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Em torno da gênese de uma personagem proustiana: tia Léonie no caminho da descoberta de uma vocação; Around a Proustian character: Léonies way in the discovery of a vocation

Santos, Liliane Silva dos
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 05/09/2014 PT
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36.99%
NO ROMANCE DE MARCEL PROUST Em busca do tempo perdidodesfilam ante os olhos do leitorum compêndio de seres enigmáticos, fragmentários, que oferecem em si, ao longo da obra, uma gama de novas imagens e possibilidades. Desse complexo conjunto de seres imprevisíveis, há um caso particular de uma personagem secundária. Figuraaparentemente dentro da narrativa como um ser anedótico, apenas para compor um ambiente cômico, pueril dentro de Combray, a cidadezinha prosaica de infância do herói do romance: a tia Léonie. O objetivo do trabalho que apresentamos não é somente analisar esse ser aparentemente risório, a eterna doente de Combray. Sobretudo, pretende-se mostrar dentro dopróprio romance proustiano que Léonie, como os tantos personagens desse trajeto rumo à descoberta da verdadeira vocação do herói, também colocará sua pequena pedra na composição monumental da obra por vir, pois, ao seu modo, também contribuirá para a composição daquele que renunciará à vida, se reservando apenas o essencial, para compor seu romance.; IN THE NOVEL OF MARCEL PROUST'S "In Search of Lost Time", parade before the reader's eyes, a compendium of enigmatic, fragmentary beings, offering itself, throughout the work, a range of new images and possibilities. In this complex set of unpredictable beings...

Differential antagonism by conotoxin p-TIA of contractions mediated by distinct alpha(1)-adrenoceptor subtypes in rat vas deferens, spleen and aorta

Lima, V; Mueller, A.; Kamikihara, S. Y.; Raymundi, V; Alewood, D.; Lewis, R. J.; Chen, Z. J.; Minneman, K. P.; Pupo, A. S.
Fonte: Elsevier B.V. Publicador: Elsevier B.V.
Tipo: Artigo de Revista Científica Formato: 183-192
ENG
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The ability of the conotoxin p-TIA, a 19-amino acid peptide isolated from the marine snail Conus tulipa, to antagonize contractions induced by noradrenaline through activation of alpha(1A)-adrenoceptors in rat vas deferens, alpha(1B)-adrenoceptors in rat spleen and alpha(ID)-adrenoceptors in rat aorta, and to inhibit the binding of [I-125]HEAT (2-[[beta-(4-hydroxyphenyl)ethyl]aminomethyl]-1-tetralone) to membranes of human embryonic kidney (HEK) 293 cells expressing each of the recombinant rat alpha(1)-adrenoceptors was investigated. p-TIA (100 nM to 1 muM) antagonized the contractions of vas deferens and aorta in response to noradrenaline without affecting maximal effects and with similar potencies (pA(2)similar to7.2, n=4). This suggests that p-TIA is a competitive antagonist of alpha(1A)- and alpha(1D)-adrenoceptors with no selectivity between these subtypes. Incubation of p-TIA (30 to 300 nM) with rat spleen caused a significant reduction of the maximal response to noradrenaline, suggesting that p-TIA is a non-competitive antagonist at alpha(1B)-adrenoceptors. After receptor inactivation with phenoxybenzamine, the potency of p-TIA in inhibiting contractions was examined with similar occupancies (similar to25%) at each subtype. Its potency (pIC(50)) was 12 times higher in spleen (8.3 +/- 0.1...

