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CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome

Silveira, Vanessa S.; Canalle, Renata; Scrideli, Carlos Alberto; Queiroz, Rosane G. P.; Lopes, Luiz Fernando; Tone, Luiz Gonzaga
Fonte: SPRINGER; DORDRECHT Publicador: SPRINGER; DORDRECHT
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
65.84%
Susceptibility to acute lymphoblastic leukemia can be highly influenced by genetic polymorphisms in metabolizing enzyme genes of environmental carcinogens. This study aimed to evaluate the impact of the CYP3A5 and NAT2 metabolizing enzyme polymorphisms on the risk of childhood acute lymphoblastic leukemia. The analysis was conducted on 204 ALL patients and in 364 controls from a Brazilian population, using PCR-RFLP. The CYP3A5*3 polymorphic homozygous genotype was more frequent among ALL patients and the *3 allele variant was significantly associated with increased risk of childhood ALL (OR = 0.29; 95% CI, 0.14-0.60). The homozygous polymorphic genotype for the *6 allele variant was extremely rare and found in only two individuals. The heterozygous frequencies were similar for the ALL group and the control group. No significant differences were observed between the groups analyzed regarding NAT2 variant polymorphisms. None of the polymorphisms analyzed was related to treatment outcome. The results suggest that CYP3A5*3 polymorphism may play an important role in the risk of childhood ALL.

Fatores preditivos para o resultado de tratamento da tuberculose pulmonar no município de Recife-PE: uma contribuição para as ações de vigilância epidemiológica; PREDICTIVE FACTORS OF PULMONARY TUBERCULOSIS TREATMENT OUTCOMES IN RECIFE-PE: a contribution to epidemiological surveillance actions

Sassaki, Cinthia Midori
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 21/12/2006 PT
Relevância na Pesquisa
56%
O objetivo desta investigação foi identificar e analisar fatores preditivos para o resultado favorável de tratamento dos casos de tuberculose pulmonar, diagnosticados no período de 2001 a 2004 e residentes no município de Recife-PE. Inicialmente, foi realizado um estudo exploratório para identificar dados perdidos (brancos, ignorados e inconsistentes) nos dados selecionados no Sistema de Informação de Agravos de Notificação (SINAN): ano do diagnóstico; município de residência; desfecho do tratamento; idade; sexo; escolaridade; ocupação; distrito de residência; forma clínica; tipo de entrada; tratamento supervisionado; data diagnóstico, início e encerramento do tratamento; distrito da unidade de saúde; HIV e outros agravos. Observou-se registros em branco nos dados Outros Agravos (42,85%) e Ocupação (82,10%); ignorados, nos dados Escolaridade (39,40%), Outros Agravos (39,73%) e Tratamento Supervisionado (63,96%) e inconsistentes, nos dados Ocupação (2,53%), Data do diagnóstico (0,98%), Data do início do tratamento (9,94%) e Data do encerramento do tratamento (17,66%). Posteriormente, foram identificados e analisados os fatores preditivos ao resultado favorável de tratamento por meio de métodos estatísticos uni e multivariado de regressão logística. Na análise univariada...

Comorbidade entre dependência de substâncias psicoativas e transtornos alimentares: perfil e evolução de mulheres em um tratamento específico para dependência química; Comorbidity between psychoactive substance dependence and eating disorders: profile and outcome of women in a specific treatment for chemical dependence

