Página 1 dos resultados de 31420 itens digitais encontrados em 0.025 segundos

City tuberculosis control coordinators` perspectives of patient adherence to DOT in Sao Paulo State, Brazil, 2005

ARCENCIO, R. A.; OLIVEIRA, M. F.; CARDOZO-GONZALES, R. I.; RUFFINO-NETTO, A.; PINTO, I. C.; VILLA, T. C. S.
Fonte: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) Publicador: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
46.34%
SETTING: Thirty-six priority cities in Sao Paulo State, Brazil, with a high incidence of tuberculosis (TB) cases, deaths and treatment default. OBJECTIVE: To identify the perspectives of city TB control coordinators regarding the most important components of adherence strategies adopted by health care teams to ensure patient adherence in 36 priority cities in the State of Sao Paulo, Brazil. DESIGN: Qualitative research with semi-structured interviews conducted with the coordinators of the National TB Control Programme involved in the management of TB treatment services in the public sector. RESULTS: The main issues thought to influence adherence to directly observed treatment (DOT) by coordinators include incentives and benefits delivered to patients, patient-health care worker bonding and comprehensive care, the encouragement given by others to follow treatment (family, neighbours and health professionals), and help provided by health professionals for patients to recover their self-esteem. CONCLUSION: The main aspects mentioned by city TB control coordinators regarding patient adherence to treatment and to DOT in Sao Paulo are improvements in communications, relationships based on trust, a humane approach and including the patients in the decision-making process concerning their health.

Guidance for the implementation of best practice for the care of patients with tuberculosis

WILLIAMS, G.; ALARCON, E.; JITTIMANEE, S.; WALUSIMBI, M.; SEBEK, M.; BERGA, E.; VILLA, T. S.
Fonte: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) Publicador: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
46.4%
The first two chapters of Best practice for the care of patients with tuberculosis: a guide for low-income countries include an introduction and guidance regarding implementation of best practice. The background to how the guide was developed is significant, as it was developed in collaboration with nurses and other health workers working in the most challenging settings. It therefore provides realistic and practical guidance for best practice where patient loads are large and resources are stretched. Guidance regarding standard setting and clinical audit is an important part of enabling people to recognise the strengths that already exist in their practice and approach those areas that require change in a systematic and practical way. The guide itself consists of a series of standards covering different aspects of patient care, from the moment they seek health care with symptoms to their diagnosis to early stages of treatment, directly observed treatment, the continuation phase and transfer of treatment. There are also standards relating specifically to HIV testing and the care of patients co-infected with tuberculosis and HIV. The standards themselves will appear in full in the subsequent chapters of this series.

Pleural fluid cytokines correlate with tissue inflammatory expression in tuberculosis

SEISCENTO, M.; VARGAS, F. S.; ACENCIO, M. M. P.; TEIXEIRA, L. R.; CAPELOZZI, V. L.; SALES, R. K. B.; ANTONANGELO, L.
Fonte: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) Publicador: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
46.34%
SETTING: A tertiary care research centre in Sao Paolo, Brazil. OBJECTIVE: To quantify interleukin (IL) 8, tumour necrosis factor alpha (TNF-alpha), vascular endothelial growth factor (VEGF) and transforming growth factor beta(1), (TGF-beta(1))in pleural fluid from tuberculous patients, correlating its values with the histopathological patterns in pleural biopsies. DESIGN: Cytokines were quantified in patients with transudatcs secondary to congestive heart failure (n = 8) and exudates secondary to tuberculosis (TB; n = 39). In parietal pleural biopsies from TB patients, the histological patterns of the inflammatory response were quantified by morphometric analysis (stereological point-counting method). RESULTS: IL-8, TNF-alpha, VEGF and TGF-beta(1) levels were higher in TB than in transudates. A positive correlation existed between components of the fibrinoid exudative phase with pleural fluid IL-8 (R = 0.52, P = 0.004) and VEGF (R = 0.42, P = 0.0021) levels. A negative correlation existed between pleural fluid IL-8 (R = -0.37, P = 0.048) and VEGF (R = -0.44, P = 0.0015) levels with tissue components of fibroproliferation. CONCLUSION: The high pleural levels of TNF-a, IL-8, VEGF and TGF-beta(1) suggest the involvement of these cytokines in the TB immunological response. The positive correlation between pleural fluid IL-8 and VEGF with the components of the acute exudative phase and the negative correlation between these cytokines with the fibroproliferative components suggest a temporary inflammatory response in the pleural space.; National Council of Research (CNPq)...

Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil

BRITO, R. C.; MELLO, F. C. Q.; ANDRADE, M. K.; OLIVEIRA, H.; COSTA, W.; MATOS, H. J.; LOURENCO, M. C.; ROLLA, V. C.; FONSECA, L.; NETTO, A. Ruffino; KRITSKI, A. L.
Fonte: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) Publicador: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
46.45%
SETTING: Tuberculosis (TB) drug resistance survey in six hospitals in Rio de Janeiro, Brazil. OBJECTIVE: To estimate resistance to at least one drug (DR) and multidrug resistance (MDR) and identify associated factors. DESIGN: One-year cross-sectional survey. Hospitals were included as a convenience sample. RESULTS: Of 595 patients investigated, 156 (26.2%) had previously undergone anti-tuberculosis treatment, 433 (72.8%) were not previously treated and information on the remaining 6 was not available. Overall, DR and MDR rates were high, at respectively 102 (17.1%, 95%CI 14.3-20.5) and 44 (7.4%, 95%CI 5.5-9.9) cases. Among individuals not previously treated, 17 had MDR (3.9%, 95%CI 2.4-6.3) and diagnosis in a TB reference hospital was independently associated with MDR (prevalence ratio [PR] 3.3, 95%CI 1.2-8.7) after multivariate analysis. Among previously treated individuals, 27 had MDR (17.3%, 95%CI 11.7-24.2). MDR-TB was independently associated with diagnosis in a TB reference hospital (PR 3.6, 95%CI 1.5-8.7), male sex (PR 2.3,95%CI 1.2-4.4) and dyspnoea (PR 0.3, 95%CI 0.1-0.7). CONCLUSION: We found high levels of DR- and MDR-TB. Our study design did not permit us to determine the contribution of community versus nosocomial transmission. Further studies are needed to establish this. Nevertheless...

Access to tuberculosis diagnosis in Itaborai City, Rio de Janeiro, Brazil: the patient`s point of view

MOTTA, M. C. S.; VILLA, T. C. S.; GOLUB, J.; KRITSKI, A. L.; RUFFINO-NETTO, A.; SILVA, D. F.; HARTER, R. G.; SCATENA, L. M.
Fonte: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) Publicador: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
46.34%
SETTING: Itaborai Municipality in Rio de Janeiro, Brazil. OBJECTIVE: To evaluate access to tuberculosis (TB) diagnosis for users of the Family Health Program (FHP) and Reference Ambulatory Units (RAUs). DESIGN : A cross-sectional study was conducted in Itaborai City, Rio de Janeiro, Brazil. Between July and October 2007, a sample of 100 TB patients registered consecutively with the TB Control Program was interviewed using the primary care assessment tool. The two highest scores, describing `almost always` and `always`, or `good` and `very good`, were used as a cut-off point to define high quality access to diagnosis. RESULTS: FHP patients were older and had less education than RAU interviewees. Sex and overcrowding did not differ in the two groups. Patient groups did not differ with regard to the number of times care was sought at a unit, transport problems, cost of attending units and availability of consultation within 24 h. Adequate access to diagnosis was identified by 62% of the FHP patients and 53% of the RAU patients (P = 0.01). CONCLUSION: In Itaborai, Rio de Janeiro, TB patients believe that the FHP units provide greater access to TB diagnosis than RAUs. These findings will be used by the Department of Health to improve access to diagnosis in Itaborai.; International Clinical...

