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Anemia e deficiência de ferro em pré-escolares da Amazônia Ocidental brasileira: prevalência e fatores associados; Anemia and iron deficiency among schoolchildren in the Western Brazilian Amazon: prevalence and associated factors

CASTRO, Teresa Gontijo de; SILVA-NUNES, Mônica; CONDE, Wolney Lisboa; MUNIZ, Pascoal Torres; CARDOSO, Marly Augusto
Fonte: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz Publicador: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
Tipo: Artigo de Revista Científica
POR
Relevância na Pesquisa
36.51%
Estudo transversal de base populacional que investigou prevalênciasde anemia e fatores associados à anemia, anemia ferropriva e deficiência de ferro entre crianças de 6 a 60 meses da área urbana de dois municípios do Acre, Brasil (N = 624). Dosagens de hemoglobina sanguínea, ferritina e receptor solúvel de transferrina plasmáticas foram realizadas mediante sangue venoso. Condições sócio-econômicas, demográficas e de morbidade foram obtidas por questionário. Razões de prevalências foram calculadas por regressão de Poisson em modelo hierárquico. As prevalências de anemia, anemia ferropriva e deficiência de ferro foram de 30,6%, 20,9% e 43,5%, respectivamente. Menores de 24 meses apresentaram maior risco para anemia, anemia ferropriva e deficiência de ferro. Pertencer ao maior tercil do índice de riqueza conferiu proteção contra anemia ferropriva (RP = 0,62; IC95%: 0,40-0,98). Pertencer ao maior quartil do índice estatura/idade foi protetor contra anemia (0,62; 0,44-0,86) e anemia ferropriva (0,51; 0,33-0,79), e ocorrência recente de diarréia representou risco (anemia: 1,47; 1,12-1,92 e anemia ferropriva: 1,44; 1,03-2,01). A infestação por geohelmintos conferiu risco para anemia, anemia ferropriva e deficiência de ferro.; This cross-sectional population-based study investigated prevalence rates and associated factors for anemia...

Avaliação fenotípica dos linfócitos T em um modelo animal de deficiência de ferro; Cells T immunophenotypic analysis in animal modelo of iron deficiency

Araujo, Felipe Saldanha de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 27/10/2006 PT
Relevância na Pesquisa
36.46%
O ferro é um elemento chave em muitos processos metabólicos, como transporte de oxigênio, síntese de hormônios esteróides, respiração celular, transporte de elétrons, síntese de DNA, proliferação e diferenciação celular e regulação gênica. A deficiência de ferro é a desordem nutricional mais comum afetando aproximadamente um terço da população mundial. Pequenos déficits no compartimento funcional de ferro têm sérias conseqüências sobre o sistema imune, principalmente na imunidade mediada por células. A abordagem dos pais ou responsáveis, as exigências éticas e a aderência de crianças da mesma faixa etária e sem outros problemas que afetem o metabolismo do ferro e o sistema imune são as principais dificuldades enfrentadas no desenvolvimento de pesquisas com seres humanos, sendo necessário o estabelecimento de modelos experimentais. Este trabalho teve como objetivo estabelecer um modelo de indução e recuperação de deficiência de ferro em camundongos, visando a sua utilização em estudos sobre alterações do sistema imune induzidas por esta deficiência. A deficiência de ferro foi induzida por ingestão de uma ração com baixo teor de ferro (5 mg /kg de ração) por 4 e 8 semanas. No termino deste período foram determinados: concentração de hemoglobina (colorimetrico)...