Brasiliano, Silvia
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 25/11/2005 PT
Relevância na Pesquisa
56.01%
A associação entre transtornos alimentares e dependência de substâncias, psicoativas tem sido freqüentemente relatada tanto em programas para dependência química, como em serviços para transtornos alimentares. No entanto, há grande variabilidade entre os diferentes estudos. Uma das hipóteses que tem sido levantada para explicar essa diversidade é que em dependentes de substâncias a associação mais freqüente seria com síndromes alimentares parciais ou subclínicas. Praticamente não há pesquisas que avaliem a influência dessa comorbidade na evolução do tratamento para dependência química. O objetivo deste estudo é comparar o perfil de três grupos de mulheres dependentes de substâncias psicoativas - com comorbidade com transtornos alimentares clínicos, com comorbidade com patologia alimentar subclínica e sem essa comorbidade - e descrever sua evolução em um programa especializado para dependência química feminina. MÉTODO: foram estudadas 80 mulheres dependentes de álcool e drogas que procuram tratamento no Programa de Atenção à Mulher Dependente Química (PROMUD) do Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da USP. As pacientes foram avaliadas para a coleta de dados sócio-demográficos e relativos ao uso de substâncias psicoativas através de um questionário padronizado; para diagnóstico clínico...

Dimensões de sintomas associados à resposta às cirurgias límbicas para o tratamento  do transtorno obsessivo-compulsivo; Limbic neurosurgery for obsessive-compulsive disorder: relations between symptom dymensions and outcome

Gentil, André Felix
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 30/10/2013 PT
Relevância na Pesquisa
56.01%
Pesquisas sobre o transtorno obsessivo-compulsivo (TOC) que reunem pacientes em subgrupos homogêneos a partir de dimensões de sintomas, e as que investigam sua validade utilizando métodos genéticos, de neuroimagem e de resposta terapêutica, têm produzido resultados de valor heurístico. Em particular, a dimensão de colecionismo mostrou ser a mais distinta quanto às características neurobiológicas e a mais associada à pior resposta aos tratamentos farmacológicos e psicoterápicos. Paralelamente, novos métodos de tratamento neurocirúrgico para os casos mais refratários e graves tem sido testados no TOC, atingindo mais eficácia e segurança. Entretanto, não há registro na literatura de uma investigação sistemática da relação entre a presença de dimensões de sintomas antes das cirurgias e o resultado clínico. O objetivo deste estudo foi investigar se dimensões de sintomas, em particular o colecionismo, poderiam influenciar a resposta terapêutica às neurocirurgias límbicas para o tratamento do TOC. Informações de 77 pacientes submetidos à cirurgias ablativas para o tratamento de TOC em três centros de pesquisa das cidades de São Paulo (Brasil, n=17), Boston (EUA, n=37) e Estocolmo (Suécia, n=23) foram analisadas utilizando a Dimensional Yale-Brown Obsessive-Compulsive Scale (DYBOCS; São xvi Paulo) ou a Yale-Brown Obsessive-Compulsive Scale Symptom Checklist (YBOCS-SC; Boston e Estocolmo) para a estratificação em dimensões de sintomas...

Alcoholic women and men: a comparative study of social and familial aspects and outcome

Simão, Maria Odete; Kerr-Corrêa, Florence; Dalben, Ivete; Smaira, Sumaia Inaty
Fonte: Associação Brasileira de Psiquiatria - ABP Publicador: Associação Brasileira de Psiquiatria - ABP
Tipo: Artigo de Revista Científica Formato: 121-129
ENG
Relevância na Pesquisa
55.9%
Objetivos: A proporção de ocorrência de alcoolismo em homens e mulheres tem uma variação de 14:1 até 2:1, mostrando a necessidade de estudos específicos para a população feminina. O objetivo deste estudo foi analisar o perfil e a evolução de alcoolistas, segundo gênero e gravidade da dependência. Métodos: Realizou-se um estudo longitudinal retrospectivo de 114 homens e 57 mulheres alcoolistas (CID-10), inscritos no ambulatório da Faculdade de Medicina de Botucatu, no período de 1990-1994 e avaliados até julho de 1997. Utilizou-se um questionário semi-estruturado, e, para avaliação da gravidade do alcoolismo, o Short Alcohol Dependence Data. Resultados/Conclusões: Os principais resultados mostraram que a estrutura familiar estava comprometida com: relacionamento difícil para 55,6% das mulheres e 65,7% dos homens; violência familiar em 74,1% das mulheres e 61,1% dos homens. As mulheres iniciaram a ingestão mais tarde que os homens (p=0,01), em geral com seus cônjuges (p=0,00). Não houve diferença de evolução no tratamento entre os gêneros. Os principais fatores associados à melhor resposta ao tratamento, independentemente do sexo, foram: nível de gravidade de dependência do álcool (dependentes leves e moderados apresentaram 5...

