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Urinary glycosaminoglycans in horse osteoarthritis. Effects of chondroitin sulfate and glucosamine

Baccarin, Raquel Y. A.; Machado, Thais S. L.; Lopes-Moraes, Ana P.; Vieira, Fabiana A. C.; Michelacci, Yara M.
Fonte: ELSEVIER SCI LTD; OXFORD Publicador: ELSEVIER SCI LTD; OXFORD
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.9%
Our objectives were to characterize the urinary excretion of glycosaminoglycans (GAGs) in horse osteoarthritis, and to investigate the effects of chondroitin sulfate (CS) and glucosamine (GlcN) upon the disease. Urinary GAGs were measured in 47 athletic horses, 20 healthy and 27 with osteoarthritis. The effects of CS and GlcN were investigated in mild osteoarthritis. In comparison to normal, urinary GAGs were increased in osteoarthritis, including mild osteoarthritis affecting only one joint. Treatment with CS + GlcN led to a long lasting increase in the urinary CS and keratan sulfate (KS), and significant improvement in flexion test of tarsocrural and metacarpophalangeal joints was observed. In conclusion, urinary CS and KS seems to reflect the turnover rates of cartilage matrix proteoglycans, and the measurement of these compounds could provide objective means of evaluating and monitoring joint diseases. (C) 2011 Elsevier Ltd. All rights reserved.; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brasilia, DF, Brazil; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brasilia, DF, Brazil; Fundacao Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brasilia, SP, Brazil; Fundacao Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)...

Efficacy of low level laser therapy associated with exercises in knee osteoarthritis: a randomized double-blind study

Alfredo, Patricia Pereira; Bjordal, Jan Magnus; Dreyer, Silvia Helena; Ferreira Meneses, Sarah Rubia; Zaguetti, Giovana; Ovanessian, Vanessa; Fukuda, Thiago Yukio; Junior, Washington Steagall; Martins, Rodrigo Alvaro Brandão Lopes; Casarotto, Raquel Apar
Fonte: SAGE PUBLICATIONS LTD; LONDON Publicador: SAGE PUBLICATIONS LTD; LONDON
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.94%
Objectives: To estimate the effects of low level laser therapy in combination with a programme of exercises on pain, functionality, range of motion, muscular strength and quality of life in patients with osteoarthritis of the knee. Design: A randomized double-blind placebo-controlled trial with sequential allocation of patients to different treatment groups. Setting: Special Rehabilitation Services. Subjects: Forty participants with knee osteoarthritis, 2-4 osteoarthritis degree, aged between 50 and 75 years and both genders. Intervention: Participants were randomized into one of two groups: the laser group (low level laser therapy dose of 3 J and exercises) or placebo group (placebo laser and exercises). Main measures: Pain was assessed using a visual analogue scale (VAS), functionality using the Lequesne questionnaire, range of motion with a universal goniometer, muscular strength using a dynamometer, and activity using the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) questionnaire at three time points: (T1) baseline, (T2) after the end of laser therapy (three weeks) and (T3) the end of the exercises (11 weeks). Results: When comparing groups, significant differences in the activity were also found (P = 0.03). No other significant differences (P > 0.05) were observed in other variables. In intragroup analysis...

"Ocorrência de moléstia degenerativa osteoarticular em pacientes atendidos em clínica de fisioterapia" ; "Occurrence of osteoarthritis in patients attending a clinic of physical therapy."