Tuberculosis incidence among contacts of active pulmonary tuberculosis

CAILLEAUX-CEZAR, M.; MELO, D. de A.; XAVIER, G. M.; SALLES, C. L. G. de; MELLO, F. C. Q. de; RUFFINO-NETTO, A.; GOLUB, J. E.; EFRON, A.; CHAISSON, R. E.; CONDE, M. B.
Fonte: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) Publicador: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
46.4%
BACKGROUND: Treatment of latent tuberculosis (TB) infection (LTBI) in Brazil is recommended only in the case of contacts of pulmonary smear-positive TB patients aged <= 15 years with a tuberculin skin test (TST) >= 10 mm and no previous bacille Calmette-Guerin (BCG) vaccination or with a TST >= 15 mm regardless of previous BCG vaccination. OBJECTIVE: To evaluate the 2-year incidence and predictors of TB among contacts who did not meet the Brazilian criteria for LTBI treatment. DESIGN: Retrospective cohort study. Contacts aged between 12 and 15 years and those aged >15 years who did not meet the Brazilian criteria for LTBI treatment were enrolled in the study. RESULTS: TB incidence was 3.2% (22/667), with an estimated TB rate of 1649 per 100000 population. Risk of TB was greater among the 349 contacts with TST >= 5 mm (5.4%) compared to the 318 contacts with TST <5 mm, (0.9%; RR 6.04, 95%CI 1.7-20.6). CONCLUSION: The high incidence of TB among contacts who did not meet the Brazilian criteria for LTBI treatment strongly suggests that these criteria should be reviewed. Furthermore, even among BCG-vaccinated contacts, TST induration >= 5 mm, was the only variable that predicted the development of TB disease within 2 years.; CNPq Conselho Nacional de Desenvolvimento Cientifico e Tecnologico[350543/2003-8]

Reactive nitrogen intermediate susceptibility of Mycobacterium tuberculosis genotypes in an urban setting

INUMARU, V. T. G.; NOGUEIRA, P. A.; BUTUEM, I. V.; RILEY, L. W.; FERRAZOLI, L.
Fonte: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) Publicador: INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
46.49%
BACKGROUND: Mycobacterium tuberculosis genotypes resistant to reactive nitrogen intermediates (RNI) predominate in certain urban communities, suggesting that this phenotype influences disease transmission. OBJECTIVE: To compare different M. tuberculosis genotypes for resistance to RNI generated in vitro. DESIGN: We genotyped 420 M. tuberculosis isolates from a neighborhood in Sao Paulo, Brazil, and analyzed them for susceptibility to RNI generated in acidified sodium nitrite (ASN) solution. RESULTS: Seventy-one (43%) of 167 recent-infection strains and 68 (43%) of 158 endogenous infection strains showed moderate- to high-level ASN resistance. CONCLUSION: ASN resistance of M. tuberculosis is not necessarily a determining factor for enhanced transmission.; Conselho Nacional cle Desenvolvimento Cientifico e Tecnologico (CNPq); NIH Fogarty International Center[TW006563]

Tuberculosis diagnosis after bleach processing for early stage tuberculosis laboratory capacity building

David, S.; Sutre, A. F.; Sanca, A.; Mane, A.; Henriques, V.; Portugal, C.; Sancho, L.; Cardoso, A.; Paixao, E.; Duarte, E. L.; Leite, C. Q. F.; Salem, J. I.; Antunes, A.
Fonte: Int Union Against Tuberculosis Lung Disease (i U A T L D) Publicador: Int Union Against Tuberculosis Lung Disease (i U A T L D)
Tipo: Artigo de Revista Científica Formato: 1535-1537
ENG
Relevância na Pesquisa
46.49%
The diagnosis of tuberculosis is seriously hampered in the absence of standard biosafety laboratory facilities for specimen concentration and Mycobacterium tuberculosis culture. Within a laboratory twinning arrangement, heat-fixed direct smear and sediment from 74 bleach-processed and 20 non-processed specimens from Cumura Hospital, Guinea-Bissau, were sent to Lisbon for molecular evaluation of rifampicin resistance. Sequence analysis of a 369 base-pair ppoB locus detected 3.2% (3/94) resistant specimens. To our knowledge, this represents the first report on the molecular analysis of M. tuberculosis from bleach-processed sputum, an alternative to current diagnostic practice in low-resource settings.

