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Predição lateralizatória da avaliação neuropsicológica de memória em pacientes com epilepsia associada à esclerose mesial temporal; Lateralizing prediction of neuropsychological memory testing in patients with epilepsy associated with mesial temporal sclerosis

Silva, Liliane Cristina de Alem-mar e
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 12/08/2011 PT
Relevância na Pesquisa
36.53%
A avaliação neuropsicológica é instrumento auxiliar para lateralização em epilepsia temporal (ET). Desempenho comprometido em memória verbal (MV) e não verbal (MNV) sugeririam, respectivamente, disfunção no sistema de memória do hemisfério dominante e não dominante. Não há consenso sobre a capacidade lateralizatória da avaliação de memória em pacientes com epilepsia. Estudou-se o poder lateralizatório da avaliação neuropsicológica em testes de memória verbal e não verbal em ET secundária a esclerose mesial temporal (EMT) unilateral. Comparamos o desempenho em memória verbal (RAVLT e o Memória Lógica) e não verbal (RVDLT e a figura complexa de Rey) em 87 pacientes destros com EMT (44 direita, 43 esquerda) e 42 controles. Pacientes e controles tinham escolaridade>8 anos, QI>70, sem comorbidades. Pacientes com EMTE tiveram desempenho rebaixado comparado a controles e EMTD em evocação livre e tardia do RAVLT. EMTE e EMTD tiveram desempenho rebaixado em relação a controles em evocação livre e tardia em Memória Lógica. EMTD tiveram desempenho rebaixado em relação a controles em evocação tardia da figura complexa de Rey. Observou-se baixa prevalência de dificuldade em ambos tipos de memória em ambos os grupos. Quando considerado acometimento de específico de MV observou-se associação com EMTE...

Relação entre funções cognitivas e perdas adquiridas na visão de cores de pacientes com esclerose múltipla tipo remitente recorrente; Relationship between cognitive functions and acquired color vision loss in patients with relapsing-remitting type of multiple sclerosis

Teixeira, Rosaní Aparecida Antunes
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 12/09/2012 PT
Relevância na Pesquisa
46.51%
A Esclerose Múltipla (EM) é uma doença inflamatória autoimune caracterizada por desmielinização e degeneração do sistema nervoso central (SNC) duas a três vezes mais frequente em mulheres. A etiologia da EM é dividida em dois subtipos principais: o tipo remitente-recorrente (EMRR) mais comum, caracterizado por dois ou mais episódios de agravamento dos sintomas que envolvem diferentes locais do SNC, separados por pelo menos 1 mês e remisão dos sintomas e o tipo progressivo é a forma menos comum, caracterizada por um contínuo agravamento dos sintomas desde o início geralmente sem recaídas claras ou remissões. A presente pesquisa teve por objetivo avaliar o comprometimento da visão de cores e de sua relação com perdas de atenção, memória visual imediata, memória visual tardia, memória operacional e funções executivas dos portadores de esclerose múltipla tipo remitente recorrente. Método: participaram 41 pacientes com esclerose múltipla de idades entre 20 e 58 anos (35,4±12,2) e 37 controles com idade (34,7±12,1) e escolaridade semelhante. A discriminação de cores foi avaliada com o Cambridge Colour Test (CCT) e a avaliação de funções neuropsicológicas foram utilizados subtestes da bateria Cambridge Neuropsychological Testing Automated Battery (CANTAB) - Pattern Recognition Memory...

Neuropsychological predictors of the outcome in non-demented subjects with cognitive complaints

Silva, Dina Lúcia Gomes da, 1981-
Fonte: Universidade de Lisboa Publicador: Universidade de Lisboa
Tipo: Tese de Doutorado
Publicado em //2012 ENG
Relevância na Pesquisa
36.44%
Tese de doutoramento, Ciências Biomédicas (Neurociências), Universidade de Lisboa, Faculdade de Medicina, 2012; Nowadays, life expectancy has increased and gradually the prevalence of neurodegenerative disorders in the aging population began to represent a major public health problem. Alzheimer’s disease (AD) is the most common dementia and affects millions of older adults. Despite recent advances in the knowledge of AD biomarkers of pathophysiological processes, clearly the phenotype remains aetiologically heterogeneous. Understanding the clinical phenotype variation contingent to the neuropathological progression is crucial to provide intervention in the earliest phases of neurodegeneration. Newly research biomarkers have been proposed for early diagnosis of AD, however cognitive impairment remains a prominent and early feature of AD. Neuropsychological markers could offer a relatively inexpensive and noninvasive indicator of future progression to dementia because biological markers are expensive, some of them only available at few specialized centers, and, in the case of lumbar puncture, invasive. Therefore, it would not be reasonable to offer the newer and expensive biomarker techniques to all patients with cognitive complaints. Importantly...

