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Coberturas Rígidas Adaptáveis na Arquitectura. Possibilidades de Transformação e Mobilidade

Luísa Barreira de Almeida
Fonte: Universidade do Porto Publicador: Universidade do Porto
Tipo: Dissertação
POR
Relevância na Pesquisa
26.44%
This essay focuses on the study of covering systems in contemporary architecture within theresolution of collective programs, of sporadic nature. This means that the study focuses on adaptivelight covers, considering the change of shape and location. Thus, this type of coverage seems to fit thecurrent socio-economic context - having the economic crisis and the imbalance of the environment asdominant concerns.The adaptive covers is a type of building in which there is a wide variety of shapes and structuralsolutions. So, its study is structured according to two adapting methods - mobility and kinetics and seeks to clarify it, through a classification, its properties. By mobility, it#8217;s understandable thepossibility of moving the structure, validating the reuse and containment of the material. By kineticsit#8217;s understandable the formal change of the structure, quite useful for adapting the same to variouscircumstances such as weather, versatility functions to the same space, and transportation logistics. Theconsideration of the kinetics and mobility lead to the need of reducing the weight of these covers, whichare intended to be light.The mobility, kinetics and lightness are characteristics inherent to the field of biology. To thiscondition...

CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

Wu, Lijun; Paxton, William A.; Kassam, Nasim; Ruffing, Nancy; Rottman, James B.; Sullivan, Nancy; Choe, Hyeryun; Sodroski, Joseph; Newman, Walter; Koup, Richard A.; Mackay, Charles R.
Fonte: The Rockefeller University Press Publicador: The Rockefeller University Press
Tipo: Artigo de Revista Científica
Publicado em 05/05/1997 EN
Relevância na Pesquisa
16.05%
Chemokine receptors serve as coreceptors for HIV entry into CD4+ cells. Their expression is thought to determine the tropism of viral strains for different cell types, and also to influence susceptibility to infection and rates of disease progression. Of the chemokine receptors, CCR5 is the most important for viral transmission, since CCR5 is the principal receptor for primary, macrophage-tropic viruses, and individuals homozygous for a defective CCR5 allele (Δ32/ Δ32) are highly resistant to infection with HIV-1. In this study, CCR5-specific mAbs were generated using transfectants expressing high levels of CCR5. The specificity of these mAbs was confirmed using a broad panel of chemokine receptor transfectants, and by their non-reactivity with T cells from Δ32/Δ32 individuals. CCR5 showed a distinct pattern of expression, being abundant on long-term activated, IL-2–stimulated T cells, on a subset of effector/memory T cells in blood, and on tissue macrophages. A comparison of normal and CCR5 Δ32 heterozygotes revealed markedly reduced expression of CCR5 on T cells from the heterozygotes. There was considerable individual to individual variability in the expression of CCR5 on blood T cells, that related to factors other than CCR5 genotype. Low expression of CCR5 correlated with the reduced infectability of T cells with macrophage-tropic HIV-1...

Patterns of neural activity associated with honest and dishonest moral decisions

Greene, Joshua D.; Paxton, Joseph M.
Fonte: National Academy of Sciences Publicador: National Academy of Sciences
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.05%
What makes people behave honestly when confronted with opportunities for dishonest gain? Research on the interplay between controlled and automatic processes in decision making suggests 2 hypotheses: According to the “Will” hypothesis, honesty results from the active resistance of temptation, comparable to the controlled cognitive processes that enable the delay of reward. According to the “Grace” hypothesis, honesty results from the absence of temptation, consistent with research emphasizing the determination of behavior by the presence or absence of automatic processes. To test these hypotheses, we examined neural activity in individuals confronted with opportunities for dishonest gain. Subjects undergoing functional magnetic resonance imaging (fMRI) gained money by accurately predicting the outcomes of computerized coin-flips. In some trials, subjects recorded their predictions in advance. In other trials, subjects were rewarded based on self-reported accuracy, allowing them to gain money dishonestly by lying about the accuracy of their predictions. Many subjects behaved dishonestly, as indicated by improbable levels of “accuracy.” Our findings support the Grace hypothesis. Individuals who behaved honestly exhibited no additional control-related activity (or other kind of activity) when choosing to behave honestly...

