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Correlation between voxel based morphometry and manual volumetry in magnetic resonance images of the human brain

UCHIDA, Ricardo R.; DEL-BEN, Cristina M.; ARAÚJO, David; BUSATTO-FILHO, Geraldo; DURAN, Fábio L.S.; CRIPPA, José A.S.; GRAEFF, Frederico G.
Fonte: Academia Brasileira de Ciências Publicador: Academia Brasileira de Ciências
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.75%
This is a comparative study between manual volumetry (MV) and voxel based morphometry (VBM) as methods of evaluating the volume of brain structures in magnetic resonance images. The volumes of the hippocampus and the amygdala of 16 panic disorder patients and 16 healthy controls measured through MV were correlated with the volumes of gray matter estimated by optimized modulated VBM. The chosen structures are composed almost exclusively of gray matter. Using a 4 mm Gaussian filter, statistically significant clusters were found bilaterally in the hippocampus and in the right amygdala in the statistical parametric map correlating with the respective manual volume. With the conventional 12 mm filter,a significant correlation was found only for the right hippocampus. Therefore,narrowfilters increase the sensitivity of the correlation procedure, especially when small brain structures are analyzed. The two techniques seem to consistently measure structural volume.; Trata-se de estudo comparativo entre a volumetria manual(VM) e a morfometria baseada no vóxel (MBV), como métodos de avaliação do volume de estruturas cerebrais. Os volumes do hipocampo e da amídala de 16 pacientes de pânico e 16 controles sadios medidos através da VM foram correlacionados com os volumes de matéria cinzenta estimados pela MBV.As estruturas escolhidas são constituídas quase exclusivamente de matéria cinzenta. Utilizando um filtro Gaussiano de 4 mm...

Morfometria e distribuição de leite alveolar e cisternal na glândula mamária de vacas Holandesa e Girolanda; Morphometry and cisternal and alveolar milk distribution in mammary gland of Holstein and Girolanda cows

PORCIONATO, M.A.F.; NEGRÃO, J.A.; PAIVA, F.A.
Fonte: Universidade Federal de Minas Gerais, Escola de Veterinária Publicador: Universidade Federal de Minas Gerais, Escola de Veterinária
Tipo: Artigo de Revista Científica
POR
Relevância na Pesquisa
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Estudaram-se a distribuição do leite nas porções alveolar e cisternal e a morfometria da glândula mamária de 14 vacas, sete da raça Holandesa, grupo H, e sete da Girolanda, grupo G, com ordem e dias de lactação semelhantes, ordenhadas duas vezes ao dia. A produção de leite foi mensurada diariamente, enquanto as frações de leite cisternal e alveolar foram medidas uma vez por semana. Durante o experimento, também foram realizadas medidas de ultrassonografia e morfometria da glândula mamária. As vacas Girolandas apresentaram úberes e tetos maiores que as vacas Holandesas. Diâmetro, espessura da parede e comprimento do canal do teto, medidos por imagens de ultrassom, também foram maiores nas Girolandas, mas a área de cisterna da glândula mamária foi maior nas Holandesas. Não houve diferença na produção de leite e nas frações de leite cisternal e alveolar entre as raças.; The milk distribution in alveolar and cisternal portions and the mammary gland morphometry were studied using 14 cows, being seven Holstein and seven Girolanda, with same parity and days in lactation, and milked twice a day. Milk yield was measured everyday, whereas alveolar and cisternal fractions were determined once a week. During the experiment...

