Página 1 dos resultados de 276 itens digitais encontrados em 0.004 segundos

Uma experiência de mobilidade virtual no contexto iberoamericano : participação da Licenciatura em Educação da Universidade Aberta no Projeto PIMA-AIESAD

Seabra, Filipa; Moreira, Darlinda
Fonte: Universidade do Minho. Centro de Competência TIC do Instituto de Educação Publicador: Universidade do Minho. Centro de Competência TIC do Instituto de Educação
Tipo: Conferência ou Objeto de Conferência
Publicado em /05/2015 POR
Relevância na Pesquisa
37.31%
A Licenciatura em Educação da Universidade Aberta (UAb) participou, nos anos 2012/13 e 13/14, num projeto-piloto de mobilidade virtual no contexto Iberoamericano – o projeto PIMA-AIESAD. Reconhecendo-se a importância da promoção da mobilidade internacional da comunidade universitária, e as especificidades da população estudantil que frequenta o ensino superior a distância – tendencialmente população adulta e profissionalmente ativa – a mobilidade virtual oferece uma oportunidade de intercâmbio e enriquecimento científico e cultural inestimável para os estudantes da UAb. Esta comunicação, da autoria de duas pessoas diretamente implicadas na promoção e acompanhamento do referido projeto e partindo de relatos de experiências dos estudantes que participaram na iniciativa, procura apresentar e discutir as mais-valias dessa experiência, refletir sobre as limitações e dificuldades encontradas e servir de apoio a outros projetos de mobilidade virtual.; The Bachelor’s degree in Education of the Universidade Aberta (Open University of Portugal) was part of a virtual mobility pilot-project in 2012/13 and 2013/14. Acknowledging the importance of promoting the academic community’s international mobility...

Glomerular function in Pima Indians with noninsulin-dependent diabetes mellitus of recent onset.

Myers, B D; Nelson, R G; Williams, G W; Bennett, P H; Hardy, S A; Berg, R L; Loon, N; Knowler, W C; Mitch, W E
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /08/1991 EN
Relevância na Pesquisa
27.48%
Differential solute clearances were used to characterize glomerular function in 20 Pima Indians with noninsulin-dependent diabetes mellitus (NIDDM) of less than 3 yr duration. 28 Pima Indians with normal glucose tolerance served as controls. In the diabetic group, the glomerular filtration rate (GFR, iothalamate clearance) exceeded the control value by 15% (140 +/- 6 vs. 122 +/- 5 ml/min, P less than 0.01). A corresponding 12% increase in renal plasma flow (RPF) was not statistically significant and did not account fully for the observed hyperfiltration, suggesting a concomitant elevation of the ultrafiltration pressure or coefficient. The median albumin excretion ratio in NIDDM exceeded control by almost twofold (10.1 vs. 5.8 mg/g creatinine), a trend which just failed to achieve statistical significance (P = 0.06). Fractional clearances of dextrans of broad size distribution were also elevated in diabetic subjects, significantly so for larger dextrans of between 48 and 60 A radius. A theoretical analysis of dextran transport through a heteroporous membrane revealed glomerular pores in NIDDM to be uniformly shifted towards pores of larger size than in controls. We conclude that an impairment of barrier size selectivity combined with high GFR elevates the filtered protein load in NIDDM of recent onset. We propose that enhanced transglomerular trafficking of protein may predispose to sclerosis of glomeruli in those Pima Indians with NIDDM who ultimately develop diabetic nephropathy.

Insulin resistance associated with lower rates of weight gain in Pima Indians.

