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Comparação entre a disponibilidade de ferro na presença de vitamina A e beta-caroteno em alimentos e medicamentos.; Comparison between iron availability in presence of vitamin A and beta-carotene in foods and medicines.

Martini, Fabiana Cristina Camargo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 12/09/2002 PT
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O ferro e a vitamina A são nutrientes essenciais para o desenvolvimento e a manutenção do organismo. Este trabalho teve por objetivos verificar a disponibilidade de ferro na presença de vitamina A, presente nos alimentos: feijão comum (F), fígado bovino (Fi) e cenoura (C) e medicamentos: Fer-In-Sol(Fer), Arovit(A) e Neutrofer (N), bem como suas combinações; quantificar a composição centesimal, minerais, antinutricionais, ferro heme e não-heme, retinol e beta-caroteno, dos alimentos e suas combinações com medicamentos. A quantidade de medicamentos adicionada aos alimentos foi calculada em função de uma prévia análise da composição de ferro e beta-caroteno dos alimentos. As quantidades de ferro sulfato (Fer1) e ferro aminoquelato (N1) correspondem à quantidade de ferro encontrada na amostra de feijão. Fer2 e N2 correspondem à concentração de ferro encontrada na amostra de fígado. A vitamina A (A1) foi calculada através da conversão do beta-caroteno da cenoura. Dos alimentos e medicamentos, originaram as seguintes combinações: (C), (C+A1), (C+N1), (C+N2), (C+Fer1), (C+Fer2), (C+F), (F), (F+A1), (F+Fer2), (F+N2), (F+Fi), (Fi), (Fi+A1), (Fi+Fer1), (Fi+N1) e (Fi+C). Os resultados obtidos foram analisados estatisticamente através do teste de Tukey (5%)...

Estudo comparativo entre os aumentos das ferremias, determinados sem a administração prévia de ferro; após as administrações de sulfato ferroso, e complexo ferro-peptídeo.; A comparative study of the increase in blood iron concentrations obtained without previous iron administration and after the administration of ferrous sulfate or an iron-peptide complex.

Sakamoto, Luiz Maçao
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 28/04/2003 PT
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A deficiência de ferro e a anemia por deficiência de ferro (anemia ferropriva) são, ainda hoje, um dos maiores problemas nutricionais e de saúde pública em todo o mundo, afeta cerca de 2 bilhões de pessoas, especialmente nos países em desenvolvimento. Em geral os programas de prevenção e tratamento da anemia apresentam baixa adesão devido entre outros fatores a efeitos colaterais relacionados ao sistema gastrointestinal, resultantes da administração oral de compostos contendo ferro especialmente o sulfato ferroso. Dessa maneira, torna-se necessário o desenvolvimento de novas estratégias, compostos ou sistemas de liberação, que apresentem alta biodisponibilidade do ferro e minimizem ou eliminem os efeitos colaterais. Nesse sentido, o complexo ferro-peptídeo (CFP), devido as suas características físico-químicas que contrastam com aquelas apresentadas pelo sulfato ferroso (SF), torna-se uma possível alternativa como fonte de ferro. É um complexo orgânico com baixa solubilidade em pH ácido e totalmente solúvel em pH neutro a alcalino. Baseado nessas características, nos aumentos das ferremias (teores de ferro sérico ligado a apotransferrina) que ocorrem, em seres humanos, durante o período diurno observados por Wiltink et al. (1973) e no estudo realizado em ratos...

