Página 1 dos resultados de 744 itens digitais encontrados em 0.007 segundos
- Instituto de Medicina Tropical
- AMER ROENTGEN RAY SOC
- ELSEVIER SCIENCE BV
- Biblioteca Digitais de Teses e Dissertações da USP
- Academia Brasileira de Neurologia - ABNEURO
- Sociedade Brasileira de Medicina Tropical - SBMT
- Liga Brasileira de Epilepsia (LBE)
- Oxford University Press
- Matrix Medical Communications
- Ordem dos Médicos
- Saunders
- Brazilian Society of Infectious Diseases
- Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
- West Indian Medical Journal
- Mais Publicadores...
Aids-related progressive multifocal leukoencephalopathy: a retrospective study in a referral center in São Paulo, Brazil; Leucoencefalopatia multifocal progressiva em pacientes com aids: estudo retrospectivo em um centro de referência de São Paulo, Brasil
Fonte: Instituto de Medicina Tropical
Publicador: Instituto de Medicina Tropical
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
37.08%
#Progressive multifocal leukoencephalopathy#Epidemiology#Diagnosis#Acquired immunodeficiency syndrome
Few data are available about progressive multifocal leukoencephalopathy (PML) in patients with acquired immunodeficiency syndrome (AIDS) from Brazil. The objectives of this study were to describe the main features of patients with PML and estimate its frequency among AIDS patients with central nervous system (CNS) opportunistic diseases admitted to the Instituto de Infectologia Emílio Ribas, São Paulo, Brazil, from April 2003 to April 2004. A retrospective and descriptive study was performed. Twelve (6%) cases of PML were identified among 219 patients with neurological diseases. The median age of patients with PML was 36 years and nine (75%) were men. Nine (75%) patients were not on antiretroviral therapy at admission. The most common clinical manifestations were: focal weakness (75%), speech disturbances (58%), visual disturbances (42%), cognitive dysfunction (42%), and impaired coordination (42%). The median CD4+ T-cell count was 45 cells/µL. Eight (67%) of 12 patients were laboratory-confirmed with PML and four (33%) were possible cases. Eleven (92%) presented classic PML and only one case had immune reconstitution inflammatory syndrome (IRIS)-related PML. In four (33%) patients, PML was the first AIDS-defining illness. During hospitalization...
Link permanente para citações:
Acute Toxic Leukoencephalopathy: Potential for Reversibility Clinically and on MRI With Diffusion-Weighted and FLAIR Imaging
Fonte: AMER ROENTGEN RAY SOC
Publicador: AMER ROENTGEN RAY SOC
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
37.43%
#diffusion-weighted MRI#FLAIR#leukoencephalopathy#MRI#toxic leukoencephalopathy#white matter#METRONIDAZOLE-INDUCED ENCEPHALOPATHY#X-LINKED ADRENOLEUKODYSTROPHY#WHITE-MATTER LESIONS#FLUORO-BETA-ALANINE#NONKETOTIC HYPERGLYCEMIA
OBJECTIVE. Toxic leukoencephalopathy may present acutely or subacutely with symmetrically reduced diffusion in the periventricular and supraventricular white matter, hereafter referred to as periventricular white matter. This entity may reverse both on imaging and clinically. However, a gathering together of the heterogeneous causes of this disorder as seen on MRI with diffusion-weighted imaging (DWI) and an analysis of their likelihood to reverse has not yet been performed. Our goals were to gather causes of acute or subacute toxic leukoencephalopathy that can present with reduced diffusion of periventricular white matter in order to promote recognition of this entity, to evaluate whether DWI with apparent diffusion coefficient (ADC) values can predict the extent of chronic FLAIR abnormality ( imaging reversibility), and to evaluate whether DWI can predict the clinical outcome ( clinical reversibility). MATERIALS AND METHODS. Two neuroradiologists retrospectively reviewed the MRI examinations of 39 patients with acute symptoms and reduced diffusion of periventricular white matter. The reviewers then scored the extent of abnormality on DWI and FLAIR. ADC ratios of affected white matter versus the unaffected periventricular white matter were obtained. Each patient`s clinical records were reviewed to determine the cause and clinical outcome. Histology findings were available in three patients. Correlations were calculated between the initial MRI markers and both the clinical course and the follow-up extent on FLAIR using Spearman`s correlation coefficient. RESULTS. Of the initial 39 patients...