Memory lost, memory regained: neuropsychological findings and neuroimaging in two cases of paraneoplastic limbic encephalitis with radically different outcomes

Bak, T; Antoun, N; Balan, K; Hodges, J
Fonte: BMJ Group Publicador: BMJ Group
Tipo: Artigo de Revista Científica
Publicado em /07/2001 EN
Relevância na Pesquisa
36.4%
OBJECTIVE—To report two cases of paraneoplastic limbic encephalitis (PNLE) with similar clinical presentation, but dramatically different outcome and to highlight the role of neuropsychological and radiological evaluation in PNLE.
METHODS—Both patients underwent an extensive battery of neuropsychological tests designed to document general intellectual function, anterograde verbal and visual memory, naming, knowledge and executive ability. In addition, structural (CT and MRI) and functional (HMPAO-SPECT) brain scans were performed.
RESULTS—Both patients presented with fairly sudden onset of profound and persistent memory loss in the absence of other neurological symptoms. Their subsequently diagnosed small cell lung cancer was treated with a combination of radiotherapy and chemotherapy, leading to remission of the tumour. The memory of patient 1 recovered fully and he died from an unrelated cause 1 year later; neuropsychological testing showed a severe, but isolated, anterograde amnesia, brain MRI was normal and HMPAO-SPECT showed left medial temporal hypoperfusion. Patient 2 remained densely amnesic despite regression of her lung tumour; neuropsychological testing disclosed both anterograde and extensive retrograde amnesia together with more generalised cognitive deficits including anomia and executive impairments...

Neuropsychological effects and attitudes in patients following electroconvulsive therapy

Feliu, Miriam; Edwards, Christopher L; Sudhakar, Shiv; McDougald, Camela; Raynor, Renee; Johnson, Stephanie; Byrd, Goldie; Whitfield, Keith; Jonassaint, Charles; Romero, Heather; Edwards, Lekisha; Wellington, Chante’; Hill, LaBarron K; Sollers, James; L
Fonte: Dove Medical Press Publicador: Dove Medical Press
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.42%
The current study examined the effects of electroconvulsive therapy (ECT) on neuropsychological test performance. Forty-six patients completed brief neuropsychological and psychological testing before and after receiving ECT for the treatment of recalcitrant and severe depression. Neuropsychological testing consisted of the Levin Selective Reminding Test (Levin) and Wechsler Memory Scale-Revised Edition (WMS-R). Self-report measures included the Beck Depression Inventory (BDI), the Short-Term Memory Questionnaire (STMQ), and several other measures of emotional functioning and patient attitudes toward ECT. The mean number of days between pre-ECT and post-ECT testing was 24. T-test revealed a significant decrease in subjective ratings of depression as rated by the BDI, t(45) = 9.82, P < 0.0001 (Pre-BDI = 27.9 ± 20.2; post-BDI = 13.5 ± 9.7). Objective ratings of memory appeared impaired following treatment, and patients’ self-report measures of memory confirmed this decline. More specifically, repeated measures MANOVA [Wilks Lambda F(11,30) = 4.3, p < 0.001] indicated significant decreases for measures of immediate recognition memory (p < 0.005), long-term storage (p < 0.05), delayed prose passage recall (p < 0.0001), percent retained of prose passages (p < 0.0001)...