Avaliação da deficiência de ferro durante o processo gestacional e sua relação com o consumo alimentar e a suplementação com ferro; Assesment of iron deficiency during pregnancy and its relation to food consumption and iron supplementation

Cruz, Rodrigo Danelon da
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 24/03/2010 PT
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A deficiência de ferro e anemia ferropriva são problemas de ordem mundial. Para as mulheres no período gestacional, a preocupação com o estado do ferro no organismo deve ser ainda maior, pois a deficiência desse elemento pode causar prejuízo na formação dos bebês. O objetivo do projeto é avaliar a evolução da freqüência de deficiência de ferro e anemia ferropriva e os parâmetros de ferro no organismo de mulheres grávidas durante toda a gestação e relacionar com dados da dieta e suplementação de ferro. Também avaliamos os dados sócio-demográficos e nutricionais maternos, além dos parâmetros de ferro, com o peso dos seus recém nascidos. Participaram do estudo 183 gestantes, 103 terminaram o protocolo e das quais foram colhidas amostras de sangue nas idades gestacionais de 16, 28 e 36 semanas. Para avaliação nutricional foram aplicados três inquéritos recordatórios de 24 horas no dia da coleta. Foram realizadas as determinações de ferro sérico, saturação de transferrina, ferritina sérica, capacidade total de ligação ao ferro (CTLF) e concentração sérica do receptor de transferrina (sTfR), além da dosagem da concentração de hemoglobina. As gestantes foram classificadas em seis grupos conforme a suplementação com ferro em cada idade gestacional: as mulheres que não utilizaram essa suplementação foram incluídas no grupo 1 (N=21); enquanto as participantes que fizeram o uso de suplementação em todas as idades gestacionais...

Implicações nutricionais decorrentes do uso de panelas brasileiras de aço inoxidavel, ferro e pedra-sabão (esteatito).; Decurrent nutricionais implications of Brazilian the stainless steel pan use, iron and rock-soap (esteatito).

Kesia Diego Quintaes
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 03/11/2004 PT
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A pedra-sabão, a cerâmica, o vidro, o ferro, o alumínio e o aço inoxidável, estão entre os diversos materiais empregados na confecção de utensílios culinários. É sabido que durante a elaboração culinária, interações entre os alimentos e os utensílios ocorrem: algumas benéficas, outras inócuas, enquanto que outras podem ser prejudiciais à saúde do comensal. O presente estudo visou avaliar as implicações nutricionais que os utensílios nacionais de ferro fundido, de pedrasabão (esteatito) e de aço inoxidável (inox), podem ter. Os utensílios foram testados com simulantes de alimentos (ácidos acético e láctico) e com preparações culinárias (arroz e molho de tomate) a fim de determinar qualitativa e quantitativamente os elementos migrantes. Os materiais apresentaram perfis de migração distintos e susceptíveis à variação, conforme o simulante (ácido acético ou lático) e a aplicação do utensílio (cocção ou estocagem). As panelas de inox e de ferro não apresentaram implicações toxicológicas, sendo que estas últimas liberaram quantidade expressiva de Fe. Já as panelas de pedra-sabão liberaram teores consideráveis de Ca, Mg, Fe e Mn durante a cocção e, Ni em quantidade indesejável foi liberado na condição de estocagem por 24horas de ácido acético. No caso dos alimentos...

Avaliação do potencial quelante de ferro de hidrolisados protéicos de soro de leite obtidos com diferentes enzimas; Evaluation of iron-binding potential from whey protein hydrolysates obtained with different enzymes

Maria Elisa Caetano Silva
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 22/03/2013 PT
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A deficiência de ferro é um dos principais problemas nutricionais no mundo, sendo a suplementação de alimentos com sais de ferro uma importante estratégia para combater essa deficiência. Porém, nessa forma, o mineral apresenta baixa biodisponibilidade e pode causar dor de estômago, diarreia, alterações de sabor e aparência dos produtos. Quelatos ferro-peptídeos têm sido apontados como uma promissora fonte de ferro mais biodisponível e com redução desses efeitos adversos. O presente estudo teve por objetivo avaliar o potencial de quelação de ferro dos peptídeos obtidos da hidrólise enzimática de isolado proteico de soro de leite (IPS) com as enzimas alcalase (HA), pancreatina (HP) ou flavourzyme (HF). Os hidrolisados foram ultrafiltrados (membrana de corte de 5 kDa) e as frações permeada (< 5 kDa) e retida (> 5 kDa) foram liofilizadas. Os hidrolisados e suas frações foram caracterizados quanto ao perfil aminoacídico, perfil de hidrofilicidade por cromatografia líquida de alta eficiência em fase reversa (CLAE-FR), perfil de massa molecular (MM) por cromatografia líquida de alta eficiência de exclusão molecular (CLAE-EM) e eletroforese SDS-PAGE Tricina. As frações foram avaliadas quanto à sua capacidade quelante de ferro...

