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Early detection of leprosy by examination of household contacts, determination of serum anti-PGL-1 antibodies and consanguinity

BAZAN-FURINI, Renata; MOTTA, Ana Carolina F; SIMÃO, João Carlos L; TARQUÍNIO, Daniela Chaves; MARQUES JR, Wilson; BARBOSA, Marcello Henrique N; FOSS, Norma Tiraboschi
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
55.82%
A cross-sectional clinical trial in which the serum anti-phenolic glycolipid (anti-PGL-1) antibodies were analysed in household contacts (HHC) of patients with leprosy as an adjunct early leprosy diagnostic marker was conducted. The families of 83 patients underwent clinical examination and serum anti-PGL1 measurement using enzyme-linked immunosorbent assay. Of 320 HHC, 98 were contacts of lepromatous leprosy (LL), 80 were contacts of borderline lepromatous (BL), 28 were contacts of borderline (BB) leprosy, 54 were contacts of borderline tuberculoid (BT), 40 were contacts of tuberculoid (TT) and 20 were contacts of indeterminate (I) leprosy. Consanguinity with the patients was determined for 232 (72.5%) HHC. Of those 232 contacts, 183 had linear consanguinity. Forty-nine HHC had collateral consanguinity. Fifty-eight contacts (18.1%) tested positive for anti-PGL1 antibodies. The number of seropositive contacts based on the clinical forms of the index case was 17 (29.3%) for LL, 15 (25.9%) for BL, one (1.7%) for BB, 14 (24.1%) for BT, three (5.2%) for TT and eight (13.7%) for I. At the one year follow-up, two (3.4%) of these seropositive contacts had developed BT leprosy. The results of the present study indicate that the serum anti-PGL-1 IgM antibody may be useful for evaluating antigen exposure and as a tool for an early leprosy diagnosis in HHC.; FAEPA; CNPq; The São Paulo State Foundation against Leprosy

Avaliação inicial de um programa de detecção precoce do câncer de mama, por meio de mamografia, na região de Barretos; Initial evaluation of the breast cancer early detection program, based on mammography, at Barretos region

Haikel Junior, Raphael Luiz
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 03/08/2010 PT
Relevância na Pesquisa
55.8%
O câncer de mama é a neoplasia maligna mais prevalente entre as mulheres no mundo e representa 23% de todos os cânceres femininos. Buscou-se avaliar a implementação de um programa de rastreamento mamográfico para as mulheres que vivem na área de Barretos usando uma unidade móvel (UM) e uma unidade fixa (UF). Um total de 54.238 mulheres com idade entre 40 a 69 anos reside nesta área e são elegíveis para a participação no programa. Os dados epidemiológicos das mulheres foram examinadas entre 01 de abril de 2003 e 31 de março de 2005. A análise estatística foi constituída pela avaliação das freqüências dos parâmetros clínicos e as características do tumor usando o teste de Qui-quadrado com correção de Bonferroni, com valor de confiança de p<0,05. Um total de 17.964 mulheres (media de 51 anos de idade) foram efetivamente examinadas por mamografia, o que representou 33,1% de todas as mulheres elegíveis (18,6 exames por dia na UF e 26,3 na UM). Setenta e seis casos foram diagnosticados como câncer de mama (41, ou 54%, no UM), o que representa 4,2 casos de câncer de mama para cada 1.000 exames. Foi observada diferença significativa na detecção de câncer entre mulheres com idade entre 50-59 e 60-69 anos (p<0...