Swinburn, B A; Nyomba, B L; Saad, M F; Zurlo, F; Raz, I; Knowler, W C; Lillioja, S; Bogardus, C; Ravussin, E
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /07/1991 EN
Relevância na Pesquisa
27.31%
Insulin resistance is commonly associated with obesity and noninsulin-dependent diabetes. Whereas it predicts the development of diabetes, its effect on body weight change is unknown. We measured glucose disposal rates at submaximally- and maximally-stimulating insulin concentrations in 192 nondiabetic Pima Indians and followed their weight change over 3.5 +/- 1.8 y (mean +/- SD). Results: (a) Insulin-resistant subjects gained less weight than insulin-sensitive subjects (3.1 vs. 7.6 kg, P less than 0.0001). (b) The percent weight change per year correlated with glucose disposal at submaximally-(r = 0.19, P less than 0.01) and maximally-stimulating (r = 0.34, P less than 0.0001) insulin concentrations independent of sex, age, initial weight, and 24-h energy expenditure; the correlations were stronger for glucose oxidation than for glucose storage. (c) Weight gain was associated with an increase in insulin resistance more than four times that predicted from the cross-sectional data. We conclude that insulin resistance is associated with a reduced risk of weight gain in nondiabetic Pima Indians.

Evidence for reduced thermic effect of insulin and glucose infusions in Pima Indians.

Bogardus, C; Lillioja, S; Mott, D; Zawadzki, J; Young, A; Abbott, W
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /04/1985 EN
Relevância na Pesquisa
27.31%
Several authors have reported a reduced thermic effect of food in obese subjects. The hyperinsulinemic-euglycemic clamp technique has been used to measure one component of the thermic effect of food, insulin and insulin-mediated glucose disposal. We used this technique to measure the thermic responses to insulin and glucose infusions in 120 glucose-tolerant Pima Indians, a population with a high prevalence of obesity. During high-dose insulin infusions (400 mU/m2 per min) the measured increase in energy expenditure (MEE), 150 +/- 6 cal/min, was greater than the predicted increase in energy expenditure (PEE), 72 +/- 2 cal/min, for glucose storage as glycogen. During low-dose insulin infusions (40 mU/m2 per min) the mean MEE, 6 +/- 5 cal/min, was not significantly different from zero and was not greater than the mean PEE, 9 +/- 1 cal/min. These data were in contrast to results obtained from Caucasians by others and suggested a markedly reduced thermic effect of low-dose insulin and glucose infusions in Pima Indians. We also studied 23 glucose-tolerant male Caucasians and compared their results with the results from male Indians matched for glucose storage rates and obesity. The results showed that the thermic response to insulin and glucose infusions was similar in the two racial groups during high-dose insulin infusions but was markedly reduced in the Indians compared with the Caucasians during low-dose insulin infusions.

An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians.

Pratley, R E; Thompson, D B; Prochazka, M; Baier, L; Mott, D; Ravussin, E; Sakul, H; Ehm, M G; Burns, D K; Foroud, T; Garvey, W T; Hanson, R L; Knowler, W C; Bennett, P H; Bogardus, C
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 15/04/1998 EN
Relevância na Pesquisa
27.48%
Type 2 diabetes mellitus is a common chronic disease that is thought to have a substantial genetic basis. Identification of the genes responsible has been hampered by the complex nature of the syndrome. Abnormalities in insulin secretion and insulin action predict the development of type 2 diabetes and are, themselves, highly heritable traits. Since fewer genes may contribute to these precursors of type 2 diabetes than to the overall syndrome, such genes may be easier to identify. We, therefore, undertook an autosomal genomic scan to identify loci linked to prediabetic traits in Pima Indians, a population with a high prevalence of type 2 diabetes. 363 nondiabetic Pima Indians were genotyped at 516 polymorphic microsatellite markers on all 22 autosomes. Linkage analyses were performed using three methods (single-marker, nonparametric multipoint [MAPMAKER/SIBS], and variance components multipoint). These analyses provided evidence for linkage at several chromosomal regions, including 3q21-24 linked to fasting plasma insulin concentration and in vivo insulin action, 4p15-q12 linked to fasting plasma insulin concentration, 9q21 linked to 2-h insulin concentration during oral glucose tolerance testing, and 22q12-13 linked to fasting plasma glucose concentration. These results suggest loci that may harbor genes contributing to type 2 diabetes in Pima Indians. None of the linkages exceeded a LOD score of 3.6 (a 5% probability of occurring in a genome-wide scan). These findings must...

