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Mapping the EQ-5D index by UPDRS and PDQ-8 in patients with Parkinson’s disease

Dams, Judith; Klotsche, Jens; Bornschein, Bernhard; Reese, Jens P; Balzer-Geldsetzer, Monika; Winter, Yaroslav; Schrag, Anette; Siderowf, Andrew; Oertel, Wolfgang H; Deuschl, Günther; Siebert, Uwe; Dodel, Richard
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
EN_US
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66.28%
Background: Clinical studies employ the Unified Parkinson’s Disease Rating Scale (UPDRS) to measure the severity of Parkinson’s disease. Evaluations often fail to consider the health-related quality of life (HrQoL) or apply disease-specific instruments. Health-economic studies normally use estimates of utilities to calculate quality-adjusted life years. We aimed to develop an estimation algorithm for EuroQol- 5 dimensions (EQ-5D)-based utilities from the clinical UPDRS or disease-specific HrQoL data in the absence of original utilities estimates. Methods: Linear and fractional polynomial regression analyses were performed with data from a study of Parkinson’s disease patients (n=138) to predict the EQ-5D index values from UPDRS and Parkinson’s disease questionnaire eight dimensions (PDQ-8) data. German and European weights were used to calculate the EQ-5D index. The models were compared by R2, the root mean square error (RMS), the Bayesian information criterion, and Pregibon’s link test. Three independent data sets validated the models. Results: The regression analyses resulted in a single best prediction model (R2: 0.713 and 0.684, RMS: 0.139 and 13.78 for indices with German and European weights, respectively) consisting of UPDRS subscores II...

Analyse der biologischen Funktion des Parkinson assoziierten Proteins LRRK2 in Knockdown Modellen; Analysis of the biological function of the Parkinson’s disease associated protein LRRK2 in knockdown models

Häbig, Karina
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
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Das Parkinson-Syndrom (PS) ist die zweithäufigste neurodegenerative Erkrankung. Aus diesem Grund ist die Erforschung ihrer Pathogenese von zentraler Bedeutung. In dieser Arbeit wurde die biologische Funktion der Leucine-rich repeat kinase 2 (LRRK2) untersucht. Dieses Protein, welches 2004 identifiziert wurde, ist nicht nur verantwortlich für 5-6% der autosomal dominanten, sondern auch für 1-2% der sporadischen Parkinson-Syndrome. Diese Arbeit beschreibt erstmals die gesamtgenomischen Auswirkungen des Verlustes von LRRK2 in humanen dopaminergen Zellen und gibt damit einen Einblick in LRRK2-abhängige Signalkaskaden. Dieser Verlust („Knockdown“) konnte auf RNA- und Proteinebene mit Hilfe von RNA-Interferenz erreicht werden. Die Analyse der Gene und Signalkaskaden, welche durch den Verlust von LRRK2 differentiell reguliert werden, führt in dieser Arbeit zu der Betrachtung von drei grundlegenden Fragestellungen. Apoptoseprozesse werden mit der Pathogenese des PS in Zusammenhang gebracht. Aus diesem Grund befasst sich die erste Fragestellung dieser Arbeit mit dem Einfluss von LRRK2 auf Apoptose-Signalkaskaden. Das gesamtgenomische Expressionsprofil des humanen Zellkulturmodells zeigt einen deutlichen Einfluss des LRRK2-Verlustes auf p53-abhängige Signalkaskaden. Dabei ist p53 ein entscheidender Regulator der Apoptoseprozesse. Auch die Expressionsanalyse von Gehirnen LRRK2-defizienter Tiere bestätigt dieses Ergebnis. Die anschließende funktionelle Analyse im humanen LRRK2-Knockdown-Modell verdeutlicht eine antiapoptotische Wirkung des LRRK2-Verlustes...

