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"Prevalência das doenças periodontais em pacientes com doença isquêmica coronariana aterosclerótica, em Hospital Universitário" ; Prevalence of periodontal diseases in patients with ischaemic coronary disease in an University Hospital, 2003.

Barilli, Ana Lucia de Azevedo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 06/02/2003 PT
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As doenças periodontais (DP) são precedidas em importância apenas pela cárie dentária como problema de saúde bucal coletiva no Brasil. Ambas são doenças infecciosas ainda muito prevalentes, entretanto é dada às DP uma importância questionavelmente secundária, pois não são sistematicamente investigadas e prevenidas em saúde pública. Pelo fato de sua prevalência ser atualmente desconhecida no Brasil, a alta freqüência das formas leves e moderadas das doenças periodontais na população como um todo e de suas formas mais graves em grupos ou indivíduos de risco, dentre estes os portadores de cardiopatias isquêmicas, motivou este estudo no Ambulatório de Cardiopatia Isquêmica do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, cotejando os resultados com outros obtidos em grupo de pessoas não-cardiopatas atendidas na mesma instituição. Foi investigada a prevalência e gravidade das doenças periodontais, bem como a prevalência de seus fatores de risco, história médica da presença de doenças de interesse à periodontia (diabetes, hipertensão, acidente vascular cerebral) e comportamento relativo à higiene bucal. Dentre as 634 pessoas examinadas na fase de recrutamento dos participantes...

Envolvimento de sinais co-estimulatórios na progressão das doenças periodontais humanas; Differential expression of costimulatory molecules in human periodontal diseases

Figueira, Eduardo Aleixo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 21/06/2007 PT
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A manutenção da resposta imune depende de uma fina regulação da ativação dos linfócitos. A ativação das células T requer dois sinais, um mediado pelo complexo TCR, após o reconhecimento do antígeno, e o outro mediado pela interação dos receptores coestimulatórios. CD28 e ICOS são receptores estimuladores, enquanto CTLA-4 e PD-1 induzem um sinal inibitório para a ativação das células T. Para compreender o envolvimento de células T na progressão da doença periodontal humana avaliamos o perfil de ativação de células T sangüíneas, a presença destas células no foco da infecção, bem como os fatores que estas células estariam produzindo. Os resultados mostraram que linfócitos sangüíneos de pacientes com doenças periodontais proliferaram frente à estimulação policlonal, de maneira similar aos linfócitos de indivíduos saudáveis. Entretanto, a estimulação com antígenos de Aa e Pg induziu apenas um discreto aumento na resposta proliferativa de linfócitos de pacientes com gengivite. Os dados também demonstraram que antígenos de periodontopatógenos induzem a produção de citocinas, IFN- e IL-10, por linfócitos de pacientes e indivíduos controle. As células sangüíneas de indivíduos com doenças periodontais apresentaram uma alta expressão de moléculas inibitórias...

Perfis microbianos subgengivais e doenças periodontais em uma população isolada brasileira; Subgingival microbial profiles and periodontal diseases in an isolated population from Brazil

Corraini, Priscila
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 29/02/2012 PT
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66.42%
OBJETIVOS: investigar a prevalência e a presença de distintos perfis microbianos no biofilme subgengival e avaliar o seu papel no diagnóstico e risco das doenças periodontais destrutivas em uma população isolada brasileira sem acesso à tratamento periodontal e tradição ao uso de métodos de higiene bucal. MATERIAL E MÉTODOS: A população-alvo consistiu de todos os indivíduos com 12 ou mais anos de idade (N= 264) residentes na microárea Cajaíba, identificados por meio de um censo. Estes indivíduos foram entrevistados por meio de um questionário estruturado e submetidos a um exame periodontal completo que consistiu na avaliação de 6 sítios por dente em toda a boca e na coleta de amostras do biofilme subgengival em 4 sítios por indivíduo. A detecção dos micro-organismos A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia e C. rectus, bem como a distribuição dos sorotipos e presença do clone JP2 do A. actinomycetemcomitans foram avaliadas por meio da reação em cadeia da polimerase (PCR). RESULTADOS: A. actinomycetemcomitans foi detectado em 25% dos indivíduos, enquanto que P. gingivalis T. forsythia, P.intermedia e C. rectus foram detectados em 64%, 59%, 38% e 90% dos indivíduos, respectivamente. Entre as amostras positivas para o A. actinomycetemcomitans (n=42)...

