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Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes

SALES, Cristiane Hermes; PEDROSA, Lucia Fatima Campos; LIMA, Josivan Gomes; LEMOS, Telma Maria Araujo Moura; COLLI, Celia
Fonte: CHURCHILL LIVINGSTONE Publicador: CHURCHILL LIVINGSTONE
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
37.03%
Background & aims: This study was undertaken to assess magnesium intake and magnesium status in patients with type 2 diabetes, and to identify the parameters that best predict alterations in fasting glucose and plasma magnesium. Methods: A cross-sectional study was carried out in patients with type 2 diabetes (n = 51; 53.6 +/- 10.5 y) selected within the inclusion factors, at the University Hospital Onofre Lopes. Magnesium intake was assessed by three 24-h recalls. Urine, plasma and erythrocytes magnesium, fasting and 2-h postprandial glucose, HbA1, microalbuminuria, proteinuria, and serum and urine creatinine were measured. Results: Mean magnesium intake (9.37 +/- 1.76 mmol/d), urine magnesium (2.80 +/- 1.51 mmol/d), plasma magnesium (0.71 +/- 0.08 mmol/L) and erythrocyte magnesium (1.92 +/- 0.23 mmol/L) levels were low. Seventy-seven percent of participants presented one or more magnesium status parameters below the cut-off points of 3.00 mmol/L for urine, 0.75 mmol/L for plasma and 1.65 mmol/L for erythrocytes. Subjects presented poor blood glucose control with fasting glucose of 8.1 +/- 3.7 mmol/L, 2-h postprandial glucose of 11.1 +/- 5.1 mmol/L, and HbA1 of 11.4 +/- 3.0%. The parameters that influenced fasting glucose were urine...

Suprimento combinado de fósforo e magnésio para a produção e nutrição do capim-Tanzânia; Combined supply of phosphorus and magnesium for Tanzania grass production and mineral nutrition

Lange, Jackson Locks
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 26/02/2007 PT
Relevância na Pesquisa
37%
Em razão do potencial produtivo e do possível alto valor nutricional, o capim- Tanzânia é um dos cultivares de destaque da espécie Panicum maximum na pecuária brasileira. É caracterizado como relativamente exigente em fertilidade do solo. Objetivou-se avaliar as respostas do capim-Tanzânia ao fornecimento de combinações de doses de fósforo e magnésio, quanto ao número de folhas e perfilhos, unidades SPAD, área foliar, produção de massa seca da parte aérea e das raízes, superfície e comprimento radiculares, superfície e comprimento radiculares específicos, concentrações de fósforo, magnésio, cálcio, potássio e zinco nas folhas diagnósticas, bem como de fósforo e magnésio nas raízes, proporção entre os cátions magnésio, cálcio e potássio presentes na parte aérea e sintomas visuais de deficiência. O experimento foi conduzido em casa de vegetação, utilizando soluções nutritivas e quartzo moído como substrato, no período de outubro de 2005 a janeiro de 2006, no município de Piracicaba, Estado de São Paulo. O delineamento estatístico constituiu-se de um fatorial 52 fracionado, com cinco doses de fósforo (0,20; 0,60; 1,00; 1,40 e 1,80 mmol L-1) combinadas com cinco de magnésio (0,05; 0,70; 1...

Características produtivas, nutricionais e metabólicas do capim-marandu submetido a doses de nitrogênio e magnésio; Productive, nutritional and metabolic characteristics of marandu palisadegrass grown with nitrogen and magnesium rates