Pathological changes in dendrites of substantia nigra neurons in Parkinson's disease: a Golgi study

Patt, Stephan; Gertz, Hermann-Josef; Gerhard, Lieselotte; Cervós-Navarro, J.
Fonte: Murcia : F. Hernández Publicador: Murcia : F. Hernández
Tipo: Artigo de Revista Científica Formato: application/pdf
ENG
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Neurons of the substantia nigra show severe morphological changes in Parkinson's disease. Pathological alterations of cell bodies have been described, whereas those of neuronal processes have hardly been investigated. Golgi impregnation has been the chosen method for demonstrating neuronal processes and dendritic and somatic spines. We therefore used the Golgi-Braitenberg method to qualitatively and semi-quantitatively study the substantia nigra of eight patients with Parkinson's disease compared with eight control cases. Golgi impregnation of substantia nigra neurons was good in al1 control cases. In full agreement with the analysis of Braak and Braak (1986) three neuronal types within the substantia nigra were found. In cases of Parkinson's disease, severe pathological changes such as decrease of dendritic length, loss of dendritic spines and severa1 types of dendritic varicosities were found only in the melanin-containing pars compacta neurons. Pars reticulata nerve cells were intact. These findings support the predominant role played by the dopaminergic efferent pathway in the degenerative process. The afferent pathway was not affected. This suggests that the substantia nigra lesion is primary in Parkinson's disease. Loss of neurons found in H & E sections corresponded to a lesser amount of impregnated pars compacta neurons in cases with Parkinson's disease when compared to controls. Evidences exist that the duration of the disease may be related to the extent of pathologically altered Golgi-impregnated pars compacta cells. The amount of Lewy bodies in H & E sections corresponded to the quantity of round varicosities in impregnated pars compacta neurons. These round dendritic varicosities were considered to be Lewy body inclusions. They seem to have no influence on the dendritic spine density and morphology in most cases.

Verhaltenspharmakologische und histologische Charakterisierung der Funktion von Dopamin und Glutamat bei der 'nigralen' und 'extranigralen' Pathologie in einem Tiermodell der Parkinson-Krankheit; Neuropharmacological and histological characterisation of the function of dopamine and glutamate in the ‘nigral’ and ‘extranigral’ pathology in an animal model of Parkinson’s disease

Pedersen, Vera
Fonte: Universität Tübingen Publicador: Universität Tübingen
Tipo: Dissertation; info:eu-repo/semantics/doctoralThesis
DE_DE
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66.29%
In der vorliegenden Arbeit wurde im Tiermodell die Rolle des dopamin (DA)ergen und glutamat (GLU)ergen Systems bei den neurodegenerativen Prozessen, die der Parkinson-Krankheit zugrundeliegen, untersucht. Die Versuche wurden mit verhaltenspharmakologischen Methoden an der Ratte durchgeführt und durch neurochemische, biochemische und histologische Techniken ergänzt. Es wurde ein Tiermodell weiterentwickelt, mit dem das frühe klinische Stadium der Parkinson-Krankheit erfasst werden kann. Das Modell weist durch seine vergleichbaren Verhaltensveränderungen sowie den spezifischen Degenerationsmustern und Veränderungen der Neurotransmittersysteme eine hohe Validität auf und ermöglicht die Untersuchung von selektiven Eingriffen in das DAerge und GLUerge Transmittersystem und deren Auswirkung auf die degenerativen Prozesse. Die Ergebnisse der einzelnen Versuche unterstützen die Eignung dieses Tiermodells zur präklinischen Untersuchung neuer Therapiestrategien für die Parkinson-Krankheit. Die Ergebnisse dieser Arbeit zeigen, dass die Degeneration der DAergen Neurotransmission entscheidend zur Progression der ‚nigralen‘ und ‚extranigralen‘ Pathologie bei der Parkinson-Krankheit beitragen kann. Pathologische neuroadaptative Mechanismen des kompromitierten DAergen Systems sind ebenfalls für die motorischen Komplikationen...