Cinética de expressão de moléculas co-estimulatórias de osteoclastos no desenvolvimento da doença periodontal experimental e sua modulação por citocinas; Kinetics of osteoclast co-stimulatory molecules throughout experimental periodontitis and mice and its modulation by cytokines

Repeke, Carlos Eduardo Palanch
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 03/10/2012 PT
Relevância na Pesquisa
56.35%
O processo de diferenciação e ativação de osteoclastos, essencial para a manutenção da homeostasia do tecido ósseo e também envolvido na patogênese de diversas patologias caracterizadas pela atividade osteolítica, depende de um sistema central de controle que envolve a ligação das moléculas RANK/RANKL. Além do sistema RANK/RANKL, moléculas co-estimulatórias de osteoclastos, tais como os complexos DAP-12, TREM-2 e SIRP1, e FcR, OSCAR e PIR-A, também apresentam um papel importante na geração e ativação de osteoclastos. Entretanto, a possível contribuição de tais moléculas para a progressão da doença periodontal (DP) permanece desconhecida, assim como o possível impacto de citocinas na modulação de sua expressão no microambiente periodontal. Nosso objetivo foi investigar, por RealTimePCR, o padrão de expressão de moléculas co-estimulatórias de osteoclastos (DAP-12, TREM-2 e SIRP1, e FcR, OSCAR e PIR-A) na periodontite crônica em humanos, além de avaliar a cinética de expressão destas moléculas e a sua modulação por citocinas (TNF-, IFN-, IL-17 e IL-10) ao longo do curso da DP em camundongos em camundongos C57Bl/6 wild-type (WT) e geneticamente modificados (TNFp55KO, IFNKO, IL17KO, IL10KO. Nossos resultados demonstram que nas lesões periodontais crônicas a expressão de todas as moléculas co-estimulatórias de osteoclastos apresentaram-se significativamente aumentadas quando comparadas às amostras controle. Com relação à periodontite experimental...

Efeito do tratamento periodontal não cirúrgico na atividade da peroxidase na saliva da glândula parótida e no fluído gengival; Effect of non Surgical Periodontal Therapy on Peroxidase Activity in Parotid Saliva and Gingival Crevicular Fluid

Gonçalves, Rogéria Pereira
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 10/09/2012 PT
Relevância na Pesquisa
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Dois importantes fatores inter-relacionados estão envolvidos na patogênese da doença periodontal: ativação do sistema imune e produção de peroxidases. Os objetivos deste estudo foram comparar os níveis da atividade do sistema peroxidase presentes no fluido gengival (MPO/FG) e saliva da parótida (POS) em pacientes portadores de periodontite crônica em relação a pacientes periodontalmente saudáveis e avaliar o efeito do tratamento periodontal não cirúrgico nestes indivíduos nestes parâmetros enzimáticos. MATERIAL E MÉTODO: Foram coletados dados dos parâmetros clínicos periodontais e amostras de FG e saliva da glândula parótida de 17 pacientes clinicamente saudáveis (GC) e de 17 pacientes portadores de periodontite crônica generalizada (GP) antes e depois do tratamento periodontal pareados em idade e sexo. As atividades de MPO/FG e POS Parótida foram avaliadas por espectofotometria. RESULTADOS: O GP apresentou valores maiores nos parâmetros clínicos periodontais em relação ao GC, sendo que os mesmos foram reduzidos após tratamento periodontal. Além disso, o GP apresentou valores mais elevados de atividade de MPO no FG (p=0,04) do que o GC. Após tratamento periodontal os níveis de MPO/FG (p<0,001) e POS parótida (p=0...

Periodontal diseases in a representative urban population in south Brazil

Susin, Cristiano
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Tese de Doutorado Formato: application/pdf
ENG
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Background and Aims: There is little information about the epidemiology and risk factors of periodontal diseases in Latin America in general, and Brazil in particular. The principal aims of this study were to: 1) describe the prevalence and severity of periodontal attachment loss and gingival recession, and to assess the contribution of demographic, behavioral, and environmental exposures to the occurrence of periodontal disease outcomes in a sample representative of the urban population in the state of Rio Grande do Sul in south Brazil; and 2) report the epidemiology and risk indicators of aggressive periodontitis in this population. Methods: A representative sample consisting of 1,586 subjects 14-103 years of age (mean 38 y) and comprising 45.3% males and 54.7% females was selected using a multi-stage, probability, cluster sampling strategy. The subjects were interviewed using a structured questionnaire and underwent a full-mouth, six sites per tooth clinical examination in a mobile examination center. Results: Moderate and severe clinical attachment loss and gingival recession were widespread among adults in this population. The prevalence and extent of attachment loss ³5 and ³7 mm were 79% and 52% subjects, and 36% and 16% teeth; and for gingival recession ³3 mm and ³5 mm were 52% and 22% subjects...

