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Assessment of disease-free survival in patients with laryngeal squamous cell carcinoma treated with radiotherapy associated or not with chemotherapy

CHEDID, Helma Maria; LEHN, Carlos Neutzling; RAPOPORT, Abrao; AMAR, Ali; FRANZI, Sergio Altino
Fonte: ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL Publicador: ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.77%
In early stage (I and II) laryngeal squamous cell carcinoma, both surgery and radiotherapy results in significant local and regional control. In advanced tumors (III and IV), radiotherapy alone has local-regional control rates of 32-43%. Aim: To assess disease-free survival in SCC laryngeal carcinoma patients submitted to radiotherapy alone and/or associated with chemotherapy. Materials and Methods: Retrospective study involving 84 cases of laryngeal SCC treated with radiotherapy or chemotherapy together with radiotherapy. Fifty-three cases were treated with intension to cure and 31 because of impossibility to resect the disease. As to clinical stage (CS), 12 were CS I, 15 II, 21 III and 5 IV. In the second group, 11 cases were EC III and 20 IV. Results: Mean age was 60 years, 84.5% were men. Fifty-eight (69.1%) cases had complete response and 26 (30.9%) had persistent or residual disease. Five-year disease-free survival was of 42.5%; 62.5% of the patients with organ preservation indication and 9.75 in the group of irressecable disease. Conclusion: disease-free survival of those patients submitted to radiotherapy because of laryngeal SCC was of 62.5%

Repercussões tardias da radioterapia sobre a função pulmonar em pacientes com câncer de mama; Long-term pulmonary effects of radiotherapy detected by pulmonary function in breast cancer patients

Gomide, Liana Barbaresco
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 17/11/2006 PT
Relevância na Pesquisa
36.77%
A realização de radioterapia adjuvante no tratamento do câncer de mama está comumente associada com complicações pulmonares em curto prazo, mas é questionável se essas alterações podem estar presentes também ao longo do tempo. Este trabalho teve como objetivo avaliar, em mulheres que foram diagnosticadas com câncer de mama, o comportamento da função pulmonar e a presença de dispnéia 18 meses após o término da radioterapia. Para tanto, foi realizado um estudo caso-controle em um grupo de 40 voluntárias não tabagistas e sem doenças cardiorrespiratórias que foram divididas em: irradiadas e controle. No grupo irradiado foram incluídas pacientes que realizaram tratamento conservador para o câncer de mama e que receberam radioterapia adjuvante. No grupo controle participaram voluntárias saudáveis com características físicas, etárias e antropométricas semelhantes ao grupo irradiado. Os parâmetros da função pulmonar como volumes (inclusive residual), capacidade vital forçada, fluxos expiratórios máximos e capacidade de difusão foram obtidos por meio do espirômetro GS Plus da Collins. O sintoma de dispnéia em pacientes irradiadas foi quantificado pela escala de dispnéia do Conselho Britânico de Pesquisas Médicas (MRC). As pacientes que realizaram radioterapia apresentaram valores de CPT...

Os significados da experiência da radioterapia oncológica na visão de pacientes e familiares cuidadores; The meanings of the experience of the radiotherapy oncológica in the vision of patients and family caretakers

Muniz, Rosani Manfrin
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 29/05/2008 PT
Relevância na Pesquisa
36.8%
O presente estudo teve como objetivo compreender os sentidos da experiência da radioterapia oncológica para o paciente e o familiar cuidador, e integrá-los em significados socialmente construídos, por meio da análise etnográfica interpretativa. Para isso tomou-se apoio no referencial teórico da antropologia interpretativa de Clifford Geertz, da corrente da antropologia médica e do método da etnografia em centros urbanos. Foi uma pesquisa com abordagem metodológica qualitativa, realizada no Centro Regional de Oncologia em um município do sul do Brasil. Participaram do estudo 20 informantes, sendo 10 pacientes e 10 familiares cuidadores, que freqüentaram o serviço no período de março a agosto de 2007. Para a coleta de dados foram realizadas observações participantes e entrevistas semi-estruturadas no domicílio dos informantes, durante o período da radioterapia e trinta dias após o seu término; também foram elaborados os genograma e ecomapa para a contextualização dos informantes. A análise dos dados apoiou-se nos pressupostos analíticos de Hammersley e Atkinson, dentre outros autores. Foram identificados os códigos que apontaram o sentido da experiência para os informantes e que, posteriormente, serviram de guia para as unidades de sentidos e a construção dos núcleos de significados: "Do adoecer por câncer à radioterapia - uma trajetória construída"; "A experiência da radioterapia: remédio e veneno" e "As teias da sobrevivência oncológica". No primeiro núcleo...

