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Avaliação do consumo de etanol e tabaco e dos hábitos alimentares como fatores preditivos para o desenvolvimento de câncer de esôfago em pacientes portadores de neoplasia primária de cabeça e pescoço; Evaluation of ethanol consumption, tobacco smoking and dietary habits as predictive factors for the development of esophageal cancer in patients with primary tumors in the head and neck

Rossini, Alessandra Rita Asayama Lopes
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 26/04/2007 PT
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35.92%
O carcinoma espinocelular é o principal tipo histológico de neoplasia esofágica, com o pico de incidência ocorrendo na 6ª década de vida, o que sugere a ação prolongada de agente(s) carcinogênico(s) do ambiente externo como fator etiológico. A associação entre câncer de cabeça e pescoço e esôfago é conhecida de longa data, ocorrendo em 2 a 36% dos pacientes, com risco relativo 10 a 30 vezes maior comparado ao da população em geral. Uma das hipóteses sobre a ocorrência de tumores malignos múltiplos baseia-se na teoria da cancerização de área (field cancerization) descrita por Slaughter et al. em 1953, a qual explica a ação de fatores causais atuando em conjunto sobre o trato aerodigestivo e originando a carcinogênese. No Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brasil, foi realizado um estudo retrospectivo com a finalidade de examinar pacientes portadores de neoplasia primária de cabeça e pescoço quanto a: prevalência de câncer esofágico, consumo de etanol, tabaco e hábitos alimentares como fatores de risco. No período de dezembro de 1995 a outubro de 2000, 326 pacientes com neoplasia primária de cabeça e pescoço foram avaliados clínica e endoscopicamente com auxílio de corante (cromoendoscopia com lugol). Foram detectados 36 casos de câncer esofágico (prevalência: 11...

Uso da solução de Lugol para a detecção de segundos tumores primários de boca e orofaringe em portadores de carcinoma epidermóide na cabeça e pescoço: correlação dos achados na histopatologia com a imunoexpressão do p53 e metalotioneína; Using the Lugols solution for detection of seconds primary tumors of oral and oropharyngeal in patients with head and neck squamous cell carcinoma: correlation of histopathology findings with immunohistochemical p53 expression and metallothionein.

Simões, Cesar Augusto
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 27/05/2009 PT
Relevância na Pesquisa
45.81%
O diagnóstico precoce dos Segundos Tumores Primários (STP) em pacientes já tratados por um carcinoma de cabeça e pescoço deve ser realizado, pois possibilita um tratamento resolutivo com baixa morbidade. O objetivo deste trabalho é avaliar se a cromoscopia com Lugol permite uma melhora na identificação de lesões malignas ou pré malignas em fases iniciais na boca e orofaringe, bem como se a imunoexpressão do p53 e da Metalotioneína no tumor índice predizem o aparecimento de um STP. Foi realizado um estudo prospectivo onde dois grupos comparáveis de portadores de carcinoma epidermóide de cabeça e pescoço foram formados (um com 106 pacientes e outro com 105 pacientes). Foram acompanhados durante um período médio de 25 meses aproximadamente. No primeiro grupo (grupo A) não foram utilizados corantes, já no segundo (grupo B) utilizou-se o Lugol. Foi observado um número de diagnósticos 200% maior no grupo em que foi utilizada a coloração de Lugol (grupo B) em relação ao grupo A. A imunoexpressão aumentada do p53 no tumor índice foi estatisticamente significante quando o paciente desenvolveu um segundo tumor primário diagnosticado pelo Lugol, não visível sem o corante, o que não ocorreu com a metalotioneína.; The early diagnosis of seconds primary tumors (STP) in patients already treated for carcinoma of the head and neck should be done...