Early detection of leprosy by examination of household contacts, determination of serum anti-PGL-1 antibodies and consanguinity

Bazan-Furini,Renata; Motta,Ana Carolina F; Simão,João Carlos L; Tarquínio,Daniela Chaves; Marques Jr,Wilson; Barbosa,Marcello Henrique N; Foss,Norma Tiraboschi
Fonte: Instituto Oswaldo Cruz, Ministério da Saúde Publicador: Instituto Oswaldo Cruz, Ministério da Saúde
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2011 EN
Relevância na Pesquisa
55.82%
A cross-sectional clinical trial in which the serum anti-phenolic glycolipid (anti-PGL-1) antibodies were analysed in household contacts (HHC) of patients with leprosy as an adjunct early leprosy diagnostic marker was conducted. The families of 83 patients underwent clinical examination and serum anti-PGL1 measurement using enzyme-linked immunosorbent assay. Of 320 HHC, 98 were contacts of lepromatous leprosy (LL), 80 were contacts of borderline lepromatous (BL), 28 were contacts of borderline (BB) leprosy, 54 were contacts of borderline tuberculoid (BT), 40 were contacts of tuberculoid (TT) and 20 were contacts of indeterminate (I) leprosy. Consanguinity with the patients was determined for 232 (72.5%) HHC. Of those 232 contacts, 183 had linear consanguinity. Forty-nine HHC had collateral consanguinity. Fifty-eight contacts (18.1%) tested positive for anti-PGL1 antibodies. The number of seropositive contacts based on the clinical forms of the index case was 17 (29.3%) for LL, 15 (25.9%) for BL, one (1.7%) for BB, 14 (24.1%) for BT, three (5.2%) for TT and eight (13.7%) for I. At the one year follow-up, two (3.4%) of these seropositive contacts had developed BT leprosy. The results of the present study indicate that the serum anti-PGL-1 IgM antibody may be useful for evaluating antigen exposure and as a tool for an early leprosy diagnosis in HHC.

New method for early detection of two random amplified polymorphic DNA (RAPD) groups of Staphylococcus aureus causing bovine mastitis infection in Paraná State, Brazil

Gonçalves,Dicezar; Gabriel,Jane Eire; Madeira,Humberto Maciel França; Schühli,Guilherme Schnell e; Vicente,Vânia Aparecida
Fonte: Instituto de Tecnologia do Paraná - Tecpar Publicador: Instituto de Tecnologia do Paraná - Tecpar
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2010 EN
Relevância na Pesquisa
55.91%
The aim of this work was to develop a fast and accurate molecular approach to allow early detection of two RAPD groups of S. aureus causing bovine mastitis. Seventy five S. aureus isolates from infected animals were characterized by RAPD. Genomic fragments isolated from the unique bands present in either group were cloned and sequenced. Based on the DNA sequences, specific primers were designed to allow for the simultaneous detection of either group by multiplex PCR of S. aureus DNA isolated from clinical and subclinical bovine mastitis. Results showed that these proposed primers set could be used to detect various clinical and subclinical S. aureus isolates as well as the detection of the microorganism in bulk milk. Their use as a specific method for effective and early diagnostic tool for S. aureus infection in dairy herds is suggested.

Deriving benefit of early detection from biomarker-based prognostic models

Inoue, L. Y. T.; Gulati, R.; Yu, C.; Kattan, M. W.; Etzioni, R.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
46.01%
Many prognostic models for cancer use biomarkers that have utility in early detection. For example, in prostate cancer, models predicting disease-specific survival use serum prostate-specific antigen levels. These models typically show that higher marker levels are associated with poorer prognosis. Consequently, they are often interpreted as indicating that detecting disease at a lower threshold of the biomarker is likely to generate a survival benefit. However, lowering the threshold of the biomarker is tantamount to early detection. For survival benefit to not be simply an artifact of starting the survival clock earlier, we must account for the lead time of early detection. It is not known whether the existing prognostic models imply a survival benefit under early detection once lead time has been accounted for. In this article, we investigate survival benefit implied by prognostic models where the predictor(s) of disease-specific survival are age and/or biomarker level at disease detection. We show that the benefit depends on the rate of biomarker change, the lead time, and the biomarker level at the original date of diagnosis as well as on the parameters of the prognostic model. Even if the prognostic model indicates that lowering the threshold of the biomarker is associated with longer disease-specific survival...