O efeito da vitamina E e do selênio na prevenção da mucosite em pacientes com tumores malignos nas vias aerodigestivas superiores submetidos a radioterapia, concomitantemente ou não com quimioterapia; The effect of the vitamin E and selenium in the mucositis prevention in patients with upper aero-digestive ducts' malign tumors submitted to radiotherapy concomitant or not with chemotherapy

Santos, Simone Brasil
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 11/12/2009 PT
Relevância na Pesquisa
36.77%
A utilização da radioterapia e da quimioterapia em maior escala no tratamento do câncer de cabeça e pescoço tem elevado a incidência de efeitos colaterais, em especial da mucosite bucal. O presente estudo estabeleceu como objetivo a avaliação do efeito da suplementação da vitamina E e do selênio na prevenção da mucosite causada pela radioterapia e/ou quimioterapia em pacientes com neoplasias malignas das vias aerodigestivas superiores. Como metodologia, decidiu-se por um ensaio clínico III, randomizado, duplo cego, realizado no Serviço de Oncologia da Faculdade de Odontologia da Universidade Federal de Minas Gerais. A amostra foi constituída por 95 pacientes portadores de câncer nas vias aerodigestivas superiores, com indicação de radioterapia, sendo 78 (82,1%) do gênero masculino e 17 (17,9%) do gênero feminino, com média de idade de 54 ± 13,4 anos, variando entre 20 e 85 anos. O mineral selênio e a vitamina E foram classificados como grupo A e grupo B, respectivamente. Do primeiro dia da sessão de radioterapia até uma semana após o término da radioterapia, os pacientes tomaram uma cápsula por dia do suplemento. A mucosite foi avaliada semanalmente pelos cirurgiões dentistas do próprio serviço. Foram coletados dados de 115 pacientes. Como 20 deles foram excluídos...

Utilização da dosimetria opticamente estimulada (OSL) na avaliação de parâmetros de qualidade de feixe em radioterapia; Utilization of optically stimulated dosimetry (OSL) to evaluate beam parameters of quality in radiotherapy

Giglioti, Roberta
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 15/06/2010 PT
Relevância na Pesquisa
36.8%
O controle de qualidade do feixe é fundamental para garantir os requisitos mínimos de operação aos serviços de radioterapia, visto que a avaliação de parâmetros como simetria, planura, penumbra, fatores filtro e bandeja além de outros parâmetros dosimétricos é imprescindível para garantir constância aos tratamentos radioterápicos minimizando erros na entrega da dose. A avaliação destes parâmetros em radioterapia normalmente é realizada através de câmaras de ionização, filmes radiográficos ou detectores semicondutores sendo eles diodos e MOSFETs. Nos últimos anos o crescimento da utilização da dosimetria opticamente estimulada (OSL) na dosimetria individual externa em diversos países da Europa, USA e America latina como México e Peru proporcionou a aplicação de detectores OSL também na dosimetria em radioterapia visando à avaliação de parâmetros de feixe. A técnica de OSL une características técnicas encontradas em filmes e TLD, acrescidas de novas propriedades não possíveis nas tecnologias utilizadas anteriormente, por exemplo: possibilidade de re-leitura do dosímetro, integração de dose com avaliação de doses intermediárias entre exposições no mesmo dosímetro e simplicidade no processo de leitura. Recentemente a Landauer Inc lançou no mercado americano fitas dosimétricas de OSL para a análise do perfil de dose em Tomografia Computadorizada (TC). Neste trabalho foi avaliada a utilização deste detector OSL em forma de fita...