A importância da tríplice endoscopia no diagnóstico de neoplasias primárias múltiplas em pacientes com carcinoma epidermóide de vias aerodigestivas superiores; Importance of triple endoscopy in the diagnosis of multiple primary tumors in patients with upper aerodigestive tract squamous cell carcinoma

Priante, Antonio Vitor Martins
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 12/03/2010 PT
Relevância na Pesquisa
55.93%
INTRODUÇÃO: Pacientes com carcinomas das vias aerodigestivas superiores (VADS) apresentam um alto risco de desenvolver outros cânceres tanto simultaneamente quanto subsequentemente. A maioria destes tumores ocorre nas VADS, pulmões ou esôfago. A tríplice endoscopia (laringoscopia, endoscopia digestiva alta e broncoscopia) possibilita o diagnostico de lesões precursoras e de tumores invasivos. No entanto, a maioria dos estudos limita-se a descrever a frequência de diagnósticos, mas não os resultados do tratamento e o impacto na sobrevida. OBJETIVOS: Avaliar a importância da tríplice endoscopia para o diagnóstico de neoplasias primárias múltiplas e as diferenças no estadiamento e nas taxas de sobrevida de pacientes com carcinoma epidermóide de VADS. Caracterizar o perfil e analisar fatores de risco para neoplasias primárias múltiplas. MÉTODOS: Trata-se de estudo caso-controle retrospectivo em que foram incluídos pacientes com carcinoma epidermóide de VADS, submetidos à tríplice endoscopia antes do início do tratamento (grupo tríplice endoscopia), pareados, por sexo, idade e localização, estádio clínico e tratamento do tumor primário, com pacientes não submetidos à tríplice endoscopia na avaliação inicial (grupo controle). RESULTADOS: Foram incluídos 135 pacientes em cada grupo. No grupo tríplice endoscopia ocorreram mais diagnósticos de segundo tumor primário (STP)...

Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract

RIBEIRO Jr.,Ulysses; CECCONELLO,Ivan; SAFATLE-RIBEIRO,Adriana Vaz; ZILBERSTEIN,Bruno; PINOTTI,Henrique Walter
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/1999 EN
Relevância na Pesquisa
56%
Squamous cell carcinoma of the esophagus is frequently associated with other, synchronous or metachronous tumors, in the upper aerodigestive tract. All 264 patients with squamous cell carcinoma of the esophagus, treated in the Gastrointestinal Surgery, Esophagus section, of the "Hospital das Clínicas" (São Paulo University Medical School, Brazil), between 1979 and 1989 were analyzed retrospectively with regards to the occurrence of multiple primary tumors in the upper aerodigestive tract. Multiple primary tumors were encountered in 10 (3.8%) patients. All patients were male and the mean age at the time of the first primary was 52.2 years. Tobacco smoke and alcohol were the principal carcinogens in these patients (n = 10). The sites of the tumors were: larynx (n = 4), tongue (n = 4), lung (n = 2), and oral cavity (n = 1). Two simultaneous, three synchronous and five metachronous multiple primary carcinomas were detected. The esophagus was the second primary tumor in nine patients. The mean overall survival after the diagnosis of the second primary was 2.8 months (SD = 0.89). Inquiry regarding other malignancies, associated with panendoscopy should be carry out prior to the treatment of the first primary to diagnose simultaneous or synchronous primary tumors...

Second primary neoplasms in patients with retinoblastoma.

Draper, G. J.; Sanders, B. M.; Kingston, J. E.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /05/1986 EN
Relevância na Pesquisa
46.19%
In a series of 882 retinoblastoma patients, 384 known to have the genetic form of the disease and 498 others, 30 patients developed second primary neoplasms. The spectrum of these second neoplasms is discussed in relation to the forms of treatment used for the retinoblastoma. Cumulative incidence rates of second tumours in the whole series are 2.0% at 12 years after diagnosis and 4.2% after 18 years. For patients with the genetic form of retinoblastoma the cumulative incidence rate after 18 years is 8.4% for all second neoplasms and 6.0% for osteosarcomas alone. The inherent risk among survivors from genetic retinoblastoma of developing an osteosarcoma, excluding all possible effects of treatment, is estimated to be 2.2% after 18 years. Within the field of radiation treatment the cumulative incidence rate for all second neoplasms after 18 years is 6.6% and for osteosarcomas alone 3.7%. There is some evidence that patients with genetic retinoblastoma are particularly sensitive to the carcinogenic effects of radiation. The results also suggest that the use of cyclophosphamide may increase the risk of second primary neoplasms in patients with genetic retinoblastoma. The incidence rates of second primary neoplasms in retinoblastoma survivors reported here are lower than those quoted for previously published series. Evidence from this and other papers strongly suggests an association between retinoblastoma and malignant melanoma.

