Página 1 dos resultados de 896 itens digitais encontrados em 0.004 segundos

## 3DNA: a software package for the analysis, rebuilding and visualization of three-dimensional nucleic acid structures

Lu, Xiang-Jun; Olson, Wilma K.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
Publicado em 01/09/2003 EN
Relevância na Pesquisa
26.79%
We present a comprehensive software package, 3DNA, for the analysis, reconstruction and visualization of three-dimensional nucleic acid structures. Starting from a coordinate file in Protein Data Bank (PDB) format, 3DNA can handle antiparallel and parallel double helices, single-stranded structures, triplexes, quadruplexes and other complex tertiary folding motifs found in both DNA and RNA structures. The analysis routines identify and categorize all base interactions and classify the double helical character of appropriate base pair steps. The program makes use of a recently recommended reference frame for the description of nucleic acid base pair geometry and a rigorous matrix-based scheme to calculate local conformational parameters and rebuild the structure from these parameters. The rebuilding routines produce rectangular block representations of nucleic acids as well as full atomic models with the sugar–phosphate backbone and publication quality ‘standardized’ base stacking diagrams. Utilities are provided to locate the base pairs and helical regions in a structure and to reorient structures for effective visualization. Regular helical models based on X-ray diffraction measurements of various repeating sequences can also be generated within the program.

## Rebuilding immunity in cancer patients

Vuk-Pavlovic, Stanimir
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.04%
Rebuilding and maintaining immunity is paramount to the success of cancer immunotherapy and hematopoietic stem cell transplantation. If immune surveillance indeed can protect from cancer, the very manifestation of malignancy means that the disease has prevailed over immunity. Yet, often, tumor–specific T cells can be found in cancer patients irrespective of vaccination. Interestingly, patients suffering from malignancy often harbor unexpectedly high levels of immature CD14+HLA-DR− monocytes, although the abundance of CD4+ cells, CD8+ cells and CD4+CD25high cells may be normal. It is plausible that in cancer such cells suppress T cell function, analogous to CD14+HLA-DR− cells in sepsis and major trauma, in addition to their likely failure to re–present tumor-associated antigens once dendritic cells have initiated the T cell response. Recent evidence indicates that tumor–borne adenosine, lactate and hypoxia in the tumor environment may modulate tumor–specific immunity to a significant extent, but their effects on myeloid cell function is unclear. Thus, understanding and controlling these factors may appreciably impact the success of rebuilding and maintaining immunity in cancer patients.

## Interpretation of ensembles created by multiple iterative rebuilding of macromolecular models

Terwilliger, Thomas C.; Grosse-Kunstleve, Ralf W.; Afonine, Pavel V.; Adams, Paul D.; Moriarty, Nigel W.; Zwart, Peter; Read, Randy J.; Turk, Dusan; Hung, Li-Wei
Fonte: International Union of Crystallography Publicador: International Union of Crystallography
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
26.79%
Heterogeneity in ensembles generated by independent model rebuilding principally reflects the limitations of the data and of the model-building process rather than the diversity of structures in the crystal.

## The Research of Sequential Images: Rebuilding of Gray (Position) ~ Time Function on Direction Lines and Their Applications

Lin, Qiang; Li, Wei
Fonte: Bentham Open Publicador: Bentham Open
Tipo: Artigo de Revista Científica
Publicado em 27/07/2011 EN
Relevância na Pesquisa
26.79%
Contrasted with other information carriers, such as speech and text, images contains larger amount of information, especially in sequential images, that is waiting to be exploited, in particular the dynamic information of correlation, difference, and temporal relationship between different frames. This dynamic information contributes a great deal in analysis of 4D images. This paper proposes a method for detecting dynamic information from sequential images, based on the rebuilding of their gray (position)~time function on direction lines, an approach that has been analyzed and studied extensively on the setting of various direction lines. This method is based on motion that is presented on sequential images. In particular, the method, Omni directional M-mode Echocardiography system, which we have studied extensively, will be described leading to a robust way of diagnosing heart diseases.

## Benefits of Rebuilding Global Marine Fisheries Outweigh Costs

Sumaila, Ussif Rashid; Cheung, William; Dyck, Andrew; Gueye, Kamal; Huang, Ling; Lam, Vicky; Pauly, Daniel; Srinivasan, Thara; Swartz, Wilf; Watson, Reginald; Zeller, Dirk
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 13/07/2012 EN
Relevância na Pesquisa
27.3%

## MDS Array Codes with Optimal Rebuilding

Tamo, Itzhak; Wang, Zhiying; Bruck, Jehoshua
Fonte: California Institute of Technology Publicador: California Institute of Technology
Tipo: Report or Paper; PeerReviewed Formato: application/pdf
Relevância na Pesquisa
27.38%
MDS array codes are widely used in storage systems to protect data against erasures. We address the rebuilding ratio problem, namely, in the case of erasures, what is the the fraction of the remaining information that needs to be accessed in order to rebuild exactly the lost information? It is clear that when the number of erasures equals the maximum number of erasures that an MDS code can correct then the rebuilding ratio is 1 (access all the remaining information). However, the interesting (and more practical) case is when the number of erasures is smaller than the erasure correcting capability of the code. For example, consider an MDS code that can correct two erasures: What is the smallest amount of information that one needs to access in order to correct a single erasure? Previous work showed that the rebuilding ratio is bounded between 1/2 and 3/4 , however, the exact value was left as an open problem. In this paper, we solve this open problem and prove that for the case of a single erasure with a 2-erasure correcting code, the rebuilding ratio is 1/2 . In general, we construct a new family of r-erasure correcting MDS array codes that has optimal rebuilding ratio of 1/r in the case of a single erasure. Our array codes have efficient encoding and decoding algorithms (for the case r = 2 they use a finite field of size 3) and an optimal update property.

## On Codes for Optimal Rebuilding Access

Wang, Zhiying; Tamo, Itzhak; Bruck, Jehoshua
Fonte: California Institute of Technology Publicador: California Institute of Technology
Tipo: Report or Paper; PeerReviewed Formato: application/pdf
Relevância na Pesquisa
27.49%
MDS (maximum distance separable) array codes are widely used in storage systems due to their computationally efficient encoding and decoding procedures. An MDS code with r redundancy nodes can correct any r erasures by accessing (reading) all the remaining information in both the systematic nodes and the parity (redundancy) nodes. However, in practice, a single erasure is the most likely failure event; hence, a natural question is how much information do we need to access in order to rebuild a single storage node? We define the rebuilding ratio as the fraction of remaining information accessed during the rebuilding of a single erasure. In our previous work we showed that the optimal rebuilding ratio of 1/r is achievable (using our newly constructed array codes) for the rebuilding of any systematic node, however, all the information needs to be accessed for the rebuilding of the parity nodes. Namely, constructing array codes with a rebuilding ratio of 1/r was left as an open problem. In this paper, we solve this open problem and present array codes that achieve the lower bound of 1/r for rebuilding any single systematic or parity node.

## Rebuilding St. Georges Hundred

Jicha, III., Hubert F.; Bensinger, Trish
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
27.2%
The twenty-eight sites included in the thematic nomination, "Rebuilding St. Georges Hundred, 1850 - 1880", are representative of a broad pattern of historically documented architectural, agricultural, and social change that swept through southern New Castle County, Delaware, in the second and third quarters of the 19th century. The selected sites all document one of three major areas of change in domestic architecture as it relates to rebuilding cycles: the improvement of standing buildings, the replacement of standing structures , and the development of new sites (often at the cost of abandoning earlier settings). Also associated with these dwellings and the social processes they represent and articulate are a number of agricultural buildings reflecting the new design options for work space developed in the course of the rebuilding.

## Book review: Coming home to New Orleans: neighborhood rebuilding after Katrina

Martin, Richard
Fonte: Blog post from London School of Economics & Political Science Publicador: Blog post from London School of Economics & Political Science
Tipo: Website; NonPeerReviewed Formato: application/pdf
Publicado em 31/08/2013 EN; EN
Relevância na Pesquisa
27.2%
"Coming Home to New Orleans: Neighborhood Rebuilding after Katrina." Karl F. Seidman. Oxford University Press. April 2013. --- Coming Home to New Orleans documents grassroots rebuilding efforts in New Orleans neighbourhoods after hurricane Katrina, and draws lessons on their contribution to the post-disaster recovery of cities. With chapters on rebuilding narratives, socio-economic factors, and volunteer initiatives, this rigorous book demonstrates the fascinating range of cultures that continue to shape this unique city, concludes Richard Martin.