Impacto orofacial da radioterapia de cabeça e pescoço; Orofacial impact of head and neck radiotherapy

Ribas, Priscila Fernandes
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 23/02/2011 PT
Relevância na Pesquisa
36.84%
A radioterapia de cabeça e pescoço quando direcionada às glândulas salivares, articulação temporomandibular e músculos da mastigação, provoca sequelas na cavidade oral muitas vezes irreversíveis. Objetivo: Comparar a saúde oral, condição periodontal e função mandibular, antes e após a radioterapia da região de cabeça e pescoço. Métodos: Vinte e seis pacientes com diagnóstico de tumores malignos de cabeça e pescoço foram avaliados 30 dias antes, 30 e 90 dias após a radioterapia. A avaliação orofacial incluiu: avaliação dentária, periodontal e função mandibular. Também foram observadas as características gerais como tipo histológico do tumor e dose de radioterapia. Resultados: A idade média da amostra foi de 58 anos, sendo que 21 indivíduos (80,76%) eram do gênero masculino. Observamos um aumento do número de dentes cariados, entre a primeira e terceira avaliação (2,08±2,31 vs 4,19±3,41, p0,001) e um aumento do número de dentes perdidos (14±6,34 vs 14,46±6,23, p=0,006) e obturados (2,04±3,38 vs 2,73±3,54, p=0,004) a partir da segunda avaliação, provavelmente pelo preparo oral da radioterapia. Noventa dias após o término do tratamento radioterápico, observamos diminuição da inserção clínica periodontal (3...

Avaliação dos fatores de crescimento endotelial vascular VEGF e de seus principais receptores VEGFR-1 e -2 no processo de cicatrização com influência da radioterapia em ratos da linhagem Wistar; Evaluation of vascular endothelial growth factors VEGF and their main receptor VEGFR-1 and -2 in the healing process with the influence of radiotherapy in Wistar rats

Gomes, Luana Pimenta
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 16/08/2013 PT
Relevância na Pesquisa
36.77%
Danos teciduais de qualquer natureza desencadeiam uma série de eventos que irão promover a regeneração ou a cicatrização do tecido lesado. Este reparo é um processo complexo que envolve a interação de diversos tipos celulares que são ativados por uma vasta gama de mediadores químicos, componentes da matriz extracelular, microorganismos e alterações físico químicas no microambiente da lesão e das áreas adjacentes. A participação do fator de crescimento endotelial vascular (VEGF) e de seus dois principais receptores (VEGFR-1 e -2) é de grande importância nos processos de cicatrização levando-se em conta a neovascularização. Após uma análise circunstanciada da literatura sobre os efeitos da radioterapia na neovascularização e a relação com a expressão do VEGF e VEGFR-1 e -2 na cicatrização observou-se que ainda há uma série de questões a serem investigadas. O objetivo desse projeto de pesquisa é estudar a expressão imuno-histoquímica do VEGF e VEGFR-1 e -2 e a densidade vascular sanguínea (DVS) após incisão e reparação cutânea em animais sob influência da radioterapia e em um período de aproximadamente seis meses. Neste estudo foram utilizados 60 ratos da linhagem Wistar distribuídos aleatoriamente em seis grupos (controle 3 e 6 meses...

Influence of preventive dental treatment on mutans streptococci counts in patients undergoing head and neck radiotherapy

Meca, Lívia Buzati; Souza, Fátima Regina Nunes de; Tanimoto, Helio Massaioshi; Castro, Alvimar Lima de; Gaetti-Jardim Júnior, Elerson
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 5-12
ENG
Relevância na Pesquisa
36.8%
The aim of this study was to evaluate the influence of chlorhexidine gluconate, sodium fluoride and sodium iodine on mutans streptococci counts in saliva of irradiated patients. Forty-five patients were separated into three experimental groups and received chlorhexidine (0.12%), sodium fluoride (0.5%) or sodium iodine (2%), which were used daily during radiotherapy and for 6 months after the conclusion of the treatment. In addition, a fourth group, composed by 15 additional oncologic patients, who did not receive the mouthwash or initial dental treatment, constituted the control group. Clinical evaluations were performed in the first visit to dental clinic, after initial dental treatment, immediately before radiotherapy, after radiotherapy and 30, 60, 90 days and 6 months after the conclusion of radiotherapy. After clinical examinations, samples of saliva were inoculated on SB20 selective agar and incubated under anaerobiosis, at 37oC for 48 h. Total mutans streptococci counts were also evaluated by using real-time PCR, through TaqMan system, with specific primers and probes for S. mutans and S. sobrinus. All preventive protocols were able to reduce significantly mutans streptococci counts, but chlorhexidine gluconate was the most effective...

