Dependent Long-Term Depression and Long-Term Potentiation
RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
Cell type-specific long-term plasticity at glutamatergic synapses onto hippocampal interneurons expressing either parvalbumin or CB1 cannabinoid receptor
A Novel Learning Rule for Long-Term Plasticity of Short-Term Synaptic Plasticity Enhances Temporal Processing
Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus
ASYMMETRIES IN LONG-TERM AND SHORT-TERM PLASTICITY AT THALAMIC AND CORTICAL INPUTS TO THE AMYGDALA IN VIVO
Presynaptic long-term plasticity
Long-term plasticity determines the postsynaptic response to correlated afferents with multivesicular short-term synaptic depression
Dopamine D1/D5 Receptors Mediate Informational Saliency that Promotes Persistent Hippocampal Long-Term Plasticity
Interplay between Short- and Long-Term Plasticity in Cell-Assembly Formation
Acute Stress, But not Corticosterone, Disrupts Short- and Long-Term Synaptic Plasticity in Rat Dorsal Subiculum Via Glucocorticoid Receptor Activation
Dopaminergic Modulation of Striatal Inhibitory Transmission and Long-Term Plasticity
Mécanismes traductionnels impliqués dans la potentialisation à long-terme de la transmission synaptique des cellules pyramidales de l’hippocampe chez le rongeur.
Modulation of short- and long-term plasticity in the rat auditory cortex
Molecular Mechanisms for Presynaptic Long-term Potentiation
Long-term plasticity, the long-lasting, activity-dependent change in synaptic efficacy, is a fundamental property of the nervous system. Presynaptic forms of long-term plasticity are widely expressed throughout the brain, having been described in regions such as the cortex, cerebellum, hippocampus, thalamus, amygdala and striatum. Presynaptic long-term potentiation (LTP) is associated with an increase in presynaptic release probability, but further evidence of the cellular basis for the change in release probability is not known. At the molecular level, presynaptic LTP is known to require protein kinase A, the synaptic vesicle protein, Rab3A, and the active zone protein, RIM1alpha. RIM1alpha, a presynaptic scaffold protein, binds to many molecules with known functions at different stages of the neurotransmitter release process and the synaptic vesicle cycle. Understanding which interactions of RIM1alpha mediate presynaptic LTP would shed light on the molecular and cellular mechanisms for presynaptic long-term plasticity.
Here I developed a novel platform to achieve robust acute genetic
manipulation of presynaptic proteins at hippocampal mossy fiber synapses, where presynaptic LTP is expressed. With this platform, I perform structure-function analysis of RIM1alpha in presynaptic LTP. I find that RIM1alpha phosphorylation by PKA at serine 413 is not required for mossy fiber LTP...