Link permanente para citações:
Molecular characterization of human polyomavirus JC in Brazilian AIDS patients with and without progressive multifocal leukoencephalopathy
Fonte: ELSEVIER SCIENCE BV
Publicador: ELSEVIER SCIENCE BV
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
37.08%
#JC virus#Progressive multifocal leukoencephalopathy (PML)#AIDS#Genotypes#Amino acid replacement#CEREBROSPINAL-FLUID#CONTROL REGION#VIRUS#GENOTYPES#INDIVIDUALS#POPULATION
Background: JC virus (JCV), the causative agent of progressive multifocal leukoencephalopathy (PML), is classified in 8 different genotypes. Previous reports have suggested a positive association between specific genotypes and PML. Objective: To compare genotypes and adaptive mutations of JCV strains from Brazilian AIDS patients with and without PML. Study design: The VP1 region of JCV was amplified by polymerase chain reaction from cerebrospinal fluid samples from 51 patients with PML and from urine samples of 47 patients with AIDS without central nervous system disease. Genotyping was done by phylogenetic analysis. Amino acid replacement and selection pressures were also investigated. Results: JCV genotype frequency distributions showed that genotypes 2 (32.7%), 1 (26.5%) and 3 (23.5%) were the most prevalent. Genotype 1 had a positive association (p < 0.0001) and genotype 3 showed an inverse association (p < 0.001) with PML. A previously undescribed point mutation at residue 91 (L/I or L/V) and (L/P), non-genotype-associated, was found in 5/49 (10.2%) and 2/47 (4.3%) JCV sequences from PML and non-PML patients, respectively. This mutation was under positive selection only in PML patients. A previously described substitution of T-A in position 128 showed a significant difference between PML and non-PML cases (70% versus 16%...
Link permanente para citações:
Distribuição genotípica do poliomavirus humano JC em pacientes com aids, com e sem leucoencefalopatia multifocal progressiva, em São Paulo, Brasil; Genotype distribution of human polyomavirus JC in AIDS patients with and without progressive multifocal leukoencephalopathy, in Sao Paulo, Brazil
Fonte: Biblioteca Digitais de Teses e Dissertações da USP
Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado
Formato: application/pdf
Publicado em 12/03/2010
PT
Relevância na Pesquisa
37.24%
#Genótipo#Genotype#JC virus#Leucoencefalopatia multifocal progressiva#Leukoencephalopathy progressive multifocal#Polymerase chain reaction#Reação em cadeia da polimerase#Virus JC
A relação entre os diferentes genótipos do VJC e a patogênese da LEMP permanece ainda uma questão controversa. O presente estudo visou a caracterização genotipica do vírus JC (VJC) e sua associação com a leucoencefalopatia multifocal progressiva (LEMP) em pacientes com aids em São Paulo, no período de 2000 a 2008. Foram avaliadas 51 amostras de líquor de pacientes com LEMP e 47 amostras de pacientes com aids sem LEMP positivas para os genes T e VP1 pela reação em cadeia por polimerase (PCR). Foram identificados, através do sequenciamento genômico os genótipos 1, 2, 3, 4 e 6, sendo que os mais prevalentes foram os genótipos 2 (33%), 1 (27%), seguidos pelo genótipo 3 (23%). O genótipo 1 e mostrou associação positiva com a LEMP (p<0,05), enquanto que o genótipo 3 mostrou associação inversa à LEMP. Durante a internação em que foi diagnosticada LEMP observamos evolução para óbito em 27 (59%) pacientes e alta em 19 (41%). Não houve associação entre os genótipos do VJC ou carga viral liquórica e a evolução para óbito, mas houve associação significante entre o número de linfócitos TCD4+ e o óbito. No presente estudo, uma mutação no sítio 91 do gene VP1 com substituição da leucina para isoleucina ou valina...