Qualidade de vida e eventos adversos após a radioterapia em mulheres com câncer ginecológico : um estudo de coorte prospectivo; Quality of life and adverse events after radiotherapy in gynecologic cancer survivors : a cohort study

Ana Francisca Vaz
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 25/05/2011 PT
Relevância na Pesquisa
36.85%
Objetivos: Investigar a frequência de eventos adversos antes e após a radioterapia, a proporção de mulheres sexualmente ativas, avaliar a qualidade de vida (QV) e identificar seus preditores em uma coorte de mulheres com câncer ginecológico. Métodos: Estudo de coorte prospectivo com 107 mulheres com câncer ginecológico (colo do útero ou endométrio), idade (21 a 75) anos, tratadas com radioterapia, 89 (teleterapia e braquiterapia) 10 (braquiterapia) 8 (teleterapia) no Hospital da Mulher Prof. Dr. José Aristodemo Pinotti CAISM/UNICAMP. A QV foi avaliada através do questionário da Organização Mundial da Saúde - (WHOQOL-breve), antes da radioterapia (T0), 4 meses (T1), 1ano (T2) e 3 anos (T3) após o tratamento. Os eventos adversos após a radioterapia foram graduados de acordo com a escala Common Terminology Criteria Adverse Event (CTCAE) v 3.0. Os escores de QV foram avaliados através do teste de Wilcoxon pareado e os seus preditores identificados por meio de regressão linear. Utilizou-se o teste de McNemar para avaliar as diferenças entre as frequências de sintomas sexuais e da menopausa, e da proporção de mulheres sexualmente ativas após a radioterapia em relação à avaliação inicial. Resultados: A mediana da idade das participantes antes da radioterapia foi 60 anos. O domínio meio ambiente e a saúde geral eram os mais comprometidos antes da radioterapia. Dor (49...

Does residential distance to the nearest cancer centre affect radiotherapy use following breast-conserving surgery?

Churcher, Lauren
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado Formato: 367616 bytes; application/msword
EN
Relevância na Pesquisa
36.85%
Radiotherapy, in combination with breast-conserving surgery, is an effective treatment option for early stage breast cancer; however previous studies have shown that Ontario residents do not have equitable access to radiotherapy services in Ontario. The objective of this study is to determine the association between residential distance to the nearest cancer centre (km), and radiotherapy following breast-conserving surgery for women diagnosed with breast cancer in Ontario between 1990 and 2002. The effect of age at diagnosis, socioeconomic status, and level of radiotherapy services at the hospital of diagnosis on the relationship between the main exposure and outcome were also examined. It was found that women who resided 160 to <325 km to the nearest cancer centre were significantly less likely to receive radiotherapy after breast-conserving surgery than individuals living close to cancer centres (Odds Ratio (OR): 0.72, 95% Confidence Interval (CI): 0.63-0.83). Women who lived ≥ 325 km from a cancer centre were also significantly less likely to receive radiotherapy after breast-conserving surgery (OR: 0.67, 95% CI: 0.50-0.91). Similar associations were found for overall radiotherapy utilization within one year of diagnosis. Age at diagnosis...

Monte Carlo modelling of tumour growth, hypoxia and radiotherapy in head and neck squamous cell carcinoma.