Second primary malignancies in patients with male breast cancer

Hemminki, K; Scélo, G; Boffetta, P; Mellemkjaer, L; Tracey, E; Andersen, A; Brewster, D H; Pukkala, E; McBride, M; Kliewer, E V; Chia, K-S; Pompe-Kirn, V; Martos, C; Jonasson, J G; Li, X; Brennan, P
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
46.01%
An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, 1.35–12.7), rectum (1.78, 1.20–2.54), pancreas (1.93, 1.14–3.05), skin (nonmelanoma, 1.65, 1.16–2.29), prostate (1.61, 1.34–1.93) and lymphohaematopoietic system (1.63, 1.12–2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after lymphohaematopoietic neoplasms. BRCA2 (and to some extent BRCA1) mutations may explain the findings for pancreatic and prostate cancers. Increases at other sites may be related to unknown factors or to chance. This large study shows that the risks for second discordant tumours after male breast cancer pose only a moderate excess risk.

Second primary oral melanoma: A rare presentation

Nayak, Meghanand T; Singh, Anjali; Mathur, RM; Wadhwani, Puneet
Fonte: Medknow Publications & Media Pvt Ltd Publicador: Medknow Publications & Media Pvt Ltd
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
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46.04%
Melanomas are neoplasms of melanocytic origin. They are aggressive neoplasms with an unpredictable behavior, and can involve virtually any organ of the body. Oral melanomas are very rare and have an extremely poor prognosis. Early diagnosis and prompt treatment is the key to reduce the morbidity and mortality. A second primary tumor is a new primary tumor developing in a person with a history of tumor, in a new site or tissue and subsequent to the initial tumor. Patients with previous history of melanoma are associated with a higher risk of developing second primaries. A case of second primary oral melanoma in a 55-year-old female is reported here. The anachronistic presentation of the primary and the second primary lesions make this case clinically interesting. Noteworthy immunohistochemical findings were recorded, HMB-45 positive and S-100 negative.

Null Association Between Histology of First and Second Primary Malignancies in Men With Bilateral Testicular Germ Cell Tumors

Thomas, Jennifer Phay Johnson; Davis-Dao, Carol; Lewinger, Juan Pablo; Siegmund, Kimberly D.; Hamilton, Ann S.; Daneshmand, Siamak; Skinner, Eila C.; Thomas, Duncan C.; Cortessis, Victoria K.
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
EN
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45.87%
Testicular germ cell tumors (TGCTs), the most common neoplasms of young men, are categorized histologically as either seminomas or nonseminomas/mixed germ cell tumors. These subtypes differ by age at diagnosis and clinical course, but little is known about etiological distinctions. To test the hypothesis that histological subtypes have distinct sets of unrecognized etiological factors, we used a recently described approach, estimating the association between histological types of first and second tumors of men with 2 primary TGCTs. The study population of 488 men each with 2 primary TGCTs was ascertained through population-based cancer registries in the United States between 1972 and 2006. Univariate logistic regression analysis revealed that the histology of second primary TGCTs was associated with the histology of first TGCTs (odds ratio = 1.70, 95% confidence interval: 1.14, 2.52); however, the association did not persist in analyses adjusted for age at diagnosis of first TGCT (odds ratio = 1.09, 95% confidence interval: 0.71, 1.70). These results would be expected if the subtypes share etiology but experience different rates of progression to diagnosis or if the histological fate of TGCTs is influenced by age-related processes. Men with 2 primary TGCTs provide novel opportunities to learn whether histological subtypes are likely to share etiology...