Link permanente para citações:
Progressive multifocal leukoencephalopathy in a child with acquired immunodeficiency syndrome (AIDS)
Fonte: Academia Brasileira de Neurologia - ABNEURO
Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica
Formato: text/html
Publicado em 01/01/1997
EN
Relevância na Pesquisa
37.24%
Progressive multifocal leukoencephalopathy is a rare viral-induced demyelinating disease associated to immunodeficiency. A 10-year-old boy with AIDS is reported, who developed subacute cerebellar signs and symptoms with multiple cranial nerve involvement and dementia. A computed tomography scan revealed a focal nonenhancing area of low attenuation in the cerebellum. On magnetic resonance imaging high signal lesions in T2 weighted sequences were shown. The biopsy of one of those lesions showed the typical histological findings of progressive multifocal leukoencephalopathy. It seems important to consider this diagnosis in children with AIDS who present with progressive neurological features.
Link permanente para citações:
Head tremor and progressive multifocal leukoencephalopathy in AIDS patients: report of two cases
Fonte: Academia Brasileira de Neurologia - ABNEURO
Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica
Formato: text/html
Publicado em 01/03/2005
EN
Relevância na Pesquisa
37.08%
Progressive multifocal leukoencephalopathy (PML) is caused by replication of JC virus in oligodendrocytes of immunocompromised patients. Common manifestations are focal motor and sensory deficits, gait abnormalities, speech and language disturbances, cognitive disorders, headache, and visual impairment. Although the occurrence of movement disorders is rare in PML, bradykinesia, rigidity, dystonia, myoclonic jerks and myoclonic ataxia have been described. Head tremor associated with PML has not been previously reported. We report two cases of PML in whom head tremor was present.
Link permanente para citações:
Studying the evolution and the magnetic resonance findings of reversible posterior leukoencephalopathy in children
Fonte: Academia Brasileira de Neurologia - ABNEURO
Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica
Formato: text/html
Publicado em 01/09/2006
EN
Relevância na Pesquisa
37.08%
PURPOSE: To describe the evolution and the magnetic resonance imaging (MRI) findings of the reversible posterior leukoencephalopathy (RLPS) in children. METHOD: Nine children with neurologic symptoms and sudden increase of the arterial pressure were studied by brain MRI. RESULTS: All children evaluated had lesions seen on FLAIR-weighted images of the parietal-occipital regions. Other regions were also involved. Four patients presented restriction on diffusion-weighted images and only two with reduction of the apparent diffusion coefficient (ADC), whitch evolved with neurologic sequels and persistence of the lesions on the control examination. The other patients had complete regression of the lesions after therapy. CONCLUSION: MRI is important to suggest the diagnosis of RPLS in patients with arterial hypertension and unspecific neurologic symptoms. Moreover, the outcome is not favorable all the time and the association of D-WI with ADC can be an instrument capable of predicting irreversible lesions.
Link permanente para citações:
Leukoencephalopathy with brainstem and spinal cord involvement and high brain lactate: report of three brazilian patients
Fonte: Academia Brasileira de Neurologia - ABNEURO
Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica
Formato: text/html
Publicado em 01/06/2007
EN
Relevância na Pesquisa
37.24%
A novel leukoencephalopathy was recently identified based on magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (¹H-MRS) findings. Leukoencephalopathy with brainstem and spinal cord involvement and high lactate (LBSL) is an autosomal recessive disorder characterized by early onset of symptoms and slowly progressive cerebellar, pyramidal and spinal cord dorsal column dysfunction. MRI and ¹H-MRS typically show abnormalities within cerebral and cerebellar white matter, a characteristic involvement of brainstem and spinal cord tracts and elevated lactate in the abnormal white matter. We present three cases with characteristic clinical and neuroimaging findings of this disorder. Some additional unique findings of our patients are discussed, like distal motor neuropathy and elevated creatine kinase in the serum.