The use of the "Once-Upon-A-Time…" Test in treatment outcome assessment

Pires, Rute; Fagulha, Teresa
Fonte: Universidade de Lisboa Publicador: Universidade de Lisboa
Tipo: Conferência ou Objeto de Conferência
Publicado em /07/2005 ENG
Relevância na Pesquisa
65.88%
In an era in which the advent of managed health care is questioning the value of traditional psychological assessment, we discuss the role of the "Once-upon-a-time…" Test in treatment outcome assessment. The "Once upon a time..." Test (Fagulha, 1992, 1997) is a storytelling projective technique whose purpose is to describe the way children deal with the emotions of anxiety and pleasure. In psychodynamic theories, these emotions have an important adaptive function for psychological development (Freud, 1926/1978; Klein, 1932/1969). The “Once upon a time..." Test task is to complete seven stories which are presented as pictures in a cartoon format. Each story depicts common situations in the life of any child that evoke emotions of anxiety and of pleasure. Five cards refer to anxiety provoking situations and two refer to pleasurable experiences. For each card there are nine scenes that represent different possible ways of dealing with the emotional experience evoked by the card. These scenes are grouped into three categories of three scenes each – the Anxiety category (A), the Fantasy category (F) and the Reality category (R). The child is asked to complete the story drawn on the card by selecting and then placing three of these nine scenes in sequence. The categories of the scenes chosen by the child and the sequences organized with these scenes reflect the way children deal with their emotions...

Treatment outcome of tuberculosis patients under directly observed treatment in Addis Ababa, Ethiopia

Getahun,Belete; Ameni,Gobena; Medhin,Girmay; Biadgilign,Sibhatu
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2013 EN
Relevância na Pesquisa
66.04%
BACKGROUND: Tuberculosis is one of the leading causes of mortality among infectious diseases worldwide. For effective tuberculosis control, it is a pre-requisite to detect the cases as early as possible, and to ensure that the tuberculosis patients complete their treatment and get cured. However, in many resource-constrained settings treatment outcome for tuberculosis has not been satisfactory. OBJECTIVE: The aim of the study was to assess the treatment outcome of tuberculosis patients and investigate the association of demographic and clinical factors with treatment success of patients enrolled in Directly Observed Treatment Short Course program in government owned health centers over the course of five consecutive years in Addis Ababa, Ethiopia. METHODS: A register based historical cohort study covering the period of July 2004 to June 2009 was conducted to determine the treatment outcome of Directly Observed Treatment Short Course in government owned health centers in Addis Ababa. Sex and age of tuberculosis patients, health center at which the patient was treated, year of treatment, type of tuberculosis for which the patient was treated, type of treatment offered to the patient, follow-up status and documented treatment outcome were extracted from the Directly Observed Treatment Short Course clinics of three randomly selected health centers. RESULT: Records of 6450 registered tuberculosis patients (n = 3147 males and 3433 females) were included in this document review. Of these patients 18.1% were reported as being cured...

Treatment outcome of human immunodeficiency virus and tuberculosis co-infected patients in public hospitals of eastern and southern zone of Tigray region, Ethiopia