HIV-1 Autologous Antibody Neutralization Associates with Mother to Child Transmission

Baan, Elly; de Ronde, Anthony; Stax, Martijn; Sanders, Rogier W.; Luchters, Stanley; Vyankandondera, Joseph; Lange, Joep M.; Pollakis, Georgios; Paxton, William A
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 17/07/2013 EN
Relevância na Pesquisa
16.05%
The HIV-1 characteristics associated with mother to child transmission (MTCT) are still poorly understood and if known would indicate where intervention strategies should be targeted. In contrast to horizontally infected individuals, exposed infants possess inherited antibodies (Abs) from their mother with the potential to protect against infection. We investigated the HIV-1 gp160 envelope proteins from seven transmitting mothers (TM) whose children were infected either during gestation or soon after delivery and from four non-transmitting mothers (NTM) with similar viral loads and CD4 counts. Using pseudo-typed viruses we tested gp160 envelope glycoproteins for TZM-bl infectivity, CD4 and CCR5 interactions, DC-SIGN capture and transfer and neutralization with an array of common neutralizing Abs (NAbs) (2F5, 2G12, 4E10 and b12) as well as mother and infant plasma. We found no viral correlates associated with HIV-1 MTCT nor did we find differences in neutralization with the panel of NAbs. We did, however, find that TM possessed significantly higher plasma neutralization capacities than NTM (P = 0.002). Furthermore, we found that in utero (IU) TM had a higher neutralization capacity than mothers transmitting either peri-partum (PP) or via breastfeeding (BF) (P = 0.002). Plasma from children infected IU neutralized viruses carrying autologous gp160 viral envelopes as well as those from their corresponding mothers whilst plasma from children infected PP and/or BF demonstrated poor neutralizing capacity. Our results demonstrate heightened autologous NAb responses against gp120/gp41 can associate with a greater risk of HIV-1 MTCT and more specifically in those infants infected IU. Although the number of HIV-1 transmitting pairs is low our results indicate that autologous NAb responses in mothers and infants do not protect against MTCT and may in fact be detrimental when considering IU HIV-1 transmissions.

Large and forgotten in rural Australia: assessment, attitudes and possible approaches to losing weight in young adult males

Mendis, Kumara; Forster, Tanya; Paxton, Karen; Hyland, Karen; Yelverton, Jason; McLean, Rick; Canalese, Joseph; Brown, Anthony; Steinbeck, Katharine
Fonte: BioMed Central Publicador: BioMed Central
Tipo: Artigo de Revista Científica
Publicado em 11/03/2014 EN
Relevância na Pesquisa
16.05%

Dorsomedial Hypothalamic Lesions Block Syrian Hamster Testicular Regression in Short Day Lengths Without Diminishing Increased Testosterone Negative-Feedback Sensitivity1

Jarjisian, Stephan G.; Piekarski, David J.; Place, Ned J.; Driscoll, Joseph R.; Paxton, Eve G.; Kriegsfeld, Lance J.; Zucker, Irving
Fonte: Society for the Study of Reproduction, Inc. Publicador: Society for the Study of Reproduction, Inc.
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.05%
The dorsomedial nucleus (DMN) of the hypothalamus, the only site within the mediobasal hypothalamus of Syrian hamsters that both binds melatonin and has abundant concentrations of androgen receptors, has been proposed as a target tissue for induction of seasonal changes in brain sensitivity to steroid negative feedback. We tested whether DMN ablation, which does not interfere with pineal gland secretion of melatonin in short day lengths, prevents testicular regression by altering sensitivity to steroid negative feedback. Hamsters with DMN lesions, unlike control hamsters, failed to undergo testicular regression after transfer from a long (14 h light/day) to a short day length (8 h light/day); however, increased negative-feedback inhibition of follicle-stimulating hormone by testosterone was not compromised by ablation of the DMN, indicating that this tissue is not an essential mediator of seasonal changes in feedback sensitivity. We propose a redundant neural network comprised of multiple structures, each of which contributes to neuroendocrine mechanisms, that determines the effect of short days on gonadal function.

Patterns of Neural Activity Associated with Honest and Dishonest Moral Decisions

Greene, Joshua D.; Paxton, Joseph M.
Fonte: National Academy of Sciences Publicador: National Academy of Sciences
Tipo: Artigo de Revista Científica
EN_US
Relevância na Pesquisa
16.05%
What makes people behave honestly when confronted with opportunities for dishonest gain? Research on the interplay between controlled and automatic processes in decision making suggests 2 hypotheses: According to the “Will” hypothesis, honesty results from the active resistance of temptation, comparable to the controlled cognitive processes that enable the delay of reward. According to the “Grace” hypothesis, honesty results from the absence of temptation, consistent with research emphasizing the determination of behavior by the presence or absence of automatic processes. To test these hypotheses, we examined neural activity in individuals confronted with opportunities for dishonest gain. Subjects undergoing functional magnetic resonance imaging (fMRI) gained money by accurately predicting the outcomes of computerized coin-flips. In some trials, subjects recorded their predictions in advance. In other trials, subjects were rewarded based on self-reported accuracy, allowing them to gain money dishonestly by lying about the accuracy of their predictions. Many subjects behaved dishonestly, as indicated by improbable levels of “accuracy.” Our findings support the Grace hypothesis. Individuals who behaved honestly exhibited no additional control-related activity (or other kind of activity) when choosing to behave honestly...

