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T-cell large granular lymphocytic leukemia: treatment experience with fludarabine

Costa, Renata Oliveira; Bellesso, Marcelo; Chamone, Dalton Alencar Fischer; Ruiz, Milton Artur; Hallack Neto, Abrahao Elias; Aldred, Vera Lucia; Pereira, Juliana
Fonte: HOSPITAL CLINICAS, UNIV SAO PAULO; SÃO PAULO Publicador: HOSPITAL CLINICAS, UNIV SAO PAULO; SÃO PAULO
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
35.8%
OBJECTIVES: The aim of this retrospective study was to investigate the results of T-cell large granular lymphocytic leukemia treatment with fludarabine by assessing the complete hematologic response, the complete molecular response, progression-free survival, and overall survival. METHODS: We evaluated the records of six patients with T-cell large granular lymphocytic leukemia who were treated with fludarabine as a first-, second-, or third-line therapy, at a dose of 40 mg/m(2), for three to five days per month and 6 to 8 cycles. RESULTS: Of the six patients investigated with T-cell large granular lymphocytic leukemia who were treated with fludarabine, five (83.3%) were female, and their median age was 36.5 years (range 18 to 73). The median lymphocyte level was 3.4x10(9)/L (0.5 to 8.9). All patients exhibited a monoclonal T-cell receptor gamma gene rearrangement at diagnosis. Two (33.3%) patients received fludarabine as first-line treatment, two (33.3%) for refractory disease, one (16.6%) for relapsed disease after the suspension of methotrexate treatment due to liver toxicity, and one (16.6%) due to dyspesia. A complete hematologic response was achieved in all cases, and a complete molecular response was achieved in five out six cases (83.3%). During a mean follow-up period of 12 months...

Reviewing Large LAMA2 Deletions and Duplications in Congenital MuscularDystrophy Patients

Oliveira, Jorge; Gonçalves, Ana; Oliveira, Márcia E.; Fineza, Isabel; Pavanello, Rita C. M.; Vainzof, Mariz; Bronze-da-Rocha, Elsa; Santos, Rosário; Sousa, Mário
Fonte: IOS Press; Amsterdam Publicador: IOS Press; Amsterdam
Tipo: Artigo de Revista Científica
ENG
Relevância na Pesquisa
35.83%
Background: Congenital muscular dystrophy (CMD) type 1A (MDC1A) is caused by recessive mutations in laminin-α2 (LAMA2) gene. Laminin-211, a heterotrimeric glycoprotein that contains the α2 chain, is crucial for muscle stability establishing a bond between the sarcolemma and the extracellular matrix. More than 215 mutations are listed in the locus specific database (LSDB) for LAMA2 gene (May 2014). Objective: A limited number of large deletions/duplications have been reported in LAMA2. Our main objective was the identification of additional large rearrangements in LAMA2 found in CMD patients and a systematic review of cases in the literature and LSDB. Methods: In four of the fifty-two patients studied over the last 10 years, only one heterozygous mutation was identified, after sequencing and screening for a frequent LAMA2 deletion. Initial screening of large mutations was performed by multiplex ligation-dependent probe application (MLPA). Further characterization implied several techniques: long-range PCR, cDNA and Southern-blot analysis. Results: Three novel large deletions in LAMA2 and the first pathogenic large duplication were successfully identified, allowing a definitive molecular diagnosis, carrier screening and prenatal diagnosis. A total of fifteen deletions and two duplications previously reported were also reviewed. Two possible mutational “hotspots” for deletions may exist...

Mamíferos terrestres de maior porte e a invasão de cães domésticos em remanescentes de uma paisagem fragmentada de Mata Atlântica: avaliação da eficiência de métodos de amostragem e da importância de múltiplos fatores sobre a distribuição das espécies; Terrestrial large mammals and invasion of domestic dogs in remnants of an Atlantic Forest fragmented landscape: evaluation of the efficiency of sampling methods and of the importance of multiple factors on species distribution.