Independent patterns of damage within magno-, parvo- and koniocellular pathways in Parkinson's disease

Silva, M. F.; Faria, P.; Regateiro, F. S.; Forjaz, V.; Januário, C.; Freire, A.; Castelo-Branco, M.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
ENG
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Sensory deficits have been documented in Parkinson's disease, in particular within the visual domain. However, ageing factors related to the brain and to neural and non-neural ocular structures could explain some of the previously reported results, in particular the claimed impairment within the koniocellular pathway. This study addressed visual impairment attributable to the magno- (luminance), parvo- (red-green) and koniocellular (blue-yellow) pathways in a population of Parkinson's disease patients. To avoid potentially confounding factors, all subjects underwent a full neurophthalmological assessment which led to exclusion of subjects with increased intraocular pressure, diabetes even in the absence of retinopathy, and ocular abnormalities (from a total of 72 patients' eyes, 12 were excluded). Both parvo- and koniocellular pathways were studied by means of contrast sensitivity (CS) measurements along protan, tritan and deutan axes and also by fitting chromatic discrimination ellipses using eight measured contrast axes. Magnocellular function was assessed, using stimuli that induce a frequency doubling illusion, in 17 locations in the fovea and periphery. Achromatic (luminance modulation) thresholds were significantly higher in Parkinson's disease both in foveal and peripheral locations. A significant impairment was observed along protan and deutan axes...

Motor learning, retention and transfer after virtual-reality-based training in Parkinson's disease - effect of motor and cognitive demands of games: a longitudinal, controlled clinical study

Santos Mendes, Felipe Augusto dos; Pompeu, Jose Eduardo; Lobo, Alexandra Modenesi; Silva, Keyte Guedes da; Oliveira, Tatiana de Paula; Zomignani, Andrea Peterson; Pimentel Piemonte, Maria Elisa
Fonte: ELSEVIER SCI LTD; OXFORD Publicador: ELSEVIER SCI LTD; OXFORD
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
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Objectives To evaluate the learning, retention and transfer of performance improvements after Nintendo Wii Fit (TM) training in patients with Parkinson's disease and healthy elderly people. Design Longitudinal, controlled clinical study. Participants Sixteen patients with early-stage Parkinson's disease and 11 healthy elderly people. Interventions Warm-up exercises and Wii Fit training that involved training motor (shifts centre of gravity and step alternation) and cognitive skills. A follow-up evaluative Wii Fit session was held 60 days after the end of training. Participants performed a functional reach test before and after training as a measure of learning transfer. Main outcome measures Learning and retention were determined based on the scores of 10 Wii Fit games over eight sessions. Transfer of learning was assessed after training using the functional reach test. Results Patients with Parkinson's disease showed no deficit in learning or retention on seven of the 10 games, despite showing poorer performance on five games compared with the healthy elderly group. Patients with Parkinson's disease showed marked learning deficits on three other games, independent of poorer initial performance. This deficit appears to be associated with cognitive demands of the games which require decision-making...

Effect of Nintendo Wii (TM)-based motor and cognitive training on activities of daily living in patients with Parkinson's disease: A randomised clinical trial

Pompeu, Jose Eduardo; dos Santos Mendes, Felipe Augusto; da Silva, Keyte Guedes; Lobo, Alexandra Modenesi; Oliveira, Tatiana de Paula; Zomignani, Andrea Peterson; Pimentel Piemonte, Maria Elisa
Fonte: ELSEVIER SCI LTD; OXFORD Publicador: ELSEVIER SCI LTD; OXFORD
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
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Objectives To investigate the effect of Nintendo Wii (TM)-based motor cognitive training versus balance exercise therapy on activities of daily living in patients with Parkinson's disease. Design Parallel, prospective, single-blind, randomised clinical trial. Setting Brazilian Parkinson Association. Participants Thirty-two patients with Parkinson's disease (Hoehn and Yahr stages 1 and 2). Interventions Fourteen training sessions consisting of 30 minutes of stretching, strengthening and axial mobility exercises, plus 30 minutes of balance training. The control group performed balance exercises without feedback or cognitive stimulation, and the experimental group performed 10 Wii Fit (TM) games. Main outcome measure Section II of the Unified Parkinson's Disease Rating Scale (UPDRS-II). Randomisation Participants were randomised into a control group (n = 16) and an experimental group (n = 16) through blinded drawing of names. Statistical analysis Repeated-measures analysis of variance (RM-ANOVA). Results Both groups showed improvement in the UPDRS-II with assessment effect (RM-ANOVA P < 0.001, observed power = 0.999). There was no difference between the control group and the experimental group before training {8.9 [standard deviation (SD) 2.9] vs 10.1 (SD 3.8)}...