Avaliação do crescimento craniofacial e das extremidades de pacientes com deficiência de hormônio de crescimento ou síndrome de Turner em tratamento prolongado com hormônio de crescimento; Craniofacial and extremities growth evaluation of patients with GH deficiency or Turner syndrome during long-term growth hormone treatment

Faria, Maria Estela Justamante de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 17/08/2007 PT
Relevância na Pesquisa
36.46%
INTRODUÇÃO: Pacientes com deficiência de GH e síndrome de Turner, associados a baixa estatura, são beneficiados com o tratamento com GH. Há controvérsias sobre a atuação deletéria do GH no crescimento craniofacial, porém a maioria dos trabalhos é retrospectiva. Nosso objetivo foi realizar estudo prospectivo para avaliar o crescimento craniofacial de pacientes em tratamento com GH e o possível desenvolvimento de traços acromegálicos. CASUÍSTICA: 30 pacientes com idade cronológica de 4,6 a 23 anos e idade óssea de 1,5 a 13 anos divididos em 3 grupos baseados no diagnóstico e uso de GH: grupo 1- pacientes virgem de tratamento com GH portadores de hipopituitarismo e deficiência isolada (n=6); grupo 2: pacientes já em tratamento com GH: portadores de hipopituitarismo e deficiência isolada (n=16); grupo 3: pacientes com síndrome de Turner em tratamento com GH (n=8). A dose do GH utilizada foi de 0.1 a 0.15 U/kg/dia, via subcutânea, à noite, por 2 a 11 anos. MÉTODOS: medidas antropométricas (altura, pés e mãos), radiografia panorâmica, telerradiografia seguida pela análise cefalométrica de Ricketts e medidas lineares da base do crânio, altura facial, terço inferior da face, mandíbula e maxila, e fotografia facial de frente e perfil anualmente...

Etanol, deficiência de ácido fólico e associação desses dois fatores durante a gestação de camundongos swiss; Etanol, Deficiency of Acid Fólico and Association Of these Two Factors During the Gestation of Swiss Mice

Gutierrez, Cristiane Minot
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 09/02/2007 PT
Relevância na Pesquisa
36.47%
Embora os efeitos teratogênicos do etanol sejam bem conhecidos, ele ainda é um agente exógeno muito usado por mulheres em idade reprodutiva e sabe-se que ele interfere com o transporte, absorção e metabolismo do ácido fólico. O objetivo deste trabalho foi determinar os efeitos da administração de etanol, da deficiência do ácido fólico na dieta e da associação desses dois fatores durante a gestação de camundongos Swiss. O estudo foi feito com dois experimentos, no primeiro examinou-se a influência do etanol diluído em salina a 25% (v/v) em doses baixa (0,4g/Kg de peso corporal) e alta (4,0g/Kg de peso corporal) em animais alimentados com ração comercial e no segundo a influência do etanol nas mesmas doses em animais alimentados com dieta deficiente em folato. Em ambos os experimentos os animais foram divididos em 6 grupos com 6 animais cada: C= controle; Eb= etanol baixa dose; Ea= etanol alta dose (Experimento 1) e DF= controle da deficiência de folato; DFEb= deficiência de folato + etanol baixa dose; DFEa= deficiência de folato + etanol alta dose (Experimento 2). Os animais dos Grupos C e DF receberam apenas salina. Etanol e salina foram administrados por via intraperitoneal, em três dias consecutivos da gestação: 7°...

Avaliação da deficiência de ferro durante o processo gestacional e sua relação com o consumo alimentar e a suplementação com ferro; Assesment of iron deficiency during pregnancy and its relation to food consumption and iron supplementation

Cruz, Rodrigo Danelon da
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 24/03/2010 PT
Relevância na Pesquisa
36.47%
A deficiência de ferro e anemia ferropriva são problemas de ordem mundial. Para as mulheres no período gestacional, a preocupação com o estado do ferro no organismo deve ser ainda maior, pois a deficiência desse elemento pode causar prejuízo na formação dos bebês. O objetivo do projeto é avaliar a evolução da freqüência de deficiência de ferro e anemia ferropriva e os parâmetros de ferro no organismo de mulheres grávidas durante toda a gestação e relacionar com dados da dieta e suplementação de ferro. Também avaliamos os dados sócio-demográficos e nutricionais maternos, além dos parâmetros de ferro, com o peso dos seus recém nascidos. Participaram do estudo 183 gestantes, 103 terminaram o protocolo e das quais foram colhidas amostras de sangue nas idades gestacionais de 16, 28 e 36 semanas. Para avaliação nutricional foram aplicados três inquéritos recordatórios de 24 horas no dia da coleta. Foram realizadas as determinações de ferro sérico, saturação de transferrina, ferritina sérica, capacidade total de ligação ao ferro (CTLF) e concentração sérica do receptor de transferrina (sTfR), além da dosagem da concentração de hemoglobina. As gestantes foram classificadas em seis grupos conforme a suplementação com ferro em cada idade gestacional: as mulheres que não utilizaram essa suplementação foram incluídas no grupo 1 (N=21); enquanto as participantes que fizeram o uso de suplementação em todas as idades gestacionais...