Espartosa, Karina Dias
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 12/03/2009 PT
Relevância na Pesquisa
35.84%
Nessa dissertação, avaliei a eficiência e congruência de métodos para amostragem de mamíferos de maior porte e investiguei a influência de fatores múltiplos correlacionados, comuns em paisagens fragmentadas, sobre a distribuição destes animais em remanescentes de Mata Atlântica. Através de amostragens padronizadas em 24 remanescentes florestais de uma paisagem rural com 49% de remanescentes florestais no Planalto Paulista e de um delineamento pareado, no capítulo 2 comparei o desempenho e a congruência de dois métodos (pegadas em parcelas de areia e armadilhas fotográficas) e de dois tipos de isca (banana e iscas de cheiro) para a estimativa da riqueza e taxa de ocorrência de mamíferos de maior porte. Ambos os métodos se mostraram adequados para o estudo destes animais em florestas tropicais e dos fatores que afetam sua distribuição em paisagens alteradas, pois (1) registram as espécies de menor porte e noturnas, (2) podem ser padronizados entre áreas heterogêneas, (3) apresentam desempenho semelhante no registro da maioria das espécies e da riqueza de espécies, e (4) refletem de maneira similar o padrão de ocorrência das espécies entre diferentes áreas. Frente às iscas de cheiro utilizadas, a banana foi a isca mais eficiente na amostragem tanto das espécies herbívoras/frugívoras quanto das espécies onívoras...

Análise espacial da distribuição da fauna de vertebrados de médio e grande porte frente a dois padrões de desmatamento típicos da floresta Amazônica, na região de Alta Floresta - MT; Spatial analysis of midsized and large-bodied vertebrates according to two typical deforestation patterns of the Amazon forest in Alta Floresta region - MT State

Prist, Paula Ribeiro
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 25/08/2011 PT
Relevância na Pesquisa
35.88%
A Amazônia Brasileira possui diversos tipos de padrão de desmatamento, variando do típico padrão "espinha-de-peixe", comum em pequenas propriedades, para grandes áreas desmatadas (padrão grandes propriedades), resultando em paisagens com diferentes estruturas, configuração e nível de perturbação. A teoria sugere que uma perda desproporcional de espécies ocorre quando a cobertura total de habitat cai para menos de 30% da paisagem, e a configuração passa então a ter um maior efeito sobre as espécies. Para analisar o efeito da configuração de habitat na persistência e riqueza de vertebrados de médio e grande porte (aves e mamíferos) foram amostradas 21 paisagens (4 x 4 km) do sul da Amazônia com quantidade similar de habitat (~25%), mas configurações de paisagem contrastantes. Entrevistas (n = 150) foram aplicadas de Fevereiro a Julho de 2009 para registrar a ocorrência de vertebrados, e o nível de perturbação das 21 paisagens, compostas de sete áreas controle (áreas não perturbadas de floresta contínua), sete paisagens com padrão de grandes propriedades e sete de espinhas-de-peixe. Métricas de paisagem foram extraídas de uma imagem Landsat-TM de 2009 e de 14 imagens Landsat-TM bianuais, para determinar o melhor preditor para a persistência das espécies. Existiu uma diferença significativa na riqueza de espécies entre os padrões espinha-de-peixe...

Padrão de expressão e significado prognóstico dos genes BCL2, BCL6, CCND2, FN1, LMO2 e SCYA3 pela técnica de PCR em tempo real com linfoma difuso de grandes células B tratado com rituximabe; Gene expression profile and prognostic significance of the genes BCL2, BCL6, CCND2, FN1, LMO2 and SCYA3 by means of real-time PCR technique in diffuse large B-cell lymphoma treated with rituximab