Design of a CMOS amplifier for breast cancer detection

Carvalho, João Ricardo Carvalho Magalhães de
Fonte: Universidade Nova de Lisboa Publicador: Universidade Nova de Lisboa
Tipo: Dissertação de Mestrado
Publicado em /09/2014 ENG
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27.46%
A transimpedance amplifier (TIA) is used, in radiation detectors like the positron emission tomography(PET), to transform the current pulse produced by a photo-sensitive device into an output voltage pulse with a desired amplitude and shape. The TIA must have the lowest noise possible to maximize the output. To achieve a low noise, a circuit topology is proposed where an auxiliary path is added to the feedback TIA input, In this auxiliary path a differential transconductance block is used to transform the node voltage in to a current, this current is then converted to a voltage pulse by a second feedback TIA complementary to the first one, with the same amplitude but 180º out of phase with the first feedback TIA. With this circuit the input signal of the TIA appears differential at the output, this is used to try an reduced the circuit noise. The circuit is tested with two different devices, the Avalanche photodiodes (APD) and the Silicon photomultiplier (SIPMs). From the simulations we find that when using s SIPM with Rx=20kΩ and Cx=50fF the signal to noise ratio is increased from 59 when using only one feedback TIA to 68.3 when we use an auxiliary path in conjunction with the feedback TIA. This values where achieved with a total power consumption of 4.82mv. While the signal to noise ratio in the case of the SIPM is increased with some penalty in power consumption.

Epithelial Cell Adherence Mediated by the Enterotoxigenic Escherichia coli Tia Protein

Mammarappallil, Joseph G.; Elsinghorst, Eric A.
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /12/2000 EN
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27.62%
In vitro studies have shown that enterotoxigenic Escherichia coli (ETEC) strains are capable of invading cultured epithelial cells derived from the human ileum and colon. Two separate invasion loci (tia and tib) have previously been isolated from the classical ETEC strain H10407. The tia locus has been shown to direct the synthesis of Tia, a 25-kDa outer membrane protein. Tia is sufficient to confer the adherence and invasion phenotypes on laboratory stains of E. coli, suggesting that this protein is an adhesin and invasin. Here we report the purification of Tia and characterize its biological activity. Tia was purified by electroelution of outer membrane proteins that had been separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Purified Tia was labeled with biotin and then shown to bind to HCT8 human ileocecal epithelial cells in a specific and saturable manner. Polyclonal anti-Tia antiserum blocked this binding. These results show that Tia acts as an adhesin. Polyclonal anti-Tia antiserum also inhibited invasion of recombinant E. coli bearing tia clones, indirectly suggesting that Tia may also act as an invasin. We predict Tia to contain eight transmembrane amphipathic β-sheets with four loops that are exposed on the surface of the bacterial cell. A peptide corresponding to 19 residues in one of the four predicted surface-exposed loops inhibits Tia-mediated epithelial cell invasion. Seeding HCT8 cells on wells coated with purified Tia reduced Tia-mediated epithelial cell invasion. Together...

Molecular characterization of the tia invasion locus from enterotoxigenic Escherichia coli.

Fleckenstein, J M; Kopecko, D J; Warren, R L; Elsinghorst, E A
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /06/1996 EN
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Enterotoxigenic Escherichia coli (ETEC) shares with other diarrheal pathogens the capacity to invade epithelial cell lines originating from the human ileum or colon, although the role of invasion in ETEC pathogenesis remains undefined. Two distinct loci (tia and tib) that direct noninvasive E. coli to adhere to and invade intestinal epithelial cell lines have previously been isolated from cosmid libraries of the classical ETEC strain H10407. Here, we report the molecular characterization of the tia locus. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of cellular fractions of E. coli DH5alpha carrying the tia-positive cosmids and recombinant plasmid subclones revealed that this locus directs the production of a 25-kDa protein (the Tia protein) that is localized to the outer membrane. The tia locus was subcloned to a maximum of 2 kb and mutagenized with bacteriophage Mud. Synthesis of this protein was directly correlated with the ability of subclones and Mud transposon mutants to adhere to and invade epithelial cells. Sequencing of the tia locus identified a 756-bp open reading frame. All transposon insertions resulting in an invasion-negative phenotype mapped to this open reading frame. The open reading frame was amplified and directionally cloned behind the lac promoter of pHG165. This construct directed DHalpha to express a 25-kDa protein and to adhere to and invade epithelial cells. The role of the tia gene in directing epithelial adherence and invasion was further assessed by the construction of chromosomal tia deletion derivatives of the parent ETEC strain...