Metachronous Multiple Primary Malignant Neoplasms of the Stomach and the Breast: Report of Two Cases With Review of Literature

Karthikeyan, Vilvapathy Senguttuvan; Sistla, Sarath Chandra; Srinivasan, Ramachandran; Basu, Debdatta; Panicker, Lakshmi C.; Ali, Sheik Manwar; Rajkumar, Nagarajan
Fonte: The International College of Surgeons, World Federation of General Surgeons and Surgical Specialists, Inc. Publicador: The International College of Surgeons, World Federation of General Surgeons and Surgical Specialists, Inc.
Tipo: Artigo de Revista Científica
Publicado em //2014 EN
Relevância na Pesquisa
36.09%
Multiple primary malignant neoplasm is the occurrence of a second primary malignancy in the same patient within 6 months of the detection of first primary (synchronous), or 6 months or more after primary detection (metachronous). Multiple primary malignant neoplasms are not very frequently encountered in clinical practice. The relative risk for a second primary malignancy increases by 1.111-fold every month from the detection of the first primary malignancy in any individual. We present 2 patients treated for carcinoma of the breast who developed a metachronous primary malignancy in the stomach to highlight the rare occurrence of multiple primary malignant neoplasms. These tumors were histologically dissimilar, with distinct immunohistochemical parameters. The importance lies in carefully identifying the second primary malignancies, not dismissing them as metastases, and treating them accordingly.

Solid Tumor Second Primary Neoplasms: Who is at Risk, What Can We Do?

Oeffinger, Kevin C.; Baxi, Shrujal S.; Friedman, Danielle Novetsky; Moskowitz, Chaya S.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /12/2013 EN
Relevância na Pesquisa
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Eighteen percent of incident malignancies in the U.S. are a second (or subsequent) cancer. Second primary neoplasms (SPN), particularly solid tumors, are a major cause of mortality and serious morbidity among cancer survivors successfully cured of their first cancer. Multiple etiologies may lead to a cancer survivor subsequently being diagnosed with an SPN, including radiotherapy for the first cancer, unhealthy lifestyle behaviors, germline and somatic mutations, aging, or an interaction between any of these factors. In this article, we discuss these factors and synthesize this information for use in clinical practice, including preventive strategies and screening recommendations for SPNs.

A recommendation for the management of lesions of unknown malignancy in multiple primary malignant neoplasm patients: A case report

XIA, XIANGYU; CUI, KAIJUN
Fonte: D.A. Spandidos Publicador: D.A. Spandidos
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
35.88%
In numerous patients with multiple primary malignant neoplasms, it is difficult to determine whether the mass is benign or malignant, and the method to treat these lesions is controversial. For patients with a history of cancer, a point of high-risk for the development of a second primary tumor occurs following a 10-year gap. To the best of our knowledge, to date, there has been no large clinical trial to observe the appropriate method to manage the lesions in patients with multiple primary malignant neoplasms. The present study reports the case of a patient who was initially diagnosed with rectal cancer, treated with Dixon’s rectectomy and post-operative chemotherapy. The patient’s disease was evaluated as complete response following these treatments. However, the patient then presented with bladder cancer and underwent transurethral resection of the bladder tumor, again achieving a complete response. The patient more recently presented with hepatocellular carcinoma, which developed from an unexplained mass in the liver. The patient underwent partial liver resection and to date, has achieved a complete response. The management of masses of unknown malignancy is also discussed. The current case provides useful insight for future research in this field.

Risk of second primary cancer following prostate cancer radiotherapy: DVH analysis using the competitive risk model

Takam, R.; Bezak, E.; Yeoh, E.
Fonte: IOP Publishing Ltd Publicador: IOP Publishing Ltd
Tipo: Artigo de Revista Científica
Publicado em //2009 EN
Relevância na Pesquisa
76.02%
This study aimed to estimate the risk of developing second primary cancer (SPC) corresponding to various radiation treatment techniques for prostate cancer. Estimation of SPC was done by analysing differential dose–volume histograms (DDVH) of normal tissues such as rectum, bladder and urethra with the competitive risk model. Differential DVHs were obtained from treatment planning systems for external beam radiotherapy (EBRT), low-dose-rate (LDR) and high-dose-rate (HDR) brachytherapy techniques. The average risk of developing SPC was no greater than 0.6% for all treatment techniques but was lower with either LDR or HDR brachytherapy alone compared with any EBRT technique. For LDR and HDR brachytherapy alone, the risk of SPC for the rectum was 2.0 × 10−4% and 8.3 × 10−5% respectively compared with 0.2% for EBRT using five-field 3D-CRT to a total dose of 74 Gy. Overall, the risk of developing SPC for urethra following all radiation treatment techniques was very low compared with the rectum and bladder. Treatment plans which deliver equivalent doses of around 3–5 Gy to normal tissues were associated with higher risks of development of SPC.; R. Takam, E. Bezak and E. E. Yeoh