Xavier, Flavia Dias
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 13/05/2013 PT
Relevância na Pesquisa
35.82%
Introdução: O linfoma difuso de grandes células B é o mais freqüente grupo de linfoma não- Hodgkin, perfazendo quase 50% dos casos no serviço de hematologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo e Instituto do Câncer do Estado de São Paulo. Possui heterogeneidade clínica e biológica traduzida em mais de vinte subtipos na Organização Mundial da Saúde. Sua terapêutica se baseia na associação do anticorpo monoclonal anti-CD20 e quimioterapia com antracíclico, esquema que resulta em 43,5% de sobrevida global em 10 anos. Determinantes de prognóstico clínico como o Índice Internacional de Prognóstico e o Índice Internacional de Prognóstico Revisado carecem de acurácia, pois até 20% dos pacientes de baixo risco falecerão da doença e 60% dos pacientes de alto risco estarão vivos em quatro anos. Essas discrepâncias podem, em parte, ser atribuídas a fatores genéticos. A assinatura gênica do linfoma difuso de grandes células B tipo centro germinativo apresenta sobrevida global superior ao tipo células B ativadas (76% versus 16%, p=0,01), contudo o perfil de expressão gênica por microarray ainda não está disponível na prática clínica. Entretanto, o escore preditivo de mortalidade para linfoma difuso de grandes células B baseado no valor prognóstico da expressão dos genes BCL2...

A relação risco e retorno entre as large caps e small caps no mercado acionário brasileiro : uma abordagem comparativa ao mercado norte-americano

Wickert, Luiz Henrique Mielke
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Trabalho de Conclusão de Curso Formato: application/pdf
POR
Relevância na Pesquisa
35.86%
O mercado acionário brasileiro passa por uma gradual popularização à medida que o ambiente macroeconômico do país consolida-se estável. A queda da taxa de juros e a possibilidade de alocação dos recursos do poupador brasileiro na bolsa de valores são assuntos abordados com frequência na mídia. Apesar disso, não se distinguem, aos investidores, os tipos de empresas que possuem ações negociadas no mercado de capitais. Leigas no assunto, ao optarem pela renda variável, muitas pessoas tendem a alocar seus recursos em companhias large caps, pois elas inspiram maior confiança por serem empresas mais conhecidas pelos investidores, seja por possuírem operações por todo o país ou por manter uma marca forte. As empresas small caps, por sua vez, são menores e que, muitas vezes, possuem um rápido potencial de crescimento. Em meio a essa discussão se desenvolve este trabalho. Além disso, ressalta-se o risco das diferentes classes de empresas e analisa-se o caso norte-americano para se comparar as características daquele mercado com o brasileiro. Primeiramente, faz-se uma revisão de importantes conceitos do mercado financeiro. Segue-se o trabalho apresentando os retornos e os riscos associados às large caps e small caps nos mercados acionários do Brasil e dos Estados Unidos entre os anos de 2002 e 2011. Por fim...

T-cell large granular lymphocytic leukemia: treatment experience with fludarabine

Costa,Renata Oliveira; Bellesso,Marcelo; Chamone,Dalton Alencar Fischer; Ruiz,Milton Artur; Hallack Neto,Abrahão Elias; Aldred,Vera Lucia; Pereira,Juliana
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/07/2012 EN
Relevância na Pesquisa
35.8%
OBJECTIVES: The aim of this retrospective study was to investigate the results of T-cell large granular lymphocytic leukemia treatment with fludarabine by assessing the complete hematologic response, the complete molecular response, progression-free survival, and overall survival. METHODS: We evaluated the records of six patients with T-cell large granular lymphocytic leukemia who were treated with fludarabine as a first-, second-, or third-line therapy, at a dose of 40 mg/m², for three to five days per month and 6 to 8 cycles. RESULTS: Of the six patients investigated with T-cell large granular lymphocytic leukemia who were treated with fludarabine, five (83.3%) were female, and their median age was 36.5 years (range 18 to 73). The median lymphocyte level was 3.4x10(9)/L (0.5 to 8.9). All patients exhibited a monoclonal T-cell receptor gamma gene rearrangement at diagnosis. Two (33.3%) patients received fludarabine as first-line treatment, two (33.3%) for refractory disease, one (16.6%) for relapsed disease after the suspension of methotrexate treatment dueto liver toxicity, and one (16.6%) due to dyspesia. A complete hematologic response was achieved in all cases, and a complete molecular response was achieved in five out six cases (83.3%). During a mean follow-up period of 12 months...