Multiple Biomarker Panels for Early Detection of Breast Cancer in Peripheral Blood

Zhang, Fan; Deng, Youping; Drabier, Renee
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
46%
Detecting breast cancer at early stages can be challenging. Traditional mammography and tissue microarray that have been studied for early breast cancer detection and prediction have many drawbacks. Therefore, there is a need for more reliable diagnostic tools for early detection of breast cancer due to a number of factors and challenges. In the paper, we presented a five-marker panel approach based on SVM for early detection of breast cancer in peripheral blood and show how to use SVM to model the classification and prediction problem of early detection of breast cancer in peripheral blood. We found that the five-marker panel can improve the prediction performance (area under curve) in the testing data set from 0.5826 to 0.7879. Further pathway analysis showed that the top four five-marker panels are associated with signaling, steroid hormones, metabolism, immune system, and hemostasis, which are consistent with previous findings. Our prediction model can serve as a general model for multibiomarker panel discovery in early detection of other cancers.

Early Detection of Human Focal Seizures Based on Cortical Multiunit Activity

Park, Yun S.; Hochberg, Leigh R.; Eskandar, Emad N.; Cash, Sydney S.; Truccolo, Wilson
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /08/2014 EN
Relevância na Pesquisa
46%
Approximately 50 million people in the world suffer from epileptic seizures. Reliable early seizure detection could bring significantly beneficial therapeutic alternatives. In recent decades, most approaches have relied on scalp EEG and intracranial EEG signals, but practical early detection for closed-loop seizure control remains challenging. In this study, we present preliminary analyses of an early detection approach based on intracortical neuronal multiunit activity (MUA) recorded from a 96-microelectrode array (MEA). The approach consists of (1) MUA detection from broadband field potentials recorded at 30 kHz by the MEA; (2) MUA feature extraction; (3) cost-sensitive support vector machine classification of ictal and interictal samples; and (4) Kalman-filtering postprocessing. MUA was here defined as the number of threshold crossing (spike counts) applied to the 300 Hz – 6 kHz bandpass filtered local field potentials in 0.1 sec time windows. MUA features explored in this study included the mean, variance, and Fano-factor, computed across the MEA channels. In addition, we used the leading eigenvalues of MUA spatial and temporal correlation matrices computed in 1-sec moving time windows. We assessed the seizure detection approach on out-of-sample data from one-participant recordings with six seizure events and 4.73-hour interictal data. The proposed MUA-based detection approach yielded a 100% sensitivity (6/6) and no false positives...

Ações de detecção precoce do câncer de mama realizadas por profissionais da estratégia saúde da família

Costa, Francisca Marta de Lima
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Enfermagem; Assistência à Saúde Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Enfermagem; Assistência à Saúde
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
46.04%
This study is an exploratory descriptive study with a quantitative approach. The objective was to identify the actions for the early detection of breast cancer conducted by the health professionals of the Family Health Strategy in the Trairi region of the State of Rio Grande do Norte, Brazil. The research was conducted in nine municipalities of the region. Data were collected by means of a questionnaire with 52 Family Health Strategy professionals, 30 nurses and 22 physicians, that work in the region. Analysis was conducted using descriptive statistics. The results were organized and discussed in three areas: Knowledge about the early detection of breast cancer; Actions for early detection detection of breast cancer, and Difficulties experienced in the screening actions for breast cancer. The results indicate that these professionals (100%) have knowledge of the signs and symptoms of breast cancer and that the majority (96,2%) conduct screening actions in accordance with the recommendations of the Ministry of Health. However, a considerable number (55,8%) of these professionals encounters difficulties while conducting the screening procedures in his work setting. The difficulties varied from those of a personal nature to those of access to the procedure...

Atenção precoce do câncer de mama :um olhar sobre o cotidiano institucional de uma unidade de saúde de Natal; Breast Cancer Early Detection: Overview of Everyday Institutional Setting at a Public