Triagem neonatal de deficiência de glicose-6-fosfato desidrogenase e prevalência das mutações G202A (G6PD A-) e C563T (G6PD Mediterrâneo) em Mato Grosso/Brasil; Neonatal Screening for glucose-6-phosphate dehydrogenase deficiency and prevalence of G202A (G6PD A-) and C563T (G6PD mediterranean) mutations in Mato Grosso / Brazil

Ferreira, Maria de Fatima de Carvalho
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 12/08/2014 PT
Relevância na Pesquisa
36.5%
Objetivos: A deficiência de glicose-6-fosfato desidrogenase (G6PD) está associada a um maior risco de encefalopatia bilirrubínica e de crise hemolítica aguda grave desencadeada por drogas como a primaquina e a dapsona. Conhecer a prevalência dessa deficiência enzimática em área onde a malária e a hanseníase ainda estão presentes e conhecer a prevalência das principais mutações traz subsídios para planejamento de estratégias com vistas à redução de riscos associados a esta deficiência enzimática. Métodos: Estudo descritivo transversal conduzido em uma região do centro-oeste do Brasil. Exame de triagem para deficiência de G6PD foi realizado em 3573 recémnascidos. Exame confirmatório foi necessário em 188 crianças triadas como possíveis portadores de deficiência. Nas crianças em que foi confirmada a deficiência de G6PD foi feita pesquisa das mutações G202A (G6PD A-) e C563T (G6PD Mediterrâneo) por PCR. Resultados: A deficiência de G6PD foi confirmada em 63 crianças, sendo 60 meninos (95,2%) e três meninas (4,8%). O percentual de exames falso-positivos na fase de triagem foi de 66,5%, estando o percentual de falso-positivos associado à temperatura e tempo de transporte das amostras. Entre as crianças que confirmaram deficiência de G6PD...

Avaliação do estresse oxidativo em pacientes idosos com anemia ferropênica; Oxidative stress evaluation in old patients with iron deficiency anaemia

Baccin, Aline Coghetto
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
36.46%
A deficiência de ferro é o resultado de um longo período de balanço negativo do ferro, culminando na exaustão do estoque de ferro do organismo. Isto é revelado quando a concentração de hemoglobina declina para valores abaixo dos limites normais e então aparece a anemia, que ocorre devido à deficiente síntese de hemoglobina, com diminuição da proliferação eritrocitária. A anemia ferropênica é considerada o maior problema de saúde no idoso e está associada com várias complicações, incluindo doença cardiovascular, disfunção cognitiva, aumento no risco de morte, e principalmente tem um significante efeito na qualidade de vida. Estudos revelam que a anemia por deficiência de ferro causa maior susceptibilidade aos agentes oxidantes. Utilizando técnica espectrofotométrica, foram determinadas as atividades das enzimas antioxidantes catalase (CAT), glutationa peroxidase (GPx) e superóxido dismutase (SOD) e quantificada a glutationa total (GSH) nos eritrócitos dos pacientes. Também determinou-se o dano oxidativo nas proteínas plasmáticas e no hemolisado celular pelo método do carbonil a 360 nm. Os níveis da peroxidação lipídica (MDA) e da vitamina C foram determinados por cromatografia líquida de alta performance (HPLC). Os participantes da pesquisa foram selecionados de Ambulatórios de Atenção Básica de Saúde da Região Norte do Rio Grande do Sul...