Nuclear morphometry in cytopathology: a prognostic indicator for canine cutaneous mast cell tumors

STREFEZZI, Ricardo De Francisco; XAVIER, Jose Guilherme; KLEEB, Silvia Regina; CATAO-DIAS, Jose Luiz
Fonte: AMER ASSOC VETERINARY LABORATORY DIAGNOSTICIANS INC Publicador: AMER ASSOC VETERINARY LABORATORY DIAGNOSTICIANS INC
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.75%
Twenty-nine canine cutaneous mast cell tumors (MCTs) were morphometrically analyzed with regard to mean nuclear area (MNA) using cytopathology smears. The results showed a correlation between MNA and survival. When graded into 2 morphometrically different groups, there were statistically significant differences among high- and low-grade MCTs, regarding both Romanowsky-type stain and hematoxylin and eosin. Cytomorphometry could also separate histologic grade II tumors with better prognosis from the more aggressive MCTs. The results indicated that nuclear morphometry on cytopathology preparations can predict the biological behavior of cutaneous MCTs in dogs in an independent manner, yielding a rapid and reproducible diagnosis, which renders the method useful for veterinary oncology.; Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP) [05/50407-3]; Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP) [97/09459-7]; Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP) [96/4903-8]; Ricardo De Francisco Strefezzi to the Departamento de Patologia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo (USP), Brazil

Brain structure and symptom dimension relationships in obsessive-compulsive disorder: A voxel-based morphometry study

GILBERT, Andrew R.; MATAIX-COLS, David; ALMEIDA, Jorge R. C.; LAWRENCE, Natalia; NUTCHE, Jeffrey; DIWADKAR, Vaibhav; KESHAVAN, Matcherl S.; PHILLIPS, Mary L.
Fonte: ELSEVIER SCIENCE BV Publicador: ELSEVIER SCIENCE BV
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
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Background: Obsessive-compulsive disorder (OCD) is a clinically heterogenous disorder characterized by temporally stable symptom dimensions. Past inconsistent results from structural neuroimaging studies of OCD may have resulted from the effects of these specific symptom dimensions as well as other socio-demographic and clinical variables upon gray matter (GM) volume. Methods: GM volume was measured in 25 adult OCD patients and 20 adult healthy controls using voxel-based morphometry (VBM), controlling for age and total brain GM volume. Univariate and multivariate regression analyses were carried out between regions of GM difference and age, age of onset, medication load, OCD severity, depression severity, and separate symptom dimension scores. Results: Significant GM volumetric differences in OCD patients relative to controls were found in dorsal cortical regions, including bilateral BA6, BA46, BA9 and right BA8 (controls > patients), and bilateral midbrain (patients > controls). Stepwise regression analyses revealed highly significant relationships between greater total OCD symptom severity and smaller GM volumes in dorsal cortical regions and larger GM volumes in bilateral midbrain. Greater age was independently associated with smaller GM volumes in right BA6...

Phrenic nerve diabetic neuropathy in rats: unmyelinated fibers morphometry

FAZAN, Valeria Paula S.; RODRIGUES FILHO, Omar A.; JORDAO, Caroline E. R.; MOORE, Kenneth C.
Fonte: WILEY-BLACKWELL PUBLISHING, INC Publicador: WILEY-BLACKWELL PUBLISHING, INC
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.75%
We have demonstrated that phrenic nerves` large myelinated fibers in streptozotocin (STZ)-induced diabetic rats show axonal atrophy, which is reversed by insulin treatment. However, studies on structural abnormalities of the small myelinated and the unmyelinated fibers in the STZ-model of neuropathy are limited. Also, structural changes in the endoneural vasculature are not clearly described in this model and require detailed study. We have undertaken morphometric studies of the phrenic nerve in insulin-treated and untreated STZ-diabetic rats and non-diabetic control animals over a 12-week period. The presence of neuropathy was assessed by means of transmission electron microscopy, and morphometry of the unmyelinated fibers was performed. The most striking finding was the morphological evidence of small myelinated fiber neuropathy due to the STZ injection, which was not protected or reversed by conventional insulin treatment. This neuropathy was clearly associated with severe damage of the endoneural vessels present on both STZ groups, besides the insulin treatment. The STZ-diabetes model is widely used to investigate experimental diabetic neuropathies, but few studies have performed a detailed assessment of either unmyelinated fibers or capillary morphology in this animal model. The present study adds useful information for further investigations on the ultrastructural basis of nerve function in diabetes.; FAPESP[07/08498-7]; FAPESP[04/09139-2]; FAPESP[04-01390-8]; FAPESP[06/03200-7]; FAPESP[06/06362-8]; CNPq[303802/2006-5]; CNPq[202079/2007-4]