Guimarães, Greyce Gondim
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Psicologia; Psicologia, Sociedade e Qualidade de Vida Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Psicologia; Psicologia, Sociedade e Qualidade de Vida
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
65.99%
Breast cancer has been considered a grave global public health problem due to its increase in incidence, in women s mortality and in the amount of financial resources spent on the therapeutic interventions used in the treatment of this neoplasia. However, this scenario presents some variations. In developing countries, the incidence of breast cancer is increasing but, on the other hand, the mortality is declining among patients because of public health actions toward early diagnostic that also result in cure of patients and decreasing levels of physical and psychosocial stress. In Brazil, we face of both the increasing number of breast cancer incidence and number of mortalities. Almost always the reason for that is a delayed detection that will provide a late diagnostic. The early detection of breast cancer has been studied in several researches. Some of them are concerned with women s experiences. Despite that, there is a lack of researches on dynamic comprehension of early attention to breast cancer from the health professionals points of view. The present research was carried out at the Unidade Mista de Felipe Camarão (UMFC) and it was conducted with 11 professionals who work in the Family Health Program (PSF). The aim was to understand how early diagnostic and attention to breast cancer is being planned...

Towards early intervention for youth mental health in primary care: a mixed methods investigation

Leahy, Dorothy
Fonte: University of Limerick Publicador: University of Limerick
Tipo: info:eu-repo/semantics/doctoralThesis; all_ul_research; ul_published_reviewed; ul_theses_dissertations
ENG
Relevância na Pesquisa
55.85%
peer-reviewed; In Ireland, psychological morbidity has been reported in 21-27% of young people and recent data has indicated that the youth suicide rate in Ireland is now the second highest (of 26 countries) in the European Union, for 0-19 year olds. Early intervention in youth mental health is increasingly viewed as easier, cheaper and more effective than traditional approaches to care. GPs, as the health care professional most often consulted by young people, have a central role in early detection of youth mental health and substance use problems. However, there is a dearth of evidence regarding the experiences and attitudes of young people and health care workers towards screening and treatment for mental and substance use disorders in primary care in Ireland. The overarching aim of this thesis was to examine the role of primary care (with a particular focus on the role of the GP) in providing early intervention and treatment for mental health and substance use problems in young people. It was a mixed methods study that involved qualitative interviews with health care workers (n=37) and young people (n=20) from primary care, secondary care and community agencies in two of Ireland’s most socio-economically disadvantaged areas...

The effect on survival of early detection of breast cancer in South Australia

Tallis, G.M; Leppard, P; O’Neill, T.J
Fonte: Universidade Nacional da Austrália Publicador: Universidade Nacional da Austrália
Tipo: Working/Technical Paper Formato: 330598 bytes; 354 bytes; application/pdf; application/octet-stream
EN_AU
Relevância na Pesquisa
65.85%
Early detection of breast cancer is an important public health policy. Programs of regular screening examinations have been widely established in an attempt to detect the disease when the primary tumour diameter is small. In South Australia, BreastScreen SA suggests that women between the ages of 50 and 70 years be screened every 24 months. Our aim in this paper is to make assessments of various screening procedures by using statistical models with parameters estimated exclusively from South Australian data. We establish a relationship between primary tumour diameter and ultimate survival time. We estimate an advantage of 2.9 (.7) years in median survival time for those women detected with the disease by BreastScreen SA, compared with an unscreened population. We construct a computer model from which we determine the consequences of using a 12 month screening interval, and also the effect of beginning screening at the age of 40 rather than the current conventional commencement age of 50 years.; no

Evidenzbasierte Literaturrecherche für eine Leitlinie zur Früherkennung und Frühbehandlung von riskantem Alkoholkonsum und Alkoholabhängigkeit in der hausärztlichen Praxis; Review of evidence based research concerning early detection and early intervention of risky alcohol consumption and alcohol abuse in general practice