Brisotti, Ivelise Paula Fiori
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 20/04/2006 PT
Relevância na Pesquisa
36.9%
A presente pesquisa foi desenvolvida com o objetivo de descrever a ocorrência de moléstia degenerativa osteoarticular (MDO) em pacientes atendidos em clínica especializada de fisioterapia, caracterizando a população de estudo segundo variáveis demográficas, socioeconômicas, prática de atividades físicas, índice de massa corporal e uso anterior de fisioterapia, verificando possíveis associações com a atividade profissional, afastamento do trabalho, antecedentes familiares e freqüência de orientação médica. Foram estudados 108 pacientes encaminhados para um serviço público de fisioterapia localizado em Sertãozinho, São Paulo, com diagnóstico clínico e radiológico comprovado de MDO. O estudo identificou que a doença predomina no sexo feminino (69,4%) e na faixa etária acima de 60 anos para ambos os sexos. A obesidade é preponderante entre as mulheres (40% contra 24,3%, respectivamente). Sessenta e dois por cento dos participantes já haviam feito fisioterapia, com índices progressivamente crescentes de indivíduos das faixas etárias mais avançadas. O estudo permite ainda identificar que as áreas da coluna foram as mais comumente atingidas (64,9%), com predomínio da atividade braçal (94...

Estudo retrospectivo de casuística, abrangendo metodologia diagnóstica da osteoartrite em eqüinos; Retropective study of casuistic, including diagnostic methodology of osteoarthritis in equine

Veiga, Ana Carolina Rocha
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 20/12/2006 PT
Relevância na Pesquisa
36.97%
Nos eqüinos, as articulações sinoviais são submetidas a graus variáveis de estresse físico, de acordo com o tipo de movimento executado. Com o trabalho ou treinamento intenso, o aumento da carga imposta aos seus tecidos pode provocar sinovite mecanicamente induzida, com produção e liberação de citocinas, e conseqüentemente estimulação de metaloproteinases e de outros componentes inflamatórios. Estes eventos podem acarretar em desequilíbrio entre os processos de síntese e degradação de proteoglicanos e glicosaminoglicanos da matriz cartilagínea, levando a osteoartrite. Perante a magnitude de ocorrência de osteoartrite em eqüinos atletas, teve-se como objetivo caracterizar a população de cavalos, com diagnóstico firmado de osteoartrite, atendida junto ao Serviço de Clínica Médica de Eqüinos do Hospital Veterinário (HOVET) da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ/USP), em um período de 10 anos. O levantamento da casuística foi executado através da análise de fichas de registro dos casos antigos. A amostragem foi composta envolvendo a totalidade de casos de eqüídeos, com diagnóstico firmado da doença articular, arrolando-se e analisando-se dados referentes a: espécie...

Medidas radiográficas relacionadas ao risco de ocorrência de osteoartrite do quadril; Radiographic measurements related to the risk of osteoarthritis of the hip

Barros, Hilton José Melo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 14/12/2009 PT
Relevância na Pesquisa
36.97%
O estudo busca determinar fatores predisponentes para osteoartrite do quadril, por meio da avaliação de parâmetros radiográficos nos quadris de indivíduos idosos. Foram realizadas medições em radiografias de 106 indivíduos com idade acima de 60 anos, sendo um grupo com osteoartrite do quadril e um segundo grupo de indivíduos sem osteoartrite (grupo controle). As incidências radiográficas utilizadas foram ântero-posterior da pelve em ortostase, falso perfil de Lequesne e Dunn a 45 graus de flexão do quadril. Após aplicação de critérios de seleção bem definidos para osteoartrite primária do quadril, o número de quadris avaliados foi 112 quadris de indivíduos normais e 72 quadris de indivíduos com osteoartrite. Os parâmetros radiográficos estudados foram ângulo centro-borda de Wiberg, ângulo de Tönnis, índice acetabular de profundidade por diâmetro, percentual de cobertura da cabeça do fêmur, ângulo colo-diafisário, ângulo centro-borda anterior, offset entre a cabeça e o colo do fêmur, ângulo alfa, esfericidade da cabeça do fêmur e versão do acetábulo. As medidas radiográficas ângulo colo-diafisário, ângulo alfa, índice acetabular de profundidade por diâmetro e percentual de cobertura da cabeça do fêmur apresentaram valores médios significativamente diferentes nos pacientes com osteoartrite primária...