Regulation of iron metabolism in different bacterial infections

Ferreira, Patrícia Daniela Oliveira
Fonte: Universidade de Aveiro Publicador: Universidade de Aveiro
Tipo: Dissertação de Mestrado
ENG
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Iron is found in almost all living organisms, playing a central role in host-pathogen interactions and being crucial for both host and pathogens. In the host, iron is a crucial element, since it plays a key role in biological processes such as oxygen transport, biosynthesis of DNA, energy production and regulation of gene expression. However, high concentrations of iron can also be toxic to cells due to the ability to generate hydroxyl radicals. Thus, vertebrates developed proteins to transport and store iron: transferrin and ferritin, respectivetly. Hepcidin is a key protein of iron metabolism, since it binds to ferroportin, the iron exporter, regulating the release of iron to the serum. On the other hand, iron is also fundamental for pathogens that required it to its growth and proliferation, to the expression of virulence factors and to metabolic processes. Thereby, during infection, the host and the pathogen compete by this metal. Pathogens developed multiple strategies to acquire iron from the host during infection. Thus, making iron unavailable for microorganisms is a central mechanism in host defense. In this work, we investigated the regulation of iron metabolism in host during infection with Listeria monocytogenes, a gram-positive bacterium and Salmonella Typhimurium...

Efficacy and safety of intravenous iron sucrose in treating adults with iron deficiency anemia

Cançado,Rodolfo Delfini; Figueiredo,Pedro Otavio Novis de; Olivato,Maria Cristina Albe; Chiattone,Carlos Sérgio
Fonte: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular Publicador: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2011 EN
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BACKGROUND: Iron deficiency is the most common disorder in the world, affecting approximately 25% of the world`s population and the most common cause of anemia. OBJECTIVE: To evaluate the efficacy and safety of intravenous iron sucrose (IS) in the treatment of adults with iron deficiency anemia METHODS: Eighty-six adult patients with iron deficiency anemia, who had intolerance or showed no effect with oral iron therapy, received a weekly dose of 200 mg of intravenous iron sucrose until the hemoglobin level was corrected or until receiving the total dose of intravenous iron calculated for each patient RESULTS: The mean hemoglobin and serum ferritin levels were 8.54 g/dL and 7.63 ng/mL (pre-treatment) and 12.1 g/dL and 99.0 ng/mL (post-treatment) (p-value < 0.0001), respectively. The average increases in hemoglobin levels were 3.29 g/dL for women and 4.58 g/dL for men; 94% of male and 84% of female patients responded (hemoglobin increased by at least 2 g/dL) to intravenous iron therapy. Correction of anemia was obtained in 47 of 69 (68.1%) female patients and in 12 of 17 male (70.6%) patients. A total of 515 intravenous infusions of iron sucrose were administered and iron sucrose was generally well tolerated with no moderate or serious adverse drug reactions recorded by the investigators. CONCLUSIONS: Our data confirm that the use of intravenous iron sucrose is a safe and effective option in the treatment of adult patients with iron deficiency anemia who lack satisfactory response to oral iron therapy. Intravenous iron sucrose is well tolerated and with a clinically manageable safety profile when using appropriate dosing and monitoring. The availability of intravenous iron sucrose would potentially improve compliance and thereby reduce morbidities from iron deficiency.

Intravenous iron therapy: how far have we come?