Robert, Kerstin
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
Relevância na Pesquisa
55.82%
Fragestellung: Für eine zukünftige Leitlinie zur Früherkennung und Therapie von riskantem Alkoholkonsum (F10.1) und Alkoholabusus (F10.2) in der allgemeinärztlichen Praxis in Deutschland soll die aktuelle Literatur im Hinblick auf den Empfehlungsgrad zu Schritten der Diagnostik und Therapie überprüft werden. Methodik: Mit Hilfe des „Reference Managers“ und „Ovid“, einer Software für Datenbanken, wurde in folgenden Datenbanken gesucht: Cochrane Database of Systematic Reviews, ACP Journal Club, Database of Abstracts of Review of Effekt, Cochrane Central Register of Controlled Trials, PsycINFO, Medline, Deutsches Ärzteblatt. Ergebnis: Über die Suchmaschinen und Handsuche wurden 1.385 Artikel gefunden, von denen 248 selektiert wurden. Diese wurden nach den einzelnen Schritten kritisch überprüft. Zu jedem Schritt (Screening, Diagnostik, Therapie) wurde der herausgefundene Artikel in Tabellen erfasst, gewertet und entsprechende Empfehlungen daraus abgeleitet. Fazit: Entgegen der Meinung vieler Autoren wird hier Screenen nicht für Praxen empfohlen, es sei denn mit Ultrakurzfragebögen, sofern nicht bereits klinische Zeichen (Aufgreifkriterien) Anlass zu gezielter Diagnostik geben. Die Diagnostik sollte auf Tests (CAGE...

Assoziationen zwischen bildgebenden, kognitiven und motorischen Testverfahren zur Früherkennung des Morbus Parkinson; Associations between imaging, cognitive and motor-function test procedures in the early detection of Parkinson's Disease

Baumann, Dorothea
Fonte: Universität Tübingen Publicador: Universität Tübingen
Tipo: Dissertation; info:eu-repo/semantics/doctoralThesis
DE_DE
Relevância na Pesquisa
55.86%
Jährlich wird bei ca. 13.000 Personen in der Bundesrepublik Deutschland die Diagnose „M. Parkinson“ gestellt. Nach anfänglich vergleichsweise milder Symptomatik ist diese Erkrankung jedoch im weiteren Verlauf durch einen zunehmenden Abbau nicht nur motorischer sondern auch kognitiver, emotionaler und vegetativer Funktionen gekennzeichnet, die die Lebensqualität stark beeinträchtigen und in Spätstadien ein hohes Maß an Pflegebedürftigkeit mit sich bringen. Im Jahr 1995 wurde bei Parkinson-Patienten erstmals eine typische Ultra-schallsignalveränderung der Substantia nigra (SN) beschrieben, die im Vergleich zur Norm in ihrer zweidimensionalen Ausbreitung vergrößert sowie signalreicher (hyperechogen; SN+) imponierte. Trotz der Notwendigkeit einer gewissen Erfahrung zur Erhebung und Interpretation des Ultraschallbefundes besticht diese Methode aufgrund ihrer hohen Sensitivität als nicht-invasives und kostengünstiges Verfahren in der Diagnostik des M. Parkinson. Epidemiologische Studien ergaben, dass 10-16% der Allgemeinbevölkerung ebenfalls dieses Ultraschallmerkmal aufweisen. Die Assoziation von SN+ mit vier von fünf prodromalen Markern als auch mit funktionellen Veränderungen des nigro-striatalen Transmittersystems führte zu der These...

Sensorimotor testing for the early identification of individuals at risk of developing carpal tunnel syndrome

Trachter, Robert
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado Formato: 2158565 bytes; application/pdf
EN; EN
Relevância na Pesquisa
55.82%
Carpal tunnel syndrome (CTS) is one of the most common injuries responsible for lost time claims to the Workplace Safety and Insurance Board (WSIB). The main purpose of this study was to determine whether measurable sensorimotor changes exist in asymptomatic individuals who are at risk for CTS such that sensory impairment and/or functional tests may be used in the early detection and intervention to reduce the impact of CTS on individuals, industry and the health care system. Participants were recruited into three strata: (1) individuals diagnosed with mild CTS, (2) asymptomatic individuals who were deemed to be at risk of developing CTS due to exposure to etiological risk factors and (3) asymptomatic individuals who were deemed to be at minimal risk of developing CTS based on non-exposure to risk factors. The main outcome measures included two-point discrimination ability, pressure acuity, vibration sense, Purdue Pegboard Test performance and tracking error and tracking variance on a manual tracking task performed at two different speeds. Seven individuals with CTS, fourteen individuals at risk of developing CTS and nine control individuals with minimal risk participated. The CTS group was significantly different from the at-risk and control groups on the main and work sections of the DASH questionnaire...