Neuropsychological testing and biomarkers in the management of brain metastases

Baschnagel, Andrew; Wolters, Pamela L; Camphausen, Kevin
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 17/09/2008 EN
Relevância na Pesquisa
46.29%
Prognosis for patients with brain metastasis remains poor. Whole brain radiation therapy is the conventional treatment option; it can improve neurological symptoms, prevent and improve tumor associated neurocognitive decline, and prevents death from neurologic causes. In addition to whole brain radiation therapy, stereotactic radiosurgery, neurosurgery and chemotherapy also are used in the management of brain metastases. Radiosensitizers are now currently being investigated as potential treatment options. All of these treatment modalities carry a risk of central nervous system (CNS) toxicity that can lead to neurocognitive impairment in long term survivors. Neuropsychological testing and biomarkers are potential ways of measuring and better understanding CNS toxicity. These tools may help optimize current therapies and develop new treatments for these patients. This article will review the current management of brain metastases, summarize the data on the CNS effects associated with brain metastases and whole brain radiation therapy in these patients, discuss the use of neuropsychological tests as outcome measures in clinical trials evaluating treatments for brain metastases, and give an overview of the potential of biomarker development in brain metastases research.

Oculomotor and Neuropsychological Effects of Antipsychotic Treatment for Schizophrenia

Hill, S. Kristian; Reilly, James L.; Harris, Margret S. H.; Khine, Tin; Sweeney, John A.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.43%
Cognitive enhancement has become an important target for drug therapies in schizophrenia. Treatment development in this area requires assessment approaches that are sensitive to procognitive effects of antipsychotic and adjunctive treatments. Ideally, new treatments will have translational characteristics for parallel human and animal research. Previous studies of antipsychotic effects on cognition have relied primarily on paper-and-pencil neuropsychological testing. No study has directly compared neurophysiological biomarkers and neuropsychological testing as strategies for assessing cognitive effects of antipsychotic treatment early in the course of schizophrenia. Antipsychotic-naive patients with schizophrenia were tested before treatment with risperidone and again 6 weeks later. Matched healthy participants were tested over a similar time period. Test-retest reliability, effect sizes of within-subject change, and multivariate/univariate analysis of variance were used to compare 3 neurophysiological tests (visually guided saccade, memory-guided saccade, and antisaccade) with neuropsychological tests covering 4 cognitive domains (executive function, attention, memory, and manual motor function). While both measurement approaches showed robust neurocognitive impairments in patients prior to risperidone treatment...

Interpreter-Mediated Neuropsychological Testing of Monolingual Spanish Speakers

Casas, Rachel; Guzmán-Vélez, Edmarie; Cardona-Rodriguez, Javier; Rodriguez, Nayra; Quiñones, Gabriela; Juan, San; Izaguirre, Borja; Tranel, Daniel
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
46.29%
The primary objective of this study was to investigate empirically whether using an interpreter to conduct neuropsychological testing of monolingual Spanish speakers affects test scores. Participants included 40 neurologically normal Spanish-speakers with limited English proficiency, ages 18–65 years (M= 39.7, SD =13.9), who completed the Vocabulary, Similarities, Block Design, and Matrix Reasoning subtests of the Wechsler Adult Intelligence Scale-III in two counterbalanced conditions: with and without an interpreter. Results indicated that interpreter use significantly increased scores on Vocabulary and Similarities. However, scores on Block Design and Matrix Reasoning did not differ depending upon whether or not an interpreter was used. In addition, the findings suggested a trend toward higher variability in scores when an interpreter was used to administer Vocabulary and Similarities; this trend did not show up for Block Design or Matrix Reasoning. Together, the results indicate that interpreter use may significantly affect scores for some tests commonly used in neuropsychological practice, with this influence being greater for verbally mediated tests. Additional research is needed to identify the types of tests that may be most affected as well as the factors that contribute to the effects. In the meantime...