Belayneh,Mehretu; Giday,Kalayta; Lemma,Hailemariam
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2015 EN
Relevância na Pesquisa
65.96%
Background: Tuberculosis is a leading cause of death among people living with human immunodeficiency virus. In sub-Saharan Africa, tuberculosis accounts for more than 78% of all deaths among people with human immunodeficiency virus. Objectives: To assess tuberculosis treatment outcome and the associated factors in adult tuberculosis/human immunodeficiency virus co-infected patients in four public hospitals of eastern and southern zone of Tigray region, Ethiopia. Methodology: Institution based cross-sectional study design was used to examine secondary data from tuberculosis/human immunodeficiency virus co-infected patients attending four public hospitals of eastern and southern zone of Tigray, from January 2009 to August 2011. Systematic random sampling technique was used to select individual patient cards from the respective hospitals. Univariate analysis and multivariate logistic regression modeling was used to assess the impact of each variable in predicting treatment outcome. Results: Out of 342 patients included, 199 (58.2%) patients completed treatment, 43 (12.6%) patients were cured, 88 (25.7%) died, 7 (2%) defaulted, and 5 (1.5%) patients failed treatment. Treatment success rate was around 71%. In the multivariate logistic regression analysis the factors that were strongly associated with unfavorable tuberculosis treatment outcomes were WHO stage IV (AOR = 3.2...

Overvalued ideas and their impact on treatment outcome

Neziroglu,Fugen A.; Stevens,Kevin P.; Yaryura-Tobias,Jose A.
Fonte: Associação Brasileira de Psiquiatria - ABP Publicador: Associação Brasileira de Psiquiatria - ABP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/1999 EN
Relevância na Pesquisa
65.93%
BACKGROUND: The presence of overvalued ideas (OVI) in patients with obsessive-compulsive disorder (OCD) has been theoretically linked to poorer treatment outcome. However, to date there have not been any quantitative measures of overvalued ideas. Therefore, the relationship between OVI and outcome has been primarily hypothetical. Rudimentary assessments have been attempted by asking patients to rate their strength of belief from 1 to 10, clinically rating the fixity of beliefs from 1 to 5, and rating patients on item 11 (insight) on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). The purpose of this study was to determine the relationship between OVI, degree of severity of OCD symptoms, and improvement. METHOD: Twenty patients with OCD participated in the study. All patients were treated with six days a week of 90 minutes of exposure and response prevention (ERP) and selective serotonin re-uptake inhibitors. No changes in medication were made during the course of treatment and all patients had been on their respective medications for at least three months prior to entering the study. Assessment scales consisted of the Overvalued Ideas Scale (OVIS), Y-BOCS, Beck Depression Inventory, and the Beck Anxiety Inventory. RESULTS: The results indicated that overvalued ideas did not necessarily correlate with severity of symptoms on the Y-BOCS. The higher the score on the OVIS...

Alcoholic women and men: a comparative study of social and familial aspects and outcome

Simão,Maria Odete; Kerr-Corrêa,Florence; Dalben,Ivete; Smaira,Sumaia Inaty
Fonte: Associação Brasileira de Psiquiatria - ABP Publicador: Associação Brasileira de Psiquiatria - ABP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2002 EN
Relevância na Pesquisa
55.9%
Objective: Alcoholic men-women ratio has ranged from 14:1 to 2:1, suggesting that female alcoholism should be further studied. The purpose of the current study was to compare alcohol dependence severity and treatment outcome between alcoholic men and women. Methods: In this longitudinal study, 114 male and 57 female alcoholics (ICD-10 criteria), who started treatment between 1990 and 1994 at the Botucatu Medical School Outpatient Clinic, were retrospectively and prospectively assessed up to July 1997. Semi-structured interviews were conducted and the severity of alcohol dependence was assessed (Short Alcohol Dependence Data -- SADD). Results/Conclusions: The results showed poorly structured families, 55.6% of women and 65.7% of men reported relationship problems and 74.1% of women and 61.1% of men reported domestic violence. When compared to men, women started abusing alcohol later in life (p=0.01) and, usually, with their husbands (p=0.00). The course of treatment did not differ between genders. Regardless of gender, the main factors associated with a better response to treatment were: degree of alcohol dependence severity (mildly and moderately dependent users had 5.59-fold better chances of improvement than those severely dependent)...