The early stages of psychosis: Characterization of At-Risk Mental State and First-Episode Psychosis patients and The Effect of Family Environment on Outcome.

Domínguez Martínez, Tecelli
Fonte: [Barcelona] : Universitat Autònoma de Barcelona, Publicador: [Barcelona] : Universitat Autònoma de Barcelona,
Tipo: Tesis i dissertacions electròniques; info:eu-repo/semantics/doctoralThesis; info:eu-repo/semantics/publishedVersion Formato: application/pdf
Publicado em //2012 ENG
Relevância na Pesquisa
56.06%
La presente tesis doctoral se ha desarrollado dentro del marco del nuevo paradigma de la detección e intervención temprana de los trastornos psicóticos. En la primera parte de la tesis se presentan y desarrollan los principales conceptos teóricos y metodológicos, así como la justificación y el estado de la cuestión del paradigma de detección e intervención temprana en psicosis. En esta primera parte se incluyen tres artículos teóricos que han sido recientemente publicados en revistas científicas. El primer artículo presenta una revisión y actualización sobre la investigación del Trastorno Esquizotípico de la Personalidad en la adolescencia, destacando su relevancia en la detección e intervención temprana de los trastornos psicóticos. En el segundo artículo se presenta una revisión de los principales programas de detección e intervención temprana en psicosis que se han desarrollado en diferentes países, lo cual, nos ayuda a tener una visión general de los enfoques psicoterapéuticos actuales en psicosis incipiente. El tercer artículo tiene la finalidad de presentar y describir el tratamiento integrado y adaptado a las necesidades del Programa de Psicosis Incipiente-Sant Pere Claver (PPI-SPC) que se está llevando a cabo actualmente en Barcelona...

Assessing the impact of early detection biases on breast cancer survival of Catalan women

Roso Llorach, Albert; Forné, Carles; Macià, Francesc; Galceran, Jaume; Marcos-Gragera, Rafael; Rué, Montserrat
Fonte: Universidade Autônoma de Barcelona Publicador: Universidade Autônoma de Barcelona
Tipo: Artigo de Revista Científica Formato: application/pdf
Publicado em //2014 ENG
Relevância na Pesquisa
65.85%
Survival estimates for women with screen-detected breast cancer are affected by biases specific to early detection. Lead-time bias occurs due to the advance of diagnosis, and length-sampling bias because tumors detected on screening exams are more likely to have slower growth than tumors symptomatically detected. Methods proposed in the literature and simulation were used to assess the impact of these biases. If lead-time and length-sampling biases were not taken into account, the median survival time of screen-detected breast cancer cases may be overestimated by 5 years and the 5-year cumulative survival probability by between 2.5 to 5 percent units.

Towards early intervention for youth mental health in primary care: a mixed methods investigation

Leahy, Dorothy
Fonte: University of Limerick Publicador: University of Limerick
Tipo: info:eu-repo/semantics/doctoralThesis; all_ul_research; ul_published_reviewed; ul_theses_dissertations
ENG
Relevância na Pesquisa
55.85%
peer-reviewed; In Ireland, psychological morbidity has been reported in 21-27% of young people and recent data has indicated that the youth suicide rate in Ireland is now the second highest (of 26 countries) in the European Union, for 0-19 year olds. Early intervention in youth mental health is increasingly viewed as easier, cheaper and more effective than traditional approaches to care. GPs, as the health care professional most often consulted by young people, have a central role in early detection of youth mental health and substance use problems. However, there is a dearth of evidence regarding the experiences and attitudes of young people and health care workers towards screening and treatment for mental and substance use disorders in primary care in Ireland. The overarching aim of this thesis was to examine the role of primary care (with a particular focus on the role of the GP) in providing early intervention and treatment for mental health and substance use problems in young people. It was a mixed methods study that involved qualitative interviews with health care workers (n=37) and young people (n=20) from primary care, secondary care and community agencies in two of Ireland’s most socio-economically disadvantaged areas...