Die Bedeutung der Panendoskopie für die Tumorausbreitungsdiagnostik bei Tumoren im Kiefer- und Gesichtsbereich; The significance of panendoscopy in staging of head and neck carcinomas

Ulrich, Bodo Cornelius Frieder
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
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45.9%
Abstract: Patienten mit Kopf-Hals-Malignomen weisen in Abhängigkeit von der Primärtumorlokalisation eine hohe Inzidenz an Zweitkarzinomen auf. Die Panendoskopie liefert hier Schlüsselinformationen zur Tumorausbreitungsdiagnostik und Therapieplanung. Die endoskopische Untersuchung des Tracheobronchialsystems, des Epi-, Meso- und Hypopharynx sowie des oberen Gastrointestinaltrakts ist an der Tübinger Klinik für Mund- Kiefer- und Gesichtschirurgie bei Mundhöhlenkarzinomen ein wesentlicher Bestandteil der präoperativen Diagnostik. Wir berichten über die Ergebnisse einer retrospektiven, katamnestischen Studie, in welcher bei 154 Patienten mit unbehandelten Karzinomen der Mundhöhle endoskopisch dargestellte und in einem standardisierten Untersuchungsprotokoll dokumentierte Befunde erhoben wurden. Mit Hilfe der Panendoskopie konnten insgesamt 13 Mehrfachkarzinome bei 12 (7,8%) der Untersuchten nachgewiesen werden, davon waren 41,7% synchron aufgetreten, 53,8% waren metachron. Die Malignome waren im Bereich des Ösophagus (n=6), des Magens (n=1), sowie des Hypopharynx (n=1), der Trachea (n=1) und der Lunge (n=4) festzustellen, bei einem Patienten lagen multiple Manifestationen vor. Die Überlebenszeit der Patienten mit Zweitkarzinom war deutlich geringer als die des übrigen Krankenguts. Der Nachweis eines Zweitkarzinoms nahm wesentlichen Einfluss auf das jeweilige Therapiekonzept. Der bei den untersuchten Patienten z. T. ausgeprägte Nikotin- und Alkoholabusus ist Ursache einer Vielzahl von entzündlicher Begleiterkrankungen im Tracheobronchialsystem und Gastrointestinaltrakt. So waren bei 27 Patienten (17...

Out-of-field neutron and leakage photon exposures and the associated risk of second cancers in high-energy photon radiotherapy: Current status

Takam, R.; Bezak, E.; Marcu, L.; Yeoh, E.
Fonte: Radiation Research Soc Publicador: Radiation Research Soc
Tipo: Artigo de Revista Científica
Publicado em //2011 EN
Relevância na Pesquisa
65.99%
Determination and understanding of out-of-field neutron and photon doses in accelerator-based radiotherapy is an important issue since linear accelerators operating at high energies (>10 MV) produce secondary radiations that irradiate parts of the patient's anatomy distal to the target region, potentially resulting in detrimental health effects. This paper provides a compilation of data (technical and clinical) reported in the literature on the measurement and Monte Carlo simulations of peripheral neutron and photon doses produced from high-energy medical linear accelerators and the reported risk and/or incidence of second primary cancer of tissues distal to the target volume. Information in the tables facilitates easier identification of (1) the various methods and measurement techniques used to determine the out-of-field neutron and photon radiations, (2) reported linac-dependent out-of-field doses, and (3) the risk/incidence of second cancers after radiotherapy due to classic and modern treatment methods. Regardless of the measurement technique and type of accelerator, the neutron dose equivalent per unit photon dose ranges from as low as 0.1 mSv/Gy to as high as 20.4 mSv/Gy. This radiation dose potentially contributes to the induction of second primary cancer in normal tissues outside the treated area.; R. Takam...

Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958–1996: a search for common mechanisms

Dong, C; Hemminki, K
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
Publicado em /09/2001 EN
Relevância na Pesquisa
45.84%
The Swedish Family-Cancer Database was used to analyse site-specific risk of second primary malignancies following 53 159 haematolymphoproliferative disorders (HLPD) diagnosed between 1958 and 1996. Standardized incidence ratio (SIR) of a second malignancy was calculated as the ratio of observed to expected numbers of second malignancies by applying site-, sex-, age-, period-, residence- and occupation-specific rates in the corresponding population in the Database to the appropriate person-years at risk. Among 18 960 patients with non-Hodgkin's lymphoma (NHL), there was over a 3-fold significant increase in cancer of the tongue, small intestine, nose, kidney and nervous system, squamous cell carcinoma (SCC) of the skin, NHL, Hodgkin's disease (HD) and lymphoid and myeloid leukaemia. Among 5353 patients with HD, there was over a 4-fold significant increase in cancer of the salivary glands, nasopharynx and thyroid, NHL and myeloid leukaemia, and over a 1.6-fold increase in cancer of the stomach, colon, lung, breast, skin (melanoma and SCC), nervous system and soft tissues and lymphoid leukaemia. Among 28 846 patients with myeloma and leukaemia, there was a significant increase in cancer of the skin, nervous system and non-thyroid endocrine glands and all HLPD except for myeloma. Our findings showed some clustering between first and second primaries among Epstein–Barr virus-...

Second primary neoplasms following non-Hodgkin's lymphoma in New South Wales, Australia

Brennan, P; Coates, M; Armstrong, B; Colin, D; Boffetta, P
Fonte: Nature Publishing Group Publicador: Nature Publishing Group
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
46.02%
The incidence of non-Hodgkin's lymphoma (NHL) has been increasing rapidly over the last three decades. The reasons for this trend are not known although increasing exposure to sunlight has been postulated. We used data from the New South Wales Central Cancer Registry to analyse second primary neoplasms following NHL diagnosed between 1972 and 1995, to identify possible common causal agents. A total of 12 452 patients contributed 54 308 person-years of follow-up during which time there were 705 second primary neoplasms compared to 592.99 expected (standardized incidence ratio (SIR = 1.19, 95% confidence interval (CI) 1.10–1.28). There were excesses of melanomas of skin (SIR = 2.38, 95% CI 1.92–2.91), lip cancer (SIR = 2.74, 95% CI 1.59–4.38), tongue cancer (SIR = 2.53, 95% CI 1.09–4.99) and bladder cancer (SIR = 1.64, 95% CI 1.19–2.21). There was also over a threefold excess in soft tissue sarcomas (SIR = 3.61, 95% CI 1.80–6.45) and in thyroid cancer (SIR = 3.42, 95% CI 1.56–6.49). The SIR for myeloid leukaemia was 0.78 (95% CI 0.28–1.69). The increases in melanoma of the skin and cancer of the lip and tongue among patients with NHL strongly suggest sunlight exposure as a shared causal agent. The increase in soft tissue sarcomas might be due to shared effects of exposure to chemicals such as phenoxy acid herbicides. The increases in bladder and thyroid cancers are likely to be explained by effects of treatment for NHL. We did not find a chemotherapy related increased risk of myeloid leukaemia among NHL patients. © 2000 Cancer Research Campaign

Patterns of multiple primary tumours in patients treated for cancer during childhood.