The angiotensin-I converting enzyme (ACE) gene I/D polymorphism and ACE levels in Pima Indians.

Foy, C A; McCormack, L J; Knowler, W C; Barrett, J H; Catto, A; Grant, P J
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /04/1996 EN
Relevância na Pesquisa
27.31%
An insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene is associated with plasma ACE levels in white populations. The occurrence of the I/D polymorphism and relationship to ACE levels was examined in a Pima Indian group (n = 305). The frequency of the D allele was lower in Pimas than whites (0.29 v 0.52 respectively). ACE levels were significantly associated with genotype in both groups (p = 0.0001), which accounted for 6.5% of the variation in ACE levels in Pimas and 18% in whites. The association of the I/D polymorphism with ACE levels confirms the relationship across ethnic groups. The low frequency of the D allele in Pima Indians shows that ethnic differences should be accounted for when studying the ACE gene.

Variants in Hepatocyte Nuclear Factor 4α Are Modestly Associated With Type 2 Diabetes in Pima Indians

Muller, Yunhua Li; Infante, Aniello M.; Hanson, Robert L.; Love-Gregory, Latisha; Knowler, William; Bogardus, Clifton; Baier, Leslie J.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /10/2005 EN
Relevância na Pesquisa
27.48%
Single nucleotide polymorphisms (SNPs) within the hepatocyte nuclear factor 4α (HNF4α) gene are associated with type 2 diabetes in Finns and Ashkenazi Jews. Previous studies in both populations have reported linkage to type 2 diabetes near the HNF4α locus on chromosome 20q12-13. To investigate whether HNF4α is a diabetes susceptibility gene in Pima Indians, a population with the highest reported prevalence of type 2 diabetes but with no evidence for linkage of the disease on chromosome 20q, 19 SNPs across the promoter and coding region of HNF4α were genotyped for association analysis. In a group of 1,037 Pima Indians (573 diabetic and 464 nondiabetic subjects), three SNPs in HNF4α (rs3212183 and rs2071197 located in introns 3 and 1, respectively, and rs6031558, an extremely rare SNP located in the P2 promoter region) were modestly associated with type 2 diabetes (rs3212183 odds ratio [OR] 1.34 [95% CI 1.07–1.67], P = 0.009; rs2071197 1.34 [1.07–1.66], P = 0.008; and rs6031558 3.18 [1.03–9.84], P = 0.04, adjusted for age, sex, birth year, heritage, and family membership). We conclude that variants in HNF4α do not appear to be major determinants for type 2 diabetes in Pima Indians; however, HNF4α may have a minor role in type 2 diabetes susceptibility within this Native American population.

Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians.

Sakul, H; Pratley, R; Cardon, L; Ravussin, E; Mott, D; Bogardus, C
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /03/1997 EN
Relevância na Pesquisa
27.6%
Susceptibility to non-insulin-dependent diabetes mellitus (NIDDM) is largely genetically determined. In Pima Indians, obesity, insulin resistance, and a low acute insulin response (AIR) to an intravenous glucose infusion are each predictors of the disease. To ascertain whether these phenotypes are genetically determined, we estimated their familiality in nondiabetic Pima Indians with a maximum-likelihood method. Percentage body fat (PFAT) was highly familial (h2 =.76), whereas waist/ thigh circumference ratio (W/T ratio) was not significantly familial after controlling for PFAT (h2 = .16). AIR was also highly familial (h2 = .80 at 10 min), even after controlling for PFAT and insulin action (h2 = .70). Insulin action at physiologic plasma insulin concentrations was familial (h2 = .61) but less so after controlling for PFAT and W/T ratio (h2 = .38). At maximally stimulating insulin concentrations, insulin action was familial (h2 = .45) and was less influenced by controlling for PFAT and W/T ratio (h2 = .49). We conclude that in Pima Indians (1) PFAT and AIR are highly familial traits, (2) central distribution of fat is not a familial trait when controlled for PFAT, (3) 38%-49% of the variance in insulin action, independent of the effect of obesity...