Morphology and morphometry of the vagus nerve in male and female spontaneously hypertensive rats

ALCANTARA, Adriana Cristina Licursi de; SALGADO, Helio Cesar; FAZAN, Valeria Paula Sassoli
Fonte: ELSEVIER SCIENCE BV Publicador: ELSEVIER SCIENCE BV
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
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The vagus nerve is an important component of the efferent arm of the baroreflex. Blood pressure levels as well as baroreflex control of circulation are significantly different in male and female spontaneously hypertensive rats (SHR). We proposed to investigate the morphometric differences between genders using the vagus nerve of SHR. Adult animals (20 weeks old) were anesthetized and had their arterial pressure (AP) and heart rate (HR) recorded by a computerized system. The rats were then systemically perfused with a fixative solution and had their cervical vagi nerves prepared for light microscopy. Proximal and distal segments of the left and right vagi nerves were evaluated for morphometric parameters including fascicle area and diameter, myelinated fiber number, density, area and diameter. Comparisons were made between sides and segments on the same gender as well as between genders. Differences were considered significant when p<0.05. Male SHR had significantly higher AP and HR. Morphometric data showed no differences between the same levels of both sides and between segments on the same side for male and female rats. In addition, no significant morphometric differences were observed when genders were compared. This is the first description of vagus nerve morphometry in SHR indicating that gender differences in AP and HR cannot be attributed to dissimilarities in vagal innervation of the heart. These data provide a morphological basis for further studies involving functional investigations of the efferent arm of the baroreflex in hypertension. (C) 2007 Elsevier B.V. All rights reserved.

Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder

LIAO, Wei; XU, Qiang; MANTINI, Dante; DING, Jurong; MACHADO-DE-SOUSA, Joao Paulo; HALLAK, Jaime E. C.; TRZESNIAK, Clarissa; QIU, Changjian; ZENG, Ling; ZHANG, Wei; CRIPPA, Jose Alexandre S.; GONG, Qiyong; CHEN, Huafu
Fonte: ELSEVIER SCIENCE BV Publicador: ELSEVIER SCIENCE BV
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
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In social anxiety disorder (SAD), impairments in limbic/paralimbic structures are associated with emotional dysregulation and inhibition of the medial prefrontal cortex (MPFq. Little is known, however, about alterations in limbic and frontal regions associated with the integrated morphometric, functional, and structural architecture of SAD. Whether altered gray matter volume is associated with altered functional and structural connectivity in SAD. Three techniques were used with 18 SAD patients and 18 healthy controls: voxel-based morphometry; resting-state functional connectivity analysis; and diffusion tensor imaging tractography. SAD patients exhibited significantly decreased gray matter volumes in the right posterior inferior temporal gyrus (ITG) and right parahippocampal/hippocampal gyrus (PHG/HIP). Gray matter volumes in these two regions negatively correlated with the fear factor of the Liebowitz Social Anxiety Scale. In addition, we found increased functional connectivity in SAD patients between the right posterior ITG and the left inferior occipital gyrus, and between the right PHF/HIP and left middle temporal gyms. SAD patients had increased right MPFC volume, along with enhanced structural connectivity in the genu of the corpus callosum. Reduced limbic/paralimbic volume...