Garcez, Tiago Barreto
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 15/01/2010 PT
Relevância na Pesquisa
36.97%
A variação na disponibilidade de nitrogênio e magnésio pode alterar as características produtivas, nutricionais e metabólicas das plantas forrageiras. O objetivo foi de avaliar o efeito das combinações de doses de nitrogênio e de magnésio na produção da parte aérea e das raízes, nas concentrações dos nutrientes nas lâminas de folhas recém-expandidas (LR) e nas raízes, na atividade da glutamina sintetase, nas concentrações das formas inorgânicas de nitrogênio e na relação nitrogênio:magnésio nas LR do capim-marandu. O experimento foi realizado em casa de vegetação, em Piracicaba SP, com a Brachiaria brizantha cv. Marandu. Foram estudadas cinco doses de nitrogênio (2; 9; 16; 23 e 30 mmol L-1) e cinco doses de magnésio (0,05; 0,70; 1,35; 2,00 e 2,65 mmol L-1) em solução nutritiva, em esquema fatorial 52 fracionado, perfazendo treze combinações: 2/0,05; 2/1,35; 2/2,65; 9/0,70; 9/2,00; 16/0,05; 16/1,35; 16/2,65; 23/0,70; 23/2,00; 30/0,05; 30/1,35 e 30/2,65. O delineamento experimental foi o de blocos ao acaso, com quatro repetições. As plantas tiveram dois períodos de crescimento, nos quais foram avaliadas as produções de massa seca, contados perfilhos e folhas, coletado material fresco para determinação da atividade da glutamina sintetase...

Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III

Deng, Xinqing; Song, Yiqing; Manson, JoAnn E; Signorello, Lisa B; Zhang, Shumin M; Shrubsole, Martha J; Ness, Reid M; Seidner, Douglas L; Dai, Qi
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
36.99%
Background: Magnesium plays an essential role in the synthesis and metabolism of vitamin D and magnesium supplementation substantially reversed the resistance to vitamin D treatment in patients with magnesium-dependent vitamin-D-resistant rickets. We hypothesized that dietary magnesium alone, particularly its interaction with vitamin D intake, contributes to serum 25-hydroxyvitamin D (25(OH)D) levels, and the associations between serum 25(OH)D and risk of mortality may be modified by magnesium intake level. Methods: We tested these novel hypotheses utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2001 to 2006, a population-based cross-sectional study, and the NHANES III cohort, a population-based cohort study. Serum 25(OH)D was used to define vitamin D status. Mortality outcomes in the NHANES III cohort were determined by using probabilistic linkage with the National Death Index (NDI). Results: High intake of total, dietary or supplemental magnesium was independently associated with significantly reduced risks of vitamin D deficiency and insufficiency respectively. Intake of magnesium significantly interacted with intake of vitamin D in relation to risk of both vitamin D deficiency and insufficiency. Additionally...

An Assessment of Novel Biodegradable Magnesium Alloys for Endovascular Biomaterial Applications

Persaud-Sharma, Dharam
Fonte: FIU Digital Commons Publicador: FIU Digital Commons
Tipo: Artigo de Revista Científica Formato: application/pdf
Relevância na Pesquisa
36.99%
Magnesium alloys have been widely explored as potential biomaterials, but several limitations to using these materials have prevented their widespread use, such as uncontrollable degradation kinetics which alter their mechanical properties. In an attempt to further the applicability of magnesium and its alloys for biomedical purposes, two novel magnesium alloys Mg-Zn-Cu and Mg-Zn-Se were developed with the expectation of improving upon the unfavorable qualities shown by similar magnesium based materials that have previously been explored. The overall performance of these novel magnesium alloys has been assessesed in three distinct phases of research: 1) analysing the mechanical properties of the as-cast magnesium alloys, 2) evaluating the biocompatibility of the as-cast magnesium alloys through the use of in-vitro cellular studies, and 3) profiling the degradation kinetics of the as-cast magnesium alloys through the use of electrochemical potentiodynamic polarization techqnique as well as gravimetric weight-loss methods. As compared to currently available shape memory alloys and degradable as-cast alloys, these experimental alloys possess superior as-cast mechanical properties with elongation at failure values of 12% and 13% for the Mg-Zn-Se and Mg-Zn-Se alloys...