Estudo da estimulação elétrica nervosa transcutânea (TENS) nível sensório para efeito de analgesia em pacientes com osteoartrose de joelho; Study of transcutaneous electrical nerve stimulation (TENS) for the sensory effect of analgesia in patients with knee osteoarthritis

Morgan, Charles Ricardo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 13/12/2010 PT
Relevância na Pesquisa
36.94%
INTRODUÇÃO: A osteoartrose de joelho (OAJ) é uma das patologias que mais afetam o aparelho locomotor e interferem de forma considerável nas atividades da vida diária, acometendo os indivíduos em faixa etária variável e em diversos graus e níveis de dor articular. As propostas terapêuticas são bastante diversificadas para a osteoartrose (OA), a terapia física, a TENS está para colaborar no tratamento dos pacientes com osteoartrose de joelho. OBJETIVOS: Devido à importância da articulação do joelho nas atividades locomotoras e sua relação com as atividades da vida diária. Os pacientes com osteoartrose de joelho sofrem não somente pelo problema localizado, existe uma alteração funcional global que pode levar a processos dolorosos em outras articulações. Para uma eficaz orientação e avaliação do paciente primeiro é necessário que este faça a descrição clara de sua dor para que o profissional perceba como que esse estímulo doloroso prejudica sua vida. O objetivo do presente estudo foi avaliar o efeito da estimulação elétrica nervosa transcutânea (sigla em inglês TENS) nível sensório para tratamento de dor em pacientes com diagnóstico de osteoartrose de joelho, utilizando escalas de avaliação de dor...

Manual for guided home exercises for osteoarthritis of the knee

Carvalho,Nilza Aparecida de Almeida; Bittar,Simoni Teixeira; Pinto,Flávia Ribeiro de Souza; Ferreira,Mônica; Sitta,Robson Roberto
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2010 EN
Relevância na Pesquisa
36.9%
INTRODUCTION: Physiotherapy is one of the most important components of therapy for osteoarthritis of the knee. The objective of this prospective case series was to assess the efficiency of a guidance manual for patients with osteoarthritis of the knee in relation to pain, range of movement , muscle strength and function, active goniometry, manual strength test and function. METHODS: Thirty-eight adults with osteoarthritis of the knee (> 45 years old) who were referred to the physiotherapy service at the university hospital (Santa Casa de Misericórdia de São Paulo) were studied. Patients received guidance for the practice of specific physical exercises and a manual with instructions on how to perform the exercises at home. They were evaluated for pain, range of movement, muscle strength and function. These evaluations were performed before they received the manual and three months later. Patients were seen monthly regarding improvements in their exercising abilities. RESULTS: The program was effective for improving muscle strength, controlling pain, maintaining range of movement of the knee joint, and reducing functional incapacity. DISCUSSION: A review of the literature showed that there are numerous clinical benefits to the regular practice of physical therapy exercises by patients with osteoarthritis of the knee(s) in a program with appropriate guidance. This study shows that this guidance can be attained at home with the use of a proper manual. CONCLUSIONS: Even when performed at home without constant supervision...

Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)

Guermazi, Ali; Niu, Jingbo; Hayashi, Daichi; Roemer, Frank W; Englund, Martin; Neogi, Tuhina; McLennan, Christine E; Felson, David T; Aliabadi, Piran
Fonte: BMJ Publishing Group Ltd. Publicador: BMJ Publishing Group Ltd.
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
36.97%
Objective: To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity. Design: Population based observational study. Setting: Community cohort in Framingham, MA, United States (Framingham osteoarthritis study). Participants: 710 people aged >50 who had no radiographic evidence of knee osteoarthritis (Kellgren-Lawrence grade 0) and who underwent MRI of the knee. Main outcome measures: Prevalence of MRI findings that are suggestive of knee osteoarthritis (osteophytes, cartilage damage, bone marrow lesions, subchondral cysts, meniscal lesions, synovitis, attrition, and ligamentous lesions) in all participants and after stratification by age, sex, body mass index (BMI), and the presence or absence of knee pain. Pain was assessed by three different questions and also by WOMAC questionnaire. Results: Of the 710 participants, 393 (55%) were women, 660 (93%) were white, and 206 (29%) had knee pain in the past month. The mean age was 62.3 years and mean BMI was 27.9. Prevalence of “any abnormality” was 89% (631/710) overall. Osteophytes were the most common abnormality among all participants (74%...