Reason, Reflection, and Moral Change

Paxton, Joseph Michael
Fonte: Harvard University Publicador: Harvard University
Tipo: Thesis or Dissertation
EN_US
Relevância na Pesquisa
16.05%
Recent work in moral psychology emphasizes the role of immediate intuitive responses in shaping moral judgments, while at the same time questioning the causal role of more reflective reasoning processes. On this account (mainly due to Haidt, 2001), such reflective processes primarily provide post-hoc rationalizations for more immediate responses, and only appear to cause the associated judgments. This account poses a strong skeptical challenge to prior theories that focused on the role of reasoning in shaping moral judgments (most notably Kohlberg, 1969). In this dissertation, I attempt to address this challenge. I do so in Part I by reviewing the strengths and weaknesses of recent studies on moral reasoning and reflection. In Part II, I describe the results of six original studies that were designed to examine the roles of reasoning and reflection in moral judgment while accounting for skeptical interpretations. Part III concludes with a summary of the conditions under which reasoning and reflection were found to occur, along with a speculative account of the practical implications of this work and suggestions for future research on the cognitive mechanisms underlying reflective reasoning processes.; Psychology

Song and dance; String quartet [no. 2]; Song and dance

Holbrooke, Joseph (1878 - 1958)
Fonte: Paxton Publicador: Paxton
Tipo: Musical Score
Relevância na Pesquisa
26.05%
4 parts. 33 cm.

Sacred songs [for voice and piano.]

Adams, Joseph H.
Fonte: W. Paxton & Co. Publicador: W. Paxton & Co.
Tipo: Musical Score
ENG
Relevância na Pesquisa
26.05%
38 p. 31 cm. Table of Contents: Behold the dawn.--Divine love.--Gentle Shepherd.--The Lord is my Shepherd.--Nazarene.--Sun of my soul.

Bless the Lord, o my soul. Psalm CIII, for soli voices, chorus and orchestra.; Psalm CIII.; Bless the Lord, o my soul. Vocal score

Adams, Joseph H.
Fonte: W. Paxton & Co. Publicador: W. Paxton & Co.
Tipo: Musical Score
Relevância na Pesquisa
26.05%
score (65 p.) 25 cm.

Design of a deck type, three chord, space frame railway bridge

Williams, John Paxton; Lalor, Foster M.
Fonte: Rensselaer Polytechnic Institute Publicador: Rensselaer Polytechnic Institute
Tipo: Tese de Doutorado
EN_US
Relevância na Pesquisa
26.05%
This thesis document was issued under the authority of another institution, not NPS. At the time it was written, a copy was added to the NPS Library collection for reasons not now known.  It has been included in the digital archive for its historical value to NPS.  Not believed to be a CIVINS (Civilian Institutions) title.; Since all framed structures have length, breadth, and thickness, all frames actually are space structures. The designer is accustomed to study the stress analysis of a truss from a viewpoint of forces in a plane, but he must take into account the extension of the members into a third dimension when he is designing lacing bars, stay plates, and diaphragms.

La aportación estructural del Crystal Palace de la Exposición Universal de Londres 1851. Una ampliación del enfoque histórico tradicional.

López César, Isaac
Fonte: Redfundamentos Publicador: Redfundamentos
Tipo: Artigo de Revista Científica
SPA
Relevância na Pesquisa
26.05%
[Resumen] El objetivo del presente artículo es el de establecer la línea histórica que conduce desde la aplicación arquitectónica de los primeros elementos estructurales de hierro industrializado en edificios de varias plantas y cubiertas hasta la aplicación primigenia del pórtico rígido autoportante en un edificio de varias plantas. En este recorrido, el Crystal Palace de la Exposición Universal de Londres 1851 se revela como un elemento clave que articula la transición desde la tipología de entramado metálico estabilizado por muros perimetrales de fábrica hasta la moderna formalización del pórtico rígido autoestable aplicado al edificio en altura. Asimismo, se detectan las conexiones históricas existentes en dicho proceso, poniendo en valor edificios que han permanecido al margen de la historiografía arquitectónica convencional. Ampliamos, por tanto, el foco histórico centrado tradicionalmente en los logros de la Escuela de Chicago destacando y conectando históricamente los acontecimientos anteriores.; [Abstract] The aim of this paper is to establish a historical line from the first architectural application of structural elements made of industrial iron for roofs and multi-storey buildings to the first application of portal frame in a multi-storey building. With this in mind...