Parenteral magnesium sulfate versus amiodarone in the therapy of atrial tachyarhythmias: A prospective randomized study

Moran, J.; Gallagher, J.; Peake, S.; Cunningham, D.; Salagaras, M.; Leppard, P.
Fonte: Williams & Wilkins Publicador: Williams & Wilkins
Tipo: Artigo de Revista Científica
Publicado em //1995 EN
Relevância na Pesquisa
37.01%
OBJECTIVE: To compare the efficacy of parenteral magnesium sulfate vs. amiodarone in the therapy of atrial tachyarrhythmias in critically ill patients. DESIGN: Prospective, randomized study. SETTING: Multidisciplinary intensive care unit (ICU) at a university teaching hospital. PATIENTS: Forty-two patients, 21 medical and 21 surgical, of mean (SD) age 67 +/- 15 yrs and mean Acute Physiology and Chronic Health Evaluation II score of 22 +/- 6, with atrial tachyarrhythmias (ventricular response rate of > or = 120 beats/min) sustained for > or = 1 hr. INTERVENTIONS: After correction of the plasma potassium concentration to > or = 4.0 mmol/L, patients were randomly allocated to treatment with either a) magnesium sulfate 0.037 g/kg (37 mg/kg) bolus followed by 0.025 g/kg/hr (25 mg/kg/hr); or b) amiodarone 5 mg/kg bolus and 10 mg/kg/24-hr infusion. Therapeutic plasma magnesium concentration in the magnesium sulfate group was 1.4 to 2.0 mmol/L. Therapeutic end point was conversion to sinus rhythm over 24 hrs. MEASUREMENTS AND MAIN RESULTS: At study entry (time 0), initial mean ventricular response rate and systolic blood pressure were 151 +/- 16 (SD) beats/min and 127 +/- 30 mm Hg in the magnesium sulfate group vs. 153 +/- 23 beats/min and 123 +/- 23 mm Hg in the amiodarone group...

Magnesium in acute and chronic brain injury: an update

Vink, R.; Cook, N.; Van Den Heuvel, C.
Fonte: John Libbey & Co Ltd Publicador: John Libbey & Co Ltd
Tipo: Artigo de Revista Científica
Publicado em //2009 EN
Relevância na Pesquisa
36.97%
While brain free magnesium levels have been shown to decline in a number of acute and chronic brain pathologies, the mechanisms of such decline and the potential for magnesium administration as a therapeutic intervention are still unclear. In acute brain injury, magnesium therapy has failed in recent clinical trials of trauma, presumably because of an intact blood brain barrier at the time of administration reducing central penetration. Under such conditions, magnesium’s peripheral effects on cardiovascular parameters may dominate over the central, and potentially neuroprotective, effects of the compound. In contrast, magnesium has been demonstrated to be beneficial in lacunar strokes, albeit that recent animal studies indicate that this effect is without any significant reduction of lesion size. Postnatal magnesium has also been shown to improve neurological outcome in term neonates with perinatal asphyxia, although this may be limited to cases of mild to moderate brain injury; no effect is observed following severe brain injury. Prenatal magnesium has been reported to be beneficial for outcome in very preterm infants, although this may only be at low doses. Combination therapies are also showing promise in experimental studies...

Magnesium and diabetes : it’s implications for the health of indigenous Australians.

Longstreet, Diane Alicia
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2008
Relevância na Pesquisa
37.05%
Diabetes in Indigenous Australians occurs at a younger age and at almost four times the rate of non-Indigenous Australians. While the cause for this health disparity is multi-factorial, recent studies suggest that nutrition, and particularly magnesium intake, may play a role in onset of diabetes and related pathologies. No study has ever examined whether there is any relationship between diabetes and magnesium intake in Indigenous Australians, and the present study therefore sought to establish whether any such interrelationship existed. As part of this study, dietary magnesium intake was estimated in an urban cohort of Aboriginal and Torres Strait Islander subjects and compared to the average Australian dietary intake. An ecological study then explored environmental correlates, and specifically the magnesium level in drinking water, to diabetes mortality. Finally, total and free serum magnesium concentrations were determined to identify any differences in magnesium status between diabetic and non-diabetic Indigenous and non-Indigenous Australians, and also to compare which of the two parameters was a more sensitive measure of magnesium status and diabetic risk. All Aboriginal and Torres Strait Islander people that were recruited for this study were patients of the Townsville Aboriginal and Islander Health Services...