TIA-1 is a translational silencer that selectively regulates the expression of TNF-α

Piecyk, Monica; Wax, Stephen; Beck, Andreas R.P.; Kedersha, Nancy; Gupta, Mita; Maritim, Beatrice; Chen, Samantha; Gueydan, Cyril; Kruys, Veronique; Streuli, Michel; Anderson, Paul
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Publicado em 01/08/2000 EN
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27.52%
TIA-1 and TIAR are related proteins that bind to an AU-rich element (ARE) in the 3′ untranslated region of tumor necrosis factor alpha (TNF-α) transcripts. To determine the functional significance of this interaction, we used homologous recombination to produce mutant mice lacking TIA-1. Although lipopolysaccharide (LPS)-stimulated macrophages derived from wild-type and TIA-1–/– mice express similar amounts of TNF-α transcripts, macrophages lacking TIA-1 produce significantly more TNF-α protein than wild-type controls. The half-life of TNF-α transcripts is similar in wild-type and TIA-1–/– macrophages, indicating that TIA-1 does not regulate transcript stability. Rather, the absence of TIA-1 significantly increases the proportion of TNF-α transcripts that associate with polysomes, suggesting that TIA-1 normally functions as a translational silencer. TIA-1 does not appear to regulate the production of interleukin 1β, granulocyte–macrophage colony-stimulating factor or interferon γ, indicating that its effects are, at least partially, transcript specific. Mice lacking TIA-1 are hypersensitive to the toxic effects of LPS, indicating that this translational control pathway may regulate the organismal response to microbial stress.

Expression of TIA-1 and TIA-2 in T cell malignancies and T cell lymphocytosis.

Matutes, E; Coelho, E; Aguado, M J; Morilla, R; Crawford, A; Owusu-Ankomah, K; Catovsky, D
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /02/1996 EN
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OBJECTIVE: To investigate the reactivity with TIA-1 and TIA-2, two monoclonal antibodies that recognise, respectively, granular structures in T lymphocytes and the T cell receptor chain in cells from a variety of T cell disorders. METHODS: Cytoplasmic staining with TIA-1 and TIA-2 was carried out by the immunoalkaline phosphatase anti-alkaline phosphatase technique in 67 cases with a T cell disorder: 31 large granular lymphocyte (LGL) leukaemia, nine T-prolymphocytic leukaemia (T-PLL), five Sezary syndrome, four peripheral T cell lymphoma (PTCL), 13 T cell lymphocytosis, and five T-acute lymphoblastic leukaemia (T-ALL). All had over 75% abnormal T cells which were CD2+, CD3+, CD5+, CD7+, and negative with B cell markers. RESULTS: TIA-1 was positive in 77% cases of LGL leukaemia and half of the PTCL and T-ALL, whereas it was negative in all Sezary syndrome and most T-PLL (8/9) and reactive T-lymphocytosis (10/13). In LGL leukaemia, TIA-1 was positive irrespective of the membrane phenotype, whether CD8+, CD4- or CD4+, CD8-, and was more often positive in cases where cells were CD16+, CD56+, or CD57+. TIA-2 was positive in 60% of cases encompassing all diagnostic types of T cell disorder. There was no correlation between TIA-2 expression and that of other T cell markers...

Identification and Functional Outcome of mRNAs Associated with RNA-Binding Protein TIA-1

López de Silanes, Isabel; Galbán, Stefanie; Martindale, Jennifer L.; Yang, Xiaoling; Mazan-Mamczarz, Krystyna; Indig, Fred E.; Falco, Geppino; Zhan, Ming; Gorospe, Myriam
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /11/2005 EN
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27.54%
The RNA-binding protein TIA-1 (T-cell intracellular antigen 1) functions as a posttranscriptional regulator of gene expression and aggregates to form stress granules following cellular damage. TIA-1 was previously shown to bind mRNAs encoding tumor necrosis factor alpha (TNF-α) and cyclooxygenase 2 (COX-2), but TIA-1 target mRNAs have not been systematically identified. Here, immunoprecipitation (IP) of TIA-1-RNA complexes, followed by microarray-based identification and computational analysis of bound transcripts, was used to elucidate a common motif present among TIA-1 target mRNAs. The predicted TIA-1 motif was a U-rich, 30- to 37-nucleotide (nt)-long bipartite element forming loops of variable size and a bent stem. The TIA-1 motif was found in the TNF-α and COX-2 mRNAs and in 3,019 additional UniGene transcripts (∼3% of the UniGene database), localizing preferentially to the 3′ untranslated region. The interactions between TIA-1 and target transcripts were validated by IP of endogenous mRNAs, followed by reverse transcription and PCR-mediated detection, and by pulldown of biotinylated RNAs, followed by Western blotting. Further studies using RNA interference revealed that TIA-1 repressed the translation of bound mRNAs. In summary...