The role of vision in Parkinson's disease locomotion control: Free walking task

Vitorio, Rodrigo; Lirani-Silva, Ellen; Barbieri, Fabio Augusto; Raile, Vivian; Batistela, Rosangela Alice; Stella, Florindo; Bucken Gobbi, Lilian Teresa
Fonte: Elsevier B.V. Publicador: Elsevier B.V.
Tipo: Artigo de Revista Científica Formato: 175-179
ENG
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Processo FAPESP: 07/06261-0; The current study addressed the role of visual information in the control of locomotion in people with Parkinson's disease. Twelve healthy individuals and 12 mild to moderate Parkinson's disease patients were examined while walking at self-selected velocities, under three visual sampling conditions: dynamic (normal lighting), static (static visual samples) and voluntary visual sampling. Subjects wore liquid crystal glasses for visual manipulation. Outcome measures included spatial-temporal parameters, braking and propulsive impulses, number of samples and total duration of voluntary visual samples. Interaction between groups and visual conditions was not observed for kinematic parameters or braking and propulsive impulses. There were no significant differences between groups for voluntary visual sampling variables. These findings suggest that the visual control of locomotion in Parkinson's disease patients was similar to that observed in controls. Furthermore, Parkinson's disease patients were not more dependent on visual information than healthy individuals for the locomotion control. (C) 2011 Elsevier B.V. All rights reserved.

Acoustic and hearing-perceptual voice analysis in individuals with idiopathic Parkinson's disease in "on" and "off" stages

Santos,Luiza Lara M; Reis,Larissa Oliveira dos; Bassi,Iara; Guzella,Clara; Cardoso,Francisco; Reis,César; Gama,Ana Cristina Côrtes
Fonte: Academia Brasileira de Neurologia - ABNEURO Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2010 EN
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OBJECTIVE: To evaluate the voice quality of patients with idiopathic Parkinson's disease, at the "on" and "off" moments of the disease. METHOD: Five individuals with Parkinson's disease and five of the control group were assessed. All of them underwent the recording of voice and speech. The acoustic parameters analyzed were: fundamental frequency, jitter, shimmer, harmonic noise proportion and index of tremor, besides performing the hearing-perceptual analysis by means of GRBASI scale. The findings were analyzed using statistics through t test and the level of significance adopted was p<0.05. RESULTS: There was no difference in the acoustic parameters in the three analyzed groups. In the hearing-perceptual analysis, patients with idiopathic Parkinson's disease showed altered voice quality and the ones from the control group, neutral vocal quality. CONCLUSION: Patients with idiopathic Parkinson's disease present rough, breathy and unstable vocal quality in both stages. In the acoustic analysis, there are no differences in the studied parameters.

Objective and subjective analysis of women's voice with idiopathic Parkinson's disease

Graças,Riviana Rodrigues das; Gama,Ana Cristina Côrtes; Cardoso,Francisco Eduardo Costa; Lopes,Bárbara Pereira; Bassi,Iara Barreto
Fonte: Academia Brasileira de Neurologia - ABNEURO Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/07/2012 EN
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OBJECTIVE: To compare the voice quality of women with idiopathic Parkinson's disease and those without it. METHODS: An evaluation was performed including 19 female patients diagnosed with idiopathic Parkinson's disease, with an average age of 66 years, and 27 women with an average of 67 years-old in the Control Group. The assessment was performed by computed acoustic analysis and perceptual evaluation. RESULTS: Parkinson's disease patients presented moderate rough and unstable voice quality. The parameters of grade, roughness, and instability had higher scores in Parkinson's disease patients with statistically significant differences. Acoustic measures of Jitter and period perturbation quotient (PPQ) significantly differ between groups. CONCLUSIONS: Parkinson's disease female individuals showed more vocal alterations compared to the Control Group, when both perceptual and acoustic evaluations were analyzed.