Beeinflussung der Maximalkraft und der lokalen Muskelausdauer durch die Einnahme von Magnesium und Tetrazepam; The Influence of Magnesium supplementation and Tetrazepam ingestion on maximum strength and muscle fatigue

Krich-Gruschwitz, Brita Stephanie
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
Relevância na Pesquisa
37.01%
In den vergangenen Jahren wurde in der Sportmedizin wiederholt diskutiert, ob eine zusätzliche Magnesiumeinnahme zu einer Steigerung der körperlichen Leistungsfähigkeit führt. In diesem Zusammenhang wurden bisher nur wenige Studien veröffentlicht, die die Einflussnahme von Magnesium auf die Maximalkraft und die lokale Muskelausdauer untersuchten. Diese ergaben außerdem keine einheitlichen Ergebnisse. Unabhängig davon ist in der Sportmedizin verschiedentlich der kurzfristige Einsatz von zentralen Muskelrelaxantien zur Behandlung akuter muskulärer Verspannungen erforderlich. Die Auswirkungen dieser Einnahme auf verschiedene leistungsbeeinflussende Faktoren, wie die Kraftentwicklung und die lokale Muskelausdauer sollte dem behandelnden Arzt bekannt sein. In der vorliegenden Untersuchung wurde aus diesen Gründen der Einfluss einer Supplementation mit Magnesium und der Einnahme des Muskelrelaxans Tetrazepam auf die Maximalkraft und die lokale Muskelausdauer untersucht. Begleitend wurden Intensität und Dauer der in Folge der Belastung auftretenden muskulären Beschwerden erfasst. Die Studie erfolgte mit 30 Probanden (je 15 Frauen und Männer) im Cross-Over-Design. Für die Supplementation mit Magnesium wurde eine Dosierung von 20 mmol Magnesium täglich über 14 Tage und für Tetrazepam die Einnahme von zweimal 50 mg vor der Kraftmessung festgelegt. Die Maximalkraft und die lokale Muskelausdauer wurden mittels isokinetischer Tests erfasst. Mit Hilfe der Numerical Rating Scale wurden die nachfolgenden muskulären Beschwerden quantifiziert und ausgewertet. Weder durch die Supplementation von Magnesium noch durch die Einnahme von Tetrazepam ergaben sich signifikante oder tendenzielle Veränderungen der Maximalkraft oder der lokalen Muskelausdauer. Lediglich bzgl. der Ausprägung muskulärer Beschwerden zeigte sich eine tendenzielle Verminderung nach Einnahme von Tetrazepam. Auch die nach Geschlechtern differenzierte Auswertung der Ergebnisse nach Einnahme von Magnesium ergab keine Hinweise auf eine Beeinflussung der untersuchten Messgrößen.; In previous years...

Association between magnesium-deficient status and anthropometric and clinical-nutritional parameters in posmenopausal women

L??pez-Gonz??lez, Beatriz; Molina-L??pez, Jorge; Florea, Daniela Ioana; Quintero Osso, Bartolom??; P??rez de la Cruz, Antonio; Planells del Pozo, Elena Mar??a
Fonte: Aula M??dica; Sociedad Espa??ola de Nutrici??n Parenteral y Enteral (SENPE) Publicador: Aula M??dica; Sociedad Espa??ola de Nutrici??n Parenteral y Enteral (SENPE)
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
36.97%
Background: During menopause occurs weight gain and bone loss occurs due to the hormone decline during this period and other factors such as nutrition. Magnesium deficiency suggests a risk factor for obesity and osteo porosis. Objective: To evaluate the clinical and nutritional magnesium status in a population of postmenopausal women, assessing intake and serum levels of magnesium in the study population and correlation with anthropometric parameters such as body mass index (BMI) and body fat, and biochemical parameters associated. Subjects and Method: The study involved 78 healthy women aged 44-76, with postmenopausal status, from the province of Grenade, Spain. The sample was divided into two age groups: group 1, aged < 58, and group 2 aged???58. Anthropometric parameters were recorded and nutritional intake was assessed by 72-hour recall, getting the RDAs through Nutriber ?? program. To assess the biochemical parameters was performed a blood sample was taken. Magnesium was analyzed by flame atomic absorption spectrophotometry (FAAS) in erythrocyte and plasma wet-mineralized samples. Results: Our results show that 37.85% of the total subjects have an overweight status. Magnesium intake found in our population is insufficient in 36% of women...