Neuropsychological Symptoms of Juvenile-Onset Batten Disease: Experiences From 2 Studies

Adams, Heather R.; Kwon, Jennifer; Marshall, Frederick J.; de Blieck, Elisabeth A.; Pearce, David A.; Mink, Jonathan W.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /05/2007 EN
Relevância na Pesquisa
36.37%
Juvenile neuronal ceroid lipofuscinosis (Batten disease) is a progressive and fatal autosomal-recessive inherited lysosomal storage disorder of childhood. Core symptoms include vision loss, seizures, and mental and motor decline. This article presents data from 2 studies of neuropsychological function in juvenile neuronal ceroid lipofuscinosis. In the first cross-sectional pilot study, 15 children with genetic or clinicopathologic confirmation of juvenile neuronal ceroid lipofuscinosis completed a brief test of attention (mean age = 14.3 ± 2.9 years, range = 8.75-18.74 years; 7 males, 8 females). Average attention performances were significantly below age-expected normative data. A second longitudinal study was then initiated to study neuropsychological function in greater depth, including change in function over time. The authors have enrolled 18 children to date (mean age = 12.88 ± 3.59 years, range = 6.26-18.65; 11 males, 7 females). Of these, 5 children have completed a second (annual) re-evaluation. Results thus far indicate significant impairment in domains of auditory attention, memory, estimated verbal intellectual function, and verbal fluency. Neuropsychological impairment was significantly correlated with disease duration and with motor function as assessed by a disease-specific clinical neurologic rating scale. There was no significant difference between males and females in neuropsychological test performance. Neuropsychological function was worse among children with a positive seizure history. Juvenile neuronal ceroid lipofuscinosis–affected children exhibited significant and pervasive impairments on tests of auditory attention...

Improvement of Neuropsychological Function in Cognitively Impaired Multiple Sclerosis Patients Treated with Natalizumab: A Preliminary Study

Edwards, Keith R.; Goodman, William A.; Ma, Carl Y.
Fonte: The Consortium of Multiple Sclerosis Centers Publicador: The Consortium of Multiple Sclerosis Centers
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
36.37%
Treatment with natalizumab has been shown to reduce physical disability in people with multiple sclerosis (MS). However, its effect on neuropsychological dysfunction is not well understood. A single-center, open-label, retrospective study was conducted to evaluate the effect of natalizumab treatment on neuropsychological function in individuals with relapsing-remitting multiple sclerosis (RRMS) who had a measurable neuropsychological deficit prior to natalizumab treatment. A total of 40 MS patients (mean age, 48.5 years; 77.5% female) were evaluated on a neuropsychological battery of nine tests designed for MS patients before and after 6 or more months of treatment with natalizumab. Posttreatment neuropsychological testing results were compared to baseline results. The mean baseline Neuropsychological Impairment Index was 0.49, which improved to 0.41 after treatment (P = .0002) as analyzed using the Wilcoxon signed rank test. The mean Beck Depression Inventory–II (BDI-II) score improved by 2.45 points (P = .001). The mean Expanded Disability Status Scale (EDSS) score improved by 0.30 (P = .02). A total of 52.5% of patients showed neuropsychological improvement, while 30.0% showed no change and 17.5% had worsening. Magnetic resonance imaging showed no changes. The specific prior disease-modifying therapy had no influence on the results for natalizumab effect. The results of this study show that natalizumab can stabilize or improve neuropsychological function in RRMS patients. The improvement was consistent with...

Long-Term Neuropsychological Sequelae in HIV-Seronegative Cryptococcal Meningoencephalitis Patients with and without Ventriculoperitoneal Shunts: A Cine MRI Study

Chen, Meng-Hsiang; Lu, Cheng-Hsien; Wang, Hung-Chen; Chen, Hsiu-Ling; Tsai, Nai-Wen; Li, Shau-Hsuan; Hsu, Nai-Wen; Lin, Wei-Ming; Kung, Chia-Te; Lin, Wei-Che
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.33%
Background. Hydrocephalus in cryptococcal meningoencephalitis is most commonly managed with a ventriculoperitoneal shunt. This study applied cine magnetic resonance imaging (MRI) to evaluate initial disease severity on long-term cerebrospinal fluid (CSF) flow dynamics and associated neuropsychological sequelae in cryptococcal meningoencephalitis patients with and without ventriculoperitoneal shunts. Methods. Eighteen human immunodeficiency virus-seronegative cryptococcal meningoencephalitis patients (10 with shunts versus 8 without shunts) were compared with 32 age- and sex-matched healthy volunteers. All subjects underwent complete neurologic examination and neuropsychological testing. Cine MRI was conducted to evaluate CSF flow parameters. Initial CSF laboratory analysis and imaging findings were correlated with present CSF flow parameters and neuropsychological scores. Results. Patients without shunts had higher average flow than controls, suggesting chronic hydrocephalus. Initial Evans ratios and CSF glucose levels were associated with CSF peak velocity and flow. Worsening CSF flow parameters correlated with decreased neuropsychological performance. Conclusions. CSF flow parameter differences between the cryptococcal meningoencephalitis patients both with and without ventriculoperitoneal shunts could be detected by cine MRI and correlated with acute stage disease severity and chronic stage neuropsychological results. Cine MRI is useful for assessing the chronic hydrocephalus that may lead to neuropsychological deficits in cryptococcal meningoencephalitis patients.