The Translational Repressor T-cell Intracellular Antigen-1 (TIA-1) is a Key Modulator of Th2 and Th17 Responses Driving Pulmonary Inflammation Induced by Exposure to House Dust Mite

Simarro, Maria; Giannattasio, Giorgio; Xing, Wei; Lundequist, Emma-Maria; Stewart, Samantha; Stevens, Richard L.; Orduña, Antonio; Boyce, Joshua A.; Anderson, Paul J.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
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T-cell Intracellular Antigen-1 (TIA-1) is a translational repressor that dampens the production of proinflammatory cytokines and enzymes. In this study we investigated the role of TIA-1 in a mouse model of pulmonary inflammation induced by exposure to the allergenic extract (Df) of the house dust mite Dermatophagoides farinae. When intranasally challenged with a low dose of Df, mice lacking TIA-1 protein (Tia-1−/−) showed more severe airway and tissue eosinophilia, infiltration of lung bronchovascular bundles, and goblet cell metaplasia than wild-type littermates. Tia-1−/− mice also had higher levels of Df-specific IgE and IgG1 in serum and ex vivo restimulated Tia-1−/− lymph node cells and splenocytes transcribed and released more Th2/Th17 cytokines. To evaluate the site of action of TIA-1, we studied the response to Df in bone marrow chimeras. These experiments revealed that TIA-1 acts on both hematopoietic and non-hematopoietic cells to dampen pulmonary inflammation. Our results identify TIA-1 as a negative regulator of allergen-mediated pulmonary inflammation in vivo. Thus, TIA-1 might be an important player in the pathogenesis of bronchial asthma.

The Stress Granule Component TIA-1 Binds Tick-Borne Encephalitis Virus RNA and Is Recruited to Perinuclear Sites of Viral Replication To Inhibit Viral Translation

Albornoz, Amelina; Carletti, Tea; Corazza, Gianmarco; Marcello, Alessandro
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /06/2014 EN
Relevância na Pesquisa
27.52%
Flaviviruses are a major cause of disease in humans and animals worldwide. Tick-borne encephalitis virus (TBEV) is the most important arthropod-borne flavivirus endemic in Europe and is the etiological agent of tick-borne encephalitis, a potentially fatal infection of the central nervous system. However, the contributions of host proteins during TBEV infection are poorly understood. In this work, we investigate the cellular protein TIA-1 and its cognate factor TIAR, which are stress-induced RNA-binding proteins involved in the repression of initiation of translation of cellular mRNAs and in the formation of stress granules. We show that TIA-1 and TIAR interact with viral RNA in TBEV-infected cells. During TBEV infection, cytoplasmic TIA-1 and TIAR are recruited at sites of viral replication with concomitant depletion from stress granules. This effect is specific, since G3BP1, another component of these cytoplasmic structures, remains localized to stress granules. Moreover, heat shock induction of stress granules containing TIA-1, but not G3BP1, is inhibited in TBEV-infected cells. Infection of cells depleted of TIA-1 or TIAR by small interfering RNA (siRNA) or TIA-1−/− mouse fibroblasts, leads to a significant increase in TBEV extracellular infectivity. Interestingly...

K?tia Tapety: ora mulher, ora travesti? G?nero, sexualidade e identidades em tr?nsito no Brasil

GONTIJO, Fabiano
Fonte: Universidade Federal do Pará Publicador: Universidade Federal do Pará
Tipo: Artigo de Revista Científica
POR
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Servindo-nos da trajet?ria de K?tia Tapety - a primeira travesti eleita a cargo pol?tico no Brasil - e baseando-nos nos estudos seminais de Peter Fry, esbo?aremos algumas reflex?es sobre as articula??es transitivas dos sistemas de representa??es sobre a sexualidade no Brasil e as maneiras peculiares como sexualidade e g?nero, enquanto poderosos marcadores sociais da diferen?a, se relacionam na base desses sistemas de representa??es.; ABSTRACT: We analyze the biography of K?tia Tapety - the first transsexual to hold political office in Brazil - and, based on the seminal texts of Peter Fry, outline some questions about the systems of representations of sexuality in Brazil and the peculiar ways in which sexuality and gender are (or not) linked.