Detecção precoce: é possível prevenir a esquizofrenia?; Early detection: is it possible to prevent schizophrenia?

Louzã, Mário Rodrigues
Fonte: Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria Publicador: Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2007 POR
Relevância na Pesquisa
66.02%
CONTEXTO:A detecção e a intervenção precoces na esquizofrenia são uma área nova de pesquisa em grande expansão. OBJETIVO: Revisar a literatura atual sobre a detecção e intervenção precoces em esquizofrenia. MÉTODO: A literatura foi pesquisada por meio do PubMed, manuais e referências bibliográficas utilizando termos como: "alto risco", "intervenção precoce", "detecção precoce", "esquizofrenia", "psicose precoce". RESULTADOS: Utilizando os paradigmas de prevenção seletiva e de prevenção indicada de outras áreas da Medicina, a detecção e a intervenção precoces na esquizofrenia procuram estudar as manifestações iniciais da esquizofrenia, antes que o quadro psicótico tenha se manifestado claramente. CONCLUSÃO: A detecção e a intervenção precoces de pessoas com risco de desenvolver psicose visam reduzir o tempo de psicose não-tratada, melhorar a evolução e o prognóstico da esquizofrenia e talvez evitar que a pessoa chegue a desenvolver a doença.; BACKGROUND: The early detection and intervention in schizophrenia are new areas of research in great expansion. OBJECTIVE: To review the literature about early detection and intervention in schizophrenia. METHOD: Literature was studied by means of PubMed...

The need-adapted integrated treatment in Sant Pere Claver-Early Psychosis Program (SPC-EPP) in Barcelona, Spain

Domínguez Martínez,Tecelli; Vainer,Elias; Massanet,Ma. Antonia; Torices,Iván; Jané,Mercè; Barrantes-Vidal,Neus
Fonte: Instituto Mexicano de Psiquiatría Ramón de la Fuente Publicador: Instituto Mexicano de Psiquiatría Ramón de la Fuente
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2011 EN
Relevância na Pesquisa
55.91%
International interest has grown over the past 15 years in the prognostic potential of early identification and intervention in the prodromal and first-episode phases of psychosis. This focus is associated with increasing optimism about the benefits of implementing treatment as early as possible in the course of psychosis, at least to help improve the course of illness, reducing its long-term impact. A clearer framework for guiding, designing, and evaluating preventive interventions in mental disorders has been developed. As a consequence, a series of research projects and real-world services systems are currently emerging. Additionally, several influential international figures and research groups have developed and cooperated in disseminating a more optimistic set of ideas concerning early intervention in psychosis. The early psychosis programs developed worldwide have a number of common elements and goals: a) early detection of new cases, b) reducing the duration of untreated psychosis (DUP), and c) providing better and continued treatment during the <

Rationale and state of the art in early detection and intervention in psychosis

Domínguez Martínez,Tecelli; Manel Blanqué,Joan; Codina,Jordi; Montoro,Mónica; Mauri,Lluis; Barrantes-Vidal,Neus
Fonte: Instituto Mexicano de Psiquiatría Ramón de la Fuente Publicador: Instituto Mexicano de Psiquiatría Ramón de la Fuente
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2011 EN
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Schizophrenia-spectrum disorders have a chronic and episodic course that results in impairment of all life domains. Pharmacological and psychosocial treatments provide symptom relief, but there is not a cure for schizophrenia and many patients suffer chronic impairment. In addition, it is expensive both in economical terms and also in terms of personal costs for both patients and their families. International interest has grown over the past 15 years in the prognostic potential of early identification and intervention in the prodromal and first-episode phases of psychotic illness. This focus is associated with increasing optimism about the benefits of implementing treatment as early as possible in the course of psychosis at least to help improve the course of illness, reducing its long-term impact. The most recent epidemiological studies have shown that patients with longer duration of untreated psychosis (DUP) have worse short-term outcomes in terms of treatment response, positive symptoms, negative symptoms, and global functioning. Neuroimaging studies have also indicated that prolonged untreated illness is associated with more pronounced structural brain abnormalities, while this is less prominent earlier in the course of the disorder. Therefore...