Newborn screening for biotinidase deficiency in Brazil : biochemical and molecular characterizations

Camargo Neto, Eurico; Schulte, Jaqueline; Rubim, Rosália; Lewis, E.; De Mari, Jurema de Fatima; Castilhos, C.; Brites, Adriana; Giugliani, Roberto; Jensen, K.P.; Wolf, B.
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf
ENG
Relevância na Pesquisa
36.47%
Biotinidase deficiency is an inherited metabolic disorder characterized by neurological and cutaneous symptoms. Fortunately, it can be treated and the symptoms prevented by oral administration of the vitamin biotin. Using dried blood-soaked filter paper cards, biotinidase activity was determined in the sera of 225,136 newborns in Brazil. Mutation analysis performed on DNA from 21 babies with low serum biotinidase activity confirmed that 3 had profound biotinidase deficiency (less than 10% of mean normal sera biotinidase activity), 10 had partial biotinidase deficiency (10 to 30% of mean normal serum activity), 1 was homozygous for partial biotinidase deficiency, 4 were heterozygous for either profound or partial deficiency, and 3 were normal. Variability in serum enzyme activities and discrepancies with mutation analyses were probably due to inappropriate handling and storage of samples sent to the laboratory. Obtaining an appropriate control serum at the same time as that of the suspected child will undoubtedly decrease the false-positive rate (0.09%). Mutation analysis can be used to confirm the genotype of these children. The estimated incidence of biotinidase deficiency in Brazil is about 1 in 9,000, higher than in most other countries. Screening and treatment of biotinidase deficiency are effective and warranted. These results strongly suggest that biotinidase deficiency should be included in the newborn mass screening program of Brazil.

Magnesium deficiency results in an increased formation of osteoclasts

Belluci, Marina M.; Schoenmaker, Ton; Rossa-Junior, Carlos; Orrico, Silvana R.; de Vries, Teun J.; Everts, Vincent
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.46%
Magnesium (Mg2+) deficiency is a frequently occurring disorder that leads to loss of bone mass, abnormal bone growth and skeletal weakness. It is not clear whether Mg2+ deficiency affects the formation and/or activity of osteoclasts. We evaluated the effect of Mg2+ restriction on these parameters. Bone marrow cells from long bone and jaw of mice were seeded on plastic and on bone in medium containing different concentrations of Mg2+ (0.8 mM which is 100% of the normal value, 0.4, 0.08 and 0 mM). The effect of Mg2+ deficiency was evaluated on osteoclast precursors for their viability after 3 days and proliferation rate after 3 and 6 days, as was mRNA expression of osteoclastogenesis-related genes and Mg2+-related genes. After 6 days of incubation, the number of tartrate resistant acid phosphatase-positive (TRACP+) multinucleated cells was determined, and the TRACP activity of the medium was measured. Osteoclastic activity was assessed at 8 days by resorption pit analysis. Mg2+ deficiency resulted in increased numbers of osteoclast-like cells, a phenomenon found for both types of marrow. Mg2+ deficiency had no effect on cell viability and proliferation. Increased osteoclastogenesis due to Mg2+ deficiency was reflected in higher expression of osteoclast-related genes. However...

Iron deficiency and anemia are associated with low retinol levels in children aged 1 to 5 years

