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Role of beta-alanine supplementation on muscle carnosine and exercise performance

Artioli, Guilherme Giannini; Gualano, Bruno; Smith, Abbie; Stout, Jeffrey; Lancha Junior, Antonio Herbert
Fonte: LIPPINCOTT WILLIAMS & WILKINS Publicador: LIPPINCOTT WILLIAMS & WILKINS
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.73%
ARTIOLI, G. G., B. GUALANO, A. SMITH, J. STOUT, and A. H. LANCHA, JR. Role of beta-Alanine Supplementation on Muscle Carnosine and Exercise Performance. Med. Sci. Sports Exerc., Vol. 42, No. 6, pp. 1162-1173, 2010. In this narrative review, we present and discuss the current knowledge available on carnosine and beta-alanine metabolism as well as the effects of beta-alanine supplementation on exercise performance. Intramuscular acidosis has been attributed to be one of the main causes of fatigue during intense exercise. Carnosine has been shown to play a significant role in muscle pH regulation. Carnosine is synthesized in skeletal muscle from the amino acids L-histidine and beta-alanine. The rate-limiting factor of carnosine synthesis is beta-alanine availability. Supplementation with beta-alanine has been shown to increase muscle carnosine content and therefore total muscle buffer capacity, with the potential to elicit improvements in physical performance during high-intensity exercise. Studies on beta-alanine supplementation and exercise performance have demonstrated improvements in performance during multiple bouts of high-intensity exercise and in single bouts of exercise lasting more than 60 s. Similarly, beta-alanine supplementation has been shown to delay the onset of neuromuscular fatigue. Although beta-alanine does not improve maximal strength or (V) over dotO(2max)...

Creatine Supplementation Prevents the Accumulation of Fat in the Livers of Rats Fed a High-Fat Diet

DEMINICE, Rafael; SILVA, Robin P. da; LAMARRE, Simon G.; BROWN, Colin; FUREY, George N.; MCCARTER, Shannon A.; JORDAO, Alceu Afonso; KELLY, Karen B.; KING-JONES, Kirst; JACOBS, Rene L.; BROSNAN, Margaret E.; BROSNAN, John T.
Fonte: AMER SOC NUTRITIONAL SCIENCE Publicador: AMER SOC NUTRITIONAL SCIENCE
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
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The aim of the present study was to examine the effects of creatine supplementation on liver fat accumulation induced by a high-fat diet in rats. Rats were fed 1 of 3 different diets for 3 wk: a control liquid diet (C), a high-fat liquid diet (HF), or a high-fat liquid diet supplemented with creatine (HFC). The C and HF diets contained, respectively, 35 and 71% of energy derived from fat. Creatine supplementation involved the addition of 1% (wt:v) of creatine monohydrate to the liquid diet. The HF diet increased total liver fat concentration, liver TG, and liver TBARS and decreased the hepatic S-adenosylmethionine (SAM) concentration. Creatine supplementation normalized all of these perturbations. Creatine supplementation significantly decreased the renal activity of L-arginine:glycine amidinotransferase and plasma guanidinoacetate and prevented the decrease in hepatic SAM concentration in rats fed the HF diet. However, there was no change in either the phosphatidylcholine:phosphatidylethanolamine (PE) ratio or PE N-methyltransferase activity. The HF diet decreased mRNA for PPAR as well as 2 of its targets, carnitine palmitoyltransferase and long-chain acylCoA dehydrogenase. Creatine supplementation normalized these mRNA levels. In conclusion...

Effect of Fish Oil Supplementation for Two Generations on Changes of Lymphocyte Function Induced by Walker 256 Cancer Cachexia in Rats