Teleneuropsychology: Evidence for Video Teleconference-Based Neuropsychological Assessment

Cullum, C. Munro; Hynan, L.S.; Grosch, M.; Parikh, M.; Weiner, M.F.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.4%
The use of videoconference technology to deliver health care diagnostics and treatment continues to grow at a rapid pace. Telepsychiatry and telepsychology applications are well-accepted by patients and providers, and both diagnostic and treatment outcomes have generally been similar to traditional face-to-face interactions. Preliminary applications of videoconference-based neuropsychological assessment (teleneuropsychology) have yielded promising results in the feasibility and reliability of several standard tests, although large-scale studies are lacking. This investigation was conducted to determine the reliability of video teleconference (VTC) - based neuropsychological assessment using a brief battery of standard neuropsychological tests commonly used in the evaluation of known or suspected dementia. Tests included the Mini-Mental State Examination (MMSE), Hopkins Verbal Learning Test-Revised, Digit Span forward and backward, short form Boston Naming Test, Letter and Category Fluency, and Clock Drawing. Tests were administered via VTC and in-person to subjects, counterbalanced using alternate test forms and standard instructions. Two hundred two adult subjects were tested in both rural and urban settings, including 83 with cognitive impairment and 119 healthy controls. We found highly similar results across VTC and in-person conditions...

Predictors and indicators of academic outcome in children 2 years following traumatic brain injury.

Kinsella, G.; Prior, M.; Sawyer, M.; Ong, B.; Murtagh, D.; Eisenmajer, R.; Bryan, D.; Anderson, V.; Klug, G.
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Artigo de Revista Científica
Publicado em //1997 EN
Relevância na Pesquisa
36.43%
Within the context of a longitudinal study investigating outcome for children following traumatic brain injury, this paper reports on the utility of neuropsychological testing in predicting academic outcome in children 2 years following traumatic brain injury (TBI). Twenty-nine school-age children who were admitted to hospital after TBI were assessed with a battery of neuropsychological and academic measures at 3 and 24 months postinjury. The neuropsychological battery included measures of memory, learning, and speed of information processing. Academic outcome was assessed in terms of post-TBI change in school placement. According to logistic regression analysis, change in placement from regular to special education at 2 years post-TBI was predicted by injury severity and by neuropsychological performance at 3 months post-TBI. Findings suggest that neuropsychological testing is useful in identifying children with special educational needs subsequent to TBI.

Neuropsychological deficit and academic performance in children and adolescents following traumatic brain injury

Kinsella, G.; Prior, M.; Sawyer, M.; Murtagh, D.; Eisenmajer, R.; Anderson, V.; Bryan, D.; Klug, G.
Fonte: Blackwell Science Publicador: Blackwell Science
Tipo: Artigo de Revista Científica
Publicado em //1995 EN
Relevância na Pesquisa
56.6%
Evaluated the utility of neuropsychological testing in predicting academic outcome in children 1 year following traumatic brain injury (TBI). Fifty-one schoolage children who were admitted to hospital after TBI were assessed with a battery of neuropsychological measures at 3 months postinjury. Academic achievement was assessed at 3 and 12 months postinjury. The neuropsychological battery included intelligence testing and measures of memory, learning, and speed of information processing. Academic outcome was assessed in terms of post-TBI changes in reading, spelling, and arithmetic; changes in teacher ratings of school performance; and change in school placement. According to logistic regression analysis, change in placement from regular to special education at 1-year post-TBI was predicted by injury severity and by neuropsychological performance at 3 months post-TBI. Findings suggest that neuropsychological testing is useful in identifying children with special educational needs subsequent to TBI.