Saraiva,Bárbara C.A.; Soares,Michele C.C.; Santos,Luana C.dos; Pereira,Simone C.L.; Horta,Paula M.
Fonte: Sociedade Brasileira de Pediatria Publicador: Sociedade Brasileira de Pediatria
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2014 EN
Relevância na Pesquisa
36.49%
OBJECTIVE: To analyze the occurrence of anemia and iron deficiency in children aged 1 to 5 years and the association of these events and retinol deficiency. METHODS: This was an observational analytic cross-sectional study conducted in Vitoria, ES, Brazil, between April and August of 2008, with healthy children aged 1 to 5 years (n = 692) that lived in areas covered by primary healthcare services. Sociodemographic and economic conditions, dietary intake (energy, protein, iron, and vitamin A ingestion), anthropometric data (body mass index-for-age and height-for-age), and biochemical parameters (ferritin, hemoglobin, and retinol serum) were collected. RESULTS: The prevalence of anemia, iron deficiency, and retinol deficiency was 15.7%, 28.1%, and 24.7%, respectively. Univariate analysis showed a higher prevalence of anemia (PR: 4.62, 95% CI: 3.36, 6.34, p < 0.001) and iron deficiency (PR: 4.51, 95% CI: 3.30, 6.17, p < 0.001) among children with retinol deficiency. The same results were obtained after adjusting for socioeconomic and demographic conditions, dietary intake, and anthropometric variables. There was a positive association between ferritin vs. retinol serum (r = 0.597; p < 0.001) and hemoglobin vs. retinol serum (r = 0.770; p < 0.001). CONCLUSIONS: Anemia and iron deficiency were associated with low levels of serum retinol in children aged 1 to 5 years...

Diagnosis of iron deficiency anemia in children of Northeast Brazil

Carvalho,Antonio Geraldo Cidrão; Lira,Pedro Israel Cabral de; Barros,Maria de Fátima Alcântara; Aléssio,Maria Luiza Martins; Lima,Marília de Carvalho; Carbonneau,Marie Annette; Berger,Jacques; Léger,Claude Louis
Fonte: Faculdade de Saúde Pública da Universidade de São Paulo Publicador: Faculdade de Saúde Pública da Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2010 EN
Relevância na Pesquisa
36.49%
OBJECTIVE: To diagnose iron deficiency anemia in children. METHODS: The study was conducted with a sample of 301 children aged six to 30 months attending public daycare centers in the city of Recife, Northeast Brazil, in 2004. The diagnoses of anemia were based on a combination of different hematological and biochemical parameters: hemoglobin, mean corpuscular volume, ferritin, C-reactive protein, transferrin saturation and transferrin receptor. The chi-square test and ANOVA were used in the statistical analysis. RESULTS: Of all children studied, 92.4% had anemia (Hb <110 g/L) and 28.9% had moderate/severe anemia (Hb <90 g/L). Lower levels of hemoglobin were found in children aged 6-17 months. Iron deficiency was found in 51.5% of children using ferritin (<12 μg/L) as parameter. Taking into consideration the combination of hemoglobin level, ferritin and transferrin receptor, 58.1% had anemia with iron deficiency, 34.2% had anemia without iron deficiency and 2.3% had iron deficiency without anemia. Mean ferritin concentration was significantly higher in children with high C-reactive protein when compared with those with normal levels (22.1 vs. 14.8 µg/L). CONCLUSIONS: The use of several biochemical and hematological parameters allowed to diagnosing iron deficiency anemia in two thirds of children...

Newborn screening for biotinidase deficiency in Brazil: biochemical and molecular characterizations

C. Neto,E.; Schulte,J.; Rubim,R.; Lewis,E.; DeMari,J.; Castilhos,C.; Brites,A.; Giugliani,R.; Jensen,K.P.; Wolf,B.
Fonte: Associação Brasileira de Divulgação Científica Publicador: Associação Brasileira de Divulgação Científica
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2004 EN
Relevância na Pesquisa
36.47%
Biotinidase deficiency is an inherited metabolic disorder characterized by neurological and cutaneous symptoms. Fortunately, it can be treated and the symptoms prevented by oral administration of the vitamin biotin. Using dried blood-soaked filter paper cards, biotinidase activity was determined in the sera of 225,136 newborns in Brazil. Mutation analysis performed on DNA from 21 babies with low serum biotinidase activity confirmed that 3 had profound biotinidase deficiency (less than 10% of mean normal sera biotinidase activity), 10 had partial biotinidase deficiency (10 to 30% of mean normal serum activity), 1 was homozygous for partial biotinidase deficiency, 4 were heterozygous for either profound or partial deficiency, and 3 were normal. Variability in serum enzyme activities and discrepancies with mutation analyses were probably due to inappropriate handling and storage of samples sent to the laboratory. Obtaining an appropriate control serum at the same time as that of the suspected child will undoubtedly decrease the false-positive rate (0.09%). Mutation analysis can be used to confirm the genotype of these children. The estimated incidence of biotinidase deficiency in Brazil is about 1 in 9,000, higher than in most other countries. Screening and treatment of biotinidase deficiency are effective and warranted. These results strongly suggest that biotinidase deficiency should be included in the newborn mass screening program of Brazil.