Kingston, J. E.; Hawkins, M. M.; Draper, G. J.; Marsden, H. B.; Kinnier Wilson, L. M.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /09/1987 EN
Relevância na Pesquisa
36.03%
One hundred and sixty one children who have developed more than one primary neoplasm have been identified. Children with tumours of the central nervous system, retinoblastoma and leukaemia were those most frequently observed to develop a second malignancy whilst osteosarcoma was the most common second tumour. The patterns of second neoplasms appear to be changing and a recent increase in the number of children with leukaemia and lymphoma who develop second primary tumours has been observed. In this series, the two most frequent associations of tumours were retinoblastoma followed by osteosarcoma and the combination of acute leukaemia with a tumour of the central nervous system. Genetic factors which may have contributed to the development of the second primary tumour were identified in 53 patients (33%), 33 of whom had the genetic form of retinoblastoma. In an analysis of the treatment of 151 patients, for whom the interval between the two neoplasms was greater than 12 months, the second malignancy was considered to be 'radiation associated' in 93 (61%). Fifty children (33%) had been treated with either single or multiple agent chemotherapy which included an alkylating agent in 38. Forty five children had received a combination of chemotherapy and radiotherapy and of these...

Concomitant detection of hematological neoplasm and carcinoma: report on seven cases

Lira,Mariana Montenegro de Melo; Moreira,Luciana Regina; Ruano,Thais; Quintal,Maísa Momesso; Martins,Rita de Cássia Perina; Silva,Annacarolina Fabiana Lúcia da; Soares,Fernando Augusto; Vassallo,José
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/07/2008 EN
Relevância na Pesquisa
35.91%
CONTEXT: The presence of multiple neoplasms in one patient is an uncommon event. Its occurrence ranges from 1.2% to 4.5% of cancer patients in autopsy and clinical studies. In the present article, cases of synchronous diagnoses of carcinoma and lymphoid neoplasms are reported. The intention of this report was to alert clinicians and pathologists to the possibility of the existence of concomitant neoplasms, in order to prevent inaccurate or delayed diagnosis and staging. CASES:Seven patients (four female and three male) with a median age of 61.4 years were diagnosed as having concomitant epithelial and hematological neoplasms. DISCUSSION AND CONCLUSION: Lymph nodes should be carefully examined when searching for metastases, because of the possibility of a second hematological malignancy. Whenever uncommon suspicious morphological features are seen in such neoplasms, an immunohistochemical analysis is essential.

Diagnóstico de lesiones óseas con biopsia percutánea guiada por imágenes

Contreras O,Oscar; Burdiles O,Alvaro
Fonte: Sociedad Médica de Santiago Publicador: Sociedad Médica de Santiago
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2006 ES
Relevância na Pesquisa
45.83%
Background: Percutaneous biopsies have a good sensitivity and specificity for the diagnosis of bone lesions. Aim: To report the experience with 270 percutaneous bone lesions biopsies guided with fluoroscopy or computed tomography. Material and Methods: Retrospective review of the medical records of 270 patients (mean age 53.4 years, range 4 to 95 years; 134 female) subjected to a percutaneous biopsy of a bone lesion, guided either by computed tomography or fluoroscopy. The final analysis included the tumor type, tumor malignancy, tumor grade and complications of the procedure. Results: One hundred seventy nine lesions were malignant and 91 benign. Of the malignant lesions, 95 were metastatic and 84 were primary. In 3 cases, the initial diagnosis was a false negative (1.1%). Only one patient had a local hematoma after the procedure. Conclusions: Image guided percutaneous biopsy of bone lesions is a safe, effective, fast and economic procedure to obtain a pathological diagnosis of bone lesions

Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León

Muela Molinero,A.; Jorquera Plaza,F.; Ribas Ariño,T.; Malagón Rojo,R.; Espinel Díez,V.; Ballesteros del Río,B.; Olcoz Goñi,J. L.; Santos Calderón,J. A.
Fonte: Revista Española de Enfermedades Digestivas Publicador: Revista Española de Enfermedades Digestivas
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/12/2006 ENG
Relevância na Pesquisa
36.1%
Objectives: we analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN) in the Health District of León. Material and methods: using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002. A follow-up was performed until December 31, 2004, and the characteristics of patients diagnosed with a second neoplasm were analyzed. Results: MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives. The most frequent second neoplasms were digestive (26%) and urologic (21%); 87% of patients were diagnosed with a second neoplasm within the first two years. No significative differences in survival were observed among patients with synchronous or metachronous MMPN. Conclusions: MMPN in patients with gastric neoplasms is a relevant problem. While external carcinogenic agents could act as promoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development of MMPN. Secondary prevention is the best measure to avoid MMPN development.