Predictive validity of the Brazilian version of the Expected Treatment Outcome Scale in cocaine-dependent outpatients at a drug treatment referral center

Dinis,Marcelle Maria Lobo; Passos,Sonia Regina Lambert; Camacho,Luiz Antonio Bastos
Fonte: Associação Brasileira de Psiquiatria - ABP Publicador: Associação Brasileira de Psiquiatria - ABP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2005 EN
Relevância na Pesquisa
56.02%
BACKGROUND: High dropout rates among patients under treatment for cocaine dependence have stimulated research into predictors of treatment outcome. OBJECTIVE: To assess the predictive value of the Brazilian version of the Expected Treatment Outcome Scale. METHODS: The original English version of the scale was translated and back-translated. A total of 210 subjects participating in a 10-week randomized double-blind clinical trial (nefazodone versus placebo) completed the questionnaire at their first appointment. Mean Expected Treatment Outcome Scale scores were compared with treatment outcomes. RESULTS: There were ten subjects (5%) who failed to complete at least six items, and 37 (17.5%) failed to complete 1 to 3 items. The most frequently unanswered questions involved time estimates (treatment time and abstinence) and third-party judgments. The mean score was 34.4 (9.3) (median, 33.9). There were no differences in mean scores between subjects evaluated in the first to the fifth appointment 35.2 (9.3) or in the sixth to the eleventh appointment 35.2 (9.3) (p = 0.13); completing the treatment 33.8 (10.3) or not 34.6 (9.1) (p = 0.64); remaining abstinent for three weeks 34 (9.3) or not 34.8 (9.4) (p = 0.58), and medication compliance 33.9 (8.8) or noncompliance 35.3 (10.3) (p = 0.34). The ROC curve of Expected Treatment Outcome Scale scores...

Is stone radiodensity a useful parameter for predicting outcome of extracorporeal shockwave lithotripsy for stones < 2 cm?

Krishnamurthy,Mina S.; Ferucci,Paul G.; Sankey,Noel; Chandhoke,Paramjit S.
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2005 EN
Relevância na Pesquisa
55.88%
PURPOSE: Several factors determine the success of extracorporeal shockwave lithotripsy (SWL) for kidney stones: stone size, stone location within the collecting system, stone type, and the SWL machine used. It has been suggested that stone radiodensity, as determined either by plain radiography or computed tomography attenuation values, may be an independent predictor of SWL success. We examined the outcome of SWL for solitary stones less than or equal to 2 cm located within the renal pelvis, based on their radiodensity. MATERIALS AND METHODS: 211 patients with solitary renal pelvic stones measuring less than or equal to 2 cm were treated on a Dornier Doli 50 lithotriptor under general anesthesia. The radiodensity of the stone was determined to be either less than, equal to, or greater than the radiodensity of the ipsilateral 12th rib. Stone-free rates (SFR) were determined at 3 months by kidney, ureters and bladder (KUB) plain X-rays. Patients requiring re-treatment or auxiliary procedures were considered failures of SWL. RESULTS: Follow-up SFR information was available in all 211 patients. Stone composition was available in 158 (75%) treated patients, but no correlation was found between stone radiodensity and stone composition. For stones < 10 mm within the renal pelvis...

Influence of Nasal Resistance on Oral Appliance Treatment Outcome in Obstructive Sleep Apnea