Magnesium polyethylene glycol: a novel therapeutic agent for traumatic brain injury.

Busingye, Diana Sabiiti
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2015
Relevância na Pesquisa
37.01%
A number of experimental studies have shown that decline in intracellular free magnesium is a ubiquitous feature of traumatic brain injury (TBI), and that restoration of magnesium homeostasis improves both cognitive and motor outcome. However, a recent large, randomized clinical trial of magnesium in TBI failed, in part because of poor central penetration of the magnesium salt. Subsequent experimental studies in spinal cord injury have shown that magnesium penetration into the CNS can be facilitated if the magnesium salt is administered in a solution containing polyethylene glycol (PEG), a polymer that facilitates transport across the blood brain barrier and throughout the extracellular space. Accordingly, the current study characterised the therapeutic potential of high and low dose magnesium chloride, either alone or in combination with PEG, on oedema, blood brain barrier permeability, brain histology and functional outcome following moderate diffuse TBI in rats. Adult male Sprague Dawley rats (350-380 g) exposed to moderate diffuse TBI induced using the impact acceleration injury model, were administered intravenous magnesium polyethylene glycol (Mg PEG) (254 μmoles/kg MgCl₂ in 1g/kg PEG), the same concentration (optimal dose) of MgCl₂ or PEG alone...

Magnesium supplementation in pregnancy

Makrides, M.; Crowther, C.A.
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Artigo de Revista Científica
Publicado em //2001 EN
Relevância na Pesquisa
36.96%
BACKGROUND: Many women, especially those from disadvantaged backgrounds, have intakes of magnesium below recommended levels. Magnesium supplementation during pregnancy may be able to reduce fetal growth retardation and pre-eclampsia, and increase birth weight. OBJECTIVES: The objective of this review was to assess the effects of magnesium supplementation during pregnancy on maternal, neonatal and paediatric outcomes. SEARCH STRATEGY: We searched the Cochrane Cochrane Controlled Trials Register. The date of the last search was June 2001. SELECTION CRITERIA: Randomised and quasi-randomised trials of dietary magnesium supplementation during pregnancy. DATA COLLECTION AND ANALYSIS: Suitability for inclusion and methodological quality were separately assessed by each reviewer. Data were independently extracted by the two reviewers. MAIN RESULTS: Seven trials involving 2689 women were included. Six of these trials randomly allocated women to either an oral magnesium supplement or a control group, whist the largest trial with 985 women had a cluster design where randomisation was according to study centre. The analysis was conducted with and without the cluster trial. In the analysis of all trials, oral magnesium treatment from before the 25th week of gestation was associated with a lower frequency of preterm birth...