Substrate-induced Conformational Changes in the Essential Peripheral Membrane-associated Mannosyltransferase PimA from Mycobacteria: IMPLICATIONS FOR CATALYSIS*

Guerin, Marcelo E.; Schaeffer, Francis; Chaffotte, Alain; Gest, Petra; Giganti, David; Korduláková, Jana; van der Woerd, Mark; Jackson, Mary; Alzari, Pedro M.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.85%
Phosphatidyl-myo-inositol mannosyltransferase A (PimA) is an essential glycosyltransferase (GT) involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs), which are key components of the mycobacterial cell envelope. PimA is the paradigm of a large family of peripheral membrane-binding GTs for which the molecular mechanism of substrate/membrane recognition and catalysis is still unknown. Strong evidence is provided showing that PimA undergoes significant conformational changes upon substrate binding. Specifically, the binding of the donor GDP-Man triggered an important interdomain rearrangement that stabilized the enzyme and generated the binding site for the acceptor substrate, phosphatidyl-myo-inositol (PI). The interaction of PimA with the β-phosphate of GDP-Man was essential for this conformational change to occur. In contrast, binding of PI had the opposite effect, inducing the formation of a more relaxed complex with PimA. Interestingly, GDP-Man stabilized and PI destabilized PimA by a similar enthalpic amount, suggesting that they formed or disrupted an equivalent number of interactions within the PimA complexes. Furthermore, molecular docking and site-directed mutagenesis experiments provided novel insights into the architecture of the myo-inositol 1-phosphate binding site and the involvement of an essential amphiphatic α-helix in membrane binding. Altogether...

Variants in the LEPR gene are nominally associated with higher BMI and lower 24 hour energy expenditure in Pima Indians

Traurig, Michael; Perez, Jessica; Ma, Lijun; Bian, Li; Kobes, Sayuko; Hanson, Robert L.; Knowler, William C.; Krakoff, Jonathan; Bogardus, Clifton; Baier, Leslie J.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.48%
Genome-wide association studies (GWASs) have been used to search for susceptibility genes for type 2 diabetes and obesity in the Pima Indians, a population with high a prevalence of both diseases. In these studies, a variant (rs2025804) in the LEPR gene was nominally associated with BMI in 1082 subjects (P=0.03 adjusted for age, sex, birth year, and family membership). Therefore the LEPR and leptin overlapping transcript (LEPROT) genes were selected for further sequencing and genotyping in larger population-based samples for association analyses with obesity-related phenotypes. Selected variants (n=80) spanning these genes were genotyped in a sample of full-heritage Pima Indians (n=2842) and several common variants including rs2025804 were nominally associated with BMI (P=0.05-0.003 adjusted for age, sex, birth year, and family membership). Four common tag variants associated with BMI in the full-heritage Pima Indian sample were genotyped in a second sample of mixed-heritage Native Americans (n=2969) and 3 of the variants showed nominal replication (P=0.03-0.006 adjusted as above and additionally for Indian heritage). Combining both samples provided the strongest evidence for association (adjusted P=0.0003-0.0001). A subset of these individuals (n=403) had been metabolically characterized for predictors of obesity and the BMI risk alleles for the variants tagged by rs2025804 were also associated with lower 24 hour energy expenditure as assessed in a human respiratory chamber (P=0.0007 adjusted for age...