Link permanente para citações:
Progressive multifocal leukoencephalopathy: new concepts
Fonte: Academia Brasileira de Neurologia - ABNEURO
Publicador: Academia Brasileira de Neurologia - ABNEURO
Tipo: Artigo de Revista Científica
Formato: text/html
Publicado em 01/09/2013
EN
Relevância na Pesquisa
37.08%
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression. Originally, PML was observed in patients with advanced HIV infection, lymphoproliferative disorders and transplant recipients. However, the widespread use of HIV antiretroviral drugs and the new selective immunomodulatory and immunosuppressive medications, such as Rituximab and Natalizumab, has recently modified the epidemiology, clinical presentation and prognosis of PML. Herein, we discuss the new concepts on PML, emphasizing the recent modification in the epidemiology; the impact of new immunomodulatory treatments in the disease, PML-IRIS (Immune reconstitution inflammatory síndrome), new treatment strategies and other JCV related CNS diseases.
Link permanente para citações:
Aids-related progressive multifocal leukoencephalopathy: a retrospective study in a referral center in São Paulo, Brazil
Fonte: Instituto de Medicina Tropical
Publicador: Instituto de Medicina Tropical
Tipo: Artigo de Revista Científica
Formato: text/html
Publicado em 01/08/2008
EN
Relevância na Pesquisa
37.08%
#Progressive multifocal leukoencephalopathy#Epidemiology#Diagnosis#Acquired immunodeficiency syndrome
Few data are available about progressive multifocal leukoencephalopathy (PML) in patients with acquired immunodeficiency syndrome (AIDS) from Brazil. The objectives of this study were to describe the main features of patients with PML and estimate its frequency among AIDS patients with central nervous system (CNS) opportunistic diseases admitted to the Instituto de Infectologia Emílio Ribas, São Paulo, Brazil, from April 2003 to April 2004. A retrospective and descriptive study was performed. Twelve (6%) cases of PML were identified among 219 patients with neurological diseases. The median age of patients with PML was 36 years and nine (75%) were men. Nine (75%) patients were not on antiretroviral therapy at admission. The most common clinical manifestations were: focal weakness (75%), speech disturbances (58%), visual disturbances (42%), cognitive dysfunction (42%), and impaired coordination (42%). The median CD4+ T-cell count was 45 cells/µL. Eight (67%) of 12 patients were laboratory-confirmed with PML and four (33%) were possible cases. Eleven (92%) presented classic PML and only one case had immune reconstitution inflammatory syndrome (IRIS)-related PML. In four (33%) patients, PML was the first AIDS-defining illness. During hospitalization...
Link permanente para citações:
Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count
Fonte: Sociedade Brasileira de Medicina Tropical - SBMT
Publicador: Sociedade Brasileira de Medicina Tropical - SBMT
Tipo: Artigo de Revista Científica
Formato: text/html
Publicado em 01/02/2011
EN
Relevância na Pesquisa
37.08%
We present the case of a 31-year-old man with acute manifestation of progressive multifocal leukoencephalopathy (PML) as an AIDS-defining disease. The patient presented with a three-day history of neurological disease, brain lesions without mass effect or contrast uptake and a slightly increased protein concentration in cerebrospinal fluid. A serological test for HIV was positive and the CD4+ T-cell count was 427/mm³. Histological examination of the brain tissue revealed abnormalities compatible with PML. The disease progressed despite antiretroviral therapy, and the patient died three months later. PML remains an important cause of morbidity and mortality among HIV-infected patients.