Ultrastructural Morphology and Morphometry of Phrenic Nerve in Rats

FAZAN, Valeria Paula Sassoli; RODRIGUES FILHO, Omar Andrade; JORDAO, Caroline Echavarria Rodrigues; MOORE, Kenneth Charles
Fonte: WILEY-LISS Publicador: WILEY-LISS
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.88%
Despite numerous literature reports on the morphometry of the myelinated fibers of phrenic nerves in rats, a systematic study of the longitudinal and lateral symmetry of the unmyelinated fibers morphometry is not available. In this study, we have undertaken ultrastructural and morphometric studies of the phrenic nerve in adult rats, assessing two different levels (proximal and distal) from both right and left sides. Phrenic nerves of adult male Wistar rats were prepared for epoxy resin embedding and transmission electron microscopy. Morphometric analysis was performed with the aid of computer software, which took into consideration the unmyelinated fiber number, density, area, and diameter, as well as ratio between myelinated and unmyelinated fibers, and the percentage of the fascicular area occupied by the myelinated and unmyelinated fibers. Comparison of data from proximal and distal segments on the same side and from the same levels between sides was performed. Differences were considered significant when P < 0.05. The most important finding is that morphometric parameters of the phrenic nerve unmyelinated fibers in adult rats are both longitudinally and laterally symmetric. This study adds important morphometric information about the unmyelinated fibers of the phrenic nerves in adult rats for proximal and distal levels on both sides of the animal. Anat Rec...

Cultivo de células epiteliais da tuba uterina de bovinos na presença e ausência de soro fetal bovino: análise bioquímica, morfológica e morfométrica; Culture of bovine uterine tuba epithelial cells with and without bovine calf serum: biochemistry analysis, morphology, and morphometry

Goncalves, Roseli Fernandes
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 02/08/2002 PT
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Foi realizado um estudo bioquímico, morfológico e morfométrico de células epiteliais da tuba uterina de bovinos na presença e ausência de soro fetal bovino in vitro. Para determinar os efeitos dos soro fetal bovino sobre as células foram utilizados como parâmetros sua influência sobre o crescimento, a morfologia qualitativa e quantitativa, o consumo de glicose, a síntese protéica, a atividade da fosfatase láctica e da deidrogenase láctica, em diferentes dias de cultivo. Nas eletromicrografias foram analisados os seguintes componentes celulares: núcleo, grânulos de secreção, mitocôndrias, retículo endoplasmático rugoso, aparelho de Golgi e outras estruturas citoplasmáticas. A cinética de crescimento foi maior na presença de soro. A microscopia eletrônica de transmissão evidenciou inicialmente dois tipos de células, as ciliadas e as secretoras que foram gradativamente diferenciando-se durante todo o tempo de cultivo, na presença e na ausência de soro fetal bovino. Na presença de soro observou-se uma monocamada confluente no dia cinco, enquanto na ausência do mesmo não se notou monocamada confluente até o final do experimento. Um terceiro tipo celular foi observado, tratava-se de uma célula da monocamada com microvilosidades. A análise morfométrica revelou que os três tipos celulares apresentaram diferenças significativas em alguns dos parâmetros avaliados. A análise bioquímica evidenciou algumas diferenças significativas no meio de cultivo. Pode-se concluir que o soro fetal bovino não interfere nas principais características morfológicas...

Caroticoclinoid foramen in human skulls: incidence, morphometry and its clinical implications

Freire, Alexandre Rodrigues; Rossi, Ana Claudia; Prado, Felippe Bevilacqua; Groppo, Francisco Carlos; Ferreira Caria, Paulo Henrique; Botacin, Paulo Roberto
Fonte: Soc Chilena Anatomia Publicador: Soc Chilena Anatomia
Tipo: Artigo de Revista Científica Formato: 427-431
ENG
Relevância na Pesquisa
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The caroticoclinoid foramen is an inconstant structure, formed by the union of the anterior and middle clinoid processes. The aim of this study was to perform an incidence and morphometry of the caroticoclinoid foramen in Brazilian human skulls and discuss its clinical implications. Eighty dry human skulls with sex distinction were used, and 3 groups of incidence were determined: General, sex, and sides. The morphometry was performed using a manual caliper and the major diameter of the foramina was measured; the values were also divided in general, according to sex and sides. The incidence of skulls with at least one foramen was 8.5%. According to the sides, 8.5% of the skulls showed foramen on the right side and 2.5% on the left. We found 2.5% of the skulls with bilateral foramen and 6.25% with unilateral foramen. In relation to sex, the foramens were found in 5% of male skulls and 12.5% of female skulls. The major diameter of this structure presented on mean, values of 5.23 mm on general, 5.18 mm on the right side and 5.35 mm on the left, 5.30 mm in male skulls and 5.18 mm in female skulls. The anatomical characteristics of this foramen should be considered in view of its clinical implications associated with neurosurgery as clinoid process removal...