Magnesium sulphate for women at term for neuroprotection of the fetus

Nguyen, T.M.; Crowther, C.; Wilkinson, D.; Bain, E.
Fonte: Update Software Ltd Publicador: Update Software Ltd
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
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BACKGROUND Magnesium sulphate is extensively used in obstetrics for the treatment and prevention of eclampsia. A recent meta-analysis has shown that magnesium sulphate is an effective fetal neuroprotective agent when given antenatally to women at risk of very preterm birth. Term infants account for more than half of all cases of cerebral palsy, and the incidence has remained fairly constant. It is important to assess if antenatal administration of magnesium sulphate to women at term protects the fetus from brain injury, and associated neurosensory disabilities including cerebral palsy. OBJECTIVES To assess the effectiveness of magnesium sulphate given to women at term as a neuroprotective agent for the fetus. SEARCH METHODS We searched the Cochrane Pregnancy and Childbirth Group's Trial Register (31 July 2012) and the reference lists of other Cochrane reviews assessing magnesium sulphate in pregnancy. SELECTION CRITERIA Randomised controlled trials comparing antenatally administered magnesium sulphate to women at term with placebo, no treatment or a different fetal neuroprotective agent. We also planned to include cluster-randomised trials, and exclude cross-over trials and quasi-randomised trials. We planned to exclude studies reported as abstracts only. DATA COLLECTION AND ANALYSIS Two review authors independently assessed trials for eligibility and for risk of bias. Two authors independently extracted data. Data were checked for accuracy. MAIN RESULTS We included one trial (involving 135 women with mild pre-eclampsia at term). An additional six studies are awaiting further assessment. The included trial compared magnesium sulphate with a placebo and was at a low risk of bias. The trial did not report any of this review's prespecified primary outcomes. There was no significant difference between magnesium sulphate and placebo in Apgar score less than seven at five minutes (risk ratio (RR) 0.51; 95% confidence interval (CI) 0.05 to 5.46; 135 infants)...

Magnesium supplementation in pregnancy

Makrides, M.; Crosby, D.D.; Bain, E.; Crowther, C.A.
Fonte: Cochrane Collaboration Publicador: Cochrane Collaboration
Tipo: Artigo de Revista Científica
Publicado em //2014 EN
Relevância na Pesquisa
37.05%
Background: Magnesium is an essential mineral required for regulation of body temperature, nucleic acid and protein synthesis and in maintaining nerve and muscle cell electrical potentials. Many women, especially those from disadvantaged backgrounds, have low intakes of magnesium. Magnesium supplementation during pregnancy may be able to reduce fetal growth restriction and pre-eclampsia, and increase birthweight. Objectives: To assess the effects of magnesium supplementation during pregnancy on maternal, neonatal/infant and paediatric outcomes. Search methods: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 March 2013). Selection criteria: Randomised and quasi-randomised trials assessing the effects of dietary magnesium supplementation during pregnancy were included. The primary outcomes were perinatal mortality (including stillbirth and neonatal death prior to hospital discharge), small-for-gestational age, maternal mortality and pre-eclampsia. Data collection and analysis: Two review authors independently assessed study eligibility, extracted data and assessed the risk of bias of included studies. Main results: Ten trials involving 9090 women and their babies were included; one trial had a cluster design (with randomisation by study centre). All 10 trials randomly allocated women to either an oral magnesium supplement or a control group; in eight trials a placebo was used...

Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour (Review)

Han, S.; Crowther, C.; Moore, V.
Fonte: Update Software Ltd Publicador: Update Software Ltd
Tipo: Artigo de Revista Científica
Publicado em //1998 EN
Relevância na Pesquisa
36.99%
BACKGROUND: Magnesium maintenance therapy is one of the types of tocolytic therapy used after an episode of threatened preterm labour (usually treated with an initial dose of tocolytic therapy) in an attempt to prevent the onset of further preterm contractions. OBJECTIVES: To assess whether magnesium maintenance therapy is effective in preventing preterm birth after the initial threatened preterm labour is arrested. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (May 2010). SELECTION CRITERIA: Randomised controlled trials of magnesium therapy given to women after threatened preterm labour. DATA COLLECTION AND ANALYSIS: The review authors independently assessed the studies for inclusion, assessed risk of bias and carried out data extraction. We checked data entry. MAIN RESULTS: We included four trials, which recruited 422 women. Three trials had high risk of bias and none included any long-term follow up of infants. No differences in the incidence of preterm birth or perinatal mortality were seen when magnesium maintenance therapy was compared with placebo or no treatment; or alternative therapies (ritodrine or terbutaline). The risk ratio (RR) for preterm birth (less than 37 weeks) for magnesium compared with placebo or no treatment was 1.05...

