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A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria

Baraniuk, James N; Adewuyi, Oluwatoyin; Merck, Samantha Jean; Ali, Mushtaq; Ravindran, Murugan K; Timbol, Christian R; Rayhan, Rakib; Zheng, Yin; Le, Uyenphuong; Esteitie, Rania; Petrie, Kristina N
Fonte: e-Century Publishing Corporation Publicador: e-Century Publishing Corporation
Tipo: Artigo de Revista Científica
Publicado em 21/01/2013 EN
Relevância na Pesquisa
25.8%
Background: Chronic Fatigue Syndrome case designation criteria are scored as physicians’ subjective, nominal interpretations of patient fatigue, pain (headaches, myalgia, arthralgia, sore throat and lymph nodes), cognitive dysfunction, sleep and exertional exhaustion. Methods: Subjects self-reported symptoms using an anchored ordinal scale of 0 (no symptom), 1 (trivial complaints), 2 (mild), 3 (moderate), and 4 (severe). Fatigue of 3 or 4 distinguished “Fatigued” from “Not Fatigued” subjects. The sum of the 8(Sum8) ancillary criteria was tested as a proxy for fatigue. All subjects had history and physical examinations to exclude medical fatigue, and ensure categorization as healthy or CFS subjects. Results: Fatigued subjects were divided into CFS with ≥4 symptoms or Chronic Idiopathic Fatigue (CIF) with ≤3 symptoms. ROC of Sum8 for CFS and Not Fatigued subjects generated a threshold of 14 (specificity=0.934; sensitivity=0.928). CFS (n=256) and CIF (n=55) criteria were refined to include Sum8≥14 and ≤13, respectively. Not Fatigued subjects had highly skewed Sum8 responses. Healthy Controls (HC; n=269) were defined by fatigue≤2 and Sum8≤13. Those with Sum8≥14 were defined as CFS–Like With Insufficient Fatigue Syndrome (CFSLWIFS; n=20). Sum8 and Fatigue were highly correlated (R2=0.977; Cronbach’s alpha=0.924) indicating an intimate relationship between symptom constructs. Cluster analysis suggested 4 clades each in CFS and HC. Translational utility was inferred from the clustering of proteomics from cerebrospinal fluid. Conclusions: Plotting Fatigue severity versus Sum8 produced an internally consistent classifying system. This is a necessary step for translating symptom profiles into fatigue phenotypes and their pathophysiological mechanisms.

O sistema de classificação nominal Akwe-Xerente (Jê): âmbitos de análise; The system of classification Akwe-Xerente:scope of analysis

SIQUEIRA, Kênia Mara de Freitas
Fonte: Universidade Federal de Goiás; BR; UFG; Doutorado em Letras e Linguistica; Linguistica, Letras e Artes Publicador: Universidade Federal de Goiás; BR; UFG; Doutorado em Letras e Linguistica; Linguistica, Letras e Artes
Tipo: Tese de Doutorado Formato: application/pdf
POR
Relevância na Pesquisa
76.56%
The need to describe and document the languages threatened with extinction has been gaining importance in the last decades, given the growing risks of cultural loss and the knowledge accumulated by indigenous people. The purpose of continuity of each one of these languages is ensured by actions based on the results of studies which focus on the description of the sociolinguistic problem, as well as on the description and analysis of the linguistic aspects which characterize the language of a determined linguistic family, since the death of a language means, among many other things, an undetermined loss of the science of Linguistics and, above all, the disrespect for the rights of these people to preserve their immaterial richness. The present research has as objective to answer some questions regarding the use of classifiers, terms of classes and names in classifying function as components of the classifying system of the language Akwe-Xerente (Jê), spoken by the indigenous people of the same name. The Akwe-Xerente add up to about 3,100 people and inhabit indigenous lands in the region of Tocantinia, in the Tocantins State. The description of the system of the Xerente classification is based on theoretical functional references for the recognition and differentiation of some nominal radicals which may occur in the function of classifying or organizing the classes which show common characteristics amongst the designated items such as form...

Estudo morfológico e sintático da língua mundurukú (tupí)

Gomes, Dioney Moreira
Fonte: Universidade de Brasília Publicador: Universidade de Brasília
Tipo: Tese
PT_BR
Relevância na Pesquisa
26.08%
Tese(doutorado)—Universidade de Brasília, Instituto de Letras, Departamento de Linguística, Português e Línguas Classicas, Programa de Pós-Graduação em Linguística, 2006.; Esta tese aborda aspectos da morfologia e da sintaxe da língua Mundurukú (Tupí). No capítulo 1, apresentamos os marcadores pessoais e os prefixos relacionais, os primeiros de natureza clítica e os segundos sem caráter pessoal. O entendimento desses dois fenômenos é importante para compreender o restante das análises aqui feitas, uma vez que há tanto classes de palavras que ocorrem com eles (verbos, nomes e posposições), quanto classes que não os tomam (pronomes, advérbios, palavras interrogativas, conjunções e partículas). O capítulo 2 é dedicado ao verbo e mostra suas principais características morfossintáticas a partir da distinção de suas subclasses e da análise de sua morfologia flexional e derivacional. O capítulo 3 é reservado aos nomes e posposições, duas classes que compartilham marcação pessoal e flexão relacional. As demais classes e sua morfossintaxe são apresentadas no capítulo 4, que traz os pronomes, os advérbios, as palavras interrogativas, as conjunções e as partículas. Os pronomes foram divididos em três subclasses: os pessoais...