Association of Osteoarthritis with Perfluorooctanoate and Perfluorooctane Sulfonate in NHANES 2003–2008

Uhl, Sarah A.; James-Todd, Tamarra; Bell, Michelle D.
Fonte: National Institute of Environmental Health Sciences Publicador: National Institute of Environmental Health Sciences
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
36.97%
Background: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent, synthetic industrial chemicals. Perfluorinated compounds are linked to health impacts that may be relevant to osteoarthritis, cartilage repair, and inflammatory responses. Objectives: We investigated whether PFOA and PFOS exposures are associated with prevalence of osteoarthritis, and whether associations differ between men and women. Methods: We used multiple logistic regression to estimate associations between serum PFOA and PFOS concentrations and self-reported diagnosis of osteoarthritis in persons 20–84 years of age who participated in NHANES during 2003–2008. We adjusted for potential confounders including age, income, and race/ethnicity. Effects by sex were estimated using stratified models and interaction terms. Results: Those in the highest exposure quartile had higher odds of osteoarthritis compared with those in the lowest quartile [odds ratio (OR) for PFOA = 1.55; 95% CI: 0.99, 2.43; OR for PFOS = 1.77; 95% CI: 1.05, 2.96]. When stratifying by sex, we found positive associations for women, but not men. Women in the highest quartiles of PFOA and PFOS exposure had higher odds of osteoarthritis compared with those in the lowest quartiles (OR for PFOA = 1.98; 95% CI: 1.24...

Reactive Oxygen Species Mediate Lead Effects in the Genesis of Osteoarthritis

Holz, Jonathan D. ; Puzas, J. Edward
Fonte: Universidade de Rochester Publicador: Universidade de Rochester
Tipo: Tese de Doutorado
ENG
Relevância na Pesquisa
36.9%
Thesis (Ph.D.)--University of Rochester. School of Medicine and Dentistry. Dept. of Environmental Medicine, 2011.; Virtually all organ systems evaluated have proven susceptible to lead intoxication. Effects on the diarthrodial joint, however, remain an unexplored aspect of lead toxicity. Intriguingly, case-study analysis and experimental observations correlate lead exposure with joint pain and degeneration. The importance of exploring deleterious lead effects in the joint is bespoken by the magnitude and persistence of lead in the environment and the immense scope of degenerative joint diseases. Over the course of this project our goal has been to identify and describe lead effects on articular chondrocytes and the underlying mechanisms responsible for these effects. Examination of articular chondrocytes revealed that lead treatment resulted in an osteoarthritis-like phenotype. Caspase activity, type X collagen, MMPs, and oxygen consumption were all elevated while type 2 collagen was decreased. TGF-β signaling is requisite to the maintenance of normal articular chondrocyte phenotype. Interestingly, upon lead treatment TGF-β signaling intermediates, phosphoSmads2/3, were depressed and endogenous negative regulators, Smurf2 and ski...

Eine randomisierte, kontrollierte klinische Studie zur Wirksamkeit und Verträglichkeit eines standardisierten Weidenrindenextraktes in der Behandlung von Cox- und Gonarthrosen; A randomised controlled clinical trial of the efficacy and safety of a standardised willow bark extract in the treatment of osteoarthritis of the hip and the knee

