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Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil

BERMUDEZ-AZA, Elkin Hernan; KERR, Ligia Regina Franco Sansigolo; KENDALL, Carl; PINHO, Adriana Araujo; MELLO, Maeve Brito de; MOTA, Rosa Salani; GUIMARAES, Mark Drew Crosland; ALENCAR, Cecilia Salete; BRITO, Ana Maria de; DOURADO, Ines Costa; BATISTA, Son
Fonte: LIPPINCOTT WILLIAMS & WILKINS Publicador: LIPPINCOTT WILLIAMS & WILKINS
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.41%
Background: There are few studies on HIV subtypes and primary and secondary antiretroviral drug resistance (ADR) in community-recruited samples in Brazil. We analyzed HIV clade diversity and prevalence of mutations associated with ADR in men who have sex with men in all five regions of Brazil. Methods: Using respondent-driven sampling, we recruited 3515 men who have sex with men in nine cities: 299 (9.5%) were HIV-positive; 143 subjects had adequate genotyping and epidemiologic data. Forty-four (30.8%) subjects were antiretroviral therapy-experienced (AE) and 99 (69.2%) antiretroviral therapy-naive (AN). We sequenced the reverse transcriptase and protease regions of the virus and analyzed them for drug resistant mutations using World Health Organization guidelines. Results: The most common subtypes were B (81.8%), C (7.7%), and recombinant forms (6.9%). The overall prevalence of primary ADR resistance was 21.4% (i.e. among the AN) and secondary ADR was 35.8% (i.e. among the AE). The prevalence of resistance to protease inhibitors was 3.9% (AN) and 4.4% (AE); to nucleoside reverse transcriptase inhibitors 15.0% (AN) and 31.0% (AE) and to nonnucleoside reverse transcriptase inhibitors 5.5% (AN) and 13.2% (AE). The most common resistance mutation for nucleoside reverse transcriptase inhibitors was 184V (17 cases) and for nonnucleoside reverse transcriptase inhibitors 103N (16 cases). Conclusions: Our data suggest a high level of both primary and secondary ADR in men who have sex with men in Brazil. Additional studies are needed to identify the correlates and causes of antiretroviral therapy resistance to limit the development of resistance among those in care and the transmission of resistant strains in the wider epidemic.; Ministry of Health/Secretariat of Health Surveillance/Department of STD...

Persistence and Clearance of HPV From the Penis of Men Infected and Non-Infected With HIV

SILVA, R. J. C.; CASSEB, J.; ANDREOLI, M. A.; VILLA, L. L.
Fonte: WILEY-LISS Publicador: WILEY-LISS
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.45%
Due to high rates of human papillomavirus (HPV) infection, the incidence of intraepithelial neoplasia and anal cancer, most studies concerning HPV in men seropositive for HIV have focused on the anal canal. Few studies have targeted the penile region in HIV-infected men. A total of 72 men seropositive for HIV and 72 men seronegative for HIV were followed-up for 6 months, and their penile exfoliated cells were tested for HPV DNA. There were no significant differences between the HIV-positive and HIV-negative men in persistence (respectively, 69.5% vs. 66.9%), clearance (respectively, 15.3% vs. 23.1%), and those men never infected with HPV during the four follow-up visits (15.2% for HIV-positive vs. 20% for HIV-negative). High-risk HPV types were detected more frequently in penile smears from men infected with HIV, while, in HIV-seronegative men, the low-risk HPV types were more abundant (P=0.001). Multiple infections with both high- and low-risk HPV types were significantly more frequent in HIV-seropositive compared to those who were HIV-seronegative (P=0.0004). The attendance rates at follow-up visits were 86%, 78%, and 58% in months 1, 2, and 6, respectively, for men infected with HIV and 93%, 72%, and 60% for the HIV-negative group. It is concluded that HIV infection can be considered a risk factor for clearance and persistence of HPV. Multiple infections with different types of HPV including high-risk HPVs are frequent in men who are infected with HIV. J. Med. Virol. 83:127-131...

Clinical risk factors for osteoporotic fractures in Brazilian women and men: the Brazilian Osteoporosis Study (BRAZOS)

PINHEIRO, M. M.; CICONELLI, R. M.; MARTINI, L. A.; FERRAZ, M. B.
Fonte: SPRINGER LONDON LTD Publicador: SPRINGER LONDON LTD
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.4%
The Brazilian Osteoporosis Study (BRAZOS) is the first epidemiological study carried out in a representative sample of Brazilian men and women aged 40 years or older. The prevalence of fragility fractures is about 15.1% in the women and 12.8% in the men. Moreover, advanced age, sedentarism, family history of hip fracture, current smoking, recurrent falls, diabetes mellitus and poor quality of life are the main clinical risk factors associated with fragility fractures. The Brazilian Osteoporosis Study (BRAZOS) is the first epidemiological study carried out in a representative sample of Brazilian men and women aged 40 years or older with the purpose of identifying the prevalence and the main clinical risk factors (CRF) associated with osteoporotic fracture in our population. A total of 2,420 individuals (women, 70%) from 150 different cities in the five geographic regions in Brazil, and all different socio-economical classes were selected to participate in the present survey. Anthropometrical data as well as life habits, fracture history, food intake, physical activity, falls and quality of life were determined by individual quantitative interviews. The representative sampling was based on Brazilian National data provided by the 2000 and 2003 census. Low trauma fracture was defined as that resulting of a fall from standing height or less in individuals 50 years or older at specific skeletal sites: forearm...

Infecção pelo Papilomavírus Humano (HPV) em homens soropositivos e negativos ao HIV: persistência e relação histológica de lesões clínicas e subclínicas; Human Papillomavirus (HPV) infection in HIV positive and negative men: analysis of HPV persistence and histological findings in clinical and sub-clinical lesions

Silva, Roberto José Carvalho da
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 04/03/2010 PT
Relevância na Pesquisa
36.44%
INTRODUÇÃO: Co-infecção HPV / HIV altera história natural das infecções por HPV, aumentando o risco de verrugas e neoplasias malignas do trato ano-genital. Há, no entanto, escassez de estudos de coorte envolvendo HPV no pênis dessa população. MÉTODOS: Estudo longitudinal, não probabilístico, com 144 homens de 18 e 70 anos de idade, sendo 72 HIV positivos e 72 HIV soronegativos, parceiros de mulheres com patologia associada a infecção pelo HPV. O estudo foi conduzido numa clínica pública de doenças de transmissão sexual em São Paulo (CRT-DST/AIDS), entre fevereiro de 2004 a março de 2005. Os participantes do estudo foram acompanhados por 180 dias para avaliar a persistência, a aquisição e a eliminação do DNA de HPV nos esfregaços penianos por meio da PCR. Este estudo também visou: Correlacionar os aspectos clínicos das lesões genitais com a histologia e a presença de DNA HPV; Comparar a aquisição, persistência, eliminação e ausência da infecção pelo HPV com a carga viral plasmática do HIV, contagem de células T CD4 e uso de terapia anti-retroviral (HAART). RESULTADOS: Não houve associação estatisticamente significativa nos dois grupos em relação a persistência, eliminação, aquisição ou mesmo ausência de HPV durante o seguimento. O grupo HIV positivo apresentou uma maior freqüência dos tipos oncogênicos de HPV em relação ao grupo HIV negativo (P = 0...

Chlamydia trachomatis in human immunodeficiency virus-infected men treated at a referral hospital for sexually transmitted diseases in the Amazonas, Brazil

Jalkh,Alex Panizza; Miranda,Angelica Espinosa; Hurtado-Guerreiro,Jose Camilo; Ramos,Lorena Angelica Castano; Figliuolo,Guiseppe; Maia,Jussimara; Costa,Cintia Mara; Ramasawmy,Rajendranath; Ferreira,Luiz Carlos de Lima
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2014 EN
Relevância na Pesquisa
36.46%
OBJECTIVES: The aim of the present study was to determine the Chlamydia trachomatis prevalence and to identify the demographic, behavioural and clinical factors associated with C. trachomatis in human immunodeficiency virus infected men. STUDY: This was a cross-sectional study of C. trachomatis prevalence among human immunodeficiency virus-infected men enrolled at the Outpatient clinic of acquired immunodeficiency syndrome of the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado in Manaus, Amazonas, Brazil. C. trachomatis deoxyribonucleic acid from urethral samples was purified and submitted to real time polymerase chain reaction to identify the presence of C. trachomatis. RESULTS: A total of 276 human immunodeficiency virus-infected men were included in the study. The prevalence of C. trachomatis infection was 12% (95% confidence interval 8.1%-15.7%). The mean age of the participants was 34.63 (standard deviation 10.80) years. Of the 276 human immunodeficiency virus-infected men, 93 (56.2%) had more than one sexual partner in the past year and 105 (38.0%) reported having their first sexual intercourse under the age of 15 years. Men having sex with men and bisexuals amounted to 61.2% of the studied population. A total of 71.7% had received human immunodeficiency virus diagnosis in the last three years and 55.1% were using antiretroviral therapy. Factors associated with C. trachomatis infection in the logistic model were being single (p<0.034)...

Genital prevalence of HPV types and co-infection in men

Freire,Marcos P.; Pires,Daniel; Forjaz,Raphael; Sato,Sergio; Cotrim,Ismael; Stiepcich,Monica; Scarpellini,Bruno; Truzzi,Jose C.
Fonte: Sociedade Brasileira de Urologia Publicador: Sociedade Brasileira de Urologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/02/2014 EN
Relevância na Pesquisa
36.46%
Introduction: HPV infection is a highly prevalent sexually transmitted disease and there is evidence of the relationship of HPV infection and the development of genital warts, penile intraepitelial neoplasia, invasive penile carcinoma and cervical cancer. However, there is sparse data regarding the prevalence of HPV types and co-infection of different HPV types among men. Objectives: To assess the prevalence of HPV subtypes infections and rates of co-infection among men. Materials and Methods: 366 men were evaluated from March to October 2010. Men were referred to our institution for HPV diagnostic evaluation based on the following criteria: 1. presence of a genital wart; 2. presence of an atypical genital lesion; 3. absence of symptoms and a partner with a HPV diagnosis; 4. absence of symptoms and a desire to undergo a full STD diagnostic evaluation. Genital samples were collected from the urethra, penile shaft, scrotum and anus with Digene® collection and preservation kit and submitted to HPV genotype microarray detection (Papillocheck®). All men were tested for the low-risk HPV types 6-11-40-42-43-44 and for the high-risk HPV types 16-18-31-33-35-39-45-51-52-53-56-58-59-66-68-70-73-82. Results: Of the 366 men, 11 were tested inconclusive and were excluded from the analysis. 256 men (72.1% of the men from the cohort referred to our institution) tested positive with genotype micro-array detection and 99 tested negative. The most prevalent HPV-subtypes in the studied population were 6...

Sexual diversity among black men who have sex with men in an inner-city community

Miller, Maureen; Serner, Malin; Wagner, Meghan
Fonte: Springer-Verlag Publicador: Springer-Verlag
Tipo: Artigo de Revista Científica
Publicado em /03/2005 EN
Relevância na Pesquisa
36.41%
Dramatic increases in HIV-incidence rates have been documented for Black men who have sex with men (MSM). Moreover, MSM has become a more visible HIV-transmission route in the Black community, in part due to public interest in the “down low” (i.e., “straight” men who also have sex with men). Interviews were conducted with 21 Black MSM in central Brooklyn, New York City, in efforts to understand the diversity of MSM experience in a low income, high HIV-prevalence community. Two thirds of the men identified as either heterosexual (43%) or bisexual (24%) and 15 (71%) MSM reported recent sex with women. Conformity to masculine social role expectations made it difficult to identify sex partners in the community; therefore, men relied on private sex clubs and the Internet. The findings suggest that stigma surrounding both HIV and homosexuality may effectively insure that nonheterosexual preferences and practices remain hidden in the Black community. A focus on sexual orientation and bisexuality has obscured the issue of race in the HIV/AIDS epidemic among Black MSM. In the long term, public health promotion and HIV prevention will require greater tolerance and acceptance of sexual diversity in the Black community.

Physical Activity and Weight Gain Prevention in Older Men

Shiroma, Eric Jitsuo; Sesso, Howard David; Lee, I-Min
Fonte: Harvard University Publicador: Harvard University
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
36.41%
Background: Physical activity and adiposity are important predictors of mortality, even in older individuals. However, it is unclear how much physical activity is needed to prevent weight gain in older persons. Purpose To examine the associations of different amounts of physical activity with weight gain prevention in older men. Methods: 5,973 healthy men (mean age, 65.0 y) from the Harvard Alumni Health Study were followed from 1988 to 1998. At baseline (1988), in 1993, and 1998, men reported their recreational physical activity and body weight. Physical activity was categorized as: <7.5 MET-hr/week (7.5 MET-hr/week corresponds to the minimum required by the 2008 US federal guidelines), 7.5 to <21 MET-hr/week (21 MET-hr/week corresponds to the 2002 Institute of Medicine [IOM] guideline), and ≥21 MET-hr/week. Meaningful weight gain was defined as an increase of ≥3% of body weight. Results: Overall, weight tended to be stable over any 5-year period; mean change, −0.08 (SD=4.44) kg. However, ~21% of men experienced meaningful weight gain over any 5-year period. In multivariate analyses, compared to men expending ≥21 MET-hr/week, those expending 7.5 to <21 MET-hr/week had an odds ratio (OR) of 1.35 (95% confidence interval: 1.03...

Caracteriza????o, criopreserva????o e manipula????o gen??tica do s??men do linguado Paralichthys orbignyanus (Teleostei: Paralichthyiade)

Lanes, Carlos Frederico Ceccon
Fonte: Universidade Federal do Rio Grande Publicador: Universidade Federal do Rio Grande
Tipo: Dissertação de Mestrado
POR
Relevância na Pesquisa
36.44%
Disserta??ao(mestrado)- Universidade Federal do Rio Grande, Programa de P??s-Gradua????o em Aq??icultura, Instituto de Oceanografia, 2008.; O linguado Paralichthys orbignyanus ?? um importante recurso pesqueiro do oceano Atl??ntico Sul e ?? considerado uma esp??cie com grande potencial para a aq??icultura. A qualidade do s??men ?? uma importante vari??vel no manejo reprodutivo de esp??cies cultivadas, influenciando diretamente na produ????o de ovos vi??veis. Al??m disso, o conhecimento das caracter??sticas f??sicas e qu??micas do s??men ?? um importante fator no desenvolvimento de protocolos de resfriamento e criopreserva????o do s??men. O objetivo deste trabalho foi caracterizar o s??men de P. orbignyanus ao longo da esta????o reprodutiva e utilizar essas informa????es para auxiliar no processo de criopreserva????o do s??men e no desenvolvimento de um protocolo de transfer??ncia de genes mediada por espermatoz??ides (TGME). Na primeira etapa deste estudo, amostras de s??men de linguados selvagens foram coletadas ao longo da esta????o reprodutiva. Atrav??s dos resultados obtidos foi verificado que a produ????o de espermatoz??ides e a motilidade progressiva aumentam significativamente ?? medida que a esta????o reprodutiva progride para o seu final (P<0.05). A motilidade progressiva dos espermatoz??ides durou em m??dia 10 min...

Avalia??o de diferentes diluentes na criopreserva??o de s?men ovino (Ovis aries)

GUIMAR?ES, Adrianne Ara?jo
Fonte: Universidade Federal do Pará Publicador: Universidade Federal do Pará
Tipo: Dissertação de Mestrado
POR
Relevância na Pesquisa
36.41%
Durante a criopreserva??o s?o in?meras as altera??es sofridas pelas c?lulas esperm?ticas, o que conduz ? queda na motilidade e perda da sua viabilidade p?s-descongela??o. Por este motivo, surge a necessidade de aperfei?oar os processos de tecnologia do s?men, principalmente quanto ao uso de diluentes. O objetivo deste estudo foi avaliar a viabilidade de espermatoz?ides ovinos, submetidos ao processo de dilui??o e criopreserva??o, utilizando-se 3 diluentes (TES, TRIS e PBS) e 3 tempos de equil?brio (4h, 8h e 12h), sendo o estudo dividido em 9 grupos: TES-4h, TES-8h, TES-12h, TRIS-4h, TRIS-8h, TRIS-12h, PBS-4h, PBS-8h e PBS-12h. Ap?s a colheita, o s?men foi avaliado macro e microscopicamente, e pr?dilu?do nas solu??es TES, TRIS e PBS, no entanto sem a adi??o dos crioprotetores (Solu??o A), onde permaneceram por 1h. Posteriormente, o s?men foi dilu?do com as solu??es TES, TRIS e PBS, j? contendo os crioprotetores, novamente avaliado, para ent?o ser envasado, sendo submetido aos diferentes tempos de equil?brio, e em seguida, congelado. Ap?s a descongela??o, foi avaliado a motilidade e o vigor, e ap?s o TTR, a motilidade, o vigor e o desprendimento do acrossoma. Na criopreserva??o com TRIS, a motilidade e o vigor foram estatisticamente similares (p>0...

Ativa??o esperm?tica e criopreserva??o do s?men de macaco-prego (Cebus apella) em diluidores ? base de ?gua de coco in natura e TES-TRIS

OLIVEIRA, Karol Guimar?es
Fonte: Universidade Federal do Pará Publicador: Universidade Federal do Pará
Tipo: Dissertação de Mestrado
POR
Relevância na Pesquisa
36.4%
A esp?cie Cebus apella (macaco-prego) ? amplamente utilizada como modelo experimental na pesquisa biom?dica. Entretanto, s?o escassos os estudos dedicados a avaliar o s?men desses animais, que ? composto por uma fra??o l?quida e uma coagulada de dif?cil manipula??o e alta concentra??o de espermatoz?ides im?veis. Portanto, objetivou-se I) avaliar o efeito de duas concentra??es de cafe?na (6 e 10 mM/mL) dilu?das em TES-TRIS e ?gua de coco in natura (ACIN) na ativa??o de espermatoz?ides de C. apella e II) testar um protocolo de criopreserva??o do s?men comparando dois diluidores (TES-TRIS e ACIN) acrescidos de gema de ovo e glicerol. O s?men de seis animais mantidos no Centro Nacional de Primatas foi coletado por eletroejacula??o, dilu?do na fra??o-A de TES-TRIS ou ACIN, e incubado a 35?C at? dissolu??o do co?gulo seminal. O tempo de liquefa??o foi comparado. Posteriormente foi mensurado volume, concentra??o, morfologia esperm?tica e percentual de espermatoz?ides vivos. No experimento I as amostras foram dilu?das em TES-TRIS ou ACIN acrescidos de 6 e 10 mM de cafe?na ap?s o t?rmino da motilidade durante a liquefa??o e mantidas a 35?C. Motilidade e vigor foram avaliados por 5 h. Para o experimento II, ap?s liquefa??o, o s?men foi dilu?do na fra??o-B (fra??o-A + gema de ovo e glicerol) dos diluidores...

Obesity and metabolic syndrome increase the risk of incident depression in older men: The Health in Men Study

Almeida, Osvaldo P.; Calver, Janine; Jamrozik, Konrad; Hankey, Graeme J.; Flicker, Leon
Fonte: Amer Psychiatric Press Inc Publicador: Amer Psychiatric Press Inc
Tipo: Artigo de Revista Científica
Publicado em //2009 EN
Relevância na Pesquisa
36.43%
Background: Obesity has been associated with increased risk of prevalent depression among young and middle-aged adults, but the association between obesity (and its various measures, including the metabolic syndrome [MetS]) and incident depression has not been examined adequately in the elderly. Objectives: This study evaluated the association between various measures of obesity and incident depression over a 10-year period in a large cohort of community-based older men. Methods: The authors recruited 12,216 men aged 65–84 years living in Perth, Australia, between 1996 and 1998, and measured their height, weight, waist and hip circumference, and blood pressure. Participants also completed a questionnaire that included information about the clinical diagnosis and treatment for diabetes, hypertension, and high cholesterol or triglycerides. The authors then used the Western Australian Linked Data System to retrieve information about the following ICD-10 diagnoses between January 1, 1966, and December 31, 2006: depressive episode, recurrent depressive disorder, and dysthymia. Results: The authors excluded 150 men from these analyses because of prior history of depression or missing data. The mean age of our 12,066 participants was 72 ± 4 years at the time of recruitment...

Semen quality and reproductive hormone levels in men from southern Spain

Fern??ndez, Mariana F.; Duran, I.; Olea, Nicol??s; Avivar, C.; Vierula, M.; Toppari, Jorma; Skakkeb??k, Niels; J??rgensen, Niels
Fonte: European Academy of Andrology Publicador: European Academy of Andrology
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.43%
In North European countries, a significant difference in semen quality among young men has been shown. Men from the western countries, Denmark, Germany and Norway, have lower semen quality than men from the eastern countries Finland, Estonia and Lithuania. Similarly, men in the western countries have a higher risk of testicular cancer. According to the testicular dysgenesis syndrome (TDS) concept that suggests a link between risk of impaired semen quality and increased risk of testicular cancer, Spanish men would be expected to have a semen quality at a normal level because of their very low testis cancer risk. We therefore investigated 273 men from the Almeria region in the Southern Spain to test this hypothesis. The men delivered semen samples, underwent physical examinations, had a blood sample drawn and provided information on lifestyle and reproductive health parameters. The investigations took place from November 2001 to December 2002. Adjusting for effects of confounders, the median sperm concentration and total sperm count were 62 (95% confidence interval 47???82) million/mL and 206 (153???278) million, respectively. The median numbers of motile and morphologically normal spermatozoa assessed according to strict criteria were 59% (57???62%) and 9.4% (8.6???10.0%)...

Castilla y Le??n y la primera zona monumental (1934-1975): la conservaci??n monumental de Luis Men??ndez-Pidal

Mart??nez-Monedero, Miguel
Fonte: Junta de Castilla y Le??n, Consejer??a de Cultura y Turismo Publicador: Junta de Castilla y Le??n, Consejer??a de Cultura y Turismo
Tipo: Livro
SPA; ENG
Relevância na Pesquisa
36.41%
Luis Men??ndez-Pidal fue uno de los protagonistas m??s destacados de la restauraci??n arquitect??nica del patrimonio espa??ol durante el siglo XX. Desde el comienzo de su actividad profesional, a principios de los a??os 20, hasta su fallecimiento en 1975, Men??ndez-Pidal mantuvo bajo su tutela los principales monumentos del noroeste de Espa??a. M??s de 55 a??os de ejercicio profesional en los que nuestro arquitecto restaur?? cerca de 200 edificios en sus distintos cargos dentro de la Administraci??n, pero fundamentalmente en su puesto de Arquitecto Conservador de Monumentos de la Primera Zona (1941-75) donde se englobaban las provincias de Asturias, Le??n, Zamora, La Coru??a, Lugo, Orense y Pontevedra. La Catedral y la C??mara Santa de Oviedo, las catedrales de Zamora, Le??n, Santiago o Tuy, la pr??ctica totalidad del prerrom??nico asturiano, las murallas de Lugo, Le??n y Astorga, o el monasterio de Guadalupe (C??ceres) se cuentan entre sus actuaciones m??s conocidas. Sus intervenciones fueron tantas y tan profundas que podemos afirmar que el paisaje monumental que actualmente puede contemplarse en este territorio es fruto de las interpretaciones personales que Men??ndez-Pidal nos leg?? a trav??s de sus restauraciones. El estudio de su obra y de su evoluci??n intelectual es...

Feeling queer : can a primary health care approach mitigate health inequity experienced by homosexually active South Australian men ?

Rogers, Gary David
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado Formato: 324594 bytes; 2429230 bytes; 171634 bytes; application/pdf; application/pdf; application/pdf
Publicado em //2005 EN
Relevância na Pesquisa
36.41%
Health inequity refers to differences in health status between populations ( health inequalities ) that are unnecessary and avoidable and, additionally, are considered unfair or unjust. The history of the concept is reviewed and the mechanisms by which inequity affects health surveyed, with a focus on multi - level models of health production. The origins and development of the Primary Health Care approach is then considered with an emphasis on the Australian setting and on HIV / AIDS policy. The construct of homosexuality is then explored and concepts of sexual attraction, ' orientation ', identity and behaviour differentiated. What is known about the health characteristics of homosexually active men in the First World is then surveyed by means of a systematic literature review. It is concluded that there is evidence that they are affected by substantial health inequality in a range of areas including mortality, suicidality, depressive disorders, anxiety disorders, report of childhood sexual abuse and problematic substance use. Few of these inequalities have been confirmed in the Australian context, however, and almost none have been confirmed specifically in South Australia. The background to the development of a Primary Health Care programme focused on homosexually active men...

Engaging Men and Boys in Advancing Women's Agency : Where We Stand and New Directions

Fleming, Paul J.; Barker, Gary; McCleary-Sills, Jennifer; Morton, Matthew
Fonte: World Bank, Washington, DC Publicador: World Bank, Washington, DC
Tipo: Publications & Research :: Working Paper; Publications & Research
ENGLISH; EN_US
Relevância na Pesquisa
36.43%
Despite advances in gender equality, women and girls still face disadvantages and limits on their agency. Men and boys can be key stakeholders and allies to increase women's agency. This paper focuses on examining men's attitudes and behaviors related to gender equality and violence perpetration to better understand how to engage men and boys as. It uses data collected from men and women from eight countries (Bosnia, Brazil, Chile, Croatia, Democratic Republic of Congo, India, Mexico, and Rwanda) as part of the International Men and Gender Equality Survey (IMAGES). There is wide variation across countries in men's support for gender equality, equal roles for men and women, and acceptability of violence against women. Key findings of this investigation include: 1) that in most countries male perpetrators of violence are more likely to be depressed or engage in binge drinking than non-perpetrators; 2) that witnessing one's mother being abused by a partner is one of the strongest predictors of ever perpetrating violence...

Compara??o entre o TRIS, Lactose/TRIS, Ringer-Lactato e Leite Desnatado como diluidores na criopreserva??o do s?men bubalino

MIYASAKI, Michel Yoshio Almeida
Fonte: Universidade Federal do Pará Publicador: Universidade Federal do Pará
Tipo: Dissertação de Mestrado
POR
Relevância na Pesquisa
36.47%
O objetivo do experimento foi testar a efic?cia de diferentes diluidores, a base de Ringer-Lactato, Leite Desnatado, TRIS (hidroxi-methil-amino-methan) e Lactose/TRIS, na criopreserva??o de s?men bubalino. Foram utilizados tr?s machos bubalinos da ra?a Murrah em plena atividade sexual. O s?men foi colhido por vagina artificial totalizando 71 ejaculados. Ap?s a colheita, cada amostra foi submetida ?s an?lises qualitativas e quantitativas do s?men. Os ejaculados foram fracionados e dilu?dos nos quatro diluidores. O s?men dilu?do foi envasado em palhetas de 0,25ml e submetidos a um tempo de equil?brio de at? quatro horas a 5?C, com posterior congela??o em nitrog?nio l?quido. As amostras identificadas foram descongeladas em banho maria ? temperatura de 40?C por 30 segundos e seq?encialmente avaliadas quanto a motilidade, vigor, les?o de acrossoma, e percentual de patologias esperm?ticas. As amostras tamb?m foram submetidas ao teste de termo-resist?ncia, permanecendo incubadas ? temperatura de 40?C durante 30 segundos, 3-5 minutos, 30 minutos, 1 hora, 2 horas e 3 horas, onde foram avaliadas quanto a motilidade e o vigor esperm?tico. As caracter?sticas f?sicoqu?micas, ap?s an?lise do s?men in natura, encontraram-se dentro dos valores preconizados para a esp?cie bubalina e satisfat?rios para o processo de congela??o. Ap?s descongela??o do s?men...

The role of MEN (mitosis exit network) proteins in the cytokinesis of Saccharomyces cerevisiae; Función de las proteínas MEN ("mitosis exit network") en la citocinesis de Saccharomyces cerevisiae

Jiménez, Javier; Castelao, Beatriz A.; González-Novo, Alberto; Sánchez-Pérez, Miguel
Fonte: Sociedad Española de Microbiología; Springer Publicador: Sociedad Española de Microbiología; Springer
Tipo: Artículo
ENG
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[EN]: At the latest stages of their cell cycle, cells carry out crucial processes for the correct segregation of their genetic and cytoplasmic material. In this work, we provide evidence demonstrating that the cell cycle arrest of some MEN (mitosis exit network) mutants in the anaphase-telophase transition is bypassed. In addition, the ability of cdc15 diploid mutant strains to develop non-septated chains of cells, supported by nuclear division, is shown. This phenotype is also displayed by haploid cdc15 mutant strains when cell lysis is prevented by osmotic protection, and shared by other MEN mutants. By contrast, anaphase-telophase arrest is strictly observed in double MEN-FEAR (fourteen early anaphase release) mutants. In this context, the overexpression of a FEAR component, SPO12, in a MEN mutant background enhances the ability of MEN mutants to bypass cell cycle arrest. Taken together, these data suggest a critical role of Cdc15 and other MEN proteins in cytokinesis, allowing a new model for their cellular function to be proposed.; [ES]: En las últimas etapas de su ciclo celular, las células llevan a cabo procesos cruciales para la segregación correcta del material genético y citoplásmico. Es un tema de investigación de gran actualidad. En este trabajo aportamos pruebas que demuestran que en algunos mutantes MEN ("mitosis exit network") el ciclo celular no se detiene en la transición anafase-telofase. Además...

Discrimination and victimization against gay men and lesbians in Chile: Two patterns or just one?

Barrientos,Jaime; Bozon,Michel
Fonte: Interdisciplinaria Publicador: Interdisciplinaria
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2014 EN
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The Lesbian, Gay men, Bisexual and Trans -gender (LGBT) Pride Parade takes place in Santiago (Chile) every year. It gathers sexual minorities and also heterosexuals who attend to support LGBT population rights vindication. Specifically, the objective of the study was to describe gay men and lesbians who participate in the LGBT Pride Parade, from the viewpoint of discrimination and victimization. In this sense, this study is innovating because it is based on questionnaires administered in the context of LGBT Pride Parades. In Chile, data on this issue are scarce. There are few previous studies on the topic, revealing that many LGBT people report discrimination and victimization in different situations and contexts. Nevertheless, these studies have not clearly stated the existing differences in the patterns of discrimination and victimization events that affect the different groups (for example, those that affect gay men and lesbians). So, the study focused only on this population for two reasons: first, mainly LGBT subjects attend the parade and secondly, there were no previous studies to compare both groups in the country. Second, the study also aimed at showing that gay men suffer greater discrimination and victimization than lesbians. A non-probabilistic sample of 343 participants was collected. From this sample...

Health status and health-seeking behaviour of Jamaican men fifty-five years and over

Morris,C; James,K; Laws,H; Eldemire-Shearer,D
Fonte: West Indian Medical Journal Publicador: West Indian Medical Journal
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2011 EN
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OBJECTIVE: The Caribbean including Jamaica is undergoing rapid population ageing with implications for health service planning and delivery. Such planning should take into account gender differentials. This study describes and analyses the health status and health-seeking behaviour of men 55 years and over in Jamaica. METHOD: A quantitative cross-sectional survey employing cluster sampling techniques was utilized to recruit 2000 men, 55 years and older, in the parish of St Catherine, Jamaica. A 126-item questionnaire was administered and standard instruments utilized to assess functional status. RESULTS: Respondents (74%) rated their health status as excellent/good. Few men were highly dependent with regard to Activities of Daily Living with incontinence being a major concern. Medication management and shopping were the major Instrumental Activities of Daily Living domains where assistance was needed. Depression was associated with non-involvement in community/social organizations and not being in physical contact with their children. Major health conditions reported were cancers (16%), kidney/bladder conditions (12.7%), hypertension (9.2%) diabetes (6.5%) and prostate problems (7.3%). Most men (67.6%) had not visited a health provider in the year prior to the survey; 17.1% had been hospitalized after age 55 years. Only 35% of men ever had a prostate check/examination and 8.2% of men eligible for drug benefits under the Jamaica Drugs for the Elderly Programme registered for that programme. CONCLUSION: There is need to focus on older men's health and ensure that primary prevention and early interventions reach middle-aged and older men while improving health literacy. Taking programmes to 'where men are'...