Bridging the gap between PCR detection of Mycobacterium tuberculosis complex and tuberculosis diagnosis

Duarte, Elsa; Paixão, Eleonora; David, Susana
Fonte: International Union Against Tuberculosis and Lung Disease Publicador: International Union Against Tuberculosis and Lung Disease
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
46.45%
The growing demand for rapid diagnosis of tuberculosis (TB) has led to the incorporation of nucleic acid amplification (NAA) tests in case definitions. The objective of this study was to evaluate the contribution of a real-time polymerase chain reaction (PCR) assay in providing a result predictive of a confirmed TB case. Respiratory and extra-pulmonary specimens (n = 308) were subjected to NAA, culture and smear microscopy. Qualitative PCR assessment, translated by an increase in NAA cycles, disregarding template copy number, resulted in an increase in confirmed cases, helping to bridge the gap between the test’s analytical performance and its actual performance in TB diagnosis.

Trends, seasonality and forecasts of Pulmonary Tuberculosis in Portugal

Brás, Ana; Gomes, Dulce; Filipe, Patrícia A.; de Sousa, Bruno; Nunes, Carla
Fonte: The International Journal of Tuberculosis and Lung Disease Publicador: The International Journal of Tuberculosis and Lung Disease
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
46.4%
SETTING: Tuberculosis (TB) is a global public health concern. Surveillance programs present invaluable epidemiological information regarding its temporal evolution, particularly for pulmonary tuberculosis (PTB), the most common form of TB and the one that presents the biggest challenge in Public Health. OBJECTIVES: To characterize, model and predict PTB monthly incidence rates in Portugal, and disaggregated by high/low incidence areas, sex and age groups. DESIGN: PTB monthly incidence rates were estimated using PTB cases diagnosed in 2000-2010, disaggregated by population and geographic characteristics. A Seasonal-Trend Loess (STL) decomposition was employed to model trend and seasonality. SARIMA models were fit in order to characterize the series behavior and forecast PTB monthly incidence rates. RESULTS: Overall, the time series showed a downward trend and seasonality of PTB diagnosis, with a peak in March and a trough in December. The mean seasonal amplitude was consistently higher in high incidence areas, in males and in adults (25-54 years). SARIMA models were found to adequately fit and forecast the time series, thus predicting trend and seasonal persistence. CONCLUSIONS: STL and SARIMA findings were concurring and accurate. Endemic PTB seems to be slowly declining and case diagnosis is likely seasonal...

Transmission dynamics and tuberculosis control among HIV/AIDS patients

Hollm-Delgado, Maria-Graciela
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
EN
Relevância na Pesquisa
36.65%
Introduction: Les efforts globaux pour contrôler la tuberculose sont présentement restreints par la prévalence croissante du VIH/SIDA. Quoique les éclosions de la tuberculose multi résistante (TB-MDR) soient fréquemment rapportées parmi les populations atteintes du SIDA, le lien entre VIH/SIDA et le développement de résistance n’est pas clair. Objectifs: Cette recherche visait à : (1) développer une base de connaissances concernant les facteurs associés à des éclosions de la TB-MDR parmi les patients atteints du VIH/SIDA; (2) utiliser ce cadre de connaissances pour accroître des mesures préliminaires pour mieux contrôler la tuberculose pulmonaire chez les patients atteints du VIH/SIDA; et (3) afin d’améliorer l’application des ces mesures, affiner les techniques bactériologiques existantes pour Mycobacterium tuberculosis. Méthodologie: Quatre études ont été réalisées : (1) Une étude longitudinale pour identifier les facteurs associés avec une éclosion de la TB-MDR parmi les patients atteints du SIDA qui ont reçu le traitement directement supervisé de courte durée (DOTS) pour la tuberculose pulmonaire au Lima et au Pérou entre 1999 et 2005; (2) Une étude transversale pour décrire différentes étapes de l’histoire naturelle de la tuberculose...