Zeng, Biao; Ng, Andrew T.; Qian, Jin; Petocz, Peter; Darendeliler, M. Ali; Cistulli, Peter A.
Fonte: Associated Professional Sleep Societies, LLC Publicador: Associated Professional Sleep Societies, LLC
Tipo: Artigo de Revista Científica
Publicado em 01/04/2008 EN
Relevância na Pesquisa
55.99%
It has been recognized that nasal airway resistance (NAR) is elevated in patients with OSA. However, little is known regarding the influence of nasal resistance on mandibular advancement splint (MAS) treatment outcome in OSA patient. We hypothesized that nasal resistance differs between MAS responders and nonresponders and therefore may influence treatment outcome. Thirty-eight patients with known OSA underwent polysomnography while wearing a custom-made MAS. Treatment outcome was defined as follows: Responders (R) ≥50% reduction in AHI, and Nonresponders (NR) as <50% reduction in AHI. NAR was measured using posterior rhinomanometry in both sitting and supine positions, with and without MAS. The mean AHI in 26 responders was significantly reduced from 29.0 ± 2.9/h to 6.7 ± 1.2/h; P < 0.01). In 12 nonresponders there was no significant change in AHI (23.9 ± 3.0/h vs 22.0 ± 4.3/h; P=ns). Baseline NAR was significantly lower in responders in the sitting position compared to nonresponders (6.5 ± 0.5 vs 9.4 ± 1.0cm H2O; P < 0.01). There was no significant change in NAR (from baseline) with MAS in either response group while in the sitting position, but in the supine position NAR increased significantly with MAS in the nonresponder group (11.8 ± 1.5 vs 13.8 ± 1.6 cm H2O/L/s; P < 0.01). Logistic regression analysis revealed that NAR and BMI were the most important predictive factors for MAS treatment outcome. These data suggest that higher levels of NAR may negatively impact on treatment outcome with MAS.

Treatment Moderation and Secondary Outcomes: Results from a Randomized Clinical Trial

Motoca, Luci M.
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
Relevância na Pesquisa
55.96%
The present study pursued two objectives in the context of a randomized clinical trial of cognitive-behavioral therapy with parent (CBT/P) and group (GCBT) involvement. The first objective was to examine the variability in treatment outcome. There were three specific aims within the first objective, to evaluate: (1) youth characteristics (age, depressive, and externalizing disorders) as moderators of treatment outcome; (2) the differential outcome of the treatment approaches as a function of youth characteristics; and (3) the relative efficacy of the treatment approaches at each level of the moderators. The second objective was to evaluate the efficacy of anxiety treatments along secondary depressive symptoms and externalizing behaviors. There were five specific aims within the second objective, to evaluate: (1) whether anxiety treatment yields reductions in secondary problems, (2) the efficacy of anxiety treatments in reducing secondary problems as a function of approach and youth characteristics, (3) whether reductions in anxiety symptoms significantly mediate changes in secondary problems, (4) the directionality of change in the hypothesized mediated relations, and (5) whether the hypothesized mediated relations are moderated by treatment approach and youth characteristics. The specific aims were pursued using data collected from 183 youth and their mothers. Research questions were tested using multiple regressions and structural equation modeling. Age...

One year outcomes for heroin dependence: findings from the Australian Treatment Outcome Study (ATOS)

Teesson, M.; Ross, J.; Darke, S.; Lynskey, M.; Ali, R.; Ritter, A.; Cooke, R.
Fonte: Elsevier Sci Ireland Ltd Publicador: Elsevier Sci Ireland Ltd
Tipo: Artigo de Revista Científica
Publicado em //2006 EN
Relevância na Pesquisa
55.88%
Aim: To determine 1 year outcomes for drug use, criminality, psychopathology and injection-related health problems in those entering treatment for heroin dependence in Australia. Design: Longitudinal prospective cohort study. Participants: Seven hundred and forty five individuals entering treatment (methadone/buprenorphine maintenance therapy; detoxification; residential rehabilitation) and 80 heroin users not seeking treatment. Setting: Sydney, Melbourne and Adelaide, Australia. Findings: A total of 657 individuals were re-interviewed at 1 year, 80% of the original sample. There were substantial reductions in heroin and other drug use across all three treatment modalities. The majority of those who had entered treatment were heroin abstinent at 1 year (maintenance therapy 65%, detoxification 52%, residential rehabilitation 63%) compared to 25% of the non-treatment sample. The reduction in heroin use among the treatment samples was paralleled by reductions in poly drug use. There were also substantial reductions in risk-taking, crime and injection-related health problems across all treatment groups, and less marked reductions among the non-treatment group. Psychopathology was dramatically reduced among the treatment modalities, while remaining stable among the non-treatment group. Positive outcomes at 1 year were associated with a greater number of cumulative treatment days experienced over the 1 year follow-up period (‘treatment dose’) and fewer treatment episodes undertaken in that time (‘treatment stability’).; http://www.sciencedirect.com/science/journal/03768716; Maree Teesson...