Biegert, Claudia
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
Relevância na Pesquisa
36.9%
In der medikamentösen Behandlung von Arthrosen werden vor allem nichtsteroidale Antirheumatika (NSAR) und Analgetika eingesetzt. Als pflanzliches Arzneimittel zur Arthrosetherapie wird in Deutschland unter anderem Weidenrinde (WR) verwendet, die von der Kommission E des ehemaligen Bundesgesundheitsamtes für die Behandlung von rheumatischen Beschwerden, fieberhaften Erkrankungen und Kopfschmerzen befürwortet wurde. Ergebnisse aus mehreren klinischen Studien deuten auf eine analgetische Wirksamkeit von WR-Extrakt. Von Schmid et al. wurde eine placebo-kontrollierte klinische Studie mit stationären Arthrosepatienten über 14 Tage durchgeführt. Ziel der vorliegenden Studie war die Untersuchung der Wirksamkeit von WR-Extrakt gegenüber Placebo und Standardmedikation (Diclofenac) bei ambulanten Patienten über 6 Wochen. Vorbereitend zur klinischen Studie wurden Äquivalenzuntersuchungen des WR-Präparates der vorliegenden Studie und der Studie von Schmid sowie eines marktüblichen WR-Präparates (Assplant®) durchgeführt. Die Präparate zeigten eine gute Übereinstimmung in Bezug auf den Gesamtsalicingehalt (15,0% für den Extrakt der vorliegenden Studie, 14,9% für den Extrakt von Schmid und 15,2% für den Extrakt in Assplant®) und die Zerfallszeit (42 min für das vorliegende Studienpräparat...

Clinical profile, level of affection and therapeutic management of patients with osteoarthritis in primary care: the spanish multicenter study EVALÚA

Castaño Carou, Ana; Pita-Fernández, Salvador; Pértega Díaz, Sonia; Toro Santos, Francisco Javier de
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.99%
[Abstract] Objective. To determine the clinical profile, degree of involvement and management in patients with knee, hip or hand osteoarthritis. Methods. Observational study (health centres from 14 autonomous regions, n = 363 primary care physicians), involving patients with clinical and/or radiological criteria from the American College of Rheumatology, consecutively selected (n = 1258). Sociodemographic variables, clinical and radiological findings, comorbidity and therapeutic management were analysed. Results. Mean age was 68.0 ± 9.5 years old; 77.8% were women and 47.6% obese. Distribution by location was 84.3% knee, 23.4% hip, and 14.7% hands. All patients reported pain. The most frequent radiographic Kellgren-Lawrence grade was stage III for knee and hip (42.9% and 51.9%, respectively), and III (37.2%) and II (34.5%) for hip. Time since onset of osteoarthritis symptoms was 9.4 ± 7.5 years, with a mean age at onset of around 60 years and a family history of osteoarthritis in 66.0%. The most frequent comorbidities were hypertension (55.1%), depression/anxiety (24.7%) and gastroduodenal diseases (22.9%). A total of 97.6% of the patients received pharmacological treatment, with oral analgesics (paracetamol) (70.5%) and oral NSAIDs (67.9%) being the most frequent drugs. Bilateral osteoarthritis was present in 76.9% of the patients with knee osteoarthritis...

THE EFFECTS OF ALTERNATIVE JOINT MODELS IN THE STUDY OF LOWER-LIMB JOINT MOMENTS IN KNEE OSTEOARTHRITIS

Brandon, Scott
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado Formato: 1741234 bytes; application/pdf
EN; EN
Relevância na Pesquisa
36.9%
Knee osteoarthritis is a disease that affects nearly 40% of the global population over the age of seventy. It is believed that the incidence and progression of osteoarthritis can be partially attributed to changes in mechanical joint loading. Consequently, changes in lower-limb joint moments are important outcome measures for its treatment and prevention. The purpose of this study was to investigate the effect of four different anatomic joint models on the detection of changes in lower-limb joint moments due to knee osteoarthritis. Moments during gait were calculated for 44 subjects with moderate osteoarthritis and 44 asymptomatic subjects, then expressed using four joint models: Joint Coordinate System, Plane of Progression, Distal, and Proximal. Discrete peak measures and principal component scores were compared between groups. Hip adduction magnitude, knee adduction magnitude, peak early-stance knee internal rotation, and peak ankle plantarflexion moments were different between groups regardless of joint model. Differences detected using principal component analysis were less sensitive to the choice of joint model. Results support adoption of the Joint Coordinate System as a standard for joint moment expression due to its clinical relevance and ability to detect differences due to moderate knee osteoarthritis.; Thesis (Master...