Results of a standardised regimen for multidrug-resistant tuberculosis in Bangladesh

Van Deun, A.; Salim, M.; Das, A.; Bastian, I.; Portaels, F.
Fonte: Int Union Against Tuberculosis Lung Disease (i U A T L D) Publicador: Int Union Against Tuberculosis Lung Disease (i U A T L D)
Tipo: Artigo de Revista Científica
Publicado em //2004 EN
Relevância na Pesquisa
46.34%
SETTING: Individualised regimens based on drug susceptibility test results, generally used to treat multidrug-resistant tuberculosis (MDR-TB), require often unavailable expertise and resources. OBJECTIVE: To evaluate a standardised regimen based on the susceptibility profiles of locally prevalent MDR-TB strains. DESIGN: The activities of a successful DOTS programme in Bangladesh were complemented by offering treatment with a standardised 21-month regimen to patients with laboratory-confirmed MDR-TB disease. The regimen contained kanamycin, ofloxacin, prothionamide, pyrazinamide, ethambutol, isoniazid and clofazimine. Clinical and bacteriological progress was monitored quarterly until treatment completion, then 6 monthly for 2 years. RESULTS: The status at the end of treatment of this cohort of 58 documented MDR-TB patients was as follows: eight (14%) deaths, seven (12%) defaults, three (5%) failures and 40 (69%) cures. One bacteriologically-confirmed relapse was recognised. Frequent and sometimes serious side effects proved to be the main problem, suggesting the need for a better tolerated but equally effective regimen. CONCLUSION: A standardised approach may provide a reasonable alternative to individualised treatment of MDR-TB in resource-poor settings. However...

Contribution of traditional healers to a rural tuberculosis control programme in Hlabisa, South Africa

Colvin, M.; Gumede, L.; Grimwade, K.; Maher, Darryl W.; Wilkinson, David
Fonte: Int Union Against Tuberculosis Lung Disease (IUALD) Publicador: Int Union Against Tuberculosis Lung Disease (IUALD)
Tipo: Artigo de Revista Científica
Publicado em //2003 EN
Relevância na Pesquisa
46.34%
SETTING: The rural health district of Hlabisa, KwaZulu-Natal, South Africa. OBJECTIVES: To assess the acceptability and effectiveness of traditional healers as supervisors of tuberculosis (TB) treatment in an existing directly observed treatment, short-course (DOTS) programme. DESIGN: An observational study comparing treatment outcomes among new TB patients in the three intervention sub-districts offered the additional option of traditional healers for directly observed treatment (DOT) supervision with those in the remainder of the district offered the standard range of options for DOT supervision (health facility, community health worker and lay persons). A comparison was also made of treatment outcomes between different options for DOT supervision. RESULTS: A total of 3461 TB patients were registered in Hlabisa District from April 1999 to December 2000, of whom 2823 were discharged from hospital to the ambulatory DOT programme. Treatment outcomes were known for 1816 patients in Hlabisa District (275 patients in the intervention area and 1541 patients in the control area). There was no significant difference (P < 0.5) in treatment outcome in the intervention and control areas (77% vs. 75%). Among 275 patients with known outcomes in the intervention area...

Trial-of-antibiotic algorithm for the diagnosis of tuberculosis in a district hospital in a developing country with high HIV prevalence

Wilkinson, David; Newman, W.; Reid, A.; Squire, S. B.; Sturm, A. W.; Gilks, C. F.
Fonte: Int Union Against Tuberculosis Lung Disease (i U A T L D) Publicador: Int Union Against Tuberculosis Lung Disease (i U A T L D)
Tipo: Artigo de Revista Científica
Publicado em //2000 EN
Relevância na Pesquisa
46.54%
OBJECTIVE: To evaluate a diagnostic algorithm for pulmonary tuberculosis based on smear microscopy and objective response to trial of antibiotics. SETTING: Adult medical wards, Hlabisa Hospital, South Africa, 1996–1997. METHODS: Adults with chronic chest symptoms and abnormal chest X-ray had sputum examined for Ziehl-Neelsen stained acid-fast bacilli by light microscopy. Those with negative smears were treated with amoxycillin for 5 days and assessed. Those who had not improved were treated with erythromycin for 5 days and reassessed. Response was compared with mycobacterial culture. RESULTS: Of 280 suspects who completed the diagnostic pathway, 160 (57%) had a positive smear, 46 (17%) responded to amoxycillin, 34 (12%) responded to erythromycin and 40 (14%) were treated as smear-negative tuberculosis. The sensitivity (89%) and specificity (84%) of the full algorithm for culture-positive tuberculosis were high. However, 11 patients (positive predictive value [PPV] 95%) were incorrectly diagnosed with tuberculosis, and 24 cases of tuberculosis (negative predictive value [NPV] 70%) were not identified. NPV improved to 75% when anaemia was included as a predictor. Algorithm performance was independent of human immunodeficiency virus status. CONCLUSION: Sputum smear microscopy plus trial of antibiotic algorithm among a selected group of tuberculosis suspects may increase diagnostic accuracy in district hospitals in developing countries.; D. Wilkinson...