Breastfeeding exclusively and iron deficiency anemia during the first 6 months of age

Marques,Rosa F.S.V.; Taddei,José A.A.C.; Lopez,Fábio A.; Braga,Josefina A.P.
Fonte: Associação Médica Brasileira Publicador: Associação Médica Brasileira
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2014 EN
Relevância na Pesquisa
36.5%
Objective The objective was to determine the prevalence of iron deficiency and iron deficiency anemia among exclusively breastfed infants from one to six months of life and to identify associated risk factors. Methods This is a cohort study of the hemoglobin and serum ferritin levels of 102 healthy full-term infants, weighing more than 2500 grams (5.5 pounds) at birth, evaluated for growth development and supported to promote exclusive breastfeeding. Hemoglobin and ferritin levels were measured in the first, fourth, and sixth months of life. The hemoglobin and ferritin levels of the mothers were also measured in the first month postpartum. Results At four months, 5.7% presented iron deficiency and 3.4% had iron deficiency anemia. At six months, the percentage of children with iron deficiency increased more than four times, reaching 26.1%, while iron deficiency anemia was present in 23.9% of the infants studied. Iron deficiency at six months of age was significantly correlated to growth velocity. Conclusion According to the results of this study, exclusive breastfeeding protects infants from iron deficiency and iron deficiency anemia for the first four months of life. After this age, in accordance with the literature, the findings of this study demonstrated an increase in anemia and iron deficiency rates...

Iron deficiency in blood donors

Cançado,Rodolfo Delfini; Chiattone,Carlos Sérgio; Alonso,Fausto Forin; Langhi Júnior,Dante Mário; Alves,Rita de Cássia Silva
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/07/2001 EN
Relevância na Pesquisa
36.47%
CONTEXT: Blood donation results in a substantial loss of iron (200 to 250 mg) at each bleeding procedure (425 to 475 ml) and subsequent mobilization of iron from body stores. Recent reports have shown that body iron reserves generally are small and iron depletion is more frequent in blood donors than in non-donors. OBJECTIVE: The aim of this study was to evaluate the frequency of iron deficiency in blood donors and to establish the frequency of iron deficiency in blood donors according to sex, whether they were first-time or multi-time donors, and the frequency of donations per year. DESIGN: From September 20 to October 5, 1999, three hundred blood donors from Santa Casa Hemocenter of São Paulo were studied. DIAGNOSTIC TESTS: Using a combination of biochemical measurements of iron status: serum iron, total iron-binding capacity, transferrin saturation index, serum ferritin and the erythrocyte indices. RESULTS: The frequency of iron deficiency in blood donors was 11.0%, of whom 5.5% (13/237) were male and 31.7% (20/63) female donors. The frequency of iron deficiency was higher in multi-time blood donors than in first-time blood donors, for male blood donors (7.6% versus 0.0%, P < 0.05) and female ones (41.5% versus 18.5%, P < 0.05). The frequency of iron deficiency found was higher among the male blood donors with three or more donations per year (P < 0.05) and among the female blood donors with two or more donations per year (P < 0.05). CONCLUSIONS: We conclude that blood donation is a very important factor for iron deficiency in blood donors...