The association of anthropometric measures and osteoarthritis knee in non-obese subjects: a cross sectional study

Sanghi,Divya; Srivastava,Rajeshwar Nath; Singh,Ajai; Kumari,Reema; Mishra,Rachna; Mishra,Abhishek
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2011 EN
Relevância na Pesquisa
36.99%
OBJECTIVE: Body mass index (BMI) and knee osteoarthritis have a strong association, but other anthropometric measures lack such associations. To date, no study has evaluated non-obese knee osteoarthritis to negate the systemic and metabolic effects of obesity. This study examines the validity of the contention that BMI and other anthropometric measures have a significant relationship with knee osteoarthritis. METHODS: In total, 180 subjects with a diagnosis of knee osteoarthritis were recruited and classified according to Kellgren-Lawrence (KL) grades. Body mass index, mid-upper arm circumference, waist-hip ratio and triceps-skinfold thickness were recorded by standard procedures. Osteoarthritis outcome scores (WOMAC) were evaluated. RESULTS: (1) In both genders, the BMI was significantly higher for KL grade 4 than for grade 2; triceps-skinfold thickness was positively correlated with the joint space width of the tibial medial compartment. (2) In males, triceps-skinfold thickness significantly increased as the KL grades moved from 2 to 4; the significantly higher BMI found in varus aligned knees was positively correlated with WOMAC scores. (3) In females, the waist-hip ratio was significantly higher for KL grade 4 than for grade 2; a significant correlation was found between BMI and WOMAC scores. The waist-hip ratio was significantly associated with varus aligned knees and it positively correlated with WOMAC scores and with the joint space width of the tibial medial compartment. The mid-upper arm circumference demonstrated no correlation with knee osteoarthritis. CONCLUS'ON: This study validates the contention that BMI and other anthropometric measures have a significant association with knee osteoarthritis. Contrary to common belief...

Impacto do grau de obesidade nos sintomas e na capacidade funcional de mulheres com osteoartrite de joelhos; Impact of the degree of obesity on symptoms and functional capacity of women with knee osteoarthritis

Vasconcelos, Karina Simone de Souza; Dias, Marcos Domingues; Dias, Rosângela Correa
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2008 POR
Relevância na Pesquisa
36.94%
As mulheres apresentam risco aumentado para a osteoartrite (OA) de joelhos e obesidade. Associadas, essas doenças podem gerar dor e prejuízos funcionais, principalmente em atividades de locomoção. Este estudo visou comparar o impacto do grau de obesidade nos sintomas e capacidade funcional de mulheres com OA de joelhos. Foram selecionadas 13 mulheres obesas (com índice de massa corporal - IMC>;30 kg/m²) e 15 com obesidade mórbida (IMC>;40 kg/m²), todas com OA bilateral de joelhos. Os sintomas de dor, rigidez e dificuldades funcionais foram avaliados pelo questionário The Western Ontario and McMaster Osteoarthritis Index (Womac). A capacidade funcional foi verificada por quatro testes de velocidade: marcha usual, marcha rápida, subir e descer escadas. Os dois grupos apresentaram um impacto moderado da obesidade na OA de joelhos, sem diferença quanto aos sintomas. As obesas se saíram melhor do que as obesas mórbidas nos testes de marcha usual e subir escadas, mas não nas atividades de marcha rápida e descer escadas, mais complexas e estressantes para a articulação do joelho. Conclui-se que o grau de obesidade não teve impacto nos sintomas de dor, rigidez e dificuldades funcionais associadas à OA de joelhos entre mulheres obesas e obesas mórbidas. E...