The relationship between levels of income inequality and dental caries and periodontal diseases; A associação dos níveis de desigualdade de renda com cárie dental e doença periodontal

Celeste, Roger Keller; Fritzell, Johan; Nadanovsky, Paulo
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf
ENG
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Avaliar a associação entre desigualdade de renda (Gini municipal) defasada em 2 e 11 anos com dois desfechos de curta latência (cárie dentária não tratada e gengivite) e dois de longa latência (edentulismo e perda de inserção periodontal > 8mm). Foram utilizados dados do inquérito brasileiro de saúde bucal em 2002- 2003. A análise incluiu 13.405 indivíduos com idades entre 35-44 anos. Foram usados modelos de regressão multinível. Covariáveis incluídas: renda municipal per capita, renda domiciliar equivalente, idade, sexo, tempo decorrido desde a última consulta odontológica e local de residência (rural versus urbano). Estimativas brutas mostraram que apenas cárie dental não tratada estava associada ao Gini (atual e defasado no tempo), mas em modelos ajustados apenas Gini atual manteve uma relação significativa com razão de 1,19 (IC95%: 1,09-1,30) para cada dez pontos de aumento no coeficiente de Gini. Concluímos que o Gini defasado no tempo não mostrou associação com saúde bucal e o Gini atual esteve associado com cárie dentária, mas não com doença periodontal.; The objective of this study was to evaluate the association between income inequality at a lagged time of 2 and 11 years with two short latency outcomes (untreated dental caries and gingivitis) and two long latency outcomes (edentulism and periodontal attachment loss > 8mm). We used data from the Brazilian oral health survey in 2002-2003. Our analysis included 13...

The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections

Kirkwood, Keith L.; Rossa, Carlos
Fonte: Bentham Science Publ Ltd Publicador: Bentham Science Publ Ltd
Tipo: Revisão Formato: 55-67
ENG
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Periodontal disease initiation and progression occurs as a consequence of the host immune inflammatory response to oral pathogens. The innate and acquired immune systems are critical for the proper immune response. LPS, an outer membrane constituent of periodontal pathogenic bacteria, stimulates the production of inflammatory cytokines IL-1 beta TNF alpha IL-6 and RANKL either directly or indirectly. In LPS-stimulated cells, the induction of cytokine expression requires activation of several signaling pathways including the p38 MAPK pathway. This review will discuss the significance of the p38 MAPK pathway in periodontal disease progression and the potential therapeutic consequences of pharmacological antagonism of this pathway in the treatment of periodontal diseases.

MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1 beta and TNF-alpha in immortalized periodontal ligament fibroblasts

Rossa, C.; Liu, M.; Patil, C.; Kirkwood, K. L.
Fonte: Elsevier B.V. Publicador: Elsevier B.V.
Tipo: Artigo de Revista Científica Formato: 478-488
ENG
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Matrix metalloprotease-13 (MMP-13) or collagenase-3 is involved in a number of pathologic processes such as tumor metastasis and angiogenesis, osteoarthritis, rheumatoid arthritis and periodontal diseases. These conditions are associated with extensive degradation of both connective tissue and bone. This report examines gene regulation mechanisms and signal transduction pathways involved in Mmp-13 expression induced by proinflammatory cytokines in periodontal ligament (PDL) fibroblasts. Mmp-13 mRNA expression was increased 10.7 and 9.5 fold after stimulation with IL-1 beta (5 ng/mL) and TNF-alpha (10 ng/mL), respectively. However, inhibition of p38 MAPKinase with SB203580 resulted in significant (p < 0.001) induction (23.2 and 18.1 fold, respectively) of Mmp-13 mRNA as assessed by real time PCR. Negative regulation of IL-1 induced Mmp-13 expression was confirmed by inhibiting p38 MAPK gene expression with siRNA. Transient transfection of dominant negative forms of MKK3 and MKK6 also resulted in increased levels of Mmp-13 mRNA after IL-1 beta stimulation. Mmp-13 mRNA expression induced by TNF-alpha was decreased by JNK and ERK inhibition. Western blot and zymogram analysis indicated that Mmp-13 protein expression induced by the proinflammatory cytokines were also upregulated by inhibition of p38 MAPK. Reporter gene experiments using stable cell lines harboring 660-bp sequence of the murine Mmp-13 proximal promoter indicated that transcriptional mechanisms were at least partially involved in this negative regulation of Mmp-13 expression by p38 MAPK and upstream MKK3/6. These results suggest a negative transcriptional regulatory mechanism mediated by p38 MAPK and upstream MKK3/6 on Mmp-13 expression induced by proinflammatory cytokines in PDL fibroblasts. (c) 2005 Elsevier B.V./International Society of Matrix Biology. All rights reserved.

Transcriptional activation of MMP-13 by periodontal pathogenic LPS requires p38 MAP kinase

Rossa, Carlos; Liu, Min; Bronson, Paul; Kirkwood, Keith L.
Fonte: Sage Publications Ltd Publicador: Sage Publications Ltd
Tipo: Artigo de Revista Científica Formato: 85-93
ENG
Relevância na Pesquisa
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Matrix metal loprotease-13 (MMP-13) is induced by pro-inflammatory cytokines and increased expression is associated with a number of pathological conditions such as tumor metastasis, osteoarthritis, rheumatoid arthritis and periodontal diseases. MMP-13 gene regulation and the signal transduction pathways activated in response to bacterial LPS are largely unknown. In these studies, the role of the mitogen-activated protein kinase (MAPK) pathways in the regulation of MMP-13 induced by lipopolysaccharide was investigated. Lipopolysaccharide from Escherichia coli and Actinobacillus actinomycetemcomitans significantly (P < 0.05) increased MMP-13 steady-state mRNA (average of 27% and 46% increase, respectively) in murine periodontal ligament fibroblasts. MMP-13 mRNA induction was significantly reduced by inhibition of p38 MAP kinase. Immunoblot analysis indicated that p38 signaling was required for LPS-induced MMP-13 expression. Lipopolysaccharide induced proximal promoter reporter (-660/+32 mMMP-13) gene activity required p38 signaling. Collectively, these results indicate that lipopolysaccharide-induced murine MMP-13 is regulated by p38 signaling through a transcriptional mechanism.

Avaliação da sensibilidade à insulina e transdução do sinal insulínico em ratos adultos, proles de ratas com doença periodontal

Prado, Rosana Leal do
Fonte: Universidade Estadual Paulista (UNESP) Publicador: Universidade Estadual Paulista (UNESP)
Tipo: Dissertação de Mestrado Formato: 90 f. : il. + 1 CD-ROM
POR
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56.36%
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Pós-graduação em Odontologia Preventiva e Social - FOA; Nos dias atuais, a crescente incidência de diabetes mellitus no mundo torna fundamental a idéia de se identificar fatores de risco que levam ao desenvolvimento da doença e proporcionar sua prevenção. Diversos estudos têm levado a considerar as condições bucais não mais de maneira isolada, mas em suas relações com o corpo humano. Este posicionamento também é válido para as periodontopatias, que têm sido apontadas por diversos estudos como fator de risco para o desenvolvimento de doenças, entre elas o parto prematuro de bebês com baixo peso e o diabetes mellitus. O nascimento prematuro sobressai‐se como o maior problema peri‐natal em muitos países, contribuindo substancialmente para a mortalidade infantil e para o desenvolvimento de uma infância repleta de problemas. Há ainda estudos que apontam que adultos que nasceram com baixo peso tem um maior risco de desenvolver diabetes mellitus na vida adulta. A revisão destes estudos demonstra a inter‐relação entre estas doenças e alguns dos mecanismos biológicos envolvidos, buscando alertar quanto ao estilo de vida propício ao desenvolvimento de periodontopatias e a busca por hábitos preventivos...