Vergleich von subjektiven Urteilen und objektiven neuropsychologischen Leistungsparametern bei Patienten mit einer Depression; Comparison of subjective estimations and objective neuropsychological test performance among patients with depression

Kringler, Wolfgang
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
Relevância na Pesquisa
36.43%
Depressive Patienten klagen häufig über erhebliche kognitive Beeinträchtigungen, vor allem der neuropsychologischen Basisleistungen Aufmerksamkeit, Gedächtnis und Exekutivfunktionen. Demgegenüber sind die Befunde in der Literatur über die objektiven Testleistungen nicht immer einheitlich, sie reichen bei leichten bis mittelschweren Depressiven von keinen bis relevanten kognitiven Defiziten. Das Ziel der vorliegenden Untersuchung war, objektive neuropsychologische Testparameter sowie das jeweilige subjektive Urteil und klinisch-psychologische Fragebogenprofile der depressiven Probanden und der Kontrollpersonen miteinander zu vergleichen. Insgesamt wurden 34 depressive Patienten und 30 Personen der Kontrollgruppe in diese Untersuchung einbezogen und die Daten statistisch geprüft. Das besondere Merkmal dieser Untersuchung war, unmittelbar während des Untersuchungsablaufs die Probanden jeweils um ihre konkrete subjektive Einschätzung in Bezug auf die jeweilige Testdurchführung zu bitten. Bisher wurden zur Untersuchung subjektiver Urteile überwiegend Fragebögen eingesetzt. Diese waren jedoch in der Regel von der konkreten Untersuchungssituation zeitlich losgelöst und inhaltlich nicht immer auf die Testparameter bezogen. Die Ergebnisse zeigen eine systematische subjektive Unterschätzung der depressiven Patienten ihrer objektiv nur gering eingeschränkten neuropsychologischen Leistungsparameter. In Bezug auf ihre subjektiven Einschätzungen unterschieden sich die beiden Gruppen durchweg statistisch signifikant und inhaltlich bedeutsam. Die Teilnehmer der depressiven Gruppe schätzen ihre kognitive Leistungsfähigkeit in der konkreten Untersuchungssituation sowohl vorab...

Value of neuropsychological testing after head injuries in football

McCrory, P; Makdissi, M; Davis, G; Collie, A
Fonte: BMJ Group Publicador: BMJ Group
Tipo: Artigo de Revista Científica
Publicado em /08/2005 EN
Relevância na Pesquisa
46.51%
This paper reviews the pros and cons of the traditional paper and pencil and the newer computerised neuropsychological tests in the management of sports concussion. The differences between diagnosing concussion on the field and neuropsychological assessment at follow up and decision making with regard to return to play are described. The authors also discuss the issues involved in interpreting the results of neuropsychological testing (comparison with population norms versus player's own baseline test results) and potential problems of such testing in football. Finally, suggested recommendations for neuropsychological testing in football are given.

The Relation between Inflammation and Neuropsychological Test Performance

Balldin, Valerie H.; Hall, James R.; Barber, Robert C.; Hynan, Linda; Diaz-Arrastia, Ramon; O'Bryant, Sid E.
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
36.31%
Background. Considerable research documents an association between pro- and anti-inflammatory markers and Alzheimer's disease (AD), yet the differential relation between these markers and neuropsychological functioning in AD and nondemented controls has received less attention. The current study sought to evaluate the relationship between peripheral markers of inflammation (both pro- and anti-inflammatory) and neuropsychological functioning through the Texas Alzheimer's Research and Care Consortium (TARCC) cohort. Methods. There were 320 participants (Probable AD n = 124, Controls n = 196) in the TARCC Longitudinal Research Cohort available for analysis. Regression analyses were utilized to examine the relation between proinflammatory and anti-inflammatory markers and neuropsychological functioning. Follow-up analyses were conducted separately by case versus control status. Results. Proinflammatory and anti-inflammatory markers were found to be associated with neuropsychological testing. Third tertile proinflammatory markers were negatively associated with measures of attention and language, and anti-inflammatory markers were positively associated with measures of immediate verbal memory and delayed verbal and visual memory. Conclusions. These findings support the link between peripheral inflammatory markers and neuropsychological functioning and suggest the utility of examining profiles of inflammatory markers in the future.