Differentiation of deer species of the genus Mazama by track morphometry

Angeli, Thais; Oliveira, Marcio Leite de; Duarte, Jose Mauricio Barbanti
Fonte: Taylor & Francis Ltd Publicador: Taylor & Francis Ltd
Tipo: Artigo de Revista Científica Formato: 199-203
ENG
Relevância na Pesquisa
36.88%
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Processo FAPESP: 11/11631-6; We analyzed morphometric variables of tracks of the five species in the genus Mazama known from Brazil to determine if footprint morphometry can distinguish these species. Tracks from adult M. americana, M. bororo, M. gouazoubira, M. nemorivaga and M. nana maintained at the Deer Research and Conservation Center (NUPECCE) were recorded on a carpet of fine wet sand. Discriminant analysis was successful (99.28%) at classifying the Amazon Rainforest species M. americana and M. nemorivaga whereas for the Atlantic Forest species it was not possible. The analysis of variance (ANOVA) analysis showed longer and wider tracks of M. americana in comparison with other Mazama species, probably due to its larger body size. We do not recommend species identification based on the morphometry of tracks, except for the Amazonian species when imprints have been formed under similar conditions.

Associação de ciclosporina e Heteropterys aphrodisiaca (no-de-cachorro) adminstrados a ratos wistar : estrutura, ultra-estrutura e morfometria testicular; Association of cyclosporine and Heteropterys aphrodisiaca (no-de-cachorro) administered to Wistar rats : testicular structure, ultrastructure and morphometry

Juliana Castro Monteiro
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 16/02/2007 PT
Relevância na Pesquisa
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TA ciclosporina A (CsA) possui potentes propriedades imunossupressivas e tem sido amplamente usada na terapia de transplantes de órgãos, aumentando as taxas de sobrevivência dos enxertos, e no tratamento de algumas doenças auto-imunes. Apesar de ser um importante medicamento, diversas reações colaterais são verificadas, entre elas a toxicidade testicular, levando à infertilidade masculina. Heteropterys aphrodisiaca é uma planta com indicações de estimulante e potente afrodisíaco, que aumenta o peso corporal e testicular e o volume das células de Leydig nos testículos de ratos adultos. Assim o efeito da associação dessas drogas foi estudado em ratos Wistar em idade reprodutiva, com avaliação da morfometria, estrutura e ultra-estrutura testicular. Foram utilizados 30 ratos divididos em 5 grupos: I- controle; II- tratamento com CsA; III- concomitante uso de CsA e H. aphrodisiaca; IV- pré-tratamento com H. aphrodisiaca por 30 dias, seguido de CsA por 26 dias; V- tratamento com H. aphrodisiaca. CsA foi administrada na dose de 15 mg/kg/dia e H. aphrodisiaca na dose de 0.5 ml de infusão preparada com 25g de raízes secas/100 ml água fervente. Os tratamentos foram administrados diariamente por gavagem, durante 56 dias. Aumento do peso corporal foi observado em todos os grupos...

Seasonal and interpopulational morphometry variation of Platyscytus decempunctatus (Carvalho 1945) (Heteroptera: Miridae)

Pires,Evaldo Martins; Guedes,Raul Narciso Carvalho; Serrão,José Eduardo; Ferreira,Paulo Sérgio Fiuza
Fonte: Instituto Virtual da Biodiversidade | BIOTA - FAPESP Publicador: Instituto Virtual da Biodiversidade | BIOTA - FAPESP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2008 EN
Relevância na Pesquisa
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A morphometry study was carried out with Platyscytus decempunctatus (Carvalho 1945) collected during the dry and wet seasons in Viçosa county, state of Minas Gerais, Brazil and in other 23 counties from the states of Minas Gerais and Rio de Janeiro in Brazil. A total of 30 males and 30 females were collected in Viçosa at each season and additional insects (20 males and 20 females) were collected at each county surveyed. The analysis with 27 morphological traits was carried out to verify the seasonal influence, differences between sexes and among populations in specimens from Viçosa. The females of P. decempunctatus collected in Viçosa were larger than the males in most of the traits evaluated in both seasons (dry and wet). The males showed only two body traits larger than the females. Interpopulational morphometry differences of P. decempunctatus were significantly correlated with geographic distance among sampling sites.

Aflatoxin effect on the oocysts morphometry and contribution on the morphology of Eimeria bateri Bhatia, Pandey and Pande, 1965 from the japanese quail Coturnix japonica in Brazil

Berto,Bruno P.; Cardozo,Sergian V.; Teixeira Filho,Walter L.; Ferreira,Ana Maria R.; Lopes,Carlos Wilson G.
Fonte: Colégio Brasileiro de Parasitologia Veterinária Publicador: Colégio Brasileiro de Parasitologia Veterinária
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2008 EN
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The purpose of this study was to characterize Eimeria bateri oocysts and to evaluate the aflatoxin effect in the morphometry of sporulated oocysts in Japanese quails infected naturally. Of a total of 50 quails naturally infected by E. bateri were randomly divided into two groups with 25 birds each. In one of them, quails were orally administered with aflatoxin in dose of 0.04 mg/kg body weight previously. Both experimental groups shed E. bateri oocysts. These oocysts were subspherical to ellipsoidal, 25.1 x 18.9 Lim, with bi-layered wall. Micropyle and residuum were absent, but one or more polar granules were present. Sporocysts elongate ovoid, 12.5 x 7.4 μm. Stieda and substieda bodies were present. Sporocyst residuum was dispersed and sporozoites presented a nucleus and a refractile body. Histograms confirmed the presence of a single species, E. bateri. Linear regression proved that E. bateri oocysts are polymorphic, due, basically, to shape of these oocysts. The comparative morphometry between two experimental groups demonstrated that the aflatoxin influenced significantly in the E. bateri oocysts.

Altered brain morphometry in carpal tunnel syndrome is associated with median nerve pathology☆☆☆

Maeda, Yumi; Kettner, Norman; Sheehan, James; Kim, Jieun; Cina, Stephen; Malatesta, Cristina; Gerber, Jessica; McManus, Claire; Mezzacappa, Pia; Morse, Leslie R.; Audette, Joseph; Napadow, Vitaly
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
EN_US
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Objective: Carpal tunnel syndrome (CTS) is a common median nerve entrapment neuropathy characterized by pain, paresthesias, diminished peripheral nerve conduction velocity (NCV) and maladaptive functional brain neuroplasticity. We evaluated structural reorganization in brain gray matter (GM) and white matter (WM) and whether such plasticity is linked to altered median nerve function in CTS. Methods: We performed NCV testing, T1-weighted structural MRI, and diffusion tensor imaging (DTI) in 28 CTS and 28 age-matched healthy controls (HC). Voxel-based morphometry (VBM) contrasted regional GM volume for CTS versus HC. Significant clusters were correlated with clinical metrics and served as seeds to define associated WM tracts using DTI data and probabilistic tractography. Within these WM tracts, fractional anisotropy (FA), axial (AD) and radial (RD) diffusivity were evaluated for group differences and correlations with clinical metrics. Results: For CTS subjects, GM volume was significantly reduced in contralesional S1 (hand-area), pulvinar and frontal pole. GM volume in contralesional S1 correlated with median NCV. NCV was also correlated with RD and was negatively correlated with FA within U-fiber cortico-cortical association tracts identified from the contralesional S1 VBM seed. Conclusions: Our study identified clear morphometric changes in the CTS brain. This central morphometric change is likely secondary to peripheral nerve pathology and altered somatosensory afference. Enhanced axonal coherence and myelination within cortico-cortical tracts connecting primary somatosensory and motor areas may accompany peripheral nerve deafferentation. As structural plasticity was correlated with NCV and not symptomatology...

Standardization of Whole Slide Image Morphologic Assessment With Definition of a New Application: Digital Slide Dynamic Morphometry

Puppa, Giacomo; Sheahan, Kieran; Zlobec, Inti; Pecori, Sara; Langner, Cord; Nakamura, Takatoshi; Ueno, Hideki; Senore, Carlo; Herlin, Paulette; Risio, Mauro; Vieth, Michael; Lugli, Alessandro; Wang, LaiMun; Mitomi, Hiroyuki; Watanabe, Masahiko; Chasle, Ja
Fonte: Medknow Publicador: Medknow
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
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Background: In histopathology, the quantitative assessment of various morphologic features is based on methods originally conceived on specific areas observed through the microscope used. Failure to reproduce the same reference field of view using a different microscope will change the score assessed. Visualization of a digital slide on a screen through a dedicated viewer allows selection of the magnification. However, the field of view is rectangular, unlike the circular field of optical microscopy. In addition, the size of the selected area is not evident, and must be calculated. Materials and Methods: A digital slide morphometric system was conceived to reproduce the various methods published for assessing tumor budding in colorectal cancer. Eighteen international experts in colorectal cancer were invited to participate in a web-based study by assessing tumor budding with five different methods in 100 digital slides. Results: The specific areas to be tested by each method were marked by colored circles. The areas were grouped in a target-like pattern and then saved as an .xml file. When a digital slide was opened, the .xml file was imported in order to perform the measurements. Since the morphometric tool is composed of layers that can be freely moved on top of the digital slide...

A tensor-based morphometry analysis of regional differences in brain volume in relation to prenatal alcohol exposure

Meintjes, E.M.; Narr, K.L.; der Kouwe, A.J.W. van; Molteno, C.D.; Pirnia, T.; Gutman, B.; Woods, R.P.; Thompson, P.M.; Jacobson, J.L.; Jacobson, S.W.
Fonte: Elsevier Publicador: Elsevier
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
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Reductions in brain volumes represent a neurobiological signature of fetal alcohol spectrum disorders (FASD). Less clear is how regional brain tissue reductions differ after normalizing for brain size differences linked with FASD and whether these profiles can predict the degree of prenatal exposure to alcohol. To examine associations of regional brain tissue excesses/deficits with degree of prenatal alcohol exposure and diagnosis with and without correction for overall brain volume, tensor-based morphometry (TBM) methods were applied to structural imaging data from a well-characterized, demographically homogeneous sample of children diagnosed with FASD (n = 39, 9.6–11.0 years) and controls (n = 16, 9.5–11.0 years). Degree of prenatal alcohol exposure was significantly associated with regionally pervasive brain tissue reductions in: (1) the thalamus, midbrain, and ventromedial frontal lobe, (2) the superior cerebellum and inferior occipital lobe, (3) the dorsolateral frontal cortex, and (4) the precuneus and superior parietal lobule. When overall brain size was factored out of the analysis on a subject-by-subject basis, no regions showed significant associations with alcohol exposure. FASD diagnosis was associated with a similar deformation pattern...

Elevação da temperatura testicular e sua influência sobre a compactação da cromatina e morfometria espermática em coelhos (Oryctolagus cuniculus); Testicular temperature rise and its influence on compacting chromatin and sperm morphometry in rabbits (Oryctolagus cuniculus)

Kanayama, Cláudio Yudi
Fonte: Universidade Federal de Uberlândia Publicador: Universidade Federal de Uberlândia
Tipo: Dissertação
POR
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Uma abordagem mais moderna sobre a elevação da temperatura foi realizada, visando detectar alterações na compactação e morfometria da cabeça do espermatozoide pela análise computacional. O objetivo do trabalho foi avaliar a compactação da cromatina e a morfometria espermática após a elevação da temperatura testicular, por meio de criptorquidismo experimental, em coelhos. Foram utilizados 30 coelhos da raça Nova Zelândia, brancos, adultos, situados no coelhário da Universidade de Uberaba, Uberaba, MG, Brasil. Os coelhos foram separados em dois grupos de 15. Ambos os grupos foram anestesiados, mas somente um deles sofreu intervenção cirúrgica, o criptorquidismo experimental. Foram coletadas amostras de sêmen durante 69 dias. Esfregaços de sêmen de todos os coelhos foram corados com azul de toluidina e, posteriormente, analisados digitalmente por meio de microcomputador para avaliar a compactação de cromatina e morfometria. A cromatina foi avaliada quanto à intensidade de compactação (Dif%), homogeneidade pelo coeficiente de variação (CV) e cromatina anômala (Cr. An.). Na análise morfométrica foram avaliados: área, perímetro (Per.), largura (Larg.), comprimento (Comp.), razão largura:comprimento (L/C)...

Posterior cortical atrophy and Alzheimer’s disease : a meta-analytic review of neuropsychological and brain morphometry studies

Alves, Jorge; Soares, José Miguel; Sampaio, Adriana; Gonçalves, Óscar F.
Fonte: Springer Publicador: Springer
Tipo: Artigo de Revista Científica
Publicado em 28/05/2013 ENG
Relevância na Pesquisa
36.88%
This paper presents the first systematic review and meta-analysis of neuropsychological and brain morphometry studies comparing posterior cortical atrophy (PCA) to typical Alzheimer's disease (tAD). Literature searches were conducted for brain morphometry and neuropsychological studies including a PCA and a tAD group. Compared to healthy controls (HC), PCA patients exhibited significant decreases in temporal, occipital and parietal gray matter (GM) volumes, whereas tAD patients showed extensive left temporal atrophy. Compared to tAD patients, participants with PCA showed greater GM volume reduction in the right occipital gyrus extending to the posterior lobule. In addition, PCA patients showed less GM volume loss in the left parahippocampal gyrus and left hippocampus than tAD patients. PCA patients exhibit significantly greater impairment in Immediate Visuospatial Memory as well as Visuoperceptual and Visuospatial Abilities than patients with tAD. However, tAD patients showed greater impairment in Delayed Auditory/Verbal Memory than patients with PCA. PCA is characterized by significant atrophy of the occipital and parietal regions and severe impairments in visuospatial functioning.

Thymus morphometry of New Zealand White Rabbits treated with gentamicin; Morfometria do timo de coelhos Nova Zelândia branco tratados com gentamicina

Silva, Matheus Henrique Magalhães; Pacheco, Maria Rita; Universidade Estadual Paulista “Júlio de Mesquita Filho; Girardi, Annita Morais; Rosa, Marília Ferreira; Artoni, Silvana Martinez Baraldi; Araújo, Marcos Lania
Fonte: Universidade Federal de Santa Catarina Publicador: Universidade Federal de Santa Catarina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; Formato: application/pdf
Publicado em 01/01/2010 POR
Relevância na Pesquisa
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The aim of this study was to evaluate the morphometry of cortical and medullary thymic lobes individualized by determination of area (µm2), perimeter (µm), maximum and minimum diameter (µm) and shape factor in New Zealand White rabbits. The spleens of ten rabbits treated with gentamicin and ten control rabbits (males and females) were histologically processed. The gentamicin dosage and the time of administration of this aminoglicoside were according to therapeutic recommendation. This antibiotic did not cause any alteration in the morphometry of the spleen, and it seemed not to be an immunosuppressive drug.; http://dx.doi.org/10.5007/2175-7925.2010v23n3p143O objetivo deste estudo foi avaliar a morfometria da cortical e medular dos lóbulos tímicos individualizados de coelhos da raça Nova Zelândia Branco pela determinação da área (µm2), perímetro (µm), diâmetro máximo (µm), diâmetro mínimo (µm) e fator de forma. Deste modo, o timo de dez coelhos tratados com gentamicina e dez controles (machos e fêmeas) foram histologicamente processados. A dose de gentamicina utilizada e o tempo de administração deste aminoglicosídeo foram adequados e condizentes à recomendação terapêutica. Este antibiótico não alterou a morfometria deste órgão e não foi imunodepressor.