Controle profissional de biofilme dentário como estratégia para manutenção da saúde periodontal de pacientes com aparelho ortodôntico fixo: análise comparativa entre diferentes períodos

Nogueira, Marianne Nicole Marques
Fonte: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Odontologia; Odontologia Preventiva e Social; Periodontia e Prótese Dentária Publicador: Universidade Federal do Rio Grande do Norte; BR; UFRN; Programa de Pós-Graduação em Odontologia; Odontologia Preventiva e Social; Periodontia e Prótese Dentária
Tipo: Dissertação Formato: application/pdf
POR
Relevância na Pesquisa
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The presence of fixed orthodontics appliances interfere on sanitation, allowing periodontal diseases to appear, despite the fact patients keep on visiting the dentist every month. This research aims to determine a protocol for the mechanical control of the dental biofilm performed by the professional. A protocol that was able to maintain the periodontal health of the patients under orthodontic treatment with fixed appliances, and in order to do so, it used a non-controlled, randomized and blind clinical essay. The sample involved 40 adolescents who were under the installation of fixed orthodontics appliances and it was divided in three groups, as follows: monthly controlled group (group 1) composed of 11 patients, the quarterly controlled group (group 2) with 16 patients and the semestrial controlled group (group 3) with 13 patients. For data collection, an interview and clinical exams with probing depth measurement, quantity of keratinized mucosa, Gingival Index and the Plaque Index were used. On the initial exam all patients received brushing guidelines as well as the professional control of dental biofilm, with periodontal scaler, Robinson s brush and prophylactic paste. However, Group 1 returned every month for control procedures; Group 2 every three months and Group 3 after six months. The intervention had a six-month duration (for all the three groups)...

Investigation of multipotent postnatal stem cells from human periodontal ligament

Seo, B.M.; Miura, M.; Gronthos, S.; Bartold, P.; Batouli, S.; Brahim, J.; Young, M.; Robey, P.; Wang, C.Y.; Shi, S.
Fonte: Lancet Ltd Publicador: Lancet Ltd
Tipo: Artigo de Revista Científica
Publicado em //2004 EN
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BACKGROUND Periodontal diseases that lead to the destruction of periodontal tissues—including periodontal ligament (PDL), cementum, and bone—are a major cause of tooth loss in adults and are a substantial public-health burden worldwide. PDL is a specialised connective tissue that connects cementum and alveolar bone to maintain and support teeth in situ and preserve tissue homoeostasis. We investigated the notion that human PDL contains stem cells that could be used to regenerate periodontal tissue. METHODS PDL tissue was obtained from 25 surgically extracted human third molars and used to isolate PDL stem cells (PDLSCs) by single-colony selection and magnetic activated cell sorting. Immunohistochemical staining, RT-PCR, and northern and western blot analyses were used to identify putative stem-cell markers. Human PDLSCs were transplanted into immunocompromised mice (n=12) and rats (n=6) to assess capacity for tissue regeneration and periodontal repair. FINDINGS PDLSCs expressed the mesenchymal stem-cell markers STRO-1 and CD146/MUC18. Under defined culture conditions, PDLSCs differentiated into cementoblast-like cells, adipocytes, and collagen-forming cells. When transplanted into immunocompromised rodents, PDLSCs showed the capacity to generate a cementum/PDL-like structure and contribute to periodontal tissue repair. INTERPRETATION Our findings suggest that PDL contains stem cells that have the potential to generate cementum/PDL-like tissue in vivo. Transplantation of these cells...

Studies on fusobacteria associated with periodontal diseases

Rogers, A.
Fonte: Australian Dental Association Publicador: Australian Dental Association
Tipo: Artigo de Revista Científica
Publicado em //1998 EN
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66.24%
The physiological and metabolic characteristics of representative isolates of the various subspecies of Fusobacterium nucleatum were investigated by growing them in continuous culture in chemically-defined media. Behaving almost identically, these organisms were found to obtain energy from the fermentation of simple carbohydrates such as glucose or fructose or from the fermentation of certain amino acids, free or in the form of small peptides. The latter can be attacked by aminopeptidase activity which was shown to be essential for the growth of the organism in an environment lacking fermentable carbohydrate and free amino acids but replete with small peptides. This metabolic versatility may explain the presence of F nucleatum in both supra- and sub-gingival dental plaque and why it is often found together with organisms such as Porphyromonas gingivalis which display powerful endopeptidase activities. Using the technique of allozyme electrophoresis, the current subspeciation of F. nucleatum was shown to be of doubtful validity and evidence, based upon physiological and metabolic properties, for differences in pathogenicity between isolates was not detected. While this organism is a member of various bacterial consortia associated with periodontal diseases...