Efeitos da craniopuntura de Yamamoto na osteoartrite de joelho: estudo de caso; The Yamamoto scalp acupuncture effects in knee osteoarthritis: a case study

Silva, Lorine da; Taxoto, Alda Nerys; Montalvão, Elaine Meque; Marques, Amélia Pasqual; Alfredo, Patrícia Pereira
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/09/2011 POR
Relevância na Pesquisa
36.94%
O objetivo deste estudo foi verificar os efeitos da craniopuntura de Yamamoto na dor, na amplitude de movimento, qualidade de vida e funcionalidade de paciente com osteoartrite (OA) de joelho. Foi realizado um estudo de caso de uma paciente de 59 anos apresentando quadro de dor no joelho, redução funcional nos últimos três meses e radiografia constando o grau 3 de OA de joelhos. A avaliação foi feita antes e após o tratamento através da Escala Visual Analógica (EVA) para avaliação da dor, da qualidade de vida pelo questionário Western Ontario and McMaster Universities Osteoarthritis (WOMAC), da funcionalidade pelo Knee injury and Osteoarthritis Outcome Score (KOOS) e da amplitude de movimento do joelho pela goniometria. A craniopuntura foi realizada duas vezes por semana, com duração de 40 minutos cada, totalizando 10 sessões. A análise dos dados foi feita de forma descritiva. A variável utilizada foi o ganho relativo (GR) medido no pré e no pós-tratamento. A dor no joelho diminuiu (GR=100%), enquanto a amplitude de movimento aumentou em ambos os joelhos (GR=20%). Observou-se melhora na dor (GR=83%), na rigidez (GR=50%), na função (GR=80%) e no escore total da WOMAC (GR= 79%). Verificou-se, através da KOOS, melhora nos sintomas (GR=8%)...

The association of anthropometric measures and osteoarthritis knee in non-obese subjects: a cross sectional study

Sanghi, Divya; Srivastava, Rajeshwar Nath; Singh, Ajai; Kumari, Reema; Mishra, Rachna; Mishra, Abhishek
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2011 ENG
Relevância na Pesquisa
36.99%
OBJECTIVE: Body mass index (BMI) and knee osteoarthritis have a strong association, but other anthropometric measures lack such associations. To date, no study has evaluated non-obese knee osteoarthritis to negate the systemic and metabolic effects of obesity. This study examines the validity of the contention that BMI and other anthropometric measures have a significant relationship with knee osteoarthritis. METHODS: In total, 180 subjects with a diagnosis of knee osteoarthritis were recruited and classified according to Kellgren-Lawrence (KL) grades. Body mass index, mid-upper arm circumference, waist-hip ratio and triceps-skinfold thickness were recorded by standard procedures. Osteoarthritis outcome scores (WOMAC) were evaluated. RESULTS: (1) In both genders, the BMI was significantly higher for KL grade 4 than for grade 2; triceps-skinfold thickness was positively correlated with the joint space width of the tibial medial compartment. (2) In males, triceps-skinfold thickness significantly increased as the KL grades moved from 2 to 4; the significantly higher BMI found in varus aligned knees was positively correlated with WOMAC scores. (3) In females, the waist-hip ratio was significantly higher for KL grade 4 than for grade 2; a significant correlation was found between BMI and WOMAC scores. The waist-hip ratio was significantly associated with varus aligned knees and it positively correlated with WOMAC scores and with the joint space width of the tibial medial compartment. The mid-upper arm circumference demonstrated no correlation with knee osteoarthritis. CONCLUS'ON: This study validates the contention that BMI and other anthropometric measures have a significant association with knee osteoarthritis. Contrary to common belief...