Link permanente para citações:
The rare association of leukoencephalopathy, cerebral calcifications, and cysts: case report
Fonte: Liga Brasileira de Epilepsia (LBE)
Publicador: Liga Brasileira de Epilepsia (LBE)
Tipo: Artigo de Revista Científica
Formato: text/html
Publicado em 01/09/2010
EN
Relevância na Pesquisa
37.08%
Although basal ganglia calcifications were described a long time ago,1,3,11 the association of leukoencephalopathy, cerebral calcifications, and cysts (LCC) is a very rare entity described in 1996.5 We present a new case of LCC and discuss clinical, neuroradiologic, and histopathologic findings regarding this association.
Link permanente para citações:
Quantitative MRI Assessment of Leukoencephalopathy
Fonte: PubMed
Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /05/2002
EN
Relevância na Pesquisa
27.49%
Quantitative MRI assessment of leukoencephalopathy is difficult because the MRI properties of leukoencephalopathy significantly overlap those of normal tissue. This report describes the use of an automated procedure for longitudinal measurement of tissue volume and relaxation times to quantify leukoencephalopathy. Images derived by using this procedure in patients undergoing therapy for acute lymphoblastic leukemia (ALL) are presented. Five examinations from each of five volunteers (25 examinations) were used to test the reproducibility of quantitated baseline and subsequent, normal-appearing images; the coefficients of variation were less than 2% for gray and white matter. Regions of leukoencephalopathy in patients were assessed by comparison with manual segmentation. Two radiologists manually segmented images from 15 randomly chosen MRI examinations that exhibited leukoencephalopathy. Kappa analyses showed that the two radiologists’ interpretations were concordant (κ = 0.70) and that each radiologist’s interpretations agreed with the results of the automated procedure (κ = 0.57 and 0.55).The clinical application of this method was illustrated by analysis of images from sequential MR examinations of two patients who developed leukoencephalopathy during treatment for ALL. The ultimate goal is to use these quantitative MR imaging measures to better understand therapy-induced neurotoxicity...
Link permanente para citações:
Hyperperfusion in progressive multifocal leukoencephalopathy is associated with disease progression and absence of immune reconstitution inflammatory syndrome
Fonte: Oxford University Press
Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
27.49%
We sought to characterize perfusion patterns of progressive multifocal leukoencephalopathy lesions by arterial spin labelling perfusion magnetic resonance imaging and to analyse their association with immune reconstitution inflammatory syndrome, and survival. A total of 22 patients with progressive multifocal leukoencephalopathy underwent a clinical evaluation and magnetic resonance imaging of the brain within 190 days of symptom onset. The presence of immune reconstitution inflammatory syndrome was determined based on clinical and laboratory criteria. Perfusion within progressive multifocal leukoencephalopathy lesions was determined by arterial spin labelling magnetic resonance imaging. We observed intense hyperperfusion within and at the edge of progressive multifocal leukoencephalopathy lesions in a subset of subjects. This hyperperfusion was quantified by measuring the fraction of lesion volume showing perfusion in excess of twice normal appearing grey matter. Hyperperfused lesion fraction was significantly greater in progressive multifocal leukoencephalopathy progressors than in survivors (12.8% versus 3.4% P = 0.02) corresponding to a relative risk of progression for individuals with a hyperperfused lesion fraction ≥ 4.0% of 9.1 (95% confidence interval of 1.4–59.5). The presence of hyperperfusion was inversely related to the occurrence of immune reconstitution inflammatory syndrome at the time of scan (P = 0.03). Indeed...