Evaluation of red cell and reticulocyte parameters as indicative of iron deficiency in patients with anemia of chronic disease

Torino,Ana Beatriz Barbosa; Gilberti,Maria de Fátima Pererira; Costa,Edvilson da; Lima,Gisélia Aparecida Freire de; Grotto,Helena Zerlotti Wolf
Fonte: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular Publicador: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2014 EN
Relevância na Pesquisa
36.47%
Objective: The purpose of this study was to evaluate the effectiveness of mature red cell and reticulocyte parameters under three conditions: iron deficiency anemia, anemia of chronic disease, and anemia of chronic disease associated with absolute iron deficiency. Methods: Peripheral blood cells from 117 adult patients with anemia were classified according to iron status, and inflammatory activity, and the results of a hemoglobinopathy investigation as: iron deficiency anemia (n = 42), anemia of chronic disease (n = 28), anemia of chronic disease associated with iron deficiency anemia (n = 22), and heterozygous β thalassemia (n = 25). The percentage of microcytic red cells, hypochromic red cells, and levels of hemoglobin content in both reticulocytes and mature red cells were determined. Receiver operating characteristic analysis was used to evaluate the accuracy of the parameters in differentiating between the different types of anemia. Results: There was no significant difference between the iron deficient group and anemia of chronic disease associated with absolute iron deficiency in respect to any parameter. The percentage of hypochromic red cells was the best parameter to discriminate anemia of chronic disease with and without absolute iron deficiency (area under curve = 0.785; 95% confidence interval: 0.661–0.909...

Why Iron Deficiency Is Important in Infant Development1–3

Beard, John L.
Fonte: American Society for Nutrition Publicador: American Society for Nutrition
Tipo: Artigo de Revista Científica
Publicado em /12/2008 EN
Relevância na Pesquisa
36.46%
Infants who experience iron deficiency during the first 6–12 mo of life are likely to experience persistent effects of the deficiency that alter functioning in adulthood. A lack of sufficient iron intake may significantly delay the development of the central nervous system as a result of alterations in morphology, neurochemistry, and bioenergetics. Depending on the stage of development at the time of iron deficiency, there may be an opportunity to reverse adverse effects, but the success of repletion efforts appear to be time dependent. Publications in the past several years describe the emerging picture of the consequences of iron deficiency in both human and animal studies. The mechanisms for iron accumulation in the brain and perhaps redistribution are being understood. The data in human infants are consistent with altered myelination of white matter, changes in monoamine metabolism in striatum, and functioning of the hippocampus. Rodent studies also show effects of iron deficiency during gestation and lactation that persist into adulthood despite restoration of iron status at weaning. These studies indicate that gestation and early lactation are likely critical periods when iron deficiency will result in long-lasting damage.

Region-specific Impact of Iron Deficiency on Postnatal CNS Development

Lee, Dawn Leah ; Mayer-Proschel, Margot
Fonte: Universidade de Rochester Publicador: Universidade de Rochester
Tipo: Tese de Doutorado
ENG
Relevância na Pesquisa
36.47%
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Pathology and Laboratory Medicine, 2012.; Iron has been identified as an essential nutrient for sustaining life and must be absorbed through our diet. Specifically, iron plays a key role as cofactor for enzymes that are critical for many biological processes. Chronic suboptimal iron availability leads to Iron deficiency (ID) that is associated with systemic changes to cellular physiology such as decreased red blood cell generation (anemia) upon severe iron shortage. ID is the most prevalent nutritional deficiency worldwide, and anemia is the most commonly diagnosed sequela of ID due to definitive cellular and physiological hallmarks. Studies using rodent models of iron deficiency anemia (IDA) revealed long term consequences on central nervous system (CNS) metabolic processes, many of which are likely due to the hypoxic condition that is generated by the anemia. To fully understand the impact of iron deficiency on cellular and molecular components, it is imperative to separate the condition of ID from IDA. In this thesis, we show that iron deficiency without the confounding variables of anemia disrupts both conduction velocity in the auditory nerve...

Physiological and genetic investigations of iron deficiency in field peas (Pisum sativum L.).