A simplified experimental model of large-for-size liver transplantation in pigs

Leal,Antonio Jose Goncalves; Tannuri,Ana Cristina Aoun; Belon,Alessandro Rodrigo; Guimaraes,Raimundo Renato Nunes; Coelho,Maria Cecilia Mendonca; de Oliveira Goncalves,Josiane; Sokol,Suellen Serafini; De Melo,Evandro Sobroza; Otoch,Jose Pinhata; Tannuri,U
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2013 EN
Relevância na Pesquisa
35.82%
OBJECTIVE: The ideal ratio between liver graft mass and recipient body weight for liver transplantation in small infants is unknown; however, if this ratio is over 4%, a condition called large-for-size may occur. Experimental models of large-for-size liver transplants have not been described in the literature. In addition, orthotopic liver transplantation is marked by high morbidity and mortality rates in animals due to the clamping of the venous splanchnic system. Therefore, the objective of this study was to create a porcine model of large-for-size liver transplantation with clamping of the supraceliac aorta during the anhepatic phase as an alternative to venovenous bypass. METHOD: Fourteen pigs underwent liver transplantation with whole-liver grafts without venovenous bypass and were divided into two experimental groups: the control group, in which the weights of the donors were similar to the weights of the recipients; and the large-for-size group, in which the weights of the donors were nearly 2 times the weights of the recipients. Hemodynamic data, the results of serum biochemical analyses and histological examination of the transplanted livers were collected. RESULTS: The mortality rate in both groups was 16.5% (1/7). The animals in the large-for-size group had increased serum levels of potassium...

Alleviating Memory Contention in Matrix Computations on Large-Scale Shared-Memory Multiprocessors

Bianchini, Ricardo ; Crovella, Mark E. ; Kontothanassis, Leonidas I. ; LeBlanc, Thomas J.
Fonte: University of Rochester. Computer Science Department. Publicador: University of Rochester. Computer Science Department.
Tipo: Relatório
ENG
Relevância na Pesquisa
35.8%
Memory contention can be a major source of overhead in large-scale shared-memory multiprocessors. Although there are many hardware solutions to the problem of memory contention, these solutions are often complex and expensive, so software solutions are an attractive alternative. This paper evaluates one particular software solution, called block-column allocation, which is very effective at reducing memory contention for a large class of SPMD (Single-Program-Multiple-Data) programs, and can be implemented easily by the compiler. We first quantify the impact of memory contention on performance by simulating the execution of several application kernels on a large-scale multiprocessor. Our simulation results confirm that memory contention is widespread on large-scale machines; our applications suggest that contention is usually caused by synchronized access to a range of addresses (rather than to a single address). We show that block-column allocation, where each range of addresses is divided into cache lines, and each cache line is allocated to a separate memory module, can nearly eliminate this source of memory contention. As our main contribution, we compare block-column allocation to row-major allocation (a common data allocation scheme) and logarithmic broadcasting (the standard software technique for alleviating memory contention). Our analysis demonstrates the clear superiority of block-column allocation over row-major allocation in the presence of memory contention. Our analysis also indicates that the choice between block-column allocation and logarithmic broadcasting is less clear...

Logiche e dinamiche operative per la gestione delle trasformazioni urbane: il caso dei Large Scale Urban Development Projects

BOCA, ALESSANDRO
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
IT
Relevância na Pesquisa
35.86%
This research aims at investigate a topic probably not well examined by national and international literature, which is the one of the evolutions in operational rationales and patterns followed in contemporary urban planning. The hypothesis here discussed is that the transition from the so-called “modern” to the so-called “contemporary” city has engendered a number of issues, including a need for adjustment of a planning practice that is both not completed yet and can’t be longer avoided. In order to carry out such a survey two different case studies will be analyzed, the large scale urban development project of Paris Rive Gauche, in Paris, and King’s Cross Central, in London. From the late ‘70s a number of factors, among which the research pinpoints the disappearance of manufacturing industry from large urban contexts, caused a deep physical and socio-economic restructuring process in many European cities. As a consequence, also the urban planning models followed during the previous decades faced a corresponding restructuring process. In particular, what fell in crisis was the traditional plan-led rationale that for at least three decades characterized urban planning in many European countries. Indeed this rationale was considered by many scholars and practitioners no longer suitable to respond to the increased complexity characterizing contemporary urban contexts. During all the ‘80s a massive practice of deregulation has been proposed as the answer able to face such an issue. From the traditional plan-led model previously followed to implement urban strategies...