Cançado,Rodolfo Delfini; Muñoz,Manuel
Fonte: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular Publicador: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2011 EN
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Oral iron supplementation is usually the first choice for the treatment of iron deficiency anemia (IDA) because of its effectiveness and low cost. But unfortunately in many iron deficient conditions, oral iron is a less than the ideal treatment mainly because of adverse events related to the gastrointestinal tract as well as the long course required to treat anemia and replenish body iron stores. The first iron product for intravenous use was high-molecular-weight iron dextran. However, dextran-containing intravenous iron preparations are associated with an elevated risk of anaphylactic reactions, which made physicians reluctant to prescribe intravenous iron in the treatment of iron deficiency anemia for many years. In 1999 and 2001, two new intravenous iron preparations (ferric gluconate and iron sucrose) were introduced into the market as safer alternatives to iron dextran. Over the last five years, three new intravenous iron dextran-free preparations have been developed and have better safety profiles than the more traditional intravenous compounds, as none require test doses and all these products are promising in respect to a more rapid replacement of body iron stores (15-60 minutes/infusion) as they can be given at higher doses (from 500 mg to more than 1000 mg/infusion). The purpose of this review is to discuss some pertinent issues in relation to the history...

Iron Homeostasis and Nutritional Iron Deficiency123

Theil, Elizabeth C.
Fonte: American Society for Nutrition Publicador: American Society for Nutrition
Tipo: Artigo de Revista Científica
EN
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Nonheme food ferritin (FTN) iron minerals, nonheme iron complexes, and heme iron contribute to the balance between food iron absorption and body iron homeostasis. Iron absorption depends on membrane transporter proteins DMT1, PCP/HCP1, ferroportin (FPN), TRF2, and matriptase 2. Mutations in DMT1 and matriptase-2 cause iron deficiency; mutations in FPN, HFE, and TRF2 cause iron excess. Intracellular iron homeostasis depends on coordinated regulation of iron trafficking and storage proteins encoded in iron responsive element (IRE)-mRNA. The noncoding IRE-mRNA structures bind protein repressors, IRP1 or 2, during iron deficiency. Integration of the IRE-RNA in translation regulators (near the cap) or turnover elements (after the coding region) increases iron uptake (DMT1/TRF1) or decreases iron storage/efflux (FTN/FPN) when IRP binds. An antioxidant response element in FTN DNA binds Bach1, a heme-sensitive transcription factor that coordinates expression among antioxidant response proteins like FTN, thioredoxin reductase, and quinone reductase. FTN, an antioxidant because Fe2+ and O2 (reactive oxygen species generators) are consumed to make iron mineral, is also a nutritional iron concentrate that is an efficiently absorbed, nonheme source of iron from whole legumes. FTN protein cages contain thousands of mineralized iron atoms and enter cells by receptor-mediated endocytosis...

Studies of β-diketiminate iron complexes to investigate nitrogen activation and novel iron-sulfur clusters; Studies of [beta]-diketiminate iron complexes to investigate nitrogen activation and novel iron-sulfur clusters

Rodriguez, Meghan Marguerite (1985 - ); Holland, Patrick L.
Fonte: University of Rochester Publicador: University of Rochester
Tipo: Tese de Doutorado Formato: Number of Pages:xxi, 151 leaves.; Illustrations:ill. (some col.)
ENG
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Thesis (Ph. D.)--University of Rochester. Dept. of Chemistry, 2012.; The use of β-diketiminate ligands to form iron-centered coordination compounds has enabled the exploration of many chemical transformations. The diketiminate ligands are sterically and electronically tunable and therefore ideal for systematic studies. In the following chapters, we describe the use of β-diketiminate iron complexes to study nitrogen activation and formation of novel iron-sulfur clusters. Chapter 2 describes a β-diketiminate iron complex that when reduced under an atmosphere of dinitrogen forms an iron-nitride complex. Labeling studies with 15N2 are described to show that the nitride derives from dinitrogen. X-ray crystallography elucidates that the iron-nitride compound is a tetra-iron cluster where three of the iron centers are bound to two bridging nitrides. Mössbauer spectroscopy and magnetic studies are used to determine the oxidation and spin states of the iron centers. These studies suggest that multiple iron centers cooperatively cleave N2, which is relevant to nitrogenase and the Haber-Bosch process. In Chapter 3, the synthesis and characterization of dinuclear iron-sulfur clusters is discussed. Two novel routes are used to synthesize diiron(III) sulfide complexes. The reduction of one of these diiron(III) sulfide complexes yields a mixed-valence iron(II)iron(III) cluster. Two versions were crystallized...