Relação entre exame clínico e radiográfico no diagnóstico da osteoartrite equina; Relationship between clinical and radiography examination for equine osteoarthritis diagnosis

Baccarin, Raquel Yvonne Arantes; Moraes, Ana Paula Lopes de; Veiga, Ana Carolina Rocha; Fernandes, Wilson Roberto; Amaku, Marcos; Silva, Luis Claudio Lopes Correira da; Hagen, Stefano Carlo Filippo
Fonte: Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia Publicador: Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 03/09/2012 POR
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A doença articular, especificamente osteoartrite, é uma das afecções mais prevalentes e debilitantes que acometem os equinos atletas. Apesar dos avanços tecnológicos nas últimas décadas, os exames clínico e radiográfico ainda são os meios mais comumente utilizados para o diagnóstico da osteoartrite equina. Neste estudo foram compilados e confrontados dados clínicos de 2872 equinos. Foram avaliados 146 casos de osteoartrite e analisadas radiograficamente 259 articulações com osteoartrite, para verificar quanto o exame radiográfico é condizente com o exame físico, e relacionar alterações clínicas com a modalidade de atividade física executada pelos cavalos. Pode-se constatar que a osteoartrite interfalangeana e metacarpo/metatarso falangeana (dígito) quando exibe alterações radiográficas faz com que os cavalos sejam mais propensos a claudicar, comparativamente a outros que também apresentam osteoartrite evidenciada radiograficamente, porém na articulação do tarso. Contudo, os escores radiográficos não correlacionaram a imagem radiográfica com a presença ou não de claudicação. A modalidade de atividade física não interferiu na frequência dos sinais clínicos de osteoartrite. Os equinos que mais apresentaram osteoartrite possuíam idade média de 8...

Equine osteoarthritis: A Comparison of type 1 and type 2 conditions

Chadbourne, Wendy
Fonte: Rochester Instituto de Tecnologia Publicador: Rochester Instituto de Tecnologia
Tipo: Tese de Doutorado
EN_US
Relevância na Pesquisa
36.94%
In what originally began as research to answer my own questions about osteoarthritis, I learned as much as I could from reading anatomy, veterinary, and physiology books. I had to look in many places to find all the answers I wanted. The books that provided the best visual information lacked text to explain the images, and the books that provided the best text definitions usually provided simplified illustrations or very confusing clinical photographs. While trying to unite the best images with the best text explaining what was going on, an idea was formed. I decided to combine clear images with clear descriptions, comparing the two most common types of osteoarthritis found in horses, types 1 and 2. 1 wanted to design a system that could be used in veterinarians' offices to explain osteoarthritis to a client in a manner that was understandable as well as informative. The equine limb is an amazingly complex structure. It allows a thousand pound animal to run at speeds of up to 45 miles an hour, jump over six foot obstacles and sleep while standing. However, this marvel of evolution has come at a cost. The cost is a strict definition of the work expected of the limb. Horses do not have the ability nor the desire to partake in bed rest or stay off an injured limb. With this in mind...

Evaluation of interlimb symmetry in individuals with knee osteoarthritis during gait

Richardson, R. Tyler
Fonte: University of Delaware Publicador: University of Delaware
Tipo: Tese de Doutorado
Relevância na Pesquisa
36.97%
Higginson, Jill S.; Knee osteoarthritis is a degenerative joint disease and is one of the leading causes of disability in the United States. While the etiology is not fully understood, mechanics have been implicated in the disease initiation and progression. Previous research has found that individuals with knee osteoarthritis exhibit abnormal kinematic and kinetic gait patterns. These studies, however, have focused on the symptomatic limb in comparison with healthy individuals leaving the mechanics of the contralateral limb largely unknown. Furthermore, there has been evidence suggesting that alterations on the symptomatic limb may result in an increased risk of osteoarthritis on the contralateral limb. The objective of this study was to investigate the mechanics of the contralateral limb and associated symmetry of individuals with knee osteoarthritis during gait. Seventeen subjects with knee osteoarthritis were evaluated. Three-dimensional motion capture data was collected as each subject walked at self-selected speed on an instrumented split-belt treadmill. The symptomatic limb was selected as each subject???s self-described more painful knee and was verified radiographically to possess more severe osteoarthritis than the contralateral knee. Kinematic and kinetic analysis focused on sagittal plane knee motion during initial contact and early stance...