Página 1 dos resultados de 14 itens digitais encontrados em 0.001 segundos

Valutare la Disgrafia Evolutiva: il profilo neuropsicologico alla base di una cattiva scrittura

Di Brina, Carlo
Fonte: La Sapienza Publicador: La Sapienza
Tipo: Tese de Doutorado
IT
Relevância na Pesquisa
66.22%
Stefano Ferraina, Alfredo Berardelli

Epileptiform Synchronization of the Anterior Cingulate Cortex of the Rat and its Modulation by Mu-Opioid Receptor

PANUCCIO, GABRIELLA
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
EN_US
Relevância na Pesquisa
66.22%
Over the past century, the cingulate cortex has been catching the interest of both basic science and clinical research in various fields of investigation due to its involvement in several physiological functions. This brain region can in fact modulate affection and behavior, motor responses and autonomic functions, and it has been implicated in the pathophysiology of psychiatric disorders and epilepsy. The relevance of considering seizures arising from the cingulate gyrus as a distinct neurological entity has been considered in light of the capability of this brain region to directly affect the functional balance of a more extensive system, involving frontal and temporal areas. The term “cingulate epilepsy” identifies a chronic neurological syndrome, which can be distinguished from other epileptic conditions by its peculiar clinical manifestations. The anterior cingulate cortex presents with a high density of opioid receptors, which account for the involvement of this cortical area in pain perception. Nonetheless, opioid receptors may be relevant to epilepsy as well, providing their contribution as modulators of cortical activity. However, whether opioid receptors exert a pro- or an anti-convulsant effect is still matter of debate. In light of the high expression of opioid receptors...

NUOVI TRATTAMENTI PER IL DOLORE INFIAMMATORIO E NEUROPATICO

COBIANCHI, STEFANO
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
IT
Relevância na Pesquisa
67.05%
New treatments for neuropathic pain Stefano Cobianchi, Institute of Neuroscience, CNR, Rome (Italy). Experiment 1: Botulinum neurotoxins. Aim. Botulinum neurotoxins have been successfully used in clinical practice for the treatment of dystonias and a number of syndromes associated to hyperfunctioning of cholinergic terminals. Recent data support the use of Botulinum neurotoxins (BoNTs) as new therapeutic agents in pain relief. It has been demonstrated that the Botulinum neurotoxin serotype-A is able to induce analgesia in inflammatory pain conditions (1). In this study we investigated the effects of two different serotypes, A and B (BoNT/A and BoNT/B), in the development and recovering from neuropathic pain in mice subjected to the sciatic nerve ligation (Chronic Constriction Injury, Bennett and Xie model) (2, 3). Methods. Mice were subcutaneously injected into the plantar surface of both hindpaws either with BoNT/A (two doses: 7.5 or 15 pg/paw), BoNT/B (3.75 pg/paw) or saline, on different days before and after CCI. The temporal trend of neuropathy over a long time interval (80 days) was analyzed measuring the mechanical allodynic response to the Dynamic Aesthesiometer Test. Functional recovery of the injured paw was followed examining the mice walking pattern...

Functional MRI study of early non-REM sleep transients

CAPORRO, MATTEO
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
EN_US
Relevância na Pesquisa
66.22%

A sensorimotor network for actions and intentions reading: a series of TMS studies

TIDONI, EMMANUELE
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
EN
Relevância na Pesquisa
66.52%
Information relevant for our social life are immediately processed by our brain. When we walk in the street we easily and quite automatically adjust our path to avoid colliding other people. Several social activities like working in a group, playing a sport, talking with people and many others, all require the ability to carefully read others movements. Thus, kinematics and postural information of others‟ body are a fundamental medium for good survival in our social environment. Along the reading of this manuscript a series of extensive and novel studies will describe the role of sensorimotor cortices and their differential contribution in specific action observation tasks. By means of transcranial magnetic stimulation (TMS) we tested in healthy subjects both low and high cognitive level processes that may require areas of the action observation network.

Characterization of cerebral small vessel disease through diffusion tensor magnetic resonance imaging and retinal imaging

CAVALLARI, MICHELE
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
EN_US
Relevância na Pesquisa
66.83%

ACCIDENTAL FALLS AND IMBALANCE IN MULTIPLE SCEROSIS: DIAGNOSTIC CHALLENGES, NEUROPATHOLOGICAL FEATURES, AND TREATMENT STRATEGIES

PROSPERINI, LUCA
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
EN
Relevância na Pesquisa
66.85%
Lack of balance is common in Multiple Sclerosis (MS) and is among the most disabling symptoms, since it reduces mobility and independence, leads to falls and injuries, and impacts upon overall quality of life. In this research we aimed to report the efforts made to: (i) establish an objective and reliable method to measure imbalance in MS by means of static posturography; (ii) estimate the role of this method in predicting patients at risk of falls; (iii) investigate the neuropathological features leading to imbalance in MS by combining static posturography and conventional / non-coventional magnetic resonance imaging; (iv) verify the effectiveness of visuo-proprioceptive rehabilitation in reducing balance deficit and risk of falls in these patients.; Clinical research on patients with multiple sclerosis; This research was partially funded by Associazione Italiana Sclerosi Multipla (FISM grant 26/R/2010)

BRAIN’S FUNCTIONAL CONNECTIVITY ALTERATIONS IN MULTIPLE SCLEROSIS: AN fMRI INVESTIGATION

Petsas, Nikolaos
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
EN
Relevância na Pesquisa
66.62%