Harriss, Wendy Michelle
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2012
Relevância na Pesquisa
36.9%
Tumour hypoxia is the inadequate supply of oxygen in living tissue. Hypoxia is a major problem in the treatment cancer with ionising radiation because of the associated increase in radioresistance of hypoxic tumour cells. This effect can cause up to a three fold increase in the radiation dose required to kill the hypoxic cells compared to well oxygenated cells. Many locally advanced head and neck tumours exhibit hypoxia to some degree, and there is direct evidence that hypoxic tumour sub-volumes and their associated mean oxygenation levels have a direct influence on local tumour control after radiotherapy (Nordsmark 2005). Currently, head and neck cancer radiotherapy local control rates lie at approximately 80% for early stage disease, but reduce significantly (often below 50%) for locally advanced tumours. Efforts to improve these statistics through dose and fractionation modifications in randomised clinical trials have been made in recent decades using alternate fractionation schedules, but the average prognosis has not improved significantly. The effects of tumour reoxygenation during fractionated radiotherapy can assist in re-sensitising previously hypoxic tissue; however the complex dynamics and patient dependent characteristics of this phenomenon make the benefits difficult to quantify. Head and neck cancers...

Adjuvant radiotherapy versus observation alone for patients at risk of lymph-node field relapse after therapeutic lymphadenectomy for melanoma: a randomised trial

Burmeister, B.; Henderson, M.; Ainslie, J.; Fisher, R.; Di Iulio, J.; Smithers, B.; Hong, A.; Shannon, K.; Scolyer, R.; Carruthers, S.; Coventry, B.; Babington, S.; Duprat, J.; Hoekstra, H.; Thompson, J.
Fonte: The Lancet Publishing Group Publicador: The Lancet Publishing Group
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
36.89%
BACKGROUND: The use of radiotherapy after therapeutic lymphadenectomy for patients with melanoma at high risk of further lymph-node field and distant recurrence is controversial. Decisions for radiotherapy in this setting are made on the basis of retrospective, non-randomised studies. We did this randomised trial to assess the effect of adjuvant radiotherapy on lymph-node field control in patients who had undergone therapeutic lymphadenectomy for metastatic melanoma in regional lymph nodes. METHODS: This randomised controlled trial included patients from 16 hospitals in Australia, New Zealand, the Netherlands, and Brazil. To be eligible for this trial, patients had to be at high risk of lymph-node field relapse, judged on the basis of number of nodes involved, extranodal spread, and maximum size of involved nodes. After lymphadenectomy, randomisation was done centrally by computer and patients assigned by telephone in a ratio of 1:1 to receive adjuvant radiotherapy of 48 Gy in 20 fractions or observation, with institution, lymph-node field, number of involved nodes, maximum node diameter, and extent of extranodal spread as minimisation factors. Participants, those giving treatment, and those assessing outcomes were not masked to treatment allocation. The primary endpoint was lymph-node field relapse (as a first relapse)...

Radiotherapy for optic nerve sheath meningioma: a case for earlier intervention?

Adams, G.; Roos, D.; Crompton, J.
Fonte: Elsevier Science London Publicador: Elsevier Science London
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
36.84%
AIMS: To assess tumour control, visual outcomes and toxicity after radiotherapy for all patients with optic nerve sheath meningiomas (ONSM) treated by a single radiation oncologist at a single institution over a 15 year period. To explore potential predictors of outcomes. MATERIALS AND METHODS: All patients underwent ophthalmological and radiological assessments before radiotherapy. These were repeated at regular intervals after treatment. A retrospective analysis of clinical, dosimetric and radiological data was carried out. Patients with useful vision before radiotherapy were divided into two groups - those with maintained or improved vision and those with a deterioration in vision. The groups were compared using the Mann-Whitney U-test with regard to eight potential predictors of outcome. RESULTS: Seventeen patients with 18 ONSM were treated with fractionated radiotherapy (46.8-55.8 Gy in 26-31 fractions). No evaluable tumours grew after treatment: control rate 100% (95% confidence interval 82-100%). Using the most common definition of visual function described in the literature, vision was maintained or improved in 89% (95% confidence interval 67-97%) of cases. In those with useful vision before treatment (13 evaluable eyes), visual acuity was maintained or improved in eight (62%...

Influence of periodontitis on the experience of oral mucositis in cancer patients undergoing head and neck radiotherapy.