School-age outcomes of very preterm infants after antenatal treatment with magnesium sulfate vs placebo

Doyle, L.W.; Anderson, P.J.; Haslam, R.; Lee, K.J.; Crowther, C.; Darlow, B.; Austin, N.; French, N.; Campbell, C.; Carse, E.; Hayes, M.; Harding, J.; McKinlay, C.; Bevan, C.; De Paoli, A.; Sutton, L.; Rieger, I.; Wocadlo, C.; Colditz, P.; Pritchard, M.;
Fonte: JAMA Publicador: JAMA
Tipo: Artigo de Revista Científica
Publicado em //2014 EN
Relevância na Pesquisa
36.96%
IMPORTANCE: Antenatal magnesium sulfate given to pregnant women at imminent risk of very preterm delivery reduces the risk of cerebral palsy in early childhood, although its effects into school age have not been reported from randomized trials. OBJECTIVE: To determine the association between exposure to antenatal magnesium sulfate and neurological, cognitive, academic, and behavioral outcomes at school age. DESIGN, SETTING, AND PARTICIPANTS: The ACTOMgSO4 was a randomized clinical trial conducted in 16 centers in Australia and New Zealand, comparing magnesium sulfate with placebo given to pregnant women (n = 535 magnesium; n = 527 placebo) for whom imminent birth was planned or expected before 30 weeks' gestation. Children who survived from the 14 centers who participated in the school-age follow-up (n = 443 magnesium; n = 424 placebo) were invited for an assessment at 6 to 11 years of age between 2005 and 2011. MAIN OUTCOMES AND MEASURES: Mortality, cerebral palsy, motor function, IQ, basic academic skills, attention and executive function, behavior, growth, and functional outcomes. Main analyses were imputed for missing data. RESULTS: Of the 1255 fetuses known to be alive at randomization, the mortality rate to school age was 14% (88/629) in the magnesium sulfate group and 18% (110/626) in the placebo group (risk ratio [RR]...

Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour

Han, S.; Crowther, C.; Moore, V.
Fonte: Update Software Ltd Publicador: Update Software Ltd
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
37.01%
BACKGROUND Magnesium maintenance therapy is one of the types of tocolytic therapy used after an episode of threatened preterm labour (usually treated with an initial dose of tocolytic therapy) in an attempt to prevent the onset of further preterm contractions. OBJECTIVES To assess whether magnesium maintenance therapy is effective in preventing preterm birth after the initial threatened preterm labour is arrested. SEARCH METHODS We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 January 2013). SELECTION CRITERIA Randomised controlled trials of magnesium therapy given to women after threatened preterm labour. DATA COLLECTION AND ANALYSIS The review authors independently assessed the studies for inclusion, assessed risk of bias and carried out data extraction. We checked data entry. MAIN RESULTS We included four trials involving 422 women. Three trials had high risk of bias and none included any long-term follow-up of infants. No differences in the incidence of preterm birth or perinatal mortality were seen when magnesium maintenance therapy was compared with placebo or no treatment; or alternative therapies (ritodrine or terbutaline). The risk ratio (RR) for preterm birth (less than 37 weeks) for magnesium compared with placebo or no treatment was 1.05...

Differences in intracellular localization of corn stunt spiroplasmas in magnesium treated maize

Nome,Claudia; Magalhães,Paulo César; Oliveira,Elizabeth; Nome,Sergio; Laguna,Irma Graciela
Fonte: Biocell Publicador: Biocell
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2009 EN
Relevância na Pesquisa
36.97%
Maize plants infected with Spiroplasma kunkelii show symptoms similar to that of plants in a magnesium-deficient soil, and it has been shown that the spiroplasma alters the plants' magnesium absorption. In the current study we compared changes associated to either spiroplasma infection, two soil magnesium levels and their combinations. Plant symptoms were recorded and correlated with transmission electron microscopy observations. Plants grown on a high magnesium treatment showed no macroscopical alterations nor organelle ultrastructural alterations, while plants on a low magnesium treatment showed macroscopical vein yellowing and, ultrastructurally, they had most chloroplasts and mitochondrial membranes altered. Infected plants on a low magnesium treatment had an ageing aspect, ultrastructurally showed chloroplasts and mitochondrial alterations similar to those non-infected and grown on a low magnesium treatment, and spiroplasma cells were found in phloem cells, but outside their cytoplasm. Infected plants on a high magnesium treatment showed similar symptoms and ultrastructural alterations as either non-infected plants on the low magnesium treatment or in infected plants on the low magnesium treatment, but differ from them in that the spiroplasma cells were located inside the cytoplasm. Results suggest that magnesium is involved in the plant-pathogen interaction.