Evaluation of an iron specific checklist for the assessment of dietary iron intake in pregnant and postpartum women

Zhou, S.; Schilling, M.; Makrides, M.
Fonte: Elsevier Science Inc Publicador: Elsevier Science Inc
Tipo: Artigo de Revista Científica
Publicado em //2005 EN
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OBJECTIVE: This study developed and validated an iron checklist for assessing dietary iron intake of pregnant and postpartum women. METHODS: The checklist included 65 food and drink items. Iron intake measured by the checklist was compared with a diet history interview by paired t test and by the Bland-Altman method in 54 pregnant women. We then used the checklist to prospectively assess iron intake in a separate group of women in late pregnancy (n = 179) and at 6 mo postpartum (n = 177). The ability of the checklist to predict iron status was evaluated. RESULTS: There was no difference in reported mean iron intakes between the checklist and the diet history and there were good correlations between iron intake estimated from both methods (r = 0.69, P < 0.001 for food alone, r = 0.99, P < 0.001 for food plus supplements). However, the agreement between the two methods at an individual level was low. Pregnant women with low iron intake (lower than the recommended dietary intake) had lower serum ferritin levels (9.7 versus 14.5 microg/L, P < 0.001) and higher risk of iron deficiency (67.5% versus 34.9%, P < 0.0001) compared with women with adequate iron intake (at least the minimum recommended dietary intake), but these differences disappeared when women taking iron supplements were excluded. There was no association between iron intake and serum ferritin at 6 mo postpartum or between iron intake and hemoglobin levels at the end of pregnancy or at 6 mo postpartum. CONCLUSION: This simple iron checklist is a useful tool in describing iron intake of population samples of pregnant women but has limited ability to predict iron status.

Pre-operative anaemia management with intravenous iron: a systematic review.

Froessler, Bernd
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2013
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BACKGROUND Iron deficiency anaemia (IDA) is a common condition in patients presenting for surgery and is found in up to 75% of non-cardiac surgical patients. Pre-operative haemoglobin (Hb) is a strong predictor of transfusion requirement and it should, as part of a comprehensive blood conservation approach, be optimised whenever possible. Treatment options for iron deficiency anaemia include oral and intravenous iron or red blood cell transfusion. That both, anaemia and red blood cell (RBC) transfusion expose the patient to unnecessary risks is supported by an ever-increasing body of evidence. Consequently, allogeneic RBC transfusion should be avoided whenever possible and alternative treatment modalities which optimize the patient’s own red cell mass should be exhausted. However, anxiety over the short and long term effects of intravenous iron have limited its more widespread use. Newer dextran-free compounds, however, provide a safer treatment option. OBJECTIVE The objective of this systematic review was to critically appraise, synthesise and present the best available evidence related to the effectiveness and economic aspects of intravenous iron administration on the correction of iron deficiency anaemia in the peri-operative period. DATA SOURCES A comprehensive search was undertaken on major electronic databases from 2001 to 2012. The search was conducted in English...

Untersuchungen zum Eisenstoffwechsel neuraler Zellen; Investigations on iron metabolism in neural cells