Stato di Male ricorrente in pazienti affetti da epilessia: inquadramento sindromico, fattori precipitanti, trattamento ed outcome

LAPENTA, LEONARDO
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
IT
Relevância na Pesquisa
66.22%

STUDIO DELL’ EMPATIA IN ARCHITETTURA A n a l i s i _ M e t o d i _ E s p e r i m e n t i

GARRAMONE, VALENTINA
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
IT
Relevância na Pesquisa
76.74%
EXECUTIVE SUMMARY ARGOMENTO La mia ricerca si basa su un’indagine semiotico-critica dell’ architettura intesa come catalizzatore emozionale e veicolo di trasmissione ideale di contenuti socialmente condivisi. Il tema dell’ Empatia, ampiamente indagato dal punto di vista dello scenario filosofico e neuroscientifico, non è stato ancora affrontato dal punto di vista spaziale e progettuale, e risulta quindi di grande interesse. Partendo dall’ampia trattazione scientifica in estetica e neuroscienza, ho studiato il fenomeno dell’Empatia in architettura, legandolo alle nuove frontiere neuro-estetiche e tralasciando, se non per accenni, la parte più nota del filone, relativa sicuramente all’ Art-Nouveau. Questa scelta è stata fatta per volontà di rendere la trattazione agevole, possedendo già un apparato introduttivo multidisciplinare corposo, ma imprescindibile. Inoltre, poiché l’empatia è rintracciabile in tutta la storia dell’architettura, e questo testo non vuole ricadere in ambito enciclopedico, non avendone né l’interesse né la pretesa, ho piuttosto lavorato con l’ambizione di fornire un nuovo punto di vista, per quanto modesto, sia sull’empatia in architettura, sia sull’interpretazione di alcuni fenomeni architettonici contemporanei...

Disturbi Specifici dell’Apprendimento: nuclei di fragilità in relazione all’età ed all’iter clinico

D'AGOSTINI COSTA, CARLA
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
IT
Relevância na Pesquisa
66.96%
A partire dal 2006 in Italia i rappresentanti delle maggiori società scientifiche ed associazioni che si occupano di disturbi di apprendimento, attraverso varie Consensus Conference, sono pervenuti all’elaborazione di raccomandazioni cliniche e linee guida per la diagnosi dei Disturbi Specifici di Apprendimento. Nel dicembre 2010 è stata promossa un’ulteriore Consensus Conference dall’Istituto Superiore di Sanità per il Sistema Nazionale Linee Guida (SNLG-ISS, 2011) dove vengono fornite anche indicazioni per la ricerca futura. Inoltre, nel 2010 viene approvata la Legge 170 che riconosce il Disturbo Specifico dell’Apprendimento a pieno titolo. Sono stati effettuati 4 studi (longitudinali e trasversali) nei quali abbiamo scelto come parametro di riferimento l’età intesa sia come momento della valutazione che come momento della diagnosi/fase evolutiva attraversata, per indagare il peso di tale variabile sull’assetto sintomatologico con cui si manifestano dislessia e disortografia. Il campione preso in esame è tratto da una popolazione clinica afferita al “Dipartimento di Pediatria e Neuropsichiatria Infantile” e segnalato al Servizio di terzo livello di Neuropsicologia. I soggetti sono stati scelti in base ai criteri di inclusione ed esclusione definiti dall’ICD-10 (WHO...

Orienting Attentivo nei Disturbi del Movimento: Approccio Psicofisiologico

PAULETTI, CATERINA
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
IT
Relevância na Pesquisa
66.22%

MATHEMATICS IN HEALTH CARE WITH APPLICATIONS; MATEMATICA PER LA SANITA' CON APPLICAZIONI

PAULON, LUCA
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
EN
Relevância na Pesquisa
67.08%
The Author aims to show how mathematics can be useful in supporting key activities in a hospital, including: noninvasive measurement of a patient’s status (see chapter 1), evaluation of quality of services (see chapter 2), business and clinical administration (see chapter 3), and diagnosis and prognosis (see chapter 4). Such applications suggest the development of innovative projects to improve health care processes, services and systems. In this way, mathematics can be a very important tool for technological and societal development.; This thesis is a collection of health care applications of mathematical methods and models from various disciplines of mathematics. In this way, the Author intends to show the necessity and benefits of multidisciplinary knowledge as well as the importance of an attitude to drive innovation by means of mathematical tools, using probability calculus, numerical analysis, operations research, and other methods. The integration of mathematics and real-life problems can be very effective. Advanced mathematics tools allow problems to be solved in innovative ways. From a theoretical point of view, each application may suggest if and how (in what direction) the theory on which it is based can be extended. This effort can result not only in the publication of scientific papers but also in the awarding of grants to continue such research activities. This thesis is a proof of these claims. It is structured as stand-alone chapters that share a common structure: an introduction...

STUDIO DEL MOVIMENTO VOLONTARIO DELL'ARTO SUPERIORE IN SOGGETTI NORMALI E IN PAZIENTI CON DISORDINI DEL MOVIMENTO: MECCANISMI FISIOPATOLOGICI

Dinapoli, Loredana
Fonte: La Sapienza Publicador: La Sapienza
Tipo: Tese de Doutorado
IT
Relevância na Pesquisa
66.22%
Fattapposta, Mecarelli