Combining PET Images and Neuropsychological Test Data for Automatic Diagnosis of Alzheimer's Disease

Segovia, Fermín; Bastin, Christine; Salmon, Eric; Górriz, Juan Manuel; Ramírez, Javier; Phillips, Christophe
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 13/02/2014 EN
Relevância na Pesquisa
36.43%
In recent years, several approaches to develop computer aided diagnosis (CAD) systems for dementia have been proposed. Some of these systems analyze neurological brain images by means of machine learning algorithms in order to find the patterns that characterize the disorder, and a few combine several imaging modalities to improve the diagnostic accuracy. However, they usually do not use neuropsychological testing data in that analysis. The purpose of this work is to measure the advantages of using not only neuroimages as data source in CAD systems for dementia but also neuropsychological scores. To this aim, we compared the accuracy rates achieved by systems that use neuropsychological scores beside the imaging data in the classification step and systems that use only one of these data sources. In order to address the small sample size problem and facilitate the data combination, a dimensionality reduction step (implemented using three different algorithms) was also applied on the imaging data. After each image is summarized in a reduced set of image features, the data sources were combined and classified using three different data combination approaches and a Support Vector Machine classifier. That way, by testing different dimensionality reduction methods and several data combination approaches...

Combining PET Images and Neuropsychological Test Data for Automatic Diagnosis of Alzheimer's Disease

Segovia Rom??n, Ferm??n; Bastin, Christine; Salmon, Eric; G??rriz S??ez, Juan Manuel; Ram??rez P??rez de Inestrosa, Javier; Phillips, Christophe
Fonte: Public Library of Science (PLOS) Publicador: Public Library of Science (PLOS)
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
56.52%
In recent years, several approaches to develop computer aided diagnosis (CAD) systems for dementia have been proposed. Some of these systems analyze neurological brain images by means of machine learning algorithms in order to find the patterns that characterize the disorder, and a few combine several imaging modalities to improve the diagnostic accuracy. However, they usually do not use neuropsychological testing data in that analysis. The purpose of this work is to measure the advantages of using not only neuroimages as data source in CAD systems for dementia but also neuropsychological scores. To this aim, we compared the accuracy rates achieved by systems that use neuropsychological scores beside the imaging data in the classification step and systems that use only one of these data sources. In order to address the small sample size problem and facilitate the data combination, a dimensionality reduction step (implemented using three different algorithms) was also applied on the imaging data. After each image is summarized in a reduced set of image features, the data sources were combined and classified using three different data combination approaches and a Support Vector Machine classifier. That way, by testing different dimensionality reduction methods and several data combination approaches...

Balance and neuropsychological performance following an acute bout of soccer heading

Gilliam, Mary
Fonte: University of Delaware Publicador: University of Delaware
Tipo: Tese de Doutorado
Relevância na Pesquisa
36.36%
Kaminski, Thomas W.; Context: Evidence illustrates a cumulative effect of multiple concussions or mild traumatic brain injuries. Research on the effect of an acute bout of soccer heading on brain function is not conclusive. Objective: To identify the effect of an acute bout of soccer heading on neuropsychological function and balance in athletes with a history of multiple concussions. Participants: Twenty-four NCAA Division I and III, and intramural athletes with a minimum of 4 years of competitive soccer experience composing 4 groups: subjects with a self-reported history of 1-2 concussions (EXP1), subjects with a self-reported history of 3 or more concussions (EXP2), and subjects with a self-reported history of 0 concussions randomly assigned to a control group (CON) and experimental group (EXP0). Intervention(s): During baseline testing, participants completed the ImPACT test, the Balance Error Score System (BESS), and the concussion symptom checklist (CSC). During session two, subjects repeated the baseline testing, and then completed 20 purposeful headers in 20 minutes. Immediately, participants repeated the ImPACT test, BESS test, and the CSC. Main Outcome Measure(s): Neuropsychological function as measured by the (ImPACT), balance deficiencies (BESS test)...