Höpken, Hans-Hermann
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
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Eisenionen sind als Bestandteil verschiedener Kofaktoren für viele enzymatische Reaktionen wichtig und spielen zum Beispiel eine bedeutende Rolle beim Sauerstofftransport und in der mitochondrialen Atmungskette. In redoxaktiver Form können sie jedoch die Bildung hochreaktiver toxischer Hydroxylradikale verursachen. Diese toxische Wirkung des Eisens wird im Zusammenhang mit der Entstehung verschiedener neurodegenerativer Erkrankungen diskutiert. Im Rahmen dieser Arbeit sollten verschiedene Aspekte des Eisenstoffwechsels an Kulturen von Astrocyten, Microglia, Oligodendrocyten und Neuronen untersucht werden. Eisen konnte quantitativ in allen untersuchten Kulturen nachgewiesen werden, wobei Microgliazellen den höchsten spezifischen Eisengehalt aufwiesen. Durch die modifizierte Perlsfärbung zur Detektion von Eisen(III) konnte nur Microgliazellen Eisen(III) zugewiesen werden. Ferritin und Transferrinrezeptoren wurden in allen untersuchten Kulturen nachgewiesen. Durch histochemische Anfärbungen von Rattengehirnen wurden Eisen und Ferritin überwiegend in Microglia aber auch in Oligodendrocyten nachgewiesen, Transferrinrezeptoren traten vor allem auf Blutkapillaren oder den umgebenen Zellen auf. Für alle Zellkulturen konnte sowohl eine transferrinabhängige als auch eine transferrinunabhängige Eisenaufnahme nachgewiesen werden...

Microbial dissimilatory iron(III) reduction: Studies on the mechanism and on processes of environmental relevance; Mikrobielle dissimilatorische Eisen(III)-Reduktion: Untersuchungen des Mechanismus und verschiedener umweltrelevanter Prozesse

Jahn, Michael
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
EN
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Many microbes are able to respire aerobically oxygen or anaerobically other electron acceptors for example sulphate, nitrate, manganese(IV) or Fe(III). As iron minerals are widespread in nature, dissimilatory iron(III) reduction by different microorganisms is a very important process of anaerobic respiration. The general goal of this work was to improve the knowledge of processes, in which iron-reducing microbes are said to play an important role. For this purpose, in one part the focus was made on anaerobic contaminant degradation and in the other part on studies on the mechanism of microbial iron(III) reduction. Both parts were investigated in growth and cell suspension experiments with different microorganisms. At former industrial sites, monoaromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylene (BTEX), are widespread contaminants, which cause different problems due to their high solubility in water and strong toxicity. At such sites, where usually anoxic conditions prevail, the anaerobic degradation of these compounds is a very important process. In this study, the anaerobic degradation of BTEX compounds by dissimilatory iron-reducing microorganisms was examined. In order to isolate new bacterial strains, enrichment cultures with the different BTEX compounds added as sole carbon and energy source were prepared. Successful enrichment cultures were obtained for all BTEX substrates both in the presence and absence of AQDS (9...

Preoperative anemia management with intravenous iron: a systematic review

Froessler, B.; Tufanaru, C.; Cyna, A.; Pearson, A.
Fonte: University of Adelaide Publicador: University of Adelaide
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
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Background Iron deficiency anemia is a common condition in patients presenting for surgery, but despite its negative health impacts, the condition remains frequently unmanaged. Optimizing the patient's own red cell mass should be addressed in the preoperative period. Intravenous iron has been advocated as an effective treatment modality. Objectives The objective of this systematic review was to critically appraise and synthesize the best available evidence related to the effectiveness and economic aspects of intravenous iron administration on the correction of iron deficiency anemia in the preoperative period. Inclusion criteria Types of participants Adult patients 18 years of age and older receiving intravenous iron compared with those taking iron orally, and those who were not on iron or were transfused with red blood cells for the correction of anemia. Studies assessing the economic aspects of anemia management were also considered. Types of intervention(s)/phenomena of interest The quantitative component of the review considered studies that evaluated the management of anemia with iron infusions compared to oral iron treatment alone, oral iron in combination with erythropoietin, erythropoietin alone or hemoglobin correction with blood transfusion. The economic component of this review considered studies that evaluated the costs and benefits of iron infusions compared to oral iron treatment or hemoglobin correction with blood transfusion for the treatment of preoperative anemia. Types of studies The quantitative component of the review considered any experimental study design including randomized controlled trials (RCTs)...

