- Elsevier; Maryland Heights
- Biblioteca Digitais de Teses e Dissertações da USP
- Ferrata Storti Foundation
- Brazilian Society of Infectious Diseases
- Faculdade de Medicina / USP
- J Rheumatol Publ Co
- ELSEVIER SCIENCE BV
- Universidade de Tubinga
- Universidade de Adelaide
- Universidade de São Paulo. Faculdade de Medicina
- Universidade Duke
- Universidade Federal de Santa Catarina. Florianópolis, SC. Brasil
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Dendritic cells and T lymphocytes interactions in a novel 3D system
Estudo do reconhecimento de epitopos das proteínas Gag e Nef do HIV-1 por linfócitos T em indivíduos cronicamente infectados pelo HIV-1 não progressores por longo tempo; Study of the recognition of HIV-1 Gag and Nef epitopes by T lymphocytes in chronically infected HIV-1 Long-Term Non-Progressors
Caracterização fenotípica e funcional de linfócitos T de memória de indivíduos infectados pelo HIV reativos a epitopos T CD4+ derivados de sequências do consenso B do HIV-1; Phenotypic and functional characterization of memory T lymphocytes from HIV infected individuals reactive to CD4-T epitopes derived from sequences of the HIV-1 B consensus
Imunodeficiência comum variável: distúrbio de diferenciação dos linfócitos B ou distúrbio de ativação dos linfócitos T?; Common Variable Immunodeficiency: disturbance of differentiation of B lymphocytes or disorder of activation of T lymphocytes?
Controle Pós-Transcricional em Timócitos e Linfócitos T CD3+ periféricos de camundongos NOD Durante a Emergência do Diabetes Mellitus do Tipo 1; Post-transcriptional control in thymocytes and peripheral CD3+ T Lymphocytes of NOD mice during the emergence of type 1 diabetes
Investigação de efeitos imunomoduladores de veneno bruto de Tityus serrulatus sobre funções de linfócitos T humanos; Investigation of the immunomodulatory effects of crude venom of Tityus serrulatus on human T lymphocytes functions
Avaliação das subpopulações de linfócitos TCD4+, TCD8+ e da razão TCD4+:TCD8+ na pré, trans e pós terapia em cães com demodicidose generalizada; Evaluation of CD4+ and CD8+ T-lymphocytes count and CD4+:CD8+ ratio throughout treatment in dogs with generalized demodicosis
Importância da resposta aos epítopos subdominantes, da proliferação e da recirculação de linfócitos T CD8+ durante a vacinação experimental contra a infecção pelo Trypanosoma cruzi.; Importance of the response to subdominant epitope, proliferation and recirculation of CD8+ T lymphocytes during experimental vaccination against Trypanosoma cruzi infection.
Estudo do compartimento de linfócitos T CD4+ em pacientes com LLC-B: distribuição das subpopulações TH1, TH2, TH17 e TREG e avaliação da expressão de FAS e FASL.; Study of the CD4+ T lymphocytes in B-CLL patients: distribution of Th1, Th2, Th17 and Treg and expression of FAS and FASL.
Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood γδ T cells
Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis
Tumor-infiltrating CD4+ T lymphocytes in early breast cancer reflect lymph node involvement
Upregulation of synoviocyte COX-2 through interactions with T lymphocytes: Role of interleukin 17 and tumor necrosis factor-α; Upregulation of synoviocyte COX-2 through interactions with T lymphocytes: Role of interleukin 17 and tumor necrosis factor-alpha
Identification of duck T lymphocytes using and anti-human T cell (CD3) antiserum.
Vergleichende Untersuchungen zur Aktivierung der Interleukin 16-Expression in T-Lymphozyten; Comparative examinations about the activation of the interleukin 16 expression in T-lymphocytes
Effector CD4⁺ T lymphocytes in the prodrome of polyarthritis
Linfócitos T CD4+ tumor infiltrantes no câncer de mama inicial refletem envolvimento linfonodal; Tumor-infiltrating CD4+ T lymphocytes in early breast cancer reflect lymph node involvement
The Role of c-FLIP in the Regulation of Apoptosis, Necroptosis and Autophagy in T Lymphocytes
To maintain homeostasis, T lymphocytes die through caspase–dependent apoptosis. However, blockage of caspase activity in T lymphocytes does not increase cell survival. The loss of caspase 8 activity leads to programmed necrosis (necroptosis) upon T cell receptor (TCR) stimulation in T lymphocytes. Necroptosis is correlated with excessive macroautophagy, an intracellular catabolic process characterized by the sequestration of cytoplasmic compartments through double–membrane vacuoles. Meanwhile, the proper induction of macroautophagy is required for T lymphocyte survival and function. Cellular caspase 8 (FLICE)–like inhibitory protein (c–FLIP) promotes survival in T lymphocytes. c–FLIP suppresses death receptor–induced apoptosis by modulating caspase 8 activation. Whether this modulation plays a role in the regulation of necroptosis has yet to be studied. Additionally, overexpression of c–FLIP reduces autophagy induction and promotes cell survival in cell lines. It remains unclear whether c–FLIP protects primary T lymphocytes by regulating the threshold at which autophagy occurs. In this study, c–FLIP isoform–specific conditional deletion models were used to study the role of c–FLIP in necroptosis and autophagy in primary T lymphocytes.
Our results showed that the long isoform of c–FLIP (c– FLIPL) regulates necroptosis by inhibiting receptor interacting protein 1 (RIP–1). Upon TCR stimulation...