Mining Together : Large-Scale Mining Meets Artisanal Mining, A Guide for Action

World Bank
Fonte: Washington, DC Publicador: Washington, DC
EN_US
Relevância na Pesquisa
35.82%
The present guide mining together-when large-scale mining meets artisanal mining is an important step to better understanding the conflict dynamics and underlying issues between large-scale and small-scale mining. This guide for action not only points to some of the challenges that both parties need to deal with in order to build a more constructive relationship, but most importantly it sheds more light on some potential interventions for conflict prevention, management, and even transformation. This guide, then, represents a step in the right direction to start transforming the relationship between large-scale and artisanal miners through win-win solutions that emerge out of the genuine interaction and dialogue of all stakeholders involved: governments, companies, communities, miners and development organizations. Large-Scale Mining (LSM) companies increasingly come across Artisanal and Small-scale Mining (ASM) workers during their exploration or production activities in the developing world. The ASM-LSM relationship is often conflictual because both types of miners compete for the same resource or because they perceive each other as a threat. However the ASM-LSM relationship is now also undergoing a largely positive evolution in part thanks to new Corporate Social Responsibility (CSR) commitments. This guide is the result of this collaboration and provides an informative overview of the growing experiences of the most typical ASM-LSM issues and guidance for appropriate interventions.

Is Small Better? A Comparison of the Effect of Large and Small Dams on Cropland Productivity in South Africa

Blanc, Elodie; Strobl, Eric
Fonte: World Bank, Washington, DC Publicador: World Bank, Washington, DC
EN_US
Relevância na Pesquisa
35.84%
This study estimates and compares the effects of small and large irrigation dams on cropland productivity in South Africa. To this end, a panel data set of South African river basins is constructed. The econometric analysis reveals that although large dams increase cropland productivity downstream, they have a negative effect on cropland within the vicinity. However, their existence can enhance the relatively small positive impact of local small dams. Although a cost-benefit analysis of irrigation benefits shows that small dams may be more viable than large ones, large dams can play a potentially important role within a system of both types of dams.

Dietry short-chain fructooligosaccharides increase calbindin-D9k levels only in the large intestine in rats independent of dietary calcium deficiency or serum 1,25 dihydroxy vitamin D levels

Takasaki, M.; Inaba, H.; Ohta, A.; Motohashi, Y.; Sakai, K.; Morris, H.; Sakuma, K.
Fonte: Verlag Hans Huber Publicador: Verlag Hans Huber
Tipo: Artigo de Revista Científica
Publicado em //2000 EN
Relevância na Pesquisa
35.83%
Dietary short-chain fructooligosaccharides (Sc-FOS) increase mucosal calbindin-D9k (CaBP) levels in the large intestine whereas levels in the small intestine are decreased in rats. In the present study, we investigated the mechanism by which Sc-FOS induce this increase in CaBP in the large intestine by measuring intestinal CaBP levels in rats fed normal and calcium-deficient diets. Dietary groups included a calcium-containing (0.5%) diet with or without Sc-FOS (100 g/kg diet) and a calcium-deficient (abt. 0.01%) diet with or without Sc-FOS (100 g/kg diet). The rats were fed these diets for 10 days following which they were killed and the intestine removed for collection of the entire mucosa which was divided into four segments, i.e., proximal and distal segments of the small intestine, the cecum and the colorectum. Mucosal CaBP and plasma calcium (Ca), 1,25-dihydroxycholecalciferol (1,25(OH)2D3), 25-hydroxycholecalciferol (25(OH)D3), parathyroid hormone (PTH) and calcitonin levels were measured. Feeding of calcium deficient diet resulted in an increase in CaBP levels in the small intestine, but did not influence levels in the large intestine. Moreover, a significant positive correlation between plasma 1,25(OH)2D3 and CaBP levels in the case of both small intestinal segments (proximal...

Small- and large-strain behaviour of a cement-treated soil during various loading histories and testing conditions

Taheri, A.; Tatsuoka, F.
Fonte: Springer Verlag Publicador: Springer Verlag
Tipo: Artigo de Revista Científica
Publicado em //2014 ENG
Relevância na Pesquisa
35.8%
The effects of loading histories on small-strain and large-strain stiffness of a compacted cement-mixed well-graded gravelly soil were evaluated by consolidated drained triaxial compression (TC) tests. Various cyclic loading histories were applied during otherwise continuous monotonic loading at different confining pressures, r h s, and multiple-step loading with stepwise increase or decrease of r h . To evaluate small-strain stiffness, minute unload/reload cycles were applied during TC loading. The value of peak-to-peak secant modulus from a minute unload/reload cycle was defined as the equivalent Young’s modulus, E eq . The average of E eq values measured during continuous monotonic loading at low deviator stresses was rather close to the elastic modulus, E e . As the E e increased with an increase in the axial stress, the E eq value increased first and then decreased due to an increase in creep strains. The stress–strain behaviour after the start of a large-scale yielding and the peak shear strength is not noticeably affected by the previous cyclic loading with relatively large stress amplitude. However, the large-strain stiffness during reloading is significantly affected by the following factors controlled by pre-cyclic loading history; (a) strain hard- ening; (b) strain nonlinearity; (c) hysteresis effect; (d) vis- cous effect; and (e) damage to bonding by immediately preceding large unloading. The tangent stiffness...

Reconstruction of Large Scale 3D Models from Images

Parys, Roman
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
EN
Relevância na Pesquisa
35.85%
In this thesis, we focus on methods for automatic reconstruction of large 3D scenes directly from images. In the literature, methods solving this problem are referred to as multi-view stereo (MVS) algorithms, and they are a very interesting alternative to the acquisition of geometry with laser scanners, as the equipment - digital cameras - is not expensive. As the MVS reconstruction is a well-researched topic, current efforts are shifted towards a large scale reconstruction. City models require millions of images to capture their geometry. Processing such amounts of data requires a lot of computa- tional effort, even for current super-computers. Exploiting parallelization is often not sufficient, as it leads only to a linear improvement in computational complexity. This effort can be reduced, as described in this thesis, not only by using parallelization, but also with a smart algorithmic approach. The need of quality evaluation for MVS algorithms and a large number of different approaches has led researchers to establish a ranking [SCD+ 06]. The most promising approaches are from the year 2009, and recently two new publications were released in 2011, which shows a loss of interest in improving the quality, as there is not much improvement to achieve. It can be clearly seen...

Size matters : seeing the values in large technology heritage

Wain, Leonie Alison
Fonte: Universidade Nacional da Austrália Publicador: Universidade Nacional da Austrália
Tipo: Thesis (PhD); Doctor of Philosophy (PhD)
EN_AU
Relevância na Pesquisa
35.88%
Large technology heritage objects are impressive, exciting and fascinating. They can also be difficult, dangerous and expensive. When working with large technology objects every project demands more resources, every triumph is more newsworthy and every mistake is more visible. With large technology objects “getting it right” is vital. This thesis explores what “getting it right” means in both affective and practical terms, and for both producers of, and visitors to, large technology heritage displays. During 2008-9 over 80 producers and 368 visitors were interviewed at seven heritage sites and, for comparison, one non-heritage site within Australia. These interviews were analysed both qualitatively and quantitatively to examine people’s attitudes to large technology heritage, and to understand the major influences that form, maintain and change such attitudes. The thesis also examines methods of interpreting and displaying large technology objects, as well as the impact of heritage industry standards on the preservation, restoration and management of large technology heritage. The results of the study indicate that, while the practical challenges of giving big, old machines a new life as heritage are formidable...