Evaluation of PIMA™® Point of Care Technology for CD4 T Cell Enumeration in Kenya

Mwau, Matilu; Adungo, Ferdinard; Kadima, Silvia; Njagi, Ephantus; Kirwaye, Carolyne; Abubakr, Najma Salim; Okubi, Lucy Atsieno; Waihenya, Mary; Lusike, Judi; Hungu, Jackson
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 25/06/2013 EN
Relevância na Pesquisa
27.48%
CD4+ T cell enumeration is used to determine eligibility for antiretroviral therapy (ART) and to monitor the immune status of HIV-positive patients; however, many patients do not have access to this essential diagnostic test. Introducing point of care (POC) testing may improve access. We have evaluated Alere’s PIMA™, one such POC device, against conventional CD4+ testing platforms to determine its performance and validity for use in Kenya. In our hands, Alere PIMA™ had a coefficient of variability of 10.3% and of repeatability of 175.6 cells/µl. It differed from both the BD FACSCalibur™ (r2 = 0.762, mean bias −64.8 cells/µl), and the BD FACSCount™ (r2 = 0.874, mean bias 7.8 cells/µl). When compared to the FACSCalibur™ at a cutoff of 350 cells/µl, it had a sensitivity of 89.6% and a specificity of 86.7% in those aged 5 years and over (Kw = 0.7566). With the BD FACSCount™, it had a sensitivity of 79.4% and a specificity of 83.4% in those aged 5 years and over (Kw = 0.7790). The device also differed from PARTEC Cyflow™ (r2 = 0.781, mean bias −24.2 cells/µl) and GUAVA™ (r2 = 0.658, mean bias −0.3 cells/µl) platforms, which are used in some facilities in Kenya. We conclude that with refinement...

PIMA Point of Care CD4+ Cell Count Machines in Remote MNCH Settings: Lessons Learned from Seven Districts in Zimbabwe

Mtapuri-Zinyowera, Sekesai; Chiyaka, Edward T.; Mushayi, Wellington; Musuka, Godfrey; Naluyinda-Kitabire, Florence; Mushavi, Angella; Chikwasha, Vasco
Fonte: Libertas Academica Publicador: Libertas Academica
Tipo: Artigo de Revista Científica
Publicado em 09/12/2013 EN
Relevância na Pesquisa
27.69%
An evaluation was commissioned to generate evidence on the impact of PIMA point-of-care CD4+ count machines in maternal and new-born child health settings in Zimbabwe; document best practices, lessons learned, challenges, and recommendations related to scale up of this new technology. A mixed methodology approach that included 31 in-depth interviews with stakeholders involved in procurement, distribution, and use of the POC machines was employed. Additionally, data was also abstracted from 207 patient records from 35 sites with the PIMA POC CD4+ count machines and 10 other comparative sites without the machine. A clearer training strategy was found to be necessary. The average time taken to initiate clients on antiretroviral treatment (ART) was substantially less, 15 days (IQR-1-149) for sites with a PIMA POC machine as compared to 32.7 days (IQR-1-192) at sites with no PIMA POC machine. There was general satisfaction because of the presence of the PIMA POC CD4+ count machine at sites that also initiated ART.

The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo

Boldrin, Francesca; Ventura, Marcello; Degiacomi, Giulia; Ravishankar, Sudha; Sala, Claudia; Svetlikova, Zuzana; Ambady, Anisha; Dhar, Neeraj; Kordulakova, Jana; Zhang, Ming; Serafini, Agnese; Vishwas, V. G.; Kolly, Gaëlle S.; Kumar, Naveen; Palù, Giorg
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: Artigo de Revista Científica
Publicado em /10/2014 EN
Relevância na Pesquisa
27.88%
The cell envelope of Mycobacterium tuberculosis contains glycans and lipids of peculiar structure that play prominent roles in the biology and pathogenesis of tuberculosis. Consequently, the chemical structure and biosynthesis of the cell wall have been intensively investigated in order to identify novel drug targets. Here, we validate that the function of phosphatidyl-myo-inositol mannosyltransferase PimA is vital for M. tuberculosis in vitro and in vivo. PimA initiates the biosynthesis of phosphatidyl-myo-inositol mannosides by transferring a mannosyl residue from GDP-Man to phosphatidyl-myo-inositol on the cytoplasmic side of the plasma membrane. To prove the essential nature of pimA in M. tuberculosis, we constructed a pimA conditional mutant by using the TetR-Pip off system and showed that downregulation of PimA expression causes bactericidality in batch cultures. Consistent with the biochemical reaction catalyzed by PimA, this phenotype was associated with markedly reduced levels of phosphatidyl-myo-inositol dimannosides, essential structural components of the mycobacterial cell envelope. In addition, the requirement of PimA for viability was clearly demonstrated during macrophage infection and in two different mouse models of infection...