The interferon signaling pathway genes as biomarkers of hepatitis C virus disease progression and response to treatment

Helbig, K.; Beard, M.
Fonte: Future Medicine Ltd Publicador: Future Medicine Ltd
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
55.88%
Hepatitis C virus is an ever-increasing worldwide health problem with over 350,000 individuals succumbing to hepatitis C virus-related liver diseases each year. The ability to determine the outcome of an acute-phase illness may be useful in terms of implementing treatment strategies; however, to date, the predictive associations in the literature have centered around candidate gene analysis. Much greater advancements have been made in describing biomarkers from the activation of the host innate immune response, such as the interferon system, for prediction of treatment outcome in chronic hepatitis C with the advent of genome-wide association studies. Recent times has seen a major breakthrough in the field with the description of the IL28B genotype as an independent association factor for pegylated IFN-α2b/ribavirin treatment response. The ability to couple this with other easily measured biomarkers such as the interferon-stimulated gene CXCL10, serum concentration may make this predictive marker set very useful in the clinical setting.; Karla J Helbig & Michael R Beard

Possible associations of NTRK2 polymorphisms with antidepressant treatment outcome: findings from an extended tag SNP approach

Hennings, J.; Kohli, M.; Czamara, D.; Geise, M.; Eckert, A.; Wolf, C.; Heck, A.; Domschke, K.; Arolt, V.; Baune, B.; Horstmann, S.; Bruckl, T.; Klengel, T.; Menke, A.; Muller-Myhsok, B.; Ising, M.; Uhr, M.; Lucae, S.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
65.98%
BACKGROUND Data from clinical studies and results from animal models suggest an involvement of the neurotrophin system in the pathology of depression and antidepressant treatment response. Genetic variations within the genes coding for the brain-derived neurotrophic factor (BDNF) and its key receptor Trkb (NTRK2) may therefore influence the response to antidepressant treatment. METHODS We performed a single and multi-marker association study with antidepressant treatment outcome in 398 depressed Caucasian inpatients participating in the Munich Antidepressant Response Signature (MARS) project. Two Caucasian replication samples (N = 249 and N = 247) were investigated, resulting in a total number of 894 patients. 18 tagging SNPs in the BDNF gene region and 64 tagging SNPs in the NTRK2 gene region were genotyped in the discovery sample; 16 nominally associated SNPs were tested in two replication samples. RESULTS In the discovery analysis, 7 BDNF SNPs and 9 NTRK2 SNPs were nominally associated with treatment response. Three NTRK2 SNPs (rs10868223, rs1659412 and rs11140778) also showed associations in at least one replication sample and in the combined sample with the same direction of effects (P(corr) = .018, P(corr) = .015 and P(corr) = .004...

Personality traits and treatment outcome in obsessive-compulsive disorder; Traços de personalidade e resposta terapêutica no transtorno obsessivo-compulsivo

