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Heparin based nanoparticles for cancer targeting and noninvasive imaging

Nurunnabi, Md.; Khatun, Zehedina; Moon, Woo-Choon; Lee, Gibaek; Lee, Yong-Kyu
Fonte: AME Publishing Company Publicador: AME Publishing Company
Tipo: Artigo de Revista Científica
Publicado em /09/2012 EN
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45.67%
Numerous papers on heparin nanoparticles have been reported regarding targeting therapy and biomedical imaging. Here, we have summarized the prospects and opportunities of heparin as a carrier for cancer targeting and imaging. First, we proposed heparin-anticancer drug conjugates showing higher anticancer activity than free drug. The conjugated heparin (heparin-deoxycholate sodium) retained its ability to bind with angiogenic factors, showing a significant decrease in endothelial tubular formation. Second, targeting ligands conjugated heparin derivatives have introduced for a receptor mediated delivery of anticancer drug. Heparin-folic acid-retinoic acid (HFR) bioconjugates for treating cancer cells showed 3 fold higher efficacy than heparin-retinoic acid (HR). Besides active and passive targeting drug delivery, several papers have been reported regarding delivery of imaging agents by heparin nanoparticles. Finally, this research highlight has covered imaging agents such as gold nanoparticles and quantum dots (QDs) for noninvasive biomedical imaging. Very recently our group demonstrated that semiconductor QDs loaded heparin nanoparticles could also be administered through orally for noninvasive imaging. Due to promising features of heparin such as less toxic polysaccharide and easier modification...

Twenty-year fate of the radial artery graft

Achouh, Paul; Acar, Christophe
Fonte: AME Publishing Company Publicador: AME Publishing Company
Tipo: Artigo de Revista Científica
Publicado em /07/2013 EN
Relevância na Pesquisa
45.67%
It is well known that radial arteries (RA) are not the primary choice as coronary artery grafts. In this Research Highlight, we discuss the follow-up results of 629 radial artery grafts performed over 20 years. Focal stenosis occurred in 3% of RAs, while string signs were observed in 0.9%. Overall graft patency was 83%, but indication for angiographic assessment was driven by symptomatic presentation. Graft patency decreased exponentially during the first postoperative year, but patency rate declined at a linear rate with low attrition afterwards, suggesting a lack of radial graft disease. These results indicate relatively stable radial artery patency rates for up to 20 years.

Efficacy of prophylactic antibiotic administration for breast cancer surgery in overweight or obese patients: research highlight

O’Connell, Rachel L.; Rusby, Jennifer E.
Fonte: AME Publishing Company Publicador: AME Publishing Company
Tipo: Artigo de Revista Científica
Publicado em /05/2013 EN
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The rate of surgical site infection (SSI) after breast surgery is higher than expected for a ‘clean procedure’. There is currently no consensus on the use of antibiotics, and as a result there is variation in use. An infection may compromise cosmesis and delay the start of adjuvant therapy. This research highlight reviews a recent paper by Gulluoglu and colleagues investigating the use of antibiotics in overweight and obese patients undergoing breast cancer surgery and also reviews the current literature on this important topic.

Research highlight for issue 8: disease evolution and ecology across space

Koskella, Britt
Fonte: Blackwell Publishing Ltd Publicador: Blackwell Publishing Ltd
Tipo: Artigo de Revista Científica
EN
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45.67%

SWI/SNF proteins as targets in cancer therapy

Schiaffino-Ortega, Santiago; Balinas, Carlos; Cuadros, Marta; Medina, Pedro P
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 13/11/2014 EN
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45.67%
Recent identification of synthetic lethal interactions involving several proteins of the SWI/SNF complex discussed in this Research Highlight has opened the possibility of new cancer therapeutic approaches.

Evolutionary applications research highlight for issue 1

Koskella, Britt
Fonte: BlackWell Publishing Ltd Publicador: BlackWell Publishing Ltd
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
45.67%

Palbociclib: a first-in-class CDK4/CDK6 inhibitor for the treatment of hormone-receptor positive advanced breast cancer

Lu, Janice
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 13/08/2015 EN
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45.67%
Palbociclib was approved by the FDA for use in combination with letrozole for the treatment of postmenopausal women with hormone-receptor-positive, HER2-negative advanced breast cancer as initial endocrine-based therapy. In addition, the combination of palbociclib with fulvestrant resulted in superior outcome than fulvestrant alone in those who had progressed during prior endocrine therapy. This research highlight summarized the current development of CDK4/CDK6 inhibitors and future directions in the treatment of advanced hormone-receptor-positive breast cancer.

SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 2 (March 2004)

Fonte: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program Publicador: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program
Tipo: Periódico
Relevância na Pesquisa
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This issue highlights the upcoming Threat and Vulnerability Assessment Symposium to be hosted by NPS. "Organized as a symposium vice a conference, this event is designed to facilitate an exchange of ideas on where we are regarding vulnerability and threat assessment, both in forward areas and at home."; SITREP, a monthly e-news brief covering the spectrum of maritime domain defense and security research. SITREP is produced by the Maritime Defense and Security Research Program as part of the National Security Institute—a cooperative research institute whose members include the Naval Postgraduate School, University of California at Santa Barbara, and Lawrence Livermore National Laboratory. The purpose of the Maritime Defense and Security Research program is to conduct, coordinate and collaborate Maritime defense and security research, experimentation, and information exchange between partnership universities; federal, state, and local agencies; national laboratories; maritime industry, and international partners through the National Security Institute. Each month SITREP will introduce at least two on-going maritime security research projects either from the National Security Institute or other research institutions or agencies. This month we provide a glimpse at a world-wide MIO at sea experimentation program and a library repository for issues related to maritime security. In addition...

SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 4 (May 2004)

Fonte: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program Publicador: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program
Tipo: Periódico
Relevância na Pesquisa
45.6%
This issue includes the article "Applied At-Sea Technology Research: Estimation of Atmosphere and Ocean Surface Influence on Radar and IR Sensor Performance for MDP". This article addresses research on the "variations on radar and IR surveillance sensor performance caused by lower atmosphere and ocean surface conditions, emphasizing low radar cross section and low thermal cross section targets." This issue also announces that the MDP Task Force is to host two symposia, one on threat and vulnerability assessment and a Mini-MDP Symposium on Maritime Domain Protection.; SITREP, a monthly e-news brief covering the spectrum of maritime domain defense and security research. SITREP is produced by the Maritime Defense and Security Research Program as part of the National Security Institute—a cooperative research institute whose members include the Naval Postgraduate School, University of California at Santa Barbara, and Lawrence Livermore National Laboratory. The purpose of the Maritime Defense and Security Research program is to conduct, coordinate and collaborate Maritime defense and security research, experimentation, and information exchange between partnership universities; federal, state, and local agencies; national laboratories; maritime industry...

SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 9 (October 2004)

Fonte: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program Publicador: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program
Tipo: Periódico
Relevância na Pesquisa
45.6%
In this issue: "The Naval Postgraduate School Maritime Domain Protection Task Force Threat and Vulnerability Symposium Report was completed 30 September. The report summarizes findings from the 15-17 June Threat and Vulnerability Assessment Symposium held at the Naval Postgraduate School." The article "Library Support of the Maritime Domain Protection Task Force" highlights a number of resources readily available through the Dudley Knox Library.; SITREP, a monthly e-news brief covering the spectrum of maritime domain defense and security research. SITREP is produced by the Maritime Defense and Security Research Program as part of the National Security Institute—a cooperative research institute whose members include the Naval Postgraduate School, University of California at Santa Barbara, and Lawrence Livermore National Laboratory. The purpose of the Maritime Defense and Security Research program is to conduct, coordinate and collaborate Maritime defense and security research, experimentation, and information exchange between partnership universities; federal, state, and local agencies; national laboratories; maritime industry, and international partners through the National Security Institute. Each month SITREP will introduce at least two on-going maritime security research projects either from the National Security Institute or other research institutions or agencies. This month we provide a glimpse at a world-wide MIO at sea experimentation program and a library repository for issues related to maritime security. In addition...

SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 5 (June 2004)

Fonte: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program Publicador: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program
Tipo: Periódico
Relevância na Pesquisa
45.6%
This special edition outlines the two symposia scheduled during the month of June. The first event is the "Maritime Domain Protection Mini-Symposium," scheduled for June 10-11. The second event is a "Threat and Vulnerability Assessment Symposium", scheduled for June 15-17.; SITREP, a monthly e-news brief covering the spectrum of maritime domain defense and security research. SITREP is produced by the Maritime Defense and Security Research Program as part of the National Security Institute—a cooperative research institute whose members include the Naval Postgraduate School, University of California at Santa Barbara, and Lawrence Livermore National Laboratory. The purpose of the Maritime Defense and Security Research program is to conduct, coordinate and collaborate Maritime defense and security research, experimentation, and information exchange between partnership universities; federal, state, and local agencies; national laboratories; maritime industry, and international partners through the National Security Institute. Each month SITREP will introduce at least two on-going maritime security research projects either from the National Security Institute or other research institutions or agencies. This month we provide a glimpse at a world-wide MIO at sea experimentation program and a library repository for issues related to maritime security. In addition...

SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 6 (July 2004)

Fonte: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program Publicador: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program
Tipo: Periódico
Relevância na Pesquisa
45.6%
"Recent events have highlighted the importance and necessity of developing Maritime Domain Protection (MDP) and homeland security. Essential components of this development include the evolution of new doctrine, capabilities, and policies. Each of these components requires analysis and research in order to understand the second and third order effects, as well as the discovery of best practices to accelerate their successful implementation."; SITREP, a monthly e-news brief covering the spectrum of maritime domain defense and security research. SITREP is produced by the Maritime Defense and Security Research Program as part of the National Security Institute—a cooperative research institute whose members include the Naval Postgraduate School, University of California at Santa Barbara, and Lawrence Livermore National Laboratory. The purpose of the Maritime Defense and Security Research program is to conduct, coordinate and collaborate Maritime defense and security research, experimentation, and information exchange between partnership universities; federal, state, and local agencies; national laboratories; maritime industry, and international partners through the National Security Institute. Each month SITREP will introduce at least two on-going maritime security research projects either from the National Security Institute or other research institutions or agencies. This month we provide a glimpse at a world-wide MIO at sea experimentation program and a library repository for issues related to maritime security. In addition...

SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 7 (August 2004)

Fonte: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program Publicador: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program
Tipo: Periódico
Relevância na Pesquisa
45.6%
This publication looks at several of the security and sweeping issues applicable to the Naval Postgraduate School and all related personnel. This issue highlights the accomplishments of the June Threat and Vulnerability Assessment Symposium and provides some information on the upcoming 18-19 August MDP Symposium.; SITREP, a monthly e-news brief covering the spectrum of maritime domain defense and security research. SITREP is produced by the Maritime Defense and Security Research Program as part of the National Security Institute—a cooperative research institute whose members include the Naval Postgraduate School, University of California at Santa Barbara, and Lawrence Livermore National Laboratory. The purpose of the Maritime Defense and Security Research program is to conduct, coordinate and collaborate Maritime defense and security research, experimentation, and information exchange between partnership universities; federal, state, and local agencies; national laboratories; maritime industry, and international partners through the National Security Institute. Each month SITREP will introduce at least two on-going maritime security research projects either from the National Security Institute or other research institutions or agencies. This month we provide a glimpse at a world-wide MIO at sea experimentation program and a library repository for issues related to maritime security. In addition...

SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 51 (November-December 2010)

Fonte: Naval Postgraduate School (U.S.). Maritime Defense and Security Research Program Publicador: Naval Postgraduate School (U.S.). Maritime Defense and Security Research Program
Tipo: Periódico
Relevância na Pesquisa
55.57%
This issue of The Naval Postgraduate School (NPS) Maritime Domain Protection Newsletter covers topics such as interagency information sharing economics, information education, and a research highlight on Future Unmanned Naval Systems Wargame Competition.

SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 41 (October-December 2009)

Fonte: Naval Postgraduate School (U.S.). Maritime Defense and Security Research Program Publicador: Naval Postgraduate School (U.S.). Maritime Defense and Security Research Program
Tipo: Periódico
Relevância na Pesquisa
55.57%
This issue of The Naval Postgraduate School (NPS) Maritime Domain Protection Newsletter covers topics such as interagency information sharing economics, information education, and a research highlight on Maritime Domain Awareness (MDA) and the Maritime Information Exchange Model (MIEM).

SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 40 (July-September 2009)

Fonte: Naval Postgraduate School (U.S.). Maritime Defense and Security Research Program Publicador: Naval Postgraduate School (U.S.). Maritime Defense and Security Research Program
Tipo: Periódico
Relevância na Pesquisa
55.57%
This issue of The NPS Maritime Domain Protection Newsletter covers topics such as interagency information sharing economics, information education, and a research highlight on Maritime Domain Awareness (MDA) and the Maritime Information Exchange Model (MIEM).

SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v.10 (November 2004)

Fonte: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program Publicador: Monterey, California. Naval Postgraduate School; Maritime Defense and Security Research Program
Tipo: Periódico
Relevância na Pesquisa
45.61%
In this issue, the Maritime Domain Protection Task Force announces that it has changed its name and will now be known as the Maritime Domain Protection Research Group (MDP RG). Articles in this issue include: "MDP Research Group Sponsors New Project: MDP Research Group Sponsors New Project: Coalition Operating Area Surveillance and Targeting System Coalition Operating Area Surveillance and Targeting System"; "Systems Engineering and Integration Team Releases 'As Is' MDP Report"; "MDP Graduate Intern Elected President of International Law Enforcement Association"; and "Automating Institutional Knowledge for Maritime Domain Awareness"; SITREP, a monthly e-news brief covering the spectrum of maritime domain defense and security research. SITREP is produced by the Maritime Defense and Security Research Program as part of the National Security Institute—a cooperative research institute whose members include the Naval Postgraduate School, University of California at Santa Barbara, and Lawrence Livermore National Laboratory. The purpose of the Maritime Defense and Security Research program is to conduct, coordinate and collaborate Maritime defense and security research, experimentation, and information exchange between partnership universities; federal...

The role of LRRK2 in inflammatory bowel disease

Liu, Zhihua; Lenardo, Michael J
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
45.67%
LRRK2 was recently identified as a major susceptibility gene for Crohn's disease (CD) by genome-wide association studies (GWAS). LRRK2 deficiency in mice confers enhanced susceptibility to experimental colitis. In this research highlight, we discuss the current understanding of LRRK2 in the context of colitis, and postulate the future directions.

Re: Is PAWP the ‘real’ sperm factor?

Aarabi, Mahmoud; Sutovsky, Peter; Oko, Richard
Fonte: Medknow Publications & Media Pvt Ltd Publicador: Medknow Publications & Media Pvt Ltd
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
45.77%
This letter is in response to an article written by Michail Nomikos, Karl Swann and F. Anthony Lai in the Research Highlights section of the Asian Journal of Andrology (AJA). The article is entitled, “Is PAWP the ‘real’ sperm factor?” and was written in response to our article entitled, “Sperm-derived WW domain-binding protein, PAWP, elicits calcium oscillations and oocyte activation in human and mouse,” published recently in FASEB J.1 According to the Science Editor of AJA, “Research Highlight” pieces are brief articles that are meant to report on publications from the primary literature. Along those lines, we were delighted to read an insightful comment on our FASEB article prepared for AJA by Dr. George L Gerton. In stark contrast, we found that the article by Nomikos et al. was a promotion of phospholipase C zeta (PLCζ) as the “real” sperm factor, a molecule Dr. Lai's group has been working on for over a decade. In this article we found several omissions, inaccuracies and mistakes that highlight shortcomings in the study of PLCζ which point to major criteria of a “real” sperm factor that have not yet been addressed for PLCζ.

Deciphering the role of interleukin-22 in metabolic alterations

Sabat, Robert; Wolk, Kerstin
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Text
Publicado em 15/12/2015 EN
Relevância na Pesquisa
45.67%
Inflammatory processes and metabolic alterations are supposed to substantially interact. Recently, cumulating reports describe a profound role of interleukin(IL)-22 in this relationship. IL-22 is a particular kind of immune mediator that is produced by certain lymphocyte populations and regulates the function of several tissue cells but not immune cells. So far, IL-22 was known to plays a fundamental role in the elimination of bacterial infections at border surfaces of the body and to protect tissues from damage. This research highlight article arranges the facts regarding the effects of IL-22 in the context of adiposity and metabolic alterations and postulates a new function of the immune system.