INTERROGATING SUSTAINABLE DEVELOPMENT: A CASE STUDY OF LARGE-SCALE MINING IN COLOMBIA

Rivera-Sotelo, AIDA-SOFIA
Fonte: Quens University Publicador: Quens University
Tipo: Tese de Doutorado
EN; EN
Relevância na Pesquisa
35.8%
In this thesis, I examine the case of the Canadian-based multinational mining corporation GreyStar resources Ltd. in Colombia. Angosturas is GreyStar’s large-scale gold mining project in the sensitive wet highland of páramo de Santurbán in the northeast of the Andes. Although GreyStar has undertaken explorations in this area since 1994, Colombia’s Ministry of Environment denied the environmental license to the company to start with extractions in 2011. I suggest that the government’s decision must be understood in the context of massive mobilizations against the project in large cities such as Bucaramanga and Bogotá as well as the principle of sustainable development (hereafter SD). The latter forms part of the 1991 Colombian constitution, and thus, through this legal presence, is considered to provide environmental protection in the country. Despite this government’s recent ruling, GreyStar (which renamed itself ‘Eco Oro’ after the 2011 decision) and other mining companies (e.g. Ventana Gold) have continued their quest to gain permission to begin with extractions in Santurbán. I explore why these continued attempts to persuade the government regarding extraction licensing is possible. In doing so, I critically investigate the principle of SD...

Large-group psychodynamics and massive violence

Volkan,Vamik D.
Fonte: ABRASCO - Associação Brasileira de Saúde Coletiva Publicador: ABRASCO - Associação Brasileira de Saúde Coletiva
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2006 EN
Relevância na Pesquisa
35.84%
Beginning with Freud, psychoanalytic theories concerning large groups have mainly focused on individuals' perceptions of what their large groups psychologically mean to them. This chapter examines some aspects of large-group psychology in its own right and studies psychodynamics of ethnic, national, religious or ideological groups, the membership of which originates in childhood. I will compare the mourning process in individuals with the mourning process in large groups to illustrate why we need to study large-group psychology as a subject in itself. As part of this discussion I will also describe signs and symptoms of large-group regression. When there is a threat against a large-group's identity, massive violence may be initiated and this violence in turn, has an obvious impact on public health.

The potential for abomasally infused S. Boulardii to alleviate large intestinal acidosis

Davison, Kerrie
Fonte: University of Delaware Publicador: University of Delaware
Tipo: Tese de Doutorado
Relevância na Pesquisa
35.85%
Tanya Gressley; Large intestinal acidosis occurs when excessive amounts of carbohydrates are fermented in the large intestine, an event which may contribute to laminitis and gastrointestinal damage. The objectives of this study were to: a) develop a less severe model of oligofructose-induced large intestinal acidosis than the models previously utilized and b) evaluate the ability of Saccharomyces boulardii (SB) ability to alleviate this oligofructose-induced large intestinal acidosis. Six ruminally cannulated steers were used in a replicated 2x2 Latin square experiment with two-18 day (d) periods. Steers were randomly assigned to one of 2 treatments: (1) Control (0 g/d SB) and (2) and SB (10 g/d SB). Control and SB treatments administered via abomasal infusion with equal amounts provided at 10 AM and 4 PM daily. On d 16 of each period, steers were abomasally infused every 6 h for 24 h with 1 L of water containing 0.25 g/kg oligofructose. Fecal samples were periodically collected for 24 h prior to and for 48 hours following the first abomasal oligofructose infusion. The oligofructose infusions resulted in large intestinal acidosis as indicated by a decrease in fecal pH and fecal score and an increase in fecal volatile fatty acid (VFA) concentrations. This large intestinal acidosis model did not change fecal dry matter content and induced a fecal pH and fecal score decline which was less severe than those seen in previous models We found that SB treatment had no effect on pre-oligofructose challenge measurements. During the oligofructose challenge however...

Large-group psychodynamics and massive violence

Volkan,Vamik D.
Fonte: ABRASCO - Associação Brasileira de Saúde Coletiva Publicador: ABRASCO - Associação Brasileira de Saúde Coletiva
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2006 EN
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Beginning with Freud, psychoanalytic theories concerning large groups have mainly focused on individuals' perceptions of what their large groups psychologically mean to them. This chapter examines some aspects of large-group psychology in its own right and studies psychodynamics of ethnic, national, religious or ideological groups, the membership of which originates in childhood. I will compare the mourning process in individuals with the mourning process in large groups to illustrate why we need to study large-group psychology as a subject in itself. As part of this discussion I will also describe signs and symptoms of large-group regression. When there is a threat against a large-group's identity, massive violence may be initiated and this violence in turn, has an obvious impact on public health.