Bioinformatics Analysis of Small RNAs in Pima (Gossypium barbadense L.)

Hu, Hongtao; Yu, Dazhao; Liu, Hong
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 13/02/2015 EN
Relevância na Pesquisa
27.6%
Small RNAs (sRNAs) are ~20 to 24 nucleotide single-stranded RNAs that play crucial roles in regulation of gene expression. In plants, sRNAs are classified into microRNAs (miRNAs), repeat-associated siRNAs (ra-siRNAs), phased siRNAs (pha-siRNAs), cis and trans natural antisense transcript siRNAs (cis- and trans-nat siRNAs). Pima (Gossypium barbadense L.) is one of the most economically important fiber crops, producing the best and longest spinnable fiber. Although some miRNAs are profiled in Pima, little is known about siRNAs, the largest subclass of plant sRNAs. In order to profile these gene regulators in Pima, a comprehensive analysis of sRNAs was conducted by mining publicly available sRNA data, leading to identification of 678 miRNAs, 3,559,126 ra-siRNAs, 627 pha-siRNAs, 136,600 cis-nat siRNAs and 79,994 trans-nat siRNAs. The 678 miRNAs, belonging to 98 conserved and 402 lineage-specific families, were produced from 2,138 precursors, of which 297 arose from introns, exons, or intron/UTR-exon junctions of protein-coding genes. Ra-siRNAs were produced from various repeat loci, while most (97%) were yielded from retrotransposons, especially LTRs (long terminal repeats). The genes encoding auxin-signaling-related proteins, NBS-LRRs and transcription factors were major sources of pha-siRNAs...

Effect of Number of Pink Bollworm Larvae Per Boll on Yield and Quality of Pima and Upland Cotton

Fry, K. E.; Kittock, D. L.; Henneberry, T. J.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica Formato: text/html
EN
Relevância na Pesquisa
27.6%
The effects of the numbers of pink bollworm (PBW), Pectinophora gossypiella (Saunders), per boll of Deltapine 16, a cultivar of upland cotton, Gossypium hirsutum L., and Pima S-5, a cultivar of American Pima cotton, G. barbadense L., were evaluated. For each PBW per boll, lint losses were 14 and 24%, and seed weight losses were 12 and 22%, in Deltapine and Pima, respectively. The relationship between PBW per gram seed-cotton and boll dry weight was the same in both cultivars, which indicated that the infestation susceptibility was the same in both cultivars. However, in the smaller bolls with equal larval densities, the percentages of damaged seed were greater in Pima than in Deltapine. In both cultivars, the lint per seed was negatively correlated to the percentage of damaged seed. The percentage of fluorescent seed (an index of aflatoxin-forming fungus) increased with the number of larvae per boll. Lint quality decreased as the infestation level increased.