Yakop, Uyek M.
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2012
Relevância na Pesquisa
36.55%
Iron (Fe) deficiency chlorosis affects both yield and quality of many species, including cool-season food legumes and the chlorosis symptom is especially prevalent in crops grown on calcareous soils which are widely distributed in the southern region of Australia. Although Fe fertilizers have been used to correct the chlorosis and are effective for short term control, cultivation of tolerant cultivars could reduce the damage in the long term for all sensitive crops including field peas. The present study was conducted to investigate various aspects of the genetic tolerance of field pea cultivars Santi and Parafield, in particular, with the objective of providing the information to implement an efficient breeding strategy for the long-term control of Fe deficiency chlorosis. Methods to screen field peas for tolerance to Fe deficiency were developed by utilizing both solution and pot soil cultures. Nutrient solution with a high concentration (10 mM) of bicarbonate (HCO3⁻) in either the sodium (Na) or potassium (K) forms induced symptoms of Fe deficiency and it was possible to discriminate between tolerant and sensitive field pea genotypes. Plants grown in NaHCO₃ developed symptoms indicative of Na toxicity and therefore KHCO₃ was selected for solution culture studies. On the basis of this result...

Nutritional status of iron in children from 6 to 59 months of age and its relation to vitamin A deficiency

Sales,Marcia Cristina; Azevedo Paiva,Adriana de; Queiroz,Daiane de; Araújo França Costa,Renata; Lins da Cunha,Maria Auxiliadora; Figueroa Pedraza,Dixis
Fonte: Nutrición Hospitalaria Publicador: Nutrición Hospitalaria
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/06/2013 ENG
Relevância na Pesquisa
36.49%
Objective: To evaluate the iron nutritional status of children from 6 to 59 months of age and its relation to vitamin A deficiency. Method: Cross-sectional study involving 100 children, living in nine cities in the state of Paraiba, which were selected for convenience to form two study groups: children with vitamin A deficiency (serum retinol < 0.70 μmol/L; n = 50) and children without vitamin A deficiency (serum retinol > 0.70 μmol/L; n = 50). The iron nutritional status was evaluated by biochemical, hematological and hematimetric indices. The cases of subclinical infection (C-Reactive Protein > 6 mg/L) were excluded. Results: Children with vitamin A deficiency had serum iron values statistically lower than the corresponding values in children without deficiency. The other iron nutritional status indices showed no statistical difference according to presence/absence of vitamin A deficiency. Conclusion: The interaction between iron and vitamin A deficiencies was evidenced in the case of circulating iron deficiency (serum iron), suggesting failure in the transport mechanisms of the mineral in children with vitamin A deficiency.

Diagnosis of iron deficiency anemia in children of Northeast Brazil

Carvalho,Antonio Geraldo Cidrão; Lira,Pedro Israel Cabral de; Barros,Maria de Fátima Alcântara; Aléssio,Maria Luiza Martins; Lima,Marília de Carvalho; Carbonneau,Marie Annette; Berger,Jacques; Léger,Claude Louis
Fonte: Faculdade de Saúde Pública da Universidade de São Paulo Publicador: Faculdade de Saúde Pública da Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2010 EN
Relevância na Pesquisa
36.49%
OBJECTIVE: To diagnose iron deficiency anemia in children. METHODS: The study was conducted with a sample of 301 children aged six to 30 months attending public daycare centers in the city of Recife, Northeast Brazil, in 2004. The diagnoses of anemia were based on a combination of different hematological and biochemical parameters: hemoglobin, mean corpuscular volume, ferritin, C-reactive protein, transferrin saturation and transferrin receptor. The chi-square test and ANOVA were used in the statistical analysis. RESULTS: Of all children studied, 92.4% had anemia (Hb <110 g/L) and 28.9% had moderate/severe anemia (Hb <90 g/L). Lower levels of hemoglobin were found in children aged 6-17 months. Iron deficiency was found in 51.5% of children using ferritin (<12 μg/L) as parameter. Taking into consideration the combination of hemoglobin level, ferritin and transferrin receptor, 58.1% had anemia with iron deficiency, 34.2% had anemia without iron deficiency and 2.3% had iron deficiency without anemia. Mean ferritin concentration was significantly higher in children with high C-reactive protein when compared with those with normal levels (22.1 vs. 14.8 µg/L). CONCLUSIONS: The use of several biochemical and hematological parameters allowed to diagnosing iron deficiency anemia in two thirds of children...