Link permanente para citações:
A Case of Reversible Neuropsychiatry Symptoms in HIV due to Toxic Leukoencephalopathy
Fonte: Matrix Medical Communications
Publicador: Matrix Medical Communications
Tipo: Artigo de Revista Científica
Publicado em //2013
EN
Relevância na Pesquisa
27.49%
Mothball ingestion has been previously cited to induce toxic-leukoencephalopathy, secondary to the destructive effects of paradichlorobenzene on central nervous system white matter. This case presents a 37-year-old woman who experienced a neuropsychiatric syndrome consistent with paradichlorobenzene-induced toxic leukoencephalopathy after two decades of mothball abuse. Her clinical presentation was insidious, involving fluctuating cognitive decline, depression, and psychosis. This was further complicated by an human immunodeficiency virus infection and concomitant cocaine abuse. Ultimately, her clinical findings were attributed to a reversible toxic-leukoencephalopathy from mothball ingestion, and her magnetic resonance imaging findings were consistent with symmetric leukoencephalopathy and atrophy. Though leukoencephalopathy in human immunodeficiency virus has numerous potential etiologies, a patient with a history of substance abuse warrants consideration of toxin-induced leukoencephalopathy, and further inquiry regarding abuse of other substances is appropriate.
Link permanente para citações:
Clinical and Radiological Characterization of Progressive Multifocal Leukoencephalopathy in HIV-Infected Patients: A Retrospective Analysis and Review of the Literature; Caraterização Clínica e Radiológica dos Doentes com Leucoencefalopatia Multifocal Progressiva Infetados pelo Vírus da Imunodeficiência Humana: Análise Retrospetiva e Revisão da Literatura
Fonte: Ordem dos Médicos
Publicador: Ordem dos Médicos
Tipo: info:eu-repo/semantics/article; article; info:eu-repo/semantics/publishedVersion
Formato: application/pdf
Publicado em 30/06/2015
ENG
Relevância na Pesquisa
37.69%
#Antiretroviral Therapy, Highly Active#HIV Infections#Leukoencephalopathy, Progressive Multifocal/radiography#Magnetic Resonance Imaging.#Leucoencefalopatia Multifocal Progressiva#Infecções por VIH#Ressonância Magnética#Terapêutica Anti-Retrovírica, Virus da Imunodeficiência Humana.
Introduction: Progressive multifocal leukoencephalopathy is a demyelinating disease of the central nervous system caused by John Cunningham virus, mostly associated with immunodeficiency conditions, such as the human immunodeficiency virus infection. Progressive multifocal leukoencephalopathy can have multiple clinical features and usually presents a typical lesion pattern on brain magnetic resonance imaging. Its course may be rapidly progressive, although immunological responsiveness can be associated withan improved prognosis.Material and Methods: We performed a retrospective analysis of the clinical and radiological data from patients admitted in our institution between January 2005 and April 2014 with the diagnosis of definitive progressive multifocal leukoencephalopathy (ICD10:A81.2) in the setting of human immunodeficiency virus infection.Results: Twenty-one patients were included in our study, mostly men (n = 20, 95.2%). Mean age at diagnosis was 39 years. Motor deficits were the most common clinical finding. John Cunningham virus-DNA was detected in the cerebral spinal fluid in 20 patients (95.2%). Brain imaging studies most commonly disclosed bilateral supratentorial, asymmetric lesions. Four (19%) patients developed immune reconstitution inflammatory syndrome in the follow-up. Therapeutic approach included initiation and continuation/optimization of antiretroviral therapy...
Link permanente para citações:
Non-progressive leukoencephalopathy with bilateral temporal cysts
Fonte: Saunders
Publicador: Saunders
Tipo: Artigo de Revista Científica
Publicado em //2001
ENG
Relevância na Pesquisa
37.08%
#Infecções por citomegalovirus#Doenças desmielinizantes#Cytomegalovirus infections#Demyelinating diseases#Leukoencephalopathy
We report two cases of a peculiar leukoencephalopathy with temporal cysts. Both patients have a non-progressive neurological disorder with mental retardation, microcephaly and sensorineural deafness although clinical differences between them may reflect a different aetiology. The metabolic disorders with white matter involvement and the recently described leukoencephalopathies (Van Der Knaap disease, 'vanishing white matter disease') were excluded based on clinical, biologic and imaging findings. Cytomegalovirus infection is a likely possibility in the first case although the magnetic resonance imaging picture is only partially similar to previously reported cases. Our patients are strikingly similar to the patients reported by Deonna et al. and Olivier et al. We discuss the clinical and imaging findings in our patients and the differential diagnosis considering the known disorders of the white matter in childhood.