The impact of depression on survival of Parkinson's disease patients: a five-year study

Silberman,Cláudia Débora; Rodrigues,Cláudia Soares; Engelhardt,Eliasz; Laks,Jerson
Fonte: Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro Publicador: Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2013 EN
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OBJECTIVE: The aim of this study is to evaluate the survival rate in a cohort of Parkinson's disease patients with and without depression. METHODS: A total of 53 Parkinson's disease subjects were followed up from 2003-2008 and 21 were diagnosed as depressed. Mean time of follow up was 3.8 (SD 95% = 1.5) years for all the sample and there was no significant difference in mean time of follow up between depressed and nondepressed Parkinson's disease patients. Survival curves rates were fitted using the Kaplan-Meier method. In order to compare survival probabilities according to the selected covariables the Log-Rank test was used. Multivariate analysis with Cox regression was performed aiming at estimating the effect of predictive covariables on the survival. RESULTS: The cumulative global survival of this sample was 83% with nine deaths at the end of the study - five in the depressed and four in the nondepressed group, and 55.6% died in the first year of observation, and none died at the fourth and fifth year of follow up. CONCLUSION: Our finding point toward incremental death risk in depressed Parkinson's disease patients.

Pain characterization in patients with Parkinson's disease

Coriolano,Maria das Graças Wanderley de Sales; Balbino,Jenyffer Monnyk de Siqueira; Silva,Belvânia Ramos Ventura da; Cabral,Etenildo Dantas; Asano,Amdore Guescel; Lins,Otávio Gomes; Asano,Nadja Maria Jorge
Fonte: Sociedade Brasileira para o Estudo da Dor Publicador: Sociedade Brasileira para o Estudo da Dor
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2014 EN
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BACKGROUND AND OBJECTIVES: Pain in Parkinson's disease is a very frequent complaint and may precede the diagnoses of the disease. This study aimed at evaluating pain in a group of Parkinson's disease patients from a specialized treatment center. METHODS: This is a observational study of pain in Parkinson's disease patients from the Clinicas Hospital, Federal University of Pernambuco. The convenience sample, obtained between July and August 2011, was made up of 24 individuals, being 17 males and 7 females, aged between 42 and 50 (mean=64.3) years, and 48 and 66 (mean=58.7) years, respectively. Section III of the Unified Parkinson's Disease Rating Scale, Hoehn and Yahr (HY) scale according to the stage of the disease, McGill pain questionnaire and Mini Mental State Examination were used. RESULTS: Specific body region with most frequent pain was lumbar spine (50%). Categorized regions with highest complaint percentages were: trunk (66.7%) and limbs (37.5% upper; 37.5% lower). Most patients have referred pain in a single body region, regardless of analyzing specific or categorized regions (37.5%). There has been no significant difference in proportional scores obtained by each McGill questionnaire score component. Patients with rigid-akinetic Parkinson's disease had higher number of painful body regions. The comparison among McGill indices...

Neurological status predicts response to alpha-blockers in men with voiding dysfunction and Parkinson's disease

Gomes,Cristiano M.; Sammour,Zein M.; Bessa Junior,Jose de; Barbosa,Egberto R.; Lopes,Roberto I.; Sallem,Flávio S.; Trigo-Rocha,Flavio E.; Bruschini,Homero; Nitti,Victor W.; Srougi,Miguel
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2014 EN
Relevância na Pesquisa
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OBJECTIVES: To evaluate predictors of the response to doxazosin, a selective alpha-adrenoceptor antagonist, when used for the treatment of lower urinary tract symptoms in men with Parkinson's disease. METHODS: In a prospective study, 33 consecutive men (mean age 59.2±7.0 years) with Parkinson's disease and lower urinary tract symptoms were evaluated. Neurological dysfunction was assessed with the Unified Parkinson's Disease Rating Scale. Urological assessment was performed at baseline and after 12 weeks of treatment with 4 mg/day of extended-release doxazosin, including symptom evaluation with the International Continence Society male short-form questionnaire, an assessment of the impact of lower urinary tract symptoms on quality of life and urodynamics. Clinical and urodynamic predictors of response were specifically evaluated. RESULTS: Compared with the score at baseline...

Do frontal dysfunctions play a role in visual hallucinations in Alzheimer's disease as in Parkinson's disease?a comparative study

Grossi,Dario; Carotenuto,Anna; Trojano,Luigi; Manzo,Valentino; Fasanaro,Angiola Maria
Fonte: Pontificia Universidade Católica do Rio de Janeiro; Universidade de Brasília; Universidade de São Paulo Publicador: Pontificia Universidade Católica do Rio de Janeiro; Universidade de Brasília; Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2011 EN
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66.32%
Recent studies have demonstrated that nondemented patients with Parkinson's disease with visual hallucinations had lower scores on frontal-executive tasks than parkinsonian patients without hallucinations, most likely due to defective cholinergic circuitry. The aim of the present study is to investigate whether development of visual hallucinations in patients with Alzheimer's disease may also be related to more severe frontal dysfunctions. In the present study, 36 patients were included who were affected by probable Alzheimer's disease (18 with visual hallucinations and 18 without) and 38 patients affected by idiopathic Parkinson's disease (19 with visual hallucinations and 19 without). Patients completed a neuropsychological test battery and a short questionnaire to collect information about hallucination types and features. Multivariate analysis showed that patients with Alzheimer's disease scored significantly lower than patients with Parkinson's disease and that patients with hallucinations scored significantly lower than patients without hallucinations. Within both the Alzheimer's disease group and the Parkinson's disease group, patients with visual hallucinations scored significantly lower than patients without visual hallucinations...

Depression in Parkinson's disease: clinical-epidemiological correlates and comparison with a controlled group of non-parkinsonian geriatric patients

Veiga,Beatriz Azevedo dos Anjos Godke; Borges,Vanderci; Silva,Sonia Maria César de Azevedo; Goulart,Fabrício de Oliveira; Cendoroglo,Maysa Seabra; Ferraz,Henrique Ballalai
Fonte: Associação Brasileira de Psiquiatria - ABP Publicador: Associação Brasileira de Psiquiatria - ABP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2009 EN
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66.39%
OBJECTIVE: To evaluate and compare the frequency and severity of major depression in patients with Parkinson's disease and in individuals older than 60 years without neurological, rheumatological and/or oncological comorbidities. METHOD: We studied 50 patients with Parkinson's disease older than 60 years and 50 geriatric patients. Subjects with scores of Mini Mental State Examination indicating cognitive impairment were excluded. We used Diagnostic Statistical Manual of Mental Diseases-IV criteria to diagnose major depression and the Hamilton Depression Scale and the Beck Depression Inventory to rate it. The Unified Parkinson's Disease Rating Scale part 3 and the Hoehn and Yahr Scale were used to evaluate the motor severity of Parkinson's disease. RESULTS: Major depression was found in 42% of Parkinson's disease patients and in 10% of the geriatric patients (p < 0.001). The scores of the Hamilton Depression Scale and the Beck Depression Inventory were higher in Parkinson's disease patients (p < 0.001). Depressed Parkinson's disease patients had longer duration of Parkinson's disease (p = 0.020) and higher scores on the Unified Parkinson's Disease Rating Scale part 3 (p = 0.029) and the Yahr Scale (p = 0.027). CONCLUSIONS: The frequency (42%) and severity of major depression were higher in Parkinson's disease patients. Longer duration of Parkinson's disease...

Quality of life of a person with Parkinson's disease and the relationship between the time of evolution and the severity of the disease

Navarro-Peternella,Fabiana Magalhães; Marcon,Sonia Silva
Fonte: Escola de Enfermagem de Ribeirão Preto / Universidade de São Paulo Publicador: Escola de Enfermagem de Ribeirão Preto / Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2012 EN
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66.31%
Parkinson's disease can cause disability and decrease the quality of life in its sufferers. The aim of this study was to evaluate the quality of life of a group of people with Parkinson's disease and whether a relationship exists between time of evolution and severity of the disease. Secondary analysis was carried out on transversal data collected from 40 individuals with Parkinson's disease registered in the Parkinson's Association of Maringá, in Maringá-PR-Brazil. Measures: three instruments were applied: a socio-demographic questionnaire, the Hoenh and Yahr Scale and the Parkinson's Disease Questionnaire (PDQ-39). According to PDQ-39, men referred to a lower quality of life, although, statistically, there was no significant difference between the two genders. Differences were only observed in the dimensions of "activities of daily living" and "social support", in which men presented higher impairment, and "emotions" and "bodily discomfort", where women showed higher impairment. Furthermore, severity of disease tended to lead to a perception of lower quality of life regarding the dimensions of "activities of daily living" and "cognition", which is relevant to improve clinical guidance and intervention.

Clinical profile of Parkinson's disease in the Gumei community of Minhang district, Shanghai

Liu,Kangyong; Gu,Zhaohua; Dong,Liang; Shen,Liwei; Sun,Yinyi; Zhang,Ting; Shi,Nan; Zhang,Qian; Zhang,Wei; Zhao,Meizhen; Sun,Xiaojiang
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/07/2014 EN
Relevância na Pesquisa
66.3%
OBJECTIVE: We examined the demographic and clinical profiles of Parkinson's disease in Shanghai, China, to assist in disease management and provide comparative data on Parkinson's disease prevalence, phenotype, and progression among different regions and ethnic groups. METHODS: A door-to-door survey and follow-up clinical examinations identified 180 community-dwelling Han-Chinese Parkinson's disease patients (104 males, 76 females). RESULTS: The average age at onset was 65.16±9.60 years. The most common initial symptom was tremor (112 patients, 62.22%), followed by rigidity (38, 21.11%), bradykinesia (28, 15.56%) and tremor plus rigidity (2, 1.11%). Tremor as the initial symptom usually began in a single limb (83.04% of patients). The average duration from onset to mild Parkinson's disease (Hoehn-Yahr phase 1-2) was 52.74±45.64 months. Progression from mild to moderate/severe Parkinson's disease (phase≥3) was significantly slower (87.07±58.72 months; p<0.001), except for patients presenting initially with bradykinesia (53.83±24.49 months). Most patients (149/180, 82.78%) took levodopa with or without other drugs. The Hamilton Anxiety Scale revealed symptoms of clinical anxiety in 35 patients, and the Hamilton Depression Scale revealed depressive symptoms in 88 patients. The depressed or anxious subgroup (123 patients) demonstrated a significantly younger age at onset (55.54±7.68 years) compared with the overall mean (p<0.05). CONCLUSION: Unilateral limb tremor was the most common initial symptom...

The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review

Machado,Flavia Amaral; Reppold,Caroline Tozzi
Fonte: Associação de Neurologia Cognitiva e do Comportamento Publicador: Associação de Neurologia Cognitiva e do Comportamento
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2015 EN
Relevância na Pesquisa
66.26%
Deep brain stimulator (DBS) implant surgery is considered a breakthrough in the treatment of Parkinson's disease, especially in cases where motor symptoms cannot be controlled through conventional drug treatment. Its benefits have been studied extensively in the literature, particularly in relation to motor symptoms. However, the disease's cognitive aspects have been studied to a lesser extent. OBJECTIVE: This systematic review aims to assess the effects of DBS surgery on motor and cognitive symptoms in patients with Parkinson's disease. METHODS: The search strategy included MEDLINE, LILACs, SCIELO and the Cochrane Library. Randomized clinical trials with DBS surgical intervention and Parkinson's disease were included. Of the 178 studies identified, 19 met the eligibility criteria. These studies were descriptively analyzed as regards to their results. RESULTS: Control of motor symptoms, as assessed by the UPDRS Part III scale, was found in all of the studies, pointing to great interest in this outcome and demonstrating an advantage of DBS over conventional drug treatment. Regarding cognitive aspects, heterogeneity in the choice of subjects studied and the use of different assessment tools for each was evident, hampering comparisons and leading to inconclusive results. CONCLUSION: This review provides a broad overview of the effects of DBS on Parkinson's disease symptoms. However...

A randomised controlled trial evaluating the effect of an individual auditory cueing device on freezing and gait speed in people with Parkinson's disease

Ledger, Sean; Galvin, Rose; Lynch, Deirdre; Stokes, Emma K
Fonte: BioMed Central Publicador: BioMed Central
Tipo: info:eu-repo/semantics/article; all_ul_research; ul_published_reviewed
ENG
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peer-reviewed; Background: Parkinson's disease is a progressive neurological disorder resulting from a degeneration of dopamine producing cells in the substantia nigra. Clinical symptoms typically affect gait pattern and motor performance. Evidence suggests that the use of individual auditory cueing devices may be used effectively for the management of gait and freezing in people with Parkinson's disease. The primary aim of the randomised controlled trial is to evaluate the effect of an individual auditory cueing device on freezing and gait speed in people with Parkinson's disease. Methods: A prospective multi-centre randomised cross over design trial will be conducted. Fortyseven subjects will be randomised into either Group A or Group B, each with a control and intervention phase. Baseline measurements will be recorded using the Freezing of Gait Questionnaire as the primary outcome measure and 3 secondary outcome measures, the 10 m Walk Test, Timed "Up & Go" Test and the Modified Falls Efficacy Scale. Assessments are taken 3- times over a 3-week period. A follow-up assessment will be completed after three months. A secondary aim of the study is to evaluate the impact of such a device on the quality of life of people with Parkinson's disease using a qualitative methodology. Conclusion: The Apple iPod-Shuffle™ and similar devices provide a cost effective and an innovative platform for integration of individual auditory cueing devices into clinical...

Calidad de vida de las personas con enfermedad de Parkinson y su relación con la evolución en el tiempo y la gravedad de la enfermedad; Qualidade de vida de indivíduos com Parkinson e sua relação com tempo de evolução e gravidade da doença; Quality of life of a person with Parkinson's disease and the relationship between the time of evolution and the severity of the disease

Navarro-Peternella, Fabiana Magalhães; Marcon, Sonia Silva
Fonte: Universidade de São Paulo. Escola de Enfermagem de Ribeirão Preto Publicador: Universidade de São Paulo. Escola de Enfermagem de Ribeirão Preto
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Formato: application/pdf; application/pdf; application/pdf
Publicado em 01/04/2012 ENG; POR; SPA
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Parkinson's disease can cause disability and decrease the quality of life in its sufferers. The aim of this study was to evaluate the quality of life of a group of people with Parkinson's disease and whether a relationship exists between time of evolution and severity of the disease. Secondary analysis was carried out on transversal data collected from 40 individuals with Parkinson's disease registered in the Parkinson's Association of Maringá, in Maringá-PR-Brazil. Measures: three instruments were applied: a socio-demographic questionnaire, the Hoenh and Yahr Scale and the Parkinson's Disease Questionnaire (PDQ-39). According to PDQ-39, men referred to a lower quality of life, although, statistically, there was no significant difference between the two genders. Differences were only observed in the dimensions of "activities of daily living" and "social support", in which men presented higher impairment, and "emotions" and "bodily discomfort", where women showed higher impairment. Furthermore, severity of disease tended to lead to a perception of lower quality of life regarding the dimensions of "activities of daily living" and "cognition", which is relevant to improve clinical guidance and intervention.; La enfermedad de Parkinson puede llegar a ser incapacitante y afectar a la calidad de vida de los pacientes. El objetivo de este estudio fue evaluar la calidad de vida de las personas con Parkinson e identificar las relaciones con el transcurso del tiempo y la gravedad de la enfermedad. Los datos fueron recogidos en la ciudad de Maringá-PR-Brasil...