First Worldwide Proficiency Study on Variable-Number Tandem-Repeat Typing of Mycobacterium tuberculosis Complex Strains

de Beer, Jessica; Kremer, Kristin; Ködmön, Csaba; Supply, Philip; van Soolingen, Dick; Global Network for the Molecular Surveillance of Tuberculosis 2009
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em 14/12/2011 ENG
Relevância na Pesquisa
46.34%
Although variable-number tandem-repeat (VNTR) typing has gained recognition as the new standard for the DNA fingerprinting of Mycobacterium tuberculosis complex (MTBC) isolates, external quality control programs have not yet been developed. Therefore, we organized the first multicenter proficiency study on 24-locus VNTR typing. Sets of 30 DNAs of MTBC strains, including 10 duplicate DNA samples, were distributed among 37 participating laboratories in 30 different countries worldwide. Twenty-four laboratories used an in-house-adapted method with fragment sizing by gel electrophoresis or an automated DNA analyzer, nine laboratories used a commercially available kit, and four laboratories used other methods. The intra- and interlaboratory reproducibilities of VNTR typing varied from 0% to 100%, with averages of 72% and 60%, respectively. Twenty of the 37 laboratories failed to amplify particular VNTR loci; if these missing results were ignored, the number of laboratories with 100% interlaboratory reproducibility increased from 1 to 5. The average interlaboratory reproducibility of VNTR typing using a commercial kit was better (88%) than that of in-house-adapted methods using a DNA analyzer (70%) or gel electrophoresis (50%). Eleven laboratories using in-house-adapted manual typing or automated typing scored inter- and intralaboratory reproducibilities of 80% or higher...

An ethnographic study of barriers to and enabling factors for tuberculosis treatment adherence in Timor Leste

Martins, N; Grace, Jocelyn; Kelly, Paul
Fonte: International Union against Tuberculosis and Lung Disease Publicador: International Union against Tuberculosis and Lung Disease
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
46.4%
BACKGROUND: Tuberculosis (TB) is a major public health problem in Timor Leste; treatment adherence was identified by the National TB Control Programme (NTP) as an impediment to TB control. OBJECTIVE: To identify barriers to and enabling factors for the su

An alternative strategy for the storage and transport of sputum specimens for Mycobacterium Tuberculosis drug resistance surveys

Lumb, Richard; Ardian, M; Waramori, G; Syahrial, H; Tjitra, Emiliana; Maguire, Graeme; Anstey, Nicholas; Kelly, Paul
Fonte: International Union against Tuberculosis and Lung Disease Publicador: International Union against Tuberculosis and Lung Disease
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
46.45%
SETTING: A district level tuberculosis (TB) programme in Indonesia. OBJECTIVE: To evaluate whether a single sputum specimen could be stored by refrigeration for an extended period of time, then transported to a reference laboratory and successfully cultur

Tuberculosis control in conflict-affected East Timor, 1996-2004

Martins, N; Heldal, E; Sarmento, J; Araujo, RM; Ronaldsen, EB; Kelly, Paul
Fonte: International Union against Tuberculosis and Lung Disease Publicador: International Union against Tuberculosis and Lung Disease
Tipo: Artigo de Revista Científica
Relevância na Pesquisa
46.45%
SETTING: East Timor has undergone major political changes in the past 10 years. Tuberculosis (TB) control has flourished, despite chronic low tension conflict, a brief but intense period of high-level conflict and post-conflict reconstruction. OBJECTIVE:

Caracterización de la reacción citoquímica de Mycobacterium tuberculosis con rojo neutro correlación con el contenido de sulfolípido /

Soto Ospina, Carlos Yesid
Fonte: Bellaterra : Universitat Autònoma de Barcelona, Publicador: Bellaterra : Universitat Autònoma de Barcelona,
Tipo: Tesis i dissertacions electròniques; info:eu-repo/semantics/doctoralThesis Formato: application/pdf
Publicado em //2003 SPA; SPA
Relevância na Pesquisa
36.65%
Consultable des del TDX; Títol obtingut de la portada digitalitzada; CARACTERIZACIÓN DE LA REACCIÓN CITOQUÍMICA DE Mycobacterium tuberculosis CON ROJO NEUTRO. CORRELACIÓN CON EL CONTENIDO DE SULFOLÍPIDO La virulencia de M. tuberculosis se ha relacionado con diversas características fenotípicas y entre las menos exploradas se encuentran las reacciones citoquímicas con diferentes colorantes básicos. Los estudios más prometedores en este campo han sido los que describen la tinción de las cepas virulentas de M. tuberculosis con rojo neutro (RN). El principal objetivo de este trabajo ha sido evaluar el papel desempeñado por los glicolípidos de pared, especialmente sulfolípidos (SL), en la tinción de las cepas virulentas de M. tuberculosis con RN. Además, se planteó conocer la región genómica de la cepa virulenta H37Rv implicada en la fijación de RN (RN+). Se compararon los perfiles glicolipídicos de la superficie de cepas RN+ y RN- de M. tuberculosis mediante cromatografía en columna de intercambio iónico (DEAE) y de capa fina (CCF). También se purificaron diferentes fracciones glicolípidicas de la superficie y se analizó su capacidad de fijar RN (NRA). No se encontró una relación directa entre el contenido de SL...

Tuberculose e tuberculose latente na população prisional; Tuberculosis y tuberculosis latente en la población carcelaria; Tuberculosis and latent tuberculosis in prison inmates

Nogueira, Péricles Alves; Abrahão, Regina Maura Cabral de Melo; Galesi, Vera Maria Neder
Fonte: Universidade de São Paulo. Faculdade de Saúde Pública Publicador: Universidade de São Paulo. Faculdade de Saúde Pública
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; Formato: application/pdf
Publicado em 01/02/2012 ENG
Relevância na Pesquisa
36.66%
OBJETIVO: Estimar a prevalência da tuberculose e tuberculose latente em detentos. MÉTODOS: Estudo observacional foi realizado com detentos de uma penitenciária e de um centro de detenção provisória do Estado de São Paulo, SP, entre março e dezembro de 2008. Questionários foram utilizados para a coleta de dados sociodemográficos e epidemiológicos. O teste tuberculínico foi aplicado (PPD-RT23-2UT/0,1ml) e os seguintes exames laboratoriais foram realizados: baciloscopia de escarro, cultura de escarro, identificação das cepas isoladas e teste de sensibilidade às drogas antituberculose. As variáveis foram comparadas utilizando-se o teste de associação qui-quadrado de Person (Χ2), teste exato de Fisher e teste das proporções. RESULTADOS: Dos 2.435 detentos entrevistados, 2.237 (91,9%) concordaram em submeter-se ao teste tuberculínico e destes, 73,0% foram reatores. O coeficiente de prevalência da tuberculose foi de 830,6 por 100.000 detentos. Os coeficientes de prevalência foram de 1.029,5/100.000 detentos na penitenciária e de 525,7/100.000 detentos no centro de detenção provisória. As características sociodemográficas dos detentos nos dois grupos estudados foram semelhantes; a maioria dos detentos era jovem e solteiro com baixa escolaridade. As características epidemiológicas diferiram entre as unidades prisionais com o número de casos de tuberculose no passado e de contato prévio com doente maior na penitenciária e tosse...