FOLADOR, Alessandra; LIMA-SALGADO, Thais Martins de; HIRABARA, Sandro Massao; AIKAWA, Julia; YAMAZAKI, Ricardo K.; MARTINS, Edgair F.; OLIVEIRA, Heloisa Helena P. de; PIZATTO, Nathalia; KANUNFRE, Carla C.; PERES, Carmem M.; FERNANDES, Luiz C.; Curi, Rui
Fonte: LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS Publicador: LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.73%
Fish oil supplementation has been shown to improve the cachectic state of tumor-bearing animals and humans. Our previous study showed that fish oil supplementation (1 g per kg body weight per day) for 2 generations had anticancer and anticachetic effects in Walker 256 tumor-bearing rats as demonstrated by reduced tumor growth and body weight loss and increased food intake and survival. In this study, the effect of fish oil supplementation for 2 generations on membrane integrity, proliferation capacity, and CD4/CD8 ratio of lymphocytes isolated from mesenteric lymph nodes, spleen, and thymus of Walker 256 tumor-bearing animals was investigated. We also determined fish oil effect on plasma concentration and ex vivo production of cytokines [tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-4 (IL-4), IL-6, and IL-10]. Lymphocytes from thymus of tumor-bearing rats presented lower viability, but this change was abolished by fish oil supplementation. Tumor growth increased proliferation of lymphocytes from all lymphoid organs, and fish oil supplementation abolished this effect. Ex vivo production of TNF-alpha and IL-6 was reduced in supplemented animals, but IL-4 and IL-10 secretion was stimulated in both nontumor and tumor-bearing rats. IL-10 and IFN-gamma plasma levels was also decreased in supplemented animals. These results suggest that the anticachetic effects of fish oil supplementation for a long period of time (2 generations) in Walker 256 tumor-bearing rats may be associated to a decrease in lymphocyte function as demonstrated by reduced viability...

Effect of chronic supplementation with shark liver oil on immune responses of exercise-trained rats

VITORINO, Daniele Cristina; BUZZACHERA, Cosme Franklim; CURI, Rui; FERNANDES, Luiz Claudio
Fonte: SPRINGER Publicador: SPRINGER
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.73%
Previous studies have reported that chronic supplementation with shark liver oil (SLO) improves immune response of lymphocyte, macrophage and neutrophil in animal models and humans. In a similar manner, exercise training also stimulates the immune system. However, we are not aware of any study about the association of exercise and SLO supplementation on immune response. Thus, our main goal was to investigate the effect of chronic supplementation with SLO on immune responses of exercise-trained rats. Male Wistar rats were divided into four groups: sedentary with no supplementation (SED, n = 20), sedentary with SLO supplementation (SEDslo, n = 20), exercised (EX, n = 17) and exercised supplemented with SLO (EXslo, n = 19). Rats swam for 6 weeks, 1.5 h/day, in water at 32 +/- A 1A degrees C, with a load of 6.0% body weight attached to the thorax of rat. Animals were killed 48 h after the last exercise session. SLO supplementation did not change phagocytosis, lysosomal volume, superoxide anion and hydrogen peroxide production by peritoneal macrophages and blood neutrophils. Thymus and spleen lymphocyte proliferation were significantly higher in SEDslo, EX, and EXslo groups compared with SED group (P < 0.05). Gut-associated lymphocyte proliferation...

Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance

Favero, Serena Menegassi del; Roschel, Hamilton; Artioli, Guilherme Giannini; Ugrinowitsch, Carlos; Tricoli, Valmor Alberto Augusto; Costa, Andre; Barroso, Renato; Negrelli, Ana Lua; Otaduy, Maria Concepcion; Leite, Claudia da Costa; Lancha Junior, Antoni
Fonte: SPRINGER; NEW YORK Publicador: SPRINGER; NEW YORK
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
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We aimed to investigate the role of betaine supplementation on muscle phosphorylcreatine (PCr) content and strength performance in untrained subjects. Additionally, we compared the ergogenic and physiological responses to betaine versus creatine supplementation. Finally, we also tested the possible additive effects of creatine and betaine supplementation. This was a double-blind, randomized, placebo-controlled study. Subjects were assigned to receive betaine (BET; 2 g/day), creatine (CR; 20 g/day), betaine plus creatine (BET + CR; 2 + 20 g/day, respectively) or placebo (PL). At baseline and after 10 days of supplementation, we assessed muscle strength and power, muscle PCr content, and body composition. The CR and BET + CR groups presented greater increase in muscle PCr content than PL ( = 0.004 and = 0.006, respectively). PCr content was comparable between BET versus PL ( = 0.78) and CR versus BET + CR ( = 0.99). CR and BET + CR presented greater muscle power output than PL in the squat exercise following supplementation ( = 0.003 and = 0.041, respectively). Similarly, bench press average power was significantly greater for the CR-supplemented groups. CR and BET + CR groups also showed significant pre- to post-test increase in 1-RM squat and bench press (CR: = 0.027 and < 0.0001; BET + CR: = 0.03 and < 0.0001 for upper- and lower-body assessments...

Effects of creatine supplementation on muscle wasting and glucose homeostasis in rats treated with dexamethasone

Nicastro, Humberto; Gualano, Bruno; Moraes, Wilson Max Almeida Monteiro de; Painelli, Vitor de Salles; Luz, Claudia Ribeiro da; Costa, André dos Santos; Guimarães, Fabiana de Salvi; Medeiros, Alessandra; Brum, Patricia Chakur; Lancha Junior, Antonio Her
Fonte: SPRINGER; NEW YORK Publicador: SPRINGER; NEW YORK
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.73%
We aimed to investigate the possible role of creatine (CR) supplementation in counteracting dexamethasone-induced muscle wasting and insulin resistance in rats. Also, we examined whether CR intake would modulate molecular pathways involved in muscle remodeling and insulin signaling. Animals were randomly divided into four groups: (1) dexamethasone (DEX); (2) control pair-fed (CON-PF); (3) dexamethasone plus CR (DEX-CR); and (4) CR pair-fed (CR-PF). Dexamethasone (5 mg/kg/day) and CR (5 g/kg/day) were given via drinking water for 7 days. Plantaris and extensor digitorum longus (EDL) muscles were removed for analysis. Plantaris and EDL muscle mass were significantly reduced in the DEX-CR and DEX groups when compared with the CON-PF and CR-PF groups (P < 0.05). Dexamethasone significantly decreased phospho-Ser(473)-Akt protein levels compared to the CON-PF group (P < 0.05) and CR supplementation aggravated this response (P < 0.001). Serum glucose was significantly increased in the DEX group when compared with the CON-PF group (DEX 7.8 +/- A 0.6 vs. CON-PF 5.2 +/- A 0.5 mmol/l; P < 0.05). CR supplementation significantly exacerbated hyperglycemia in the dexamethasone-treated animals (DEX-CR 15.1 +/- A 2.4 mmol/l; P < 0.05 vs. others). Dexamethasone reduced GLUT-4 translocation when compared with the CON-PF and CR-PF (P < 0.05) groups and this response was aggravated by CR supplementation (P < 0.05 vs. others). In conclusion...

Efeitos da suplementação de betaína, combinada ou não com a suplementação de creatina, sobre a força máxima, potência e concentrações intramusculares de fosforilcreatina, em indivíduos não treinados em força; Effects of betaine supplementation, combined or not with creatine supplementation on maximal strength, power output and muscle phosphorylcreatine content in non-resistance trained subjects

Favero, Serena Menegassi Del
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 04/12/2012 PT
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A betaína é um trimetil derivado do aminoácido glicina. Os seus principais efeitos fisiológicos são atuar como um osmólito e como doador de radicais metil. Especulase que a betaína possa contribuir para a síntese de creatina no músculo esquelético pelo fornecimento de grupos metil, resultante da conversão de betaína em dimetilglicina, para a remetilação de homocisteína em metionina. Os efeitos da suplementação de creatina sobre o desempenho são conhecidos e relacionam-se principalmente ao aumento na ressíntese de fosforilcreatina (PCR). Autores de estudos recentes têm atribuído seus resultados positivos em relação ao aumento de força muscular a um possível efeito da betaína sobre as concentrações de PCR. Essa variável, entretanto, não foi avaliada, de maneira que os mecanismos responsáveis pelo aumento de força advindo da suplementação de betaína ainda são inexplorados em humanos. Diante disso, este estudo teve como objetivo investigar os efeitos da suplementação de betaína, combinada ou não com a suplementação de creatina, sobre as concentrações intramusculares de PCR, e a produção de força e potência muscular em indivíduos não treinados em força. Além disso, as respostas fisiológicas e ergogênicas da suplementação de betaína e creatina foram comparadas e avaliados os possíveis efeitos aditivos desses suplementos. Foi conduzido um estudo duplo-cego...

Efeito da suplementação proteica no terço final da gestação sobre a programação fetal, e o desempenho das crias submetidas a diferentes estratégias de suplementação; Effect of protein supplementation in the final third of pregnancy on fetal programming, and performance of offspring submitted to different supplementation strategies

Rocha, Filipe Marinho da
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 11/12/2012 PT
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Os objetivos deste estudo foram: 1- Avaliar o efeito da suplementação proteica, no terço final da gestação de vacas nelore, sobre a programação fetal e o desempenho de suas crias, submetidas à diferentes ritmos de crescimento até os 318 dias de vida. 2- Avaliar economicamente as diferentes estratégias de suplementação adotadas. Na fase I foram utilizadas 411 vacas da raça Nelore, no início do terço final da gestação, com idade média de 7,6 ± 2,1 anos, peso corporal médio de 429 ± 49 kg e escore de condição corporal (ECC) de 2,84 ± 0,44 (escala de 1 a 5). As vacas foram distribuídas em dois tratamentos conforme o ECC, peso corporal, idade e touro pai da cria. Os tratamentos foram: 1- grupo Vaca- Suplementada (VS) (n = 212) e 2- grupo Vaca-Controle (VC) (n = 199). Os animais do tratamento VS receberam diariamente 0,56 kg de um suplemento mineral proteico composto por 0,50 kg de farelo de soja e 0,06 kg de suplemento mineral, enquanto os animais do tratamento VC receberam somente o suplemento mineral. Na fase II, que corresponde ao período no qual a suplementação foi aplicada às crias, as vacas da primeira fase, juntamente com suas crias, foram redistribuídas, a partir do segundo mês de idade das crias em dois tratamentos. Os tratamentos foram suplementação em creep-feeding...

Efeito do desmame precoce e da suplementação com glutamina, in vitro e in vivo, sobre a funcionalidade de macrófagos peritoniais e o estado nutricional de camundongos; Effect of precocious weaning and in vitro and in vivo supplementation with glutamine on the functionality of peritoneal macrophages and on the nutritional state of mice

Rogero, Marcelo Macedo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 16/08/2007 PT
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36.73%
Bebês precocemente desmamados apresentam maior incidência de infecções, o que sugere que a ausência de ingestão de alguns fatores presentes no leite materno possa modificar processos de defesa. A glutamina (GLN) está presente em concentração significativa no leite materno, sendo o aumento de sua concentração diretamente proporcional ao período de aleitamento. Esse aminoácido é essencial para a funcionalidade de macrófagos, que apresentam aumento da utilização de GLN durante processos inflamatórios e infecciosos. Bebês apresentam necessidade aumentada de GLN, que é suprida pela ingestão do leite materno, enquanto bebês precocemente desmamados dependem da síntese endógena e do fornecimento exógeno de GLN; todavia, a concentração de GLN em fórmulas infantis artificiais é significantemente baixa ou inexistente. Diante desses fatos, o presente projeto avaliou: (i) o efeito do desmame precoce associado à ingestão de ração isenta e suplementada de GLN sobre a funcionalidade de macrófagos peritoniais e o estado nutricional de camundongos; (ii) o efeito da suplementação com GLN in vitro sobre a funcionalidade de macrófagos peritoniais de camundongos desmamados precocemente e alimentados com ração isenta de GLN; e (iii) o efeito da suplementação crônica com GLN in vivo sobre a funcionalidade de macrófagos peritoniais e o estado nutricional de camundongos desmamados precocemente e inoculados com bacilo de Calmette-Guérin (BCG). O desmame precoce associado à ingestão de ração isenta de GLN reduz o crescimento de camundongos e a concentração de proteína presente no fígado...

Suplementação energética de bovinos mantidos em pastagens tropicais com diferentes estratégias de manejo e seus efeitos sobre o consumo de forragem, comportamento ingestivo e parâmetros metabólicos; Supplementation of cattle maintained in tropical grazing with various management strategies and their effects on forage intake, feeding behavior and metabolic parameters

Santos, Murilo Garrett Moura Ferreira dos
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 16/12/2014 PT
Relevância na Pesquisa
36.73%
O objetivo do presente estudo foi avaliar o efeito da suplementação energética com dose baixa de milho moído (0 x 0,3% do PC) sobre o consumo de forragem, o comportamento ingestivo e parâmetros metabólicos (ruminais e sanguíneos) em bovinos da raça Nelore, mantidos em pastagem de capim Brachiaria Brizantha cv. Marandu. submetida à duas estratégias de manejo, 25/15cm x 35x21cm como alturas de entrada/saída dos pastos respectivamente. Foram utilizados 8 novilhos Nelores com cânulas no rumen, com PC médio de 414 kg ± 10,32. Foram utilizados 2 quadrados latinos 4X4 simultaneamente. Os animais foram alocados em 2,4 ha de pastagem de capim Brachiaria brizantha cv. Marandu. Foram estudados 2 níveis de suplementação energética (milho moído) e 2 estratégias de manejo do pastejo: T1) não suplementado e manejo 25/15 cm (alturas pré e póspastejo respectivamente); T2) suplementado com 0,3% do PC em milho moído e manejo 25/15; T3) não suplementado e manejo 35/21 cm (alturas pré e pós-pastejo respectivamente); T4) suplementado com 0,3% do PC em milho moído e manejo e 35/21 cm. Os parâmetros avaliados foram o consumo de forragem, comportamento animal, pH e amônia ruminais, concentrações de ácidos graxos de cadeia curta (AGCC)...

Effects of grass silage and soybean meal supplementation on milk production and milk fatty acid profiles of grazing dairy cows

Rego, Oldemiro Aguiar do; Regalo, S. M. M.; Rosa, Henrique José Duarte; Alves, Susana Paula A.; Borba, Alfredo Emílio Silveira de; Bessa, Rui José B.; Cabrita, Ana R. J.; Fonseca, A. J. M.
Fonte: American Dairy Science Association Publicador: American Dairy Science Association
Tipo: Artigo de Revista Científica
Publicado em /07/2008 ENG
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Copyright © American Dairy Science Association, 2008.; The effects of supplementation with grass silage and replacement of some corn in the concentrate with soybean meal (SBM) on milk production, and milk fatty acid (FA) profiles were evaluated in a replicated 4 × 4 Latin square study using 16 dairy cows grazing pasture composed of ryegrass, Kentucky bluegrass, and white clover. Each experimental period lasted for 3 wk. The 4 dietary treatments were PC, 20 h of access to grazing pasture, supplemented with 6 kg/d of corn-based concentrate mixture (96% corn; C); PCSB, 20 h of access to grazing pasture, supplemented with 6 kg/d of corn- and SBM-based concentrate mixture (78% corn and 18% SBM; CSB); SC, 7 h of access to grazing pasture during the day and 13 h of ad libitum access to grass silage at night, supplemented with 6 kg/d of C concentrate; and SCSB, 7 h of access to grazing pasture during the day and 13 h of ad libitum access to grass silage at night, supplemented with 6 kg/d of CSB concentrate. The concentrate mixtures were offered twice each day in the milking parlor and were consumed completely. Grass silage supplementation reduced dietary crude protein and concentration of total sugars, and dietary SBM inclusion increased dietary crude protein concentration and decreased dietary starch concentration. Milk yield and energy-corrected milk were increased by SBM supplementation of cows with access to grass silage. Milk protein concentration was lower in cows offered grass silage...

Effects of starter diet supplementation with arginine on broiler production performance and on small intestine morphometry

Murakami,Alice E.; Fernandes,Jovanir I. M.; Hernandes,Luzmarina; Santos,Tatiana C.
Fonte: Colégio Brasileiro de Patologia Animal - CBPA; Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Publicador: Colégio Brasileiro de Patologia Animal - CBPA; Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2012 EN
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The effects of starter diet (days 1 to 21) supplemented with arginine (Arg) on the production performance and duodenum and jejunum mucosa morphometry of broilers were studied. Male Cobb broiler chickens (990) were randomly assigned to one of five treatments in a complete random design. Measurements of 33 chicks per treatment were made in six repetitions. The treatments consisted of a basal diet with 1.390% digestible Arg (no supplementation) and four dietary levels (1.490%, 1.590%, 1.690%, and 1.790%), providing a relationship with lysine of 1.103; 1.183; 1.262; 1.341 and 1.421%, respectively. From the age of 22 days on, all birds received conventional grower diet. The data were submitted to regression analysis by polynomial decomposition of the degrees of freedom in relation to the levels of Arg. The Arg supplementation increased (P<0.05) the live weight and the feed conversion ratio without increasing the feed intake of the birds. However, no effect was observed (P>0.05) in the growth phase (days 22 to 42) in the absence of the Arg supplementation. The supplementation of Arg over of NRC recommendation during the starter phase may be necessary for the expression of the maximal weight gain potential in birds. No effect (P<0.05) of Arg dietary supplementation was observed either on small intestine weight and length at any age. However...

Effect of short period feed supplementation during early lactation on performance of cows and calves raised in extensive system

Brauner,Cássio Cassal; Pimentel,Marcelo Alves; Menezes,Leonardo de Melo; Machado,Jean Pierre Martins; Moraes,José Carlos Ferrugem
Fonte: Sociedade Brasileira de Zootecnia Publicador: Sociedade Brasileira de Zootecnia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2011 EN
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Thirty-two multiparous Angus cows at moderate body condition score (3 in a 1-5 scale) received feed supplementation at the beginning of lactation for a short time to determine the effect on milk yield and composition and on performance of cows and calves. Supplementation started on days 22 ± 3.2 after calving. The cows were randomly distributed into two groups (n =16), one group receiving feed supplementation for 35 days (supplemented group), and the other without supplementation (control group). Each cow received 0.6% of its body weight in individual troughs daily. Both groups were kept in native pasture condition during supplementation period. Milk yield evaluation, performance of cows and calves were controlled on day 0 (initial), day 14 (middle) and day 35 (final) of the supplementation period. There was no effect of feed supplementation on milk yield or on any other milk component in both groups, and on calf performance as well. Milk composition differed among periods, when fat was the highest in the middle of supplementation and lactose was the highest in the end of the period. Supplemented cows presented more daily average weight gain at the final period of supplementation than cows from the control group. Beef cow with moderate body condition score can gain weight during the lactation period as a response to increase of energy availability in a short period without any influence on milk production and composition as well as a consequence on calf performance.

Cromo e sel??nio org??nicos na dieta de poedeiras semipesadas alojadas em ambiente com temperaturas elevadas; Supplementation of organic chromium and selenium for layers under heat stress environment

MANZKE, Naiana Einhardt
Fonte: Universidade Federal de Pelotas; Zootecnia; Programa de P??s-Gradua????o em Zootecnia; UFPel; BR Publicador: Universidade Federal de Pelotas; Zootecnia; Programa de P??s-Gradua????o em Zootecnia; UFPel; BR
Tipo: Dissertação Formato: application/pdf
POR
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Animals under heat stress conditions exhibit excessive urinary excretion of minerals and this might change their nutritional requirements. The objective of this study was to evaluate the effects of mineral supplementation of chromium (Cr) and selenium (Se) in organic form, on the performance, egg quality and heterophil/lymphocyte ratio (H / L) of laying hens housed under natural heat stress. One hundred and ninety-two layers (Hisex Brown, 62 weeks old) were divided into four treatments with three cages containing sixteen birds each. The treatments were: T1) basal diet (corn and soybean meal with no organic minerals), T2) basal diet + additional supplementation of organic Se (0.3 ppm), T3) basal diet + additional supplementation of organic Cr (400 ppm), T4) basal diet + additional supplementation of organic Se (0.3 ppm) and organic Cr (400 ppm). The birds were distributed in randomized blocks, with a 2 x 2 factorial arrangement over four consecutive experimental periods of 28 days each. The data were subjected to analysis of variance using SAS GLM tool (2008). When necessary, covariates of interest were added to the model. The interaction between the factors occurred only in the feed conversion ratio per mass (p=0.07) and per dozen (p=0.008)...

A randomised controlled trial of DHA-rich fish oil supplementation during pregnancy and subsequent development of attention, working memory and inhibitory control in early childhood.

Gould, Jacqueline F.
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2013
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The last trimester of pregnancy is the period during which the fetal brain is growing at its greatest velocity, particularly the frontal lobes and hippocampus. This is also the peak period for the accumulation of omega-3 long chain polyunsaturated fatty acid (LCPUFA) docosahexaenoic acid (DHA) in neural tissues. The amount of DHA required by the fetus is thought to exceed the DHA intake of women of child-bearing age who consume a Western-style diet. This has led to the belief that maternal DHA supplementation during pregnancy will enhance child cognitive development in these populations. Cohort studies have supported this belief by linking intake of foods rich in DHA (primarily seafood) during pregnancy to enhanced child cognitive development. However, only randomised controlled trials (RCTs) can establish causality. In this thesis I report a comprehensive systematic review of the current RCTs of DHA supplementation during pregnancy (Chapter 1) using procedures described by the Cochrane collaboration and the PRISMA statement. Results of globalised standard assessments in the reviewed RCTs were compared in meta analyses. No effect of DHA supplementation was found in any age group, except in the 2-5 year-olds where the LCPUFA group was advantaged. A risk of bias assessment revealed that the majority of the trials were of poor quality...

Effects of protein supplementation frequency on physiological responses associated with reproduction in beef cows

Cappellozza, B. I.; Cooke, R. F.; Reis, M. M.; Marques, R. S.; Guarnieri Filho, T. A.; Perry, G. A.; Jump, D. B.; Lytle, K. A.; Bohnert, D. W.
Fonte: Amer Soc Animal Science Publicador: Amer Soc Animal Science
Tipo: Artigo de Revista Científica Formato: 386-394
ENG
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The objective of this experiment was to determine if frequency of protein supplementation impacts physiological responses associated with reproduction in beef cows. Fourteen nonpregnant, nonlactating beef cows were ranked by age and BW and allocated to 3 groups. Groups were assigned to a 3 x 3 Latin square design, containing 3 periods of 21 d and the following treatments: 1) soybean meal supplementation daily (D), 2) soybean meal supplementation 3 times/week (3WK), and 3) soybean meal supplementation once/week (1WK). Within each period, cows were assigned to an estrus synchronization protocol: 100 mu g of GnRH + controlled internal drug release device (CIDR) containing 1.38 g of progesterone (P-4) on d 1, 25 mg of PGF(2 alpha) on d 8, and CIDR removal + 100 mu g of GnRH on d 11. Grass-seed straw was offered for ad libitum consumption. Soybean meal was individually supplemented at a daily rate of 1 kg/cow (as-fed basis). Moreover, 3WK was supplemented on d 0, 2, 4, 7, 9, 11, 14, 16, and 18 whereas 1WK was supplemented on d 4, 11, and 18. Blood samples were collected from 0 (before) to 72 h after supplementation on d 11 and 18 and analyzed for plasma urea-N (PUN). Samples collected from 0 to 12 h were also analyzed for plasma glucose...

Aspectos nutricionais e buiquímicos da fibrose cística em paciente pediátricos : suplementação com um concentrado protéico do soro do leite bovino enriquecido com TGF-'beta' e lactoferrina; Nutritional and biochemical aspects of cystic fibrosis in pediatric patients : supplementation with whey protein concentrate enriched with TGF-'beta' and lactoferrin

Daniela Miotto Bernardi
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 16/08/2010 PT
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36.8%
A fibrose cística (FC) é caracterizada por intenso processo inflamatório, doença pulmonar obstrutiva, infecção das vias aéreas e má digestão/ má absorção de nutrientes e micronutrientes, sendo a nutrição determinante no prognóstico do paciente. Objetivo: Avaliar os efeitos imunológicos e nutricionais da suplementação de um concentrado protéico do soro do leite bovino (whey protein concentrate - WPC), enriquecido com TGF-ß e lactoferrina, em pacientes pediátricos com fibrose cística, bem como realizar perfil imunológico e nutricional destes pacientes. Métodos: O ensaio clínico de intervenção nutricional foi prospectivo, randomizado, duplo cego com placebo e teve duração de 4 meses. As crianças que participaram eram atendidas no Ambulatório Pediátrico de FC, do Hospital de Clínicas da UNICAMP, na faixa etária entre 3 e 12 anos e escore de Shwachman entre moderado e bom. Quarenta e cinco crianças iniciaram a suplementação e apenas 28 finalizaram, sendo 15 no grupo WPC-TGFß e 13 no grupo caseína (placebo). Foram incluídas 17 crianças saudáveis como grupo controle para as análises bioquímicas e imunológicas. Os suplementos (placebo e teste) foram submetidos às análises centesimais e microbiológicas. A avaliação dos pacientes ao longo da suplementação foi realizada em três tempos (T0=antes da suplementação...

Differential response of interleukin-2 production to chronic copper supplementation in healthy humans

Pizarro, Fernando; Olivares, Manuel; Arredondo Olguín, Miguel Armando; López, Marcelo; Araya, Magdalena; Muñoz, Carlos
Fonte: EUROPEAN CYTOKINE NETWORK Publicador: EUROPEAN CYTOKINE NETWORK
Tipo: Artículo de revista
EN
Relevância na Pesquisa
36.76%
Backgound. Copper (Cu) is an essential trace element for many biological processes including maintenance of both innate and acquired branches of immunity. Objective. To measure the effect of copper supplementation on IL-2 and TNF-α production in subjects with lower and higher ceuloplasmin (Cp) values within normal range. Design. Healthy adults (17 men and 16 women) with normal-low (low Cp) and normal-high Cp (high Cp) values were supplemented with 10 mg Cu/day (as CuSO4) during 2 months. Method. Before and after supplementation blood mononuclear cells were incubated in the absence or presence of phytohaemagglutinin or lipopolysaccharide for induction of IL-2 and TNF-α, respectively. The secretion of cytokines was measured by ELISA. Cu supplementation did not modify classical biochemical markers of Cu status. Results. After supplementation, a significant increase in IL-2 production was found only in subjects with normal-low plasma Cp. Before and after Cu supplementation geometric mean and range ± 1 SEM values were 1,566 (1,287-1,905) and 2,514 (2,159-2,927) pg/mL, respectively (two way ANOVA for repeated measures: Cp level p < 0.001; time = NS; interaction Cp level and time p < 0.05). We did not observe changes in TNF-α production after Cu supplementation. Conclusions. Cu supplementation increased secretion of IL-2 and not TNF-α...

Productive efficiency of buffalos in the State of Pará in different conditions of mineral supplementation; Eficiência produtiva de búfalos no Estado do Pará em diferentes condições de suplementação mineral

Cardoso, Elyzabeth da Cruz; Viana, Rinaldo Batista; Vale, William Gomes; Araújo, Cláudio Vieira de; Oliveira, Daniel Rocha de
Fonte: Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia Publicador: Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2008 POR
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36.73%
O monitoramento do consumo de diferentes misturas minerais foi avaliado em 84 búfalos mestiços distribuídos em duas fazendas (1 e 2) localizadas na Meso-região do Nordeste Paraense para a avaliação do custo benefício de cada produto. As fazendas apresentavam pastagens do tipo Brachiaria brizantha, cv. Marandú onde os animais foram mantidos durante 14 meses. Os animais foram divididos em dois lotes. O lote 1 de cada fazenda recebeu um produto comercial de suplementação mineral recomendado para bubalinos (Topbúfalo Matsuda®) e o lote 2, o produto comercial de suplementação mineral convencional da propriedade, no qual era indicado para a espécie bovina. Na fazenda 1, o consumo da mistura mineral a ser testada foi inferior ao consumo da mistura mineral convencional e na fazenda 2, o consumo de ambos os lotes foi semelhante. O produto comercial recomendado para búfalos em regime de pastagem, em ambos os sistemas, promoveu um melhor desempenho no ganho de peso dos búfalos quando comparado a produtos comerciais recomendados para a espécie bovina. O peso médio da carcaça quente dos animais que consumiram a mistura mineral a ser testada foi superior a dos animais que receberam a mistura mineral convencional. O gasto com a suplementação mineral foi superior com os produtos convencionais em ambas as fazendas...

Conjugated linoleic acid supplementation modified the body composition and serum leptin levels in weaning rats

Prais Botelho,Adriana; Ferreira Santos-Zago,Lilia; Costa de Oliveira,Admar
Fonte: Sociedad Latinoamericana de Nutrición Publicador: Sociedad Latinoamericana de Nutrición
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2008 EN
Relevância na Pesquisa
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Dietary supplementation with conjugated linoleic acid (CLA) may reduce body fat mass and increase lean body mass in various species. The objective of this study was to study the effects of conjugated linoleic acid (CLA) supplementation on body composition, serum leptin and triacylglycerol levels in Wistar rats. Rats received linoleic acid (group C) or conjugated linoleic acid (group AE, supplemented with AdvantEdge® CLA, and group CO, supplemented with CLA One®) in the concentrations of 2% of daily feed consumption. Serum leptin and triacylglycerol levels of rats were measured by means of commercial kits. After 42 days of supplementation, rats in the control group exhibited body fat contents of 53.94 ± 6.80 g, and those in groups AE and CO had 45.43 ± 4.86 g and 43.75 ± 1.93 g, respectively, corresponding to a mean body fat reduction of 18%. Water, whole body protein and ash contents of rats supplemented with CLA were statistically higher relative to control group content (corresponding to a mean increasing of 7.65%; 6.5% and 12.35%, respectively). Experimental groups AE and CO, which received CLA supplementation, had statistically lower serum leptin levels (3.45 ± 0.46 ng/mL and 3.08 ± 0.19 ng/mL, respectively) relative to the control group (4.21 ± 0.22 ng/mL) which received linoleic acid. Triacylglycerol levels did not change after CLA supplementation (p > 0.05). Supplementation with conjugated linoleic acid in the concentration of 2% of mean daily feed consumption was able to change body composition of rats after 42 days of experimentation.