Khaw, Arlene Bee Hong
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2014
Relevância na Pesquisa
36.8%
Background and aim: Virtually all patients who receive head and neck radiotherapy develop some degree of oral mucositis. Severe oral mucositis may necessitate an interruption of the course of radiotherapy and thus can serve as a dose-limiting factor. Periodontitis is a host-driven inflammatory response to a pathogenic bacterial biofilm in the subgingival environment, resulting in the progressive destruction of the tissues that support the teeth, specifically the gingiva, periodontal ligament, and alveolar bone. This disease affects more than 50% of the population. Considering that radiation-induced oral mucositis and periodontitis are both characterised by the continuing presence of systemic inflammation, they may be associated through a primed inflammatory response as proposed by the “two-hit” model. Alternatively, both conditions may be correlated as they represent a dysregulation of the inflammatory response. To date, no studies have looked into the association between these conditions. The aim of this study is to determine whether the severity of oral mucositis is associated with the severity of periodontitis in cancer patients undergoing head and neck radiotherapy. Materials and methods: Eighty-five consecutive patients seeking dental clearance prior to head and neck radiotherapy were assessed for their eligibility for participation in the study. Forty-one patients met the inclusion criteria. The severity of oral mucositis was measured according to the WHO system. The severity of periodontitis was assessed clinically and radiographically. Gingival crevicular fluid was sampled and levels of eight cytokines were determined using a multiplexed bead immunoassay. The association between radiation-induced oral mucositis and periodontitis was analysed using logistic and linear regression...

Corpuskarzinom im FIGO-Stadium IA und IB: Therapieergebnisse nach Operation und adjuvanter Strahlentherapie bei Patientinnen mit Risikofaktoren; FIGO stage I and II carcinoma of the corpus uteri: therapeutic results after surgical treatment and adjuvant radiotherapy in patients with risk factors

Angerbauer, Katharina
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
Relevância na Pesquisa
36.88%
Zielsetzung: Obwohl der positive Effekt adjuvanter Strahlentherapie bei Endometriumkarzinomen mehrfach in Studien nachgewiesen werden konnte, liegen noch immer keine einheitlichen Standardtherapien vor. In dieser Studie wurden Toxizität der adjuvanten Strahlentherapie und Outcome nach adjuvanter Therapie bei Patientinnen mit Endometriumkarzinom im FIGO-Stadium IA und IB mit Risikofaktoren untersucht. Material und Methoden: Die vorliegende Arbeit basiert auf retrospektiv erhobenen Daten von 176 Patientinnen, die in den Jahren 1990-2004 adjuvant nach Endometriumkarzinom in der Universitätsklinik für Strahlentherapie in Tübingen bestrahlt wurden. Es wurden nur Patientinnen in die Studie aufgenommen, bei denen mindestens einer der folgenden Risikofaktoren vorlag: Alter >60 Jahre, Grading G3, klarzellige Histologie oder Lymphangiosis carcinomatosa. Die Patientinnen erhielten eine Hysterektomie und wurden danach adjuvant bestrahlt. 167 Patientinnen wurden intravaginal nach der Afterloading-Methode bestrahlt, 6 Patientinnen wurden extern am Becken und 3 Patientinnen mit einer Kombination aus beiden Bestrahlungsarten bestrahlt. Ergebnisse: Akute Nebenwirkungen der Bestrahlung traten unter externer Beckenbestrahlung und kombinierter Strahlentherapie relativ betrachtet häufiger und stärker auf als unter AL-Therapie. Insgesamt betrachtet kam es aber nur zu milden akuten Nebenwirkungen der Bestrahlung...

The role of radiotherapy in soft tissue sarcomas. Retrospective study of 115 cases treated from 1979 to 1988.

Patrício, M. Brites; Radiotherapy Department, Portuguese Oncology Institute, Lisbon.; Trindade, M. Cândida; Santos, Filomena; Jorge, M. Leonor; Raposo, J. Silva; Neves, Miguel
Fonte: Ordem dos Médicos Publicador: Ordem dos Médicos
Tipo: info:eu-repo/semantics/article; article; article; info:eu-repo/semantics/publishedVersion Formato: application/pdf
Publicado em 31/12/1994 ENG
Relevância na Pesquisa
36.82%
In this study was analysed the results of a group of patients with soft tissue sarcomas treated at the IPOFG Center of Lisbon from January 1979 to December 1988. All these cases were referred to the Radiotherapy Department for radiation treatment, which was given in 84% of the patients as a complement to surgery and in 16% was either combined with chemotherapy or given as exclusive therapy. The immediate results showed complete remission in 79% and partial remission in 7% of the cases. Seventeen per cent of the patients developed relapses and 28% distant metastases after a free interval of 27.7 and 19.6 months respectively. The five year survival rates were 73.3% for the patients without recurrences, 55.4% for the patients with relapses and 21.4% for disseminated disease. The long term results varied according to the localization of the tumor, the stage of the disease, the age of the patient, the extension of surgery, the histologic type and the radiation dose. Five year survival rates also varied with the type of treatment (63.8% for surgery followed by radiotherapy with or without chemotherapy and 50.8% for preoperative radiotherapy and surgery with or without adjuvant chemotherapy). Radiotherapy with or without chemotherapy, in inoperable patients...

Zahnärztliche Prophylaxe und Behandlung bei Radiatiopatienten : Ergebnisse einer retrospektiven Untersuchung über einen Zeitraum von bis zu sieben Jahren nach Radiotherapie; Dental prophylaxis and therapy of patients treated with radiation : results of a retrospective study covering up to seven years after radiotherapy

Handtmann, Susanne; Lange, Axel; Lukas, Dieter
Fonte: Universität Tübingen Publicador: Universität Tübingen
Tipo: ResearchPaper; info:eu-repo/semantics/other
DE_DE
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Dok. 1: Textteil Dok. 2 - 11: Abbildungen und Tabellen ******************************************** Fragestellung: Die Praxis der Entfernung sämtlicher Zähne vor Beginn einer Strahlentherapie im Kiefer- Gesichts- und Halsbereich wird in dieser Arbeit kritisch überprüft. Material, Methoden und Patientengut: Die vor Beginn der Strahlentherapie belassenen Zähne wurden nach strenger Indikation ausgewählt und optimal konservierend behandelt. Anschließend wurden sie zu-verlässig mit lokalen Fluoridierungsmaßnahmen behandelt, teilweise trotz Aufklärung nur während der Bestrahlung und zum grösseren Teil entsprechend dem Behandlungskonzept auch danach. Nach Beendigung der Strahlentherapie wurden 85 Patienten unter-sucht. Der kürzeste Abstand seit Bestrahlung betrug 5 Monate und der längste 7 Jahre. Die Patienten wurden mit einer Dosis zwischen 36-72 Gy bestrahlt. Ergebnisse: Eine Osteoradionekrose war als Komplikation nur bei drei Patienten aufgetreten, in allen drei Fällen im unbezahnten Kieferbereichen, weshalb eine odontogene Ursache auszuschließen war. Es wurden 764 Zähne überprüft, die vor Beginn der Strahlentherapie noch vorhanden waren. 184 Zähne waren vor Beginn der Strahlentherapie bereits überkront. Davon gingen 15 Zähne bis zur Kontrolluntersuchung verloren...

Prostate cancer-specific suvival differences between radical prostatectomy and curative radiotherapy