Treatment for women with postpartum iron deficiency anaemia

Dodd, J.; Dare, M.; Middleton, P.
Fonte: Update Software Ltd Publicador: Update Software Ltd
Tipo: Artigo de Revista Científica
Publicado em //2004 EN
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Background: Postpartum anaemia is associated with breathlessness, tiredness, palpitations and maternal infections. Blood transfusions or iron supplementation have been used in the treatment of iron deficiency anaemia. Recently other anaemia treatments, in particular erythropoietin therapy, have also been used. Objectives: To assess the clinical effects of treatments for postpartum anaemia, including oral, intravenous or subcutaneous iron/folate supplementation and erythropoietin administration, and blood transfusion. Search strategy: We searched the Cochrane Pregnancy and Childbirth Group trials register (30 May 2004), the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2003), MEDLINE (1966 to March 2003), EMBASE (1980 to March 2003), Current Contents and ACP Journal Club (from inception to March 2003). Selection criteria: Randomised controlled trials (RCTs) comparing therapy for postpartum iron deficiency anaemia (oral, intravenous or subcutaneous administration of iron, folate, erythropoietin or blood transfusion) with placebo, another treatment or no treatment. Data collection and analysis: Two reviewers independently assessed trial quality and extracted data. Main results: Six included RCTs involving 411 women described treatment with erythropoietin or iron as their primary interventions. No RCTs were identified that assessed treatment with blood transfusion. Few outcomes relating to clinical maternal and neonatal factors were reported: studies focused largely on surrogate outcomes such as haematological indices. Overall...

Régulation de l'hepcidine et le rôle de la lipocaline 2 dans l'homéostasie du fer / Novel insights into the regulation of hepcidin and the role of lipocalin 2 in iron homeostasis

Huang, Hua
Fonte: Université de Montréal Publicador: Université de Montréal
Tipo: Thèse ou Mémoire numérique / Electronic Thesis or Dissertation
EN
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Le fer, un métal de transition, est requis pour la survie de presque tout les organismes vivant à cause de son habilité à accepter ou donner un électron et donc à catalyser plusieurs réactions biochimique fondamentales. Cependant, la même propriété permet aussi au fer ionique d’accélérer la formation de radicaux libres et donc le fer peut potentiellement avoir des effets néfastes. Conséquemment, l’homéostasie du fer doit être étroitement régulé, tant au niveau cellulaire que systémique. Notre étude met l’emphase sur deux molécules importante pour régulation du métabolisme du fer : la lipocaline 2 (Lcn2) et l’hepcidine. Lcn2, une protéine de phase aiguë, est impliquée dans le transport du fer par les sidérophores. Lcn2 est un candidat potentiel comme transporteur du fer qui pourrait être responsable de l’accumulation excessive du fer non lié à la transferrine dans le foie des patients atteints d’hémochromatose héréditaire (HH). Nous avons généré des souris double-déficiente HfeLcn2 pour évaluer l’importance de Lcn2 dans la pathogenèse de surcharge en fer hépatique dans les souris knock-out Hfe (Hfe -/-). Notre étude révèle que la délétion de Lcn2 dans les souris Hfe-/- n’influence pas leur accumulation de fer hépatique ou leur réponse à une surcharge en fer. Le phénotype des souries HfeLcn2-/- demeure indiscernable de celui des souris Hfe-/-. Nos données impliquent que Lcn2 n’est pas essentiel pour la livraison du fer aux hépatocytes dans l’HH. L’hepcidine...

Anemia ferropriva em crianças de 1 a 5 anos internadas com pneumonia : suplementação com ferro hematinico.; Iron deficiency anemia in children of 1 the 5 years interned with pneumonia: supplementation with heme iron.