TAR DNA-Binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1

McDonald, Karli K.
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
EN
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37.32%
TDP-43 est une protéine multifonctionnelle possédant des rôles dans la transcription, l'épissage des pré-ARNm, la stabilité et le transport des ARNm. TDP-43 interagit avec d'autres hnRNP, incluant hnRNP A2, via son extrémité C-terminale. Plusieurs membres de la famille des hnRNP étant impliqués dans la réponse au stress cellulaire, alors nous avons émis l’hypothèse que TDP-43 pouvait y participer aussi. Nos résultats démontrent que TDP-43 et hnRNP A2 sont localisés au niveau des granules de stress, à la suite d’un stress oxydatif, d’un choc thermique, et lors de l’exposition à la thapsigargine. TDP-43 contribue à la fois à l'assemblage et au maintien des granules de stress en réponse au stress oxydatif. TDP-43 régule aussi de façon différentielle les composants clés des granules de stress, notamment TIA-1 et G3BP. L'agrégation contrôlée de TIA-1 est perturbée en l'absence de TDP-43. En outre, TDP-43 régule le niveau d`ARNm de G3BP, un facteur de granule de stress de nucléation. La mutation associée à la sclérose latérale amyotrophique, TDP-43R361S, compromet la formation de granules de stress. Ainsi, la fonction cellulaire de TDP-43 s'étend au-delà de l’épissage; TDP-43 est aussi un composant de la réponse cellulaire au stress central et un acteur actif dans le stockage des ARNs.; TDP-43 is a multifunctional protein with roles in transcription...

Tia Neiva : a trajetória de uma líder religiosa e sua obra, o vale do amanhecer (1925-2008)

Reis, Marcelo Rodrigues dos
Fonte: Universidade de Brasília Publicador: Universidade de Brasília
Tipo: Tese
POR
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Tese (doutorado)—Universidade de Brasília, Instituto de Ciências Humanas, Departamento de História, 2008.; O presente esforço intelectual se empenha em direcionar um olhar dedicado à história da líder religiosa da comunidade do Vale do Amanhecer: a médium que ficou nacionalmente conhecida como Tia Neiva. Migrante nordestina, Neiva Chaves Zelaya, após se estabelecer provisoriamente em muitas cidades em busca de estabilidade, em 1957, radica-se na Cidade Livre, Núcleo Bandeirante, e se envolve diretamente com os esforços que resultariam na edificação da nova capital federal. Informada pelas imagens de predestinação que qualificavam Brasília como uma Terra Prometida e dotada de vigorosa religiosidade, nesse período, dá início a sua vida mística, a sua trajetória hierofânica, na esteira da qual estabelece a Doutrina do Amanhecer. Diante desse objeto de estudo, nossa proposta se associa ao esforço de compreender como a imagem de Tia Neiva, por meio das representações a que deu vida e das que se viram consignadas por atores outros e permanecem a se constituir em torno de suas apresentações temporal e espiritual, autorizam a concepção, a solidificação e garantem a preservação de sua comunidade religiosa. Considerado...

Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1

Bauer, William J.; Heath, Jason; Jenkins, Jermaine L.; Kielkopf, Clara L.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.57%
T-cell intracellular antigen-1 (TIA-1) regulates developmental and stress-responsive pathways through distinct activities at the levels of alternative pre-mRNA splicing and mRNA translation. The TIA-1 polypeptide contains three RNA recognition motifs (RRMs). The central RRM2 and C-terminal RRM3 associate with cellular mRNAs. The N-terminal RRM1 enhances interactions of a C-terminal Q-rich domain of TIA-1 with the U1-C splicing factor, despite linear separation of the domains in the TIA-1 sequence. Given the expanded functional repertoire of the RRM family, it was unknown whether TIA-1 RRM1 contributes to RNA binding as well as documented protein interactions. To address this question, we used isothermal titration calorimetry and small-angle X-ray scattering (SAXS) to dissect the roles of the TIA-1 RRMs in RNA recognition. Notably, the fas RNA exhibited two binding sites with indistinguishable affinities for TIA-1. Analyses of TIA-1 variants established that RRM1 was dispensable for binding AU-rich fas sites, yet all three RRMs were required to bind a polyU RNA with high affinity. SAXS analyses demonstrated a `V' shape for a TIA-1 construct comprising the three RRMs, and revealed that its dimensions became more compact in the RNA-bound state. The sequence-selective involvement of TIA-1 RRM1 in RNA recognition suggests a possible role for RNA sequences in regulating the distinct functions of TIA-1. Further implications for U1-C recruitment by the adjacent TIA-1 binding sites of the fas pre-mRNA and the bent TIA-1 shape...

A Q-Methodology Study of Patients' Subjective Experiences of TIA

Spurgeon, Laura; Humphreys, Glyn; James, Gill; Sackley, Cath
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.52%
Background. An expanding body of research has focused on a range of consequences of TIA. However, no work has been conducted on the patient's subjective experience of TIA. Aim. To capture patients' first-hand experiences of TIA. Method. Using Q-methodology which employs both qualitative and quantitative approaches, 39 statements relating to the clinical, physical, affective, and psychological impact of TIA were distilled from the literature and from patient narratives. Consistent with conventional Q-methodology, a purposive sample of twentythree post-TIA patients sorted these statements into a normally-distributed 39-cell grid, according to the extent to which each represented their experience of TIA. Results. Casewise factoranalysis was conducted on the sorted statements. Eight factors emerged which were labelled: lack of knowledge/awareness of TIA; life impact; anxiety; interpersonal impact; depression; physical consequences; cognitive avoidance/denial; constructive optimism. Conclusions. Five of the eight factors confirmed existing research on the impact of TIA, but three new issues emerged: deep-seated anxiety, denial and constructive optimism. The emerging perspectives highlight areas to target in the management of TIA and could inform health education messages...

Cultura de masas en la Tia Julia y el Escribidor de Mario Vargas Llosa

Jeria Conus, Jorge Alfredo
Fonte: Universidad de Chile; CyberDocs Publicador: Universidad de Chile; CyberDocs
Tipo: Tesis
ES
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El escritor Mario Vargas Llosa en La tía Julia y el escribidor (1977) ha realizado un arduo trabajo consistente en interrelacionar la literatura, o arte elevado, con la menospreciada cultura de masas o paraliteratura, logrando por medio de sus entes ficticios producir una contaminación que algunos críticos, entre ellos José Oviedo y Myrna Solotorevsky, han señalado como una de las características más sobresalientes que se desprenden de la lectura de la novela. En esta obra existe un conjunto de diversos rasgos determinados por la polisemia del texto, que giran en torno a esta problemática relación literatura-paraliteratura, en un contexto donde los medios masivos de comunicación han ido adquiriendo cada vez más preponderancia, y que el presente estudio se ha propuesto deslindar.

Narrativa de mujeres en Costa Rica : personajes femeninos en los Cuentos de mi tía Panchita

Ugarte Barquero, Marcia; Ferrús Antón, Beatriz
Fonte: Universidade Autônoma de Barcelona Publicador: Universidade Autônoma de Barcelona
Tipo: Trabalho de Conclusão de Curso Formato: application/pdf
Publicado em //2011 SPA
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37.14%
Este trabajo tiene como objetivo el adentrarse en algunos de los cuentos infantiles de una reconocida autora de Costa Rica, los Cuentos de mi tía Panchita de Carmen Lyra, y descubrir, mediante un análisis de ciertos de sus personajes femeninos desde un marco relacionado con teoría literaria feminista, elementos del discurso que permitan entrever o evidenciar la presencia de roles tradicionales de las mujeres o transgresiones a esos patrones, con mayor atención a la Costa Rica de principios del siglo XX; Aquest treball té com a objectiu el endinsar-se en alguns dels contes infantils d'una reconeguda autora de Costa Rica, els Cuentos de mi tía Panchita de Carmen Lyra, i descobrir, mitjançant una anàlisi de certs dels seus personatges femenins des d'un marc relacionat amb teoria literària feminista, elements del discurs que permetin entreveure o evidenciar la presència de rols tradicionals de les dones o transgressions a aquests patrons, amb major atenció a la Costa Rica de principis del segle XX