A molecular survey of a captive wallaby population for periodontopathogens and the co-incidence of Fusobacterium necrophorum subspecies necrophorum with periodontal diseases

Antiabong, J.; Boardman, W.; Smith, I.; Brown, M.; Ball, A.; Goodman, A.
Fonte: Elsevier Science BV Publicador: Elsevier Science BV
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
56.36%
Periodontal diseases (PD) are diseases of polymicrobial aetiology and constitute major health problems in captive macropods. Increasing knowledge of the causal pathogens is therefore crucial for effective management and prevention of these diseases. PCR survey and sequence analyses of potential periodontopathogens in captive wallaby populations revealed a co-incidence of the diseases with the detection of Fusobacterium necrophorum subsp. necrophorum (Fnn) and its encoded leukotoxin (lktA) gene. Sequence analyses showed that the outer membrane protein of Fnn in the GenBank database shared significant homology (99%) with the Fnn encoded haemagglutinin-related-protein gene fragment identified in this study. In addition, this report suggests the existence of a variant of Fnn with no detectable lktA gene and thus warrants further studies. In contrast to reports associating Porphyromonas gingivalis and F. nucleatum with PD, this study revealed that PD in macropods are associated with Porphyromonas gulae and Fnn and raises the question: is there a possible host pathogen co-evolution in the pathogenesis of PD in animals and humans? These findings contribute to the understanding of the aetiology of periodontal disease in macropods as well as opening up a new direction of research into the microbial interactions involved in the pathogenesis of PD in macropods.; John F. Antiabong...

Highlights in peptide nanoparticle carriers intended to oral diseases

Benergossi, Jessica; Calixto, Giovana; Fonseca-Santos, Bruno; Aida, Kelly Limi; Negrini, Thais de Cassia; Duque, Cristiane; Daflon Gremiao, Maria Palmira; Chorilli, Marlus
Fonte: Bentham Science Publ Ltd Publicador: Bentham Science Publ Ltd
Tipo: Revisão Formato: 345-355
ENG
Relevância na Pesquisa
56.35%
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); New biocompatible nanomaterials are leading to a range of emerging health treatments. Thus, peptide drugs present in oral diseases, such as caries, periodontal diseases and oral cancer, are highlighting into clinical practice because the peptides can have an influence the growth of tumor cells or microorganisms and its can exhibit direct cytotoxic activity towards cancer cells or microbial cells. Therefore, it is interesting to speculate what are the natural or synthetic peptides that can be used to develop novel strategies to fight cancer diseases or microbial cells, and so, to represent a novel family of anticancer or antimicrobial agents. The use of buccal drug delivery systems, especially nanoparticles, to carrier peptides shows to be very interesting, because these systems can protect the peptide against enzymatic degradation, in addition to target inaccessible sites. However, this peptide delivery system seems to be unexplored by researchers. On the hand, the application of drug delivery systems for oral diseases could be a proposed treatment for these diseases, including the treatment or co-treatment with other therapies...

Periodontal disease and systemic complications

Oppermann,Rui Vicente; Weidlich,Patricia; Musskopf,Marta Liliana
Fonte: Sociedade Brasileira de Pesquisa Odontológica - SBPqO Publicador: Sociedade Brasileira de Pesquisa Odontológica - SBPqO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2012 EN
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56.48%
Periodontal diseases comprise a number of infectious and inflammatory conditions brought about by the interaction between supragingival and subgingival biofilms and the host inflammatory response. Periodontal diseases should be considered systemic conditions. This means that they are both modulated by the body's systems and play a role as a risk factor for systemic derangements. The current evidence supports some of these interactions, such as smoking as a risk factor for periodontal disease and diabetes mellitus, as both influenced by and influencing inflammatory changes in the periodontal tissue. Other potential associations are still being researched, such as obesity, hormonal changes, cardiovascular disease, and adverse outcomes in pregnancy. These, and others, still require further investigation before the repercussions of periodontal disease can be fully elucidated. Nevertheless, at the present time, the treatment of periodontal diseases-and, most importantly, their prevention-enables adequate intervention as a means of ensuring periodontal health.