Comparative Development, Reproduction, and Oviposition of Pink Bollworm (Lepidoptera: Gelechiidae) on a Resistant Okra-Leaf Cotton and Commercial Upland and Pima Cultivars

Naranjo, Steven E.; Martin, Jeanette M.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica Formato: text/html
EN
Relevância na Pesquisa
27.81%
Selected life-history characteristics of pink bollworm, Pectinophora gossypiella(Saunders), were studied in three upland (‘Deltapine 90’,‘DES-119’, and ‘WC-12NL’), Gossypium hirsutum L., and one American Pima (‘Pima S-6’), G. barbadense L., cottons in three separate trials during 1990 and 1991. Larval developmental times (egg hatch to larval cutout from bolls) were shortest on ‘Pima S-6’ bolls in all three trials (overall mean 205 ± 4 degree-days [12 and 32.5°C lower and upper thresholds, respectively)), and longest on WC-12NL, a nectariless, okra-leaf cotton with known resistance to pink bollworm, in one of three trials (overall mean, 248 ± 5 degree-days). Prepupal (range of overall means, 56–58 degree-days) and pupal (145–150 degree-days) developmental times were not affected by cotton type. Larval survival averaged from 40 to 50%, and did not differ among cottons. Prepupal (range of overall means, 90–96%) and pupal survival (80–88%) was significantly higher on ‘WC-12NL’ bolls and lower on ‘Pima S-6’, respectively, in separate trials. Significantly fewer ‘Pima S-6’ bolls were infested with pink bollworm eggs early in the season and fewer ‘WC-12NL’ bolls were infested during the middle part of the season in 1990 and on the last sample date in 1991. The mean number of eggs per infested boll (range of overall...

Polymorphism in the 5' flanking region of the human insulin gene. Relationships with noninsulin-dependent diabetes mellitus, glucose and insulin concentrations, and diabetes treatment in the Pima Indians.

Knowler, W C; Pettitt, D J; Vasquez, B; Rotwein, P S; Andreone, T L; Permutt, M A
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /12/1984 EN
Relevância na Pesquisa
27.48%
Variations in DNA sequences flanking the insulin gene were studied in relation to noninsulin-dependent diabetes mellitus (NIDDM) in 87 unrelated Pima Indians at least 35 yr of age. DNA was isolated from nuclei of peripheral blood leukocytes and digested with restriction endonucleases. Less variation in this region was found in Pima Indians than in other racial groups previously studied. Only two classes of alleles (classes 1 and 3) were found, and there was virtually no variation within classes. At least one class 3 allele was found in 47% of the 38 nondiabetic subjects and in 37% of the 49 with NIDDM (odds ratio = 0.65, P = 0.4, 95% confidence interval for the odds ratio = 0.25 to 1.67). Homozygosity for class 3 alleles, however, was found only in diabetics. There were no differences according to genotype in obesity, fasting or postload glucose or insulin concentrations, or in the relationships between insulin and glucose concentrations. 61% (11/18) of the diabetics with a class 3 allele were receiving drug treatment for diabetes compared with only 26% (8/31) of diabetics without a class 3 allele (P = 0.03). The insulin gene polymorphism probably plays no important role in the genesis of NIDDM in Pima Indians, nor does it influence the glucose or insulin concentrations or their relationship to each other...

Interactive media audiences in Africa: A comparison of four constituencies in Kenya and Zambia

Abreu Lopes, Claudia; Mudhai, Okoth Fred; Mitullah, Winnie V.; Simutanyi, Neo; Balongo, Sam; Diepeveen, Stephanie; Fraser, Alastair; Milapo, Nalukui; Mwangi, Sammy; Tembo, Emmanuel; Srinivasan, Sharath
Fonte: CGHR, Dept. of Politics and International Studies, University of Cambridge Publicador: CGHR, Dept. of Politics and International Studies, University of Cambridge
Tipo: Working Paper; published version
EN
Relevância na Pesquisa
27.76%
The PiMA Working Papers are a series of peer-reviewed working papers that present findings and insights from Centre of Governance and Human Rights? (CGHR) Politics and Interactive Media in Africa (PiMA) research project (2012-14). The project, jointly funded by the ESRC and DFID (ES/J018945/1), focuses on expressions of ?public opinion? in broadcast media via new information and communication technologies (ICT) such as mobile phones in Kenya and Zambia. PiMA examines the political implications of such interactions in the two African countries, with a view to drawing conclusions of wider significance to practitioners and policymakers. Series Editors: Sharath Srinivasan, Stephanie Diepeveen.; To better understand who participates in media-driven public discussion and opinion-making, this working paper presents the results of a randomised household survey implemented in four constituencies in Kenya and Zambia, one urban and one rural constituency in each country. The survey was conducted as part of Politics and Interactive Media in Africa (PiMA), a collaborative research project analysing the nature and political implications of expressions of public opinion in broadcast media in Kenya and Zambia, via new information and communication technologies (ICT) such as mobile phones. This paper presents descriptive survey results that are the basis of a deeper comparative analysis of drivers of listenership and participation in interactive broadcast media shows...