Association between magnesium-deficient status and anthropometric and clinical-nutritional parameters in posmenopausal women

López-González,Beatriz; Molina-López,Jorge; Ioana Florea,Daniela; Quintero-Osso,Bartolomé; Pérez de la Cruz,Antonio; Planells del Pozo,Elena Mª
Fonte: Nutrición Hospitalaria Publicador: Nutrición Hospitalaria
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/03/2014 ENG
Relevância na Pesquisa
36.97%
Background: During menopause occurs weight gain and bone loss occurs due to the hormone decline during this period and other factors such as nutrition. Magnesium deficiency suggests a risk factor for obesity and osteoporosis. Objective: To evaluate the clinical and nutritional magnesium status in a population of postmenopausal women, assessing intake and serum levels of magnesium in the study population and correlation with anthropometric parameters such as body mass index (BMI) and body fat, and biochemical parameters associated. Subjects and Method: The study involved 78 healthy women aged 44-76, with postmenopausal status, from the province of Grenade, Spain. The sample was divided into two age groups: group 1, aged < 58, and group 2 aged > 58. Anthropometric parameters were recorded and nutritional intake was assessed by 72-hour recall, getting the RDAs through Nutriber® program. To assess the biochemical parameters was performed a blood sample was taken. Magnesium was analyzed by flame atomic absorption spectrophotometry (FAAS) in erythrocyte and plasma wet-mineralized samples. Results: Our results show that 37.85% of the total subjects have an overweight status. Magnesium intake found in our population is insufficient in 36% of women...

Efficacy of class III antiarrhythmics and magnesium combination therapy for atrial fibrillation

Wang,Amy
Fonte: Pharmacy Practice (Internet) Publicador: Pharmacy Practice (Internet)
Tipo: info:eu-repo/semantics/article; journal article; info:eu-repo/semantics/publishedVersion Formato: text/html; application/pdf
Publicado em 01/06/2012 ENG
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Atrial fibrillation is a common cardiac arrhythmia, and has been a significant financial burden. Class III antiarrhythmics such as dofetilide, ibutilide, and amiodarone are indicated for rhythm control. Magnesium may possess intrinsic antiarrhythmic properties, and may potentially increase the efficacy of class III antiarrhythmics when used concomitantly. Objective: The purpose of this article is to review the literature on the efficacy of magnesium in addition to Class III antiarrhythmics, specifically amidarone, ibutilide, and dofetilide for the cardioversion of atrial fibrillation. Methods: Databases Pubmed and CINAHL are utilized along with the search terms amiodarone, dofetilide, ibutlide, magnesium, atrial fibrillation, conversion, rhythm control, and cardioversion. Results: One study on dofetilide and 5 studies on ibutilide were identified. No studies were found on amiodarone. Patients with atrial fibrillation who received dofetilide and magnesium had higher rates of successful cardioversion as compared to those who only received dofetilide. Conversion rates were similar between the 2 treatment groups for patients with atrial flutter. As for ibutilide, 4 studies have shown that the addition of magnesium significantly increases conversion rates for patients with atrial fibrillation or typical atrial flutter. Conversion rates were similar for patients with atypical atrial flutter. One study showed that addition of magnesium did not improve efficacy of ibutilide. Higher doses of magnesium (4 g) were associated with improved outcomes. Adverse effects of magnesium were mild and included flushing...