Estado de salud periodontal en diabéticos tipo 1, de 18 a 30 años de edad, de Santiago de Chile

Pavez C,Violeta; Araya Q,Verónica; Rubio G,Alex; Ríos S,Lorena; Meza R,Patricio; Martínez R,Benjamín
Fonte: Sociedad Médica de Santiago Publicador: Sociedad Médica de Santiago
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2002 ES
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Background: The prevalence of periodontal diseases, gingivitis and periodontitis, is higher in diabetic patients and can have severe functional and esthetic consequences early in their lives. Aim: To evaluate the prevalence of periodontal disease in type 1 diabetics, aged between 18 and 30 years old, living in Santiago de Chile. Subjects and methods: One hundred male and female type 1 diabetics were examined. Glycated hemoglobin A1c, microalbuminuria, and fundoscopy were assessed in a sample of 52 subjects, separated in two groups according to the presence of periodontal disease. Results: The prevalence of gingivitis was 22%, periodontitis 41%. Only 37% of subjects were free of periodontal disease. When compared with patients without periodontal disease, in the group of patients with the disease there was a higher proportion of subjects with diabetes lasting more than 10 years (28 and 55% respectively) and a higher proportion of patients with chronic complications of diabetes (42 and 58% respectively). Conclusions: A high prevalence of periodontal diseases was observed in this sample of diabetic patients. A long history of diabetes and the presence of chronic complications were risk factors for these diseases in the analyzed sample (Rev Méd Chile 2002; 130: 402-408)

Relación entre enfermedad periodontal, infección bacteriana ascendente y patología placentaria con parto prematuro

Ovalle,Alfredo; Gamonal,Jorge; Martínez,M Angélica; Silva,Nora; Kakarieka,Elena; Fuentes,Ariel; Chaparro,Alejandra; Gajardo,Marta; León,Rubén; Ahumada,Alexis; Cisternas,Carlos
Fonte: Sociedad Médica de Santiago Publicador: Sociedad Médica de Santiago
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2009 ES
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Background: There is an association between periodontal diseases and preterm delivery. Aim: To assess the relationship between periodontal diseases, ascending bacterial infection and placental pathology with preterm delivery. Patients and methods: A periodontal examination and collection of amniotic Huid and subgingival plaque samples were performed in women with preterm labor with intact membranes, without an evident clinical cause or preterm premature rupture of membranes, without clinical chorioamnionitis or labor and a gestational age between 24 and 34 weeks. Microbial invasión ofthe amniotic cavity was defined as the presence of a positive amniotic Buid culture. Cervicovaginal infection was defined as a bacteríal vaginosis orpositive culture ofcervix or vagina with a high neutrophil count. Ascending bacterial infection was diagnosed as the microbial invasión of the amniotic cavity by ascending bacteria or cervicovaginal infection. Corioamnionitis, funisitis or vellositis were diagnosed. Resulte: Fifty-nine women were included: forty-two with preterm labor with intact membranes and seventeen with preterm premature rupture of membranes. The prevalence of periodontal diseases was 93.2%. Microbial invasión of the amniotic Buid was detected in 27.1% of patients. periodontal pathogenic bacteria were isolated in 18.6% of amniotic Buid samples and 71.2% of subgingival plaque samples. The prevalence of ascending bacterial infection was 83.1% and in 72.9% of women it was associated with periodontal disease. Preterm delivery (<37 weeks) occurred in 64.4% of patients and was significantly associated with generalized periodontal disease and with the association of ascending bacterial infection and periodontal diseases. Patients with preterm delivery and generalized periodontal disease had a higher frequency of chorioamnionitis and funisitis. Conclusions: Generalized periodontal disease and its association with ascending bacterial infection are related to preterm delivery and placental markers of bacteríal ascending infection.

Periodontal diseases as bacterial infection

Bascones Martínez,A.; Figuero Ruiz,E.
Fonte: Avances en Periodoncia e Implantología Oral Publicador: Avances en Periodoncia e Implantología Oral
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/12/2005 ENG
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56.37%
The periodontal disease is conformed by a group of illnesses affecting the gums and dental support structures. They are caused by certain bacteria found in the bacterial plaque. These bacteria are essential to the onset of illness; however, there are predisposing factors in both the host and the microorganisms that will have an effect on the pathogenesis of the illness. Periodontopathogenic bacterial microbiota is needed, but by itself, it is not enough to cause the illness, requiring the presence of a susceptible host. These diseases have been classified as gingivitis, when limited to the gums, and periodontitis, when they spread to deeper tissues. Classification of periodontal disease has varied over the years.The one used in this work was approved at the International Workshop for a Classification of Periodontal Diseases and Conditions, held in 1999. This study is an overview of the different periodontal disease syndromes. Later, the systematic use of antibiotic treatment consisting of amoxicillin, amoxicillinclavulanic acid, and metronidazole as first line coadjuvant treatment of these illnesses will be reviewed.