CORCHS, Felipe; CORREGIARI, Fábio; FERRÃO, Ygor Arzeno; TAKAKURA, Tania; MATHIS, Maria Eugênia; LOPES, Antonio Carlos; MIGUEL, Euripedes Constantino; BERNIK, Márcio
Fonte: Associação Brasileira de Psiquiatria - ABP Publicador: Associação Brasileira de Psiquiatria - ABP
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
65.91%
OBJECTIVE: Comorbidity with personality disorders in obsessive-compulsive patients has been widely reported. About 40% of obsessive-compulsive patients do not respond to first line treatments. Nevertheless, there are no direct comparisons of personality traits between treatment-responsive and non-responsive patients. This study investigates differences in personality traits based on Cloninger's Temperament and Character Inventory scores between two groups of obsessive-compulsive patients classified according to treatment outcome: responders and non-responders. METHOD: Forty-four responsive and forty-five non-responsive obsessive-compulsive patients were selected. Subjects were considered treatment-responsive (responder group) if, after having received treatment with any conventional therapy, they had presented at least a 40% decrease in the initial Yale-Brown Obsessive Compulsive Scale score, had rated "better" or "much better" on the Clinical Global Impressions scale; and had maintained improvement for at least one year. Non-responders were patients who did not achieve at least a 25% reduction in Yale-Brown Obsessive Compulsive Scale scores and had less than minimal improvement on the Clinical Global Impressions scale after having received treatment with at least three selective serotonin reuptake inhibitors (including clomipramine)...

Can countertransference at the early stage of trauma care predict patient dropout of psychiatric treatment?

Silveira Júnior,Érico de Moura; Polanczyk,Guilherme Vanoni; Hauck,Simone; Eizirik,Cláudio Laks; Ceitlin,Lúcia Helena Freitas
Fonte: Associação Brasileira de Psiquiatria - ABP Publicador: Associação Brasileira de Psiquiatria - ABP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2011 EN
Relevância na Pesquisa
56.01%
OBJECTIVES: To investigate the association between feelings of countertransference (CT) at the early psychiatric care provided to trauma victims and treatment outcome. METHOD: The Assessment of Countertransference Scale was used to access CT after the first medical appointment. Fifty psychiatric residents cared for 131 trauma victims of whom 83% were women, aged 15 to 64 years. Patients had been consecutively selected over 4 years. Were evaluated the clinical and demographic characteristics of patients and the correlation with the therapists' CT feelings. Patients were followed-up during treatment to verify the association between initial CT and treatment outcome, defined as discharge and dropout. RESULTS: The median number of appointments was 5 [4; 8], absences 1 [0; 1], and the dropout rate was 34.4%. Both groups, namely the discharge group and the dropout group, shared similar clinical and demographic characteristics. A multivariate analysis identified that patients with a reported history of childhood trauma were 61% less likely to dropout from treatment than patients with no reported history of childhood trauma (OR = 0.39, p = 0.039, CI95% 0.16-0.95). There was no association between initial CT and treatment outcome. CONCLUSIONS: In this sample...

Personality traits and treatment outcome in obsessive-compulsive disorder

Corchs,Felipe; Corregiari,Fábio; Ferrão,Ygor Arzeno; Takakura,Tania; Mathis,Maria Eugênia; Lopes,Antonio Carlos; Miguel,Euripedes Constantino; Bernik,Márcio
Fonte: Associação Brasileira de Psiquiatria - ABP Publicador: Associação Brasileira de Psiquiatria - ABP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2008 EN
Relevância na Pesquisa
65.91%
OBJECTIVE: Comorbidity with personality disorders in obsessive-compulsive patients has been widely reported. About 40% of obsessive-compulsive patients do not respond to first line treatments. Nevertheless, there are no direct comparisons of personality traits between treatment-responsive and non-responsive patients. This study investigates differences in personality traits based on Cloninger's Temperament and Character Inventory scores between two groups of obsessive-compulsive patients classified according to treatment outcome: responders and non-responders. METHOD: Forty-four responsive and forty-five non-responsive obsessive-compulsive patients were selected. Subjects were considered treatment-responsive (responder group) if, after having received treatment with any conventional therapy, they had presented at least a 40% decrease in the initial Yale-Brown Obsessive Compulsive Scale score, had rated "better" or "much better" on the Clinical Global Impressions scale; and had maintained improvement for at least one year. Non-responders were patients who did not achieve at least a 25% reduction in Yale-Brown Obsessive Compulsive Scale scores and had less than minimal improvement on the Clinical Global Impressions scale after having received treatment with at least three selective serotonin reuptake inhibitors (including clomipramine)...