PiMA Survey Design and Methodology

Mudhai, Okoth Fred; Abreu Lopes, Claudia; Mitullah, Winnie; Fraser, Alastair; Milapo, Nalukui; Mwangi, Sammy; (PI) Srinivasan, Sharath
Fonte: CGHR, Dept. of Politics and International Studies, University of Cambridge Publicador: CGHR, Dept. of Politics and International Studies, University of Cambridge
Tipo: Working Paper; published version
EN
Relevância na Pesquisa
37.69%
The PiMA Working Papers are a series of peer-reviewed working papers that present findings and insights from Centre of Governance and Human Rights? (CGHR) Politics and Interactive Media in Africa (PiMA) research project (2012-14). The project, jointly funded by the ESRC and DFID, focuses on expressions of ?public opinion? in broadcast media via new information and communication technologies (ICT) such as mobile phones in Kenya and Zambia. PiMA examines the political implications of such interactions in the two African countries, with a view to drawing conclusions of wider significance to practitioners and policymakers. Series Editors: Sharath Srinivasan, Stephanie Diepeveen; The Politics and Interactive Media in Africa (PiMA) project investigates participation in radio and television programmes through new information and communication technologies (ICTs) as it is shaped by the political, social and media context in Zambia and Kenya, as well as the implications of such interactions for democratic governance and poverty alleviation. The empirical research combines different methodologies, including interviews with key informants, focus groups with audience members, in-studio observations and surveys of the general population. This paper describes the methodology for conducting surveys in four sites in Kenya and Zambia. The objective of the surveys was to obtain representative samples of two constituencies per country. Constituencies were selected according to their social and economic characteristics...

Cláusulas relativas em pima bajo

Fernández, Zarina Estrada
Fonte: LIAMES: Línguas Indígenas Americanas Publicador: LIAMES: Línguas Indígenas Americanas
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Artigo Avaliado pelos Pares Formato: application/pdf
Publicado em 29/04/2010 POR
Relevância na Pesquisa
27.6%
ABSTRACT According to the grammaticalization approach, the main goal of this theory is to describe the way grammatical forms arise and how they are developed through time. This article deals with the grammaticalization of the demonstrative higam from Pima Bajo as a relativizer suffix. The discussion also covers the grammaticalization of other elements which are also used to mark relative clauses. The study of the relativizers in Pima Bajo argues in favor of analogy as a principle that motivates the grammaticalization of these elements.KEYWORDS: Relative clauses; Grammaticalization; Uto-Aztecan languages. RESUMEN De acuerdo a los estudios de gramaticalización, la principal meta de esta teoría es la descripción de los procesos mediante los cuales se forman nuevos elementos gramaticales y de cómo evolucionan a lo largo del tiempo. Este artículo trata sobre la gramaticalización del demostrativo higam de Pima Bajo como sufijo relativizador. La discusión abarca la gramaticalización de otros elementos que codifican construcciones funcionalmente equivalentes a las cláusulas relativas. El estudio de los relativizadores en Pima Bajo permite argumentar a favor del principio de analogía como el que motiva la gramaticalización de esos elementos.PALABRAS-CLAVES: Cláusulas relativas; Gramaticalización; Lenguas yutoaztecas.