DEGROOT, JULIE
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado Formato: 448176 bytes; application/pdf
EN; EN
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Background: The relative treatment effectiveness of surgery versus radiotherapy for early-stage prostate cancer is uncertain and randomized clinical trials are unlikely to be performed. This study describes the difference in cause-specific survival between patients treated with radiotherapy versus surgery, using a number of design and analytic steps to mitigate confounding by indication within an observational study. Methods: We conducted a population-based case-cohort study, sampling patients from the Ontario Cancer Registry who were treated or were candidates for cure by radiotherapy or surgery. Cases were those who died of prostate cancer within 10 years. Cause-specific survival was analyzed using Cox-proportional hazard regression, with variance adjustment for the case-cohort sampling. Analysis using intent to treat was compared to that using treatment received. Propensity scores were also calculated and Cox-proportional hazard regression was conducted within each propensity score quintile. We formed instrumental variable groups based on radiotherapy rates in Cancer Care Ontario Regions (CCORs) using the study population sampling frame and checked the instrumental variable assumption of equal distribution of covariates by comparing those covariates across these groups using data from the subcohort. Results: The adjusted hazard ratios for risk of prostate cancer death for radiotherapy compared to surgery were 1.44 (95% CI 0.86-2.40) and 1.84 (1.06-3.17) using intent to treat and treatment received respectively. Stratified hazard ratios comparing radiotherapy to surgery for death from prostate cancer from the lowest propensity quintile to the highest propensity quintile were 0.30 (0.04-2.28)...

Effect of a mixture of inulin and fructo-oligosaccharide on lactobacillus and bifidobacterium intestinal microbiota of patients receiving radiotherapy: a randomised, double-blind, placebo-controlled trial

García-Peris,P.; Velasco,C.; Lozano,M. A.; Moreno,Y.; Paron,L.; de la Cuerda,C.; Bretón,I.; Camblor,M.; García-Hernández,J.; Guarner,F.; Hernández,M.
Fonte: Nutrición Hospitalaria Publicador: Nutrición Hospitalaria
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/12/2012 ENG
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Background & aims: The pathogenesis of enteritis after abdominal radiotherapy is unknown, although changes in faecal microbiota may be involved. In several studies, Lactobacillus and Bifidobacterium have proven beneficial for the host. Prebiotics stimulate the proliferation of Lactobacillus and Bifidobacterium, and this may have positive effects on the intestinal mucosa during abdominal radiotherapy. Methods: We performed a randomised double-blind, placebo-controlled trial including 31 patients with gynaecological cancer who received radiotherapy (29 sessions, 52.2 Gy) after surgery. Patients were randomised to two groups: prebiotic and placebo. The first group received a mixture of fibre (50% inulin and 50% fructo-oligosaccharide) and the second received 6 g of maltodextrin twice daily from one week before to three weeks after radiotherapy. Lactobacillus and Bifidobacterium counts were determined in faeces samples (day -7 before radiotherapy, day 15 of radiotherapy, at the end of treatment, and three weeks after radiotherapy) by culture in selective media and fluorescent in situ hybridization (FISH) using genus-specific probes. Bacterial counts by FISH were significantly higher than by culture method. Results: There were no differences in baseline microbiota between groups. At the end of radiotherapy...

Development and evaluation of an instrument to measure health-related quality of life in cuban breast cancer patients receiving radiotherapy

Lugo,Josefina; Nápoles,Misleidy; Pérez,Inés; Ordaz,Niurka; Luzardo,Mario; Fernández,Leticia
Fonte: Medical Education Cooperation with Cuba Publicador: Medical Education Cooperation with Cuba
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2014 EN
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INTRODUCTION:Although modern technology has extended the survival of breast cancer patients, treatment's adverse effects impact their health-related quality of life. Currently, no instrument exists capable of identifying the range of problems affecting breast cancer patients receiving radiotherapy in Cuba's socioeconomic and cultural context. OBJECTIVES: Construct and validate an instrument to measure the effects of breast cancer and radiotherapy on health-related quality of life in Cuban patients. METHODS: The study was conducted at the Oncology and Radiobiology Institute, Havana, Cuba, from January 2010 through December 2011. Inclusion criteria were: adult female, histological diagnosis of breast cancer, treated with ambulatory radiotherapy, and written informed consent; patients unable to communicate orally or in writing, or who had neurologic or psychiatric conditions were excluded. Development phase: focus groups guided by a list of questions were carried out with 50 women. The patients reported 61 problems affecting their health-related quality-of-life. A nominal group (six oncologists and two nurses) identified the same problems. A syntactic analysis of the information was performed to create items for study and measurement scales. Content validity was determined by a nominal group of seven experts using professional judgment. Another 20 patients were selected to evaluate face validity. Validation phase: the instrument was applied to 230 patients at three different points: before radiotherapy...