RApid Primary care Initiation of Drug treatment for Transient Ischaemic Attack (RAPID?TIA): study protocol for a pilot randomised controlled trial

Edwards, Duncan; Fletcher, Kate; Deller, Rachel; McManus, Richard; Lasserson, Daniel; Giles, Matthew; Sims, Don; Norrie, John; McGuire, Graham; Cohn, Simon; Whittle, Fiona; Hobbs, Vikki; Weir, Christopher; Mant, Jonathan
Fonte: Universidade de Cambridge Publicador: Universidade de Cambridge
Tipo: Article; Published Version
EN
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27.52%
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.; Abstract Background People who have a transient ischaemic attack (TIA) or minor stroke are at high risk of a recurrent stroke, particularly in the first week after the event. Early initiation of secondary prevention drugs is associated with an 80% reduction in risk of stroke recurrence. This raises the question as to whether these drugs should be given before being seen by a specialist – that is, in primary care or in the emergency department. The aims of the RAPID-TIA pilot trial are to determine the feasibility of a randomised controlled trial, to analyse cost effectiveness and to ask: Should general practitioners and emergency doctors (primary care physicians) initiate secondary preventative measures in addition to aspirin in people they see with suspected TIA or minor stroke at the time of referral to a specialist? Methods/Design This is a pilot randomised controlled trial with a sub-study of accuracy of primary care physician diagnosis of TIA. In the pilot trial...

Identificações transversais e focalização narrativa em Tia Júlia e o escrevinhador, de Mario Vargas Llosa / Transversal identification and narrative focus on Tia Júlia e o escrevinhador, Mario Vargas Llosa

Santana, Jorge Alves; UFG – Universidade Federal de Goiás/UFMG – Universidade Federal de Minas Gerais, Goiânia-GO.
Fonte: Revista Cerrados Publicador: Revista Cerrados
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Formato: application/pdf
Publicado em 12/08/2015 POR
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“Eu estudava na San Marcos, Direito [...] embora, no fundo, me agradasse mais chegar a ser escritor”. Inicia-se, assim, o romance Tia Júlia e o escrevinhador (1977), de Mario Vargas Llosa. Analisaremos, aqui, identidades transversais nas formações discursivas e subjetivas, que dizem respeito ao “eu narrador” e ao “eu narrado”; à inusitada enunciação, dinamizada pela técnica do discurso indireto livre e pelos vasos comunicantes; e, por fim, ao painel sociocultural peruano e latino-americano, base para a rizomática formação do autor.Abstract“I studied in San Marcos, Law School […] Although, deep down, it pleased me becoming a writer”. Begins, this way, the romance Tia Júlia e o escrevinhador (1977), Mário Vargas Llosa. We are going to analyse transversal identities in the discursive and subjective formations, regarding the “me narrator” and the “me narrated”; the unusual enunciation, optimized by the free indirect speech technique by the communicating vessels; and, lastly, the Peruvian and LatinAmerican painel, groundwork for the author’s rhizomatic formation.

Acercamiento al pensamiento de Unamuno: La Tía Tula y la lucha entre fe y razón

Stenstrom,Monika
Fonte: Centro de Estudios Filosóficos Adolfo García Díaz Publicador: Centro de Estudios Filosóficos Adolfo García Díaz
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2007 ES
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La intención de este trabajo consiste en perfilar algunos de los fundamentos filosóficos que envuelven la agonía existencial que se percibe a lo largo de la obra La Tía Tula de Miguel de Unamuno. Para ello hemos comparado el pensamiento de este autor con el de Kierkegaard, siendo la idea de inmortalidad la que sirve de vínculo entre ambos. Desde esta perspectiva de análisis la lucha entre fe y razón, expuesta por Unamuno, deja claro que el anhelo de inmortalidad se enfrenta a categorías universales, mientras que para Kierkegaard la fe está por encima de la razón ante toda decisión por absurda que parezca.