Miriam Correa de Carvalho Simões
Fonte: Biblioteca Digital da Unicamp Publicador: Biblioteca Digital da Unicamp
Tipo: Tese de Doutorado Formato: application/pdf
Publicado em 03/12/2003 PT
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A anemia ferropriva, desordem nutricional mais prevalente em todo o mundo, acomete principalmente crianças menores de cinco anos como resultado do balanço negativo prolongado de ferro ou por falha do organismo em atender às necessidades fisiológicas aumentadas. A importância como problema de saúde pública está baseada em suas conseqüências para a saúde, entre elas, a diminuição da resposta imune, especialmente a celular, pode interferir negativamente na instalação e na evolução de processos infecciosos, representando assim, fator de risco para o desenvolvimento da pneumonia, principal causa de hospitalização devido às infecções respiratórias agudas (IRA). Esforços substanciais têm ocorrido para se implementar programas para reduzir a deficiência de ferro e a anemia ferropriva, sendo a suplementação uma importante estratégia para a prevenção e o tratamento da anemia em todo o mundo. O sulfato ferroso, apesar de ser um dos compostos mais utilizados na suplementação, devido ao baixo custo e a oferta, pode causar efeitos gastrointestinais indesejáveis. Neste sentido, o sangue bovino, por apresentar ferro hematínico de alta biodisponibilidade, por ser encontrado abundantemente em nosso país e por representar custo favorável...

Iron isomaltoside 1000: a new high dose option for parenteral iron therapy

Kalra,Philip A.; Bock,Klaus; Meldal,Morten
Fonte: Sociedade Portuguesa de Nefrologia Publicador: Sociedade Portuguesa de Nefrologia
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2012 EN
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Iron isomaltoside 1000 (Monofer®) is a new dextran-free parenteral iron product, currently approved in 22 EU countries. Iron isomaltoside 1000 consists of iron and a carbohydrate moiety where the iron is tightly bound in a matrix structure, which enables a controlled and slow release of iron to iron-binding proteins, avoiding toxicity. The carbohydrate,isomaltoside 1000, is a purely linear chemical structure with low immunological activity. Due to the structure of iron isomaltoside 1000 and the low anaphylactic potential, there is no requirement for a test dose, and it can be administered in high doses with a maximum dosage of 20 mg/kg within 30-60 minutes in one visit. Thus, iron isomaltoside 1000 offers the broadest dosage range compared to other parenteral iron products on the market. Due to the dose flexibility, the possibility of providing full iron correction in one single visit makes iron isomaltoside 1000 highly convenient for both the health care professional and the patient. Clinical studies of iron isomaltoside 1000 show that it is an effective and well-tolerated treatment of iron deficiency anaemia with a favourable safety profile. Furthermore, iron isomaltoside 1000 does not seem to induce hypophosphataemia.

Absorption of unlabeled reduced iron of small particle size from a commercial source: A method to predict absorption of unlabeled iron compounds in humans

González,Horacio; Mendoza,Concepción; Viteri,Fernando E
Fonte: Sociedad Latinoamericana de Nutrición Publicador: Sociedad Latinoamericana de Nutrición
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2001 EN
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The absorption of a commercial brand of small-particle reduced iron was evaluated in 10 normal subjects. For each subject, the hemoglobin incorporation method was used to measure the true absorption of 60 mg of iron from either ferrous sulfate or ferric ammonium citrate. The iron tolerance test (ITT) was also studied for these two compounds and for reduced iron. This procedure consisted of measuring the area under the curve of plasma iron elevations at specified times for 6 hours, or the peak plasma iron, corrected by the plasma iron disappearance rate obtained from measuring plasma iron at specified times for 4 hours after the slow intravenous injection of 0.4 mg of iron as ferric citrate. Only the ITT was used to measure the absorption of 60 mg of reduced iron. Reference dose iron ascorbate absorption was measured in each subject. The absorption of ferric ammonium citrate and reduced iron was expressed as percent of dose and also as absorption percent of that of ferrous sulfate. Mean % geometric "true absorptions" were 39.0 for reference dose, 10.4 for FeSO4 and 2.4 for ferric ammonium citrate. The later was 23% that of FeSO4. By ITT the mean geometric % absorptions were 7.9, 3.7 and 3.2 for FeSO4, ferric ammonium citrate and reduced iron respectively...