Link permanente para citações:
Progressive multifocal leukoencephalopathy restricted to the posterior fossa in a patient with systemic lupus erythematosus
Fonte: Brazilian Society of Infectious Diseases
Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica
Formato: text/html
Publicado em 01/12/2011
EN
Relevância na Pesquisa
37.08%
#PML#leukoencephalopathy#progressive multifocal posterior fossa#magnetic resonance#spectroscopy#diffusion weighted images
Progressive multifocal leukoencephalopathy is a neurological infectious disease caused by the John Cunningham polyomavirus (JCV), an opportunistic agent with worldwide distribution. This disease is frequently seen in immunosuppresed patients and rarely associated with systemic lupus erythematosus. In the central nervous system PML demyelinating lesions occur in the supratentorial compartment. The authors describe a rare case of PML secondary to SLE treatment with atypical presentation restricted to the posterior fossa.
Link permanente para citações:
Leucoencefalopatia multifocal progressiva em pacientes com aids: estudo retrospectivo em um centro de referência de São Paulo, Brasil; Aids-related progressive multifocal leukoencephalopathy: a retrospective study in a referral center in São Paulo, Brazil
Fonte: Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
Publicador: Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ;
Formato: application/pdf
Publicado em 01/08/2008
ENG
Relevância na Pesquisa
37.08%
#Progressive multifocal leukoencephalopathy#Epidemiology#Diagnosis#Acquired immunodeficiency syndrome
Existe informação limitada sobre a presença da leucoencefalopatia multifocal progressiva (LEMP) em pacientes com aids no Brasil. Os objetivos do presente estudo foram descrever as principais características dos pacientes com LEMP e estimar a freqüência desta doença em pacientes com aids e doenças oportunistas do sistema nervoso central (SNC) internados em um centro de referência de São Paulo, Brasil. Neste estudo retrospectivo e descritivo, identificamos 12 (6%) casos de LEMP entre 219 pacientes com doenças neurológicas oportunistas do SNC. A idade média dos pacientes com LEMP foi 36 anos e 9 (75%) eram do sexo masculino. As manifestações clínicas mais freqüentes foram: déficits focais (75%), alterações da fala (58%), alterações visuais (42%), alterações cognitivas (42%), e problemas de coordenação (42%). A média da contagem de células T-CD4+ foi 45 células/µL. Oito (67%) dos 12 pacientes com LEMP tiveram diagnóstico confirmado laboratorialmente e em quatro (33%) casos o diagnóstico foi possível. Onze (92%) pacientes apresentaram LEMP clássica e um caso teve LEMP associada à síndrome de reconstituição imune. Em quatro (33%) pacientes, a LEMP foi a primeira doença definidora de aids. Durante a internação...
Link permanente para citações:
Chronic renal disease and reversible posterior leukoencephalopathy syndrome after liver transplantation
Fonte: West Indian Medical Journal
Publicador: West Indian Medical Journal
Tipo: Artigo de Revista Científica
Formato: text/html
Publicado em 01/12/2013
EN
Relevância na Pesquisa
37.08%
This is a case report of a patient who developed chronic renal dysfunction and neurologic emergency with multiple cranial lesions after liver transplantation. Immune-complex glomerulonephritis was confirmed on the basis of histopathologic evaluation of the renal biopsy. According to clinical features and brain magnetic resonance imaging follow-up, neuroradiographic atypical reversible posterior leukoencephalopathy syndrome (RPLS) was finally diagnosed.
Link permanente para citações: