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Efeitos da dexmedetomidina, por via epidural ou infusão contínua intravenosa, em gatas anestesiadas com propofol e isofluorano e submetidas a ovariossalpingohisterectomia; Effects of dexmedetomidine by epidural or continuous intravenous infusion in cats undergoing propofol-isoflurane anesthesia to ovariohysterectomy

Souza, Sérgio dos Santos
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 05/10/2006 PT
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Este estudo determinou e comparou os efeitos da administração epidural ou infusão contínua intravenosa de dexmedetomidina em gatas anestesiadas com propofol e isofluorano para realização de ovariossalpingohisterectomia. Vinte e uma gatas (peso: 3.06±0.35 kg) foram pré-tratadas com dexmedetomidina (4 mcg.kg-1, IM). Quinze minutos depois, administrou-se propofol para permitir entubação orotraqueal seguido de manutenção anestésica com isofluorano diluído em oxigênio por um circuito Mapleson D com respiração espontânea. As gatas foram distribuídas aleatoriamente, em três grupos, onde receberam, por via epidural, lidocaína (1 mg.kg-1, G1, n=7) ou lidocaína (1 mg.kg-1) + dexmedetomidina (4 mcg.kg-1, G2, n=7) ou lidocaína (1 mg.kg-1) + infusão contínua intravenosa de dexmedetomidina (0,25 mcg.kg-1.min-1, G3, n=7). O volume da solução para administração epidural foi ajustada para 0.3 mL.kg-1 com solução salina. A profundidade anestésica foi realizada por um único avaliador que não possuía conhecimento dos fármacos empregados pela via epidural e intravenosa. Foram mensurados freqüência cardíaca (FC) e respiratória (FR), pressão arterial sistólica (PAS) e temperatura retal (TR) antes e quinze minutos após a medicação pré-anestésica. Durante a anestesia...

Estudos clínicos da infusão contínua de fentanil, quetamina ou lidocaína sobre o requerimento de isoflurano em cavalos submetidos à cirurgia de artroscopia; Clinical evaluation of the effects of continuous infusion of fentanyl, ketamine or lidocaine on the requirement of isoflurane in horses undergoing arthroscopic surgery

Souto, Maria Teresa de Mello Rêgo
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 23/07/2010 PT
Relevância na Pesquisa
36.69%
Os equinos são comumente anestesiados com agentes voláteis em procedimentos cirúrgicos acima de 60 minutos, resultando em depressão cardiovascular dosedependente, contribuindo para uma alta taxa de mortalidade. Sendo assim, este estudo objetivou determinar se o fentanil, em infusão contínua, seria capaz de diminuir a fração expirada de isoflurano, promovendo estabilidade cardiovascular transoperatória e uma melhor recuperação após cirurgia de artroscopia, em comparação à infusão de lidocaína ou quetamina, durante a manutenção da anestesia com isoflurano. Para tanto foram utilizados 20 equinos de 3 a 8 anos e pesando 350 a 500kg, submetidos a cirurgia de artroscopia em decúbito dorsal. Os animais foram divididos aleatoriamente em 4 grupos: GL (1,5 mg/kg em bolus e infusão de 0,15mg/kg/min) ; GQ (2mg/kg em bolus e infusão de 0,2mg/kg/min); GF (7µg/kg em bolus e infusão de 0,7µg/kg/min) e GI que não recebeu infusão de nenhum fármaco adjuvante. Foram avaliados os parâmetros cardiovasculares (FC, PAM, PAS e PAD), ventilatórios e de oxigenação (PaO2, PaCO2, Compl e Rva), fração expirada de isoflurano [ISSO](Fexp%), e qualidade de recuperação. Em relação à [ISSO] (Fexp%) as maiores quedas foram observadas no momento 30bolus em todos os grupos...

Treatment of invasive fungal infections : stability of voriconazole infusion solutions in pvc bags

Adams, Andréa Inês Horn; Morimoto, Lúcia Naomi; Meneghini, Leonardo Zanchetti; Bergold, Ana Maria
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf
ENG
Relevância na Pesquisa
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Voriconazole is a novel broad-spectrum antifungal drug, employed in the treatment of invasive fungal infections, and represents an alternative to amphotericin B treatment. The manufacturer recommends that any unused reconstituted product should be stored at 2ºC to 8ºC, for no more than 24 h, but no recommendations about i.v. infusion solutions are given. Previous works have reported on the stability of voriconazole in polyolefin bags and just one in 5% dextrose polyvinyl chloride (PVC) bags, at a 4 mg.mL-1 concentration. In this work, the stability of voriconazole as an i.v. infusion solution in 0.9% sodium chloride and in 5% dextrose, in PVC bags, at 0.5 mg.mL-1, stored at 4 ºC and at room temperature, protected from light, was evaluated. These infusion solutions were analyzed for a 21-day period. Chemical stability was evaluated by HPLC assay. Visual inspection was performed and pH of the solutions was measured. No color change or precipitation in the solutions was observed. The drug content remained above 90% for 11 days in 0.9% sodium chloride and for 9 days in 5% dextrose solutions. The i.v. infusion solutions stored at room temperature were not stable. At room temperature, the voriconazole content dropped down to 88.3 and 86.6%...

Anestesia por isofluorano em eqüinos submetidos à infusão contínua de medetomidina ou xilazina; Isoflurane anesthesia in horses during medetomidine or xilazine continuous infusion

Dória, Renata Gebara Sampaio; Valadão, Carlos Augusto Araújo; Canola, Paulo Aléscio; Guirro, Érica Cristina Bueno do Prado; Mendes, Marina Ceccato; Escobar, André; Ferraz, Gesiane Ribeiro Leão; Natalini, Claudio Correa
Fonte: Universidade Federal do Rio Grande do Sul Publicador: Universidade Federal do Rio Grande do Sul
Tipo: Artigo de Revista Científica Formato: application/pdf
POR
Relevância na Pesquisa
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Avaliaram-se oito eqüinos sob anestesia geral inalatória com isofluorano (1CAM) e infusão contínua de xilazina (0,35mg kg-1h-1) ou medetomidina (3,5μg kg-1h-1), em relação à freqüência cardíaca, ritmo cardíaco, freqüência respiratória, pressão arterial, hemogasometria arterial e temperatura, nos tempos T0 (imediatamente antes do início da infusão contínua) e T10 ao T60 (intervalos de 10 minutos, após início da infusão contínua). Houve redução da freqüência cardíaca e da temperatura e elevação da pressão arterial média. A paCO2 (no GM) elevou-se e a paO2 mostrou-se maior no GM que no GX. Conclui-se que a infusão contínua de doses equipotentes de xilazina e medetomidina, durante anestesia geral inalatória, com isofluorano, em eqüinos, promove alterações cardiocirculatórias, respiratórias, térmicas e hemogasométricas discretas e equivalentes.; Eight horses under inhalant general anesthesia with isoflurane (1MAC) and continuous infusion of xylazine (0.35mg kg-1h-1) or medetomidine (3.5μg kg-1h-1) were evaluated for heart rate and rhythm, respiratory rate, arterial blood pressure, arterial blood gas analysis and temperature immediately before the beginning of the continuous infusion (T0) and in intervals of 10 minutes after the beginning of the continuous infusion (T10 to T60). Heart rate and temperature decreased and mean arterial pressure increased. PaCO2 (in GM) increased and GM showed a higher paO2 than GX. We conclude that equipotent doses of continuous infusion of medetomidine and xylazine during inhalant general anesthesia with isoflurane in horses promote slight and equivalent cardiocirculatory...

Effects of intravenous glucose infusion and nutritional balance on serum concentrations of nonesterified fatty acids, glucose, insulin, and progesterone in nonlactating dairy cows

Vieira, F. V. R.; Lopes, C. N.; Cappellozza, B. I.; Scarpa, A. B.; Cooke, R. F.; Vasconcelos, J. L. M.
Fonte: Elsevier B.V. Publicador: Elsevier B.V.
Tipo: Artigo de Revista Científica Formato: 3047-3055
ENG
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Processo FAPESP: 09/506788; The objective of this study was to evaluate serum concentrations of nonesterified fatty acids, glucose, insulin, and progesterone in nonlactating dairy cows according to nutritional balance and glucose infusion. Ten nonlactating, ovariectomized Gir x Holstein cows were stratified by body weight (BW) and body condition score (BCS) on d - 28 of the study, and randomly assigned to 1) negative nutrient balance (NB) or 2) positive nutrient balance (PB). From d -28 to d 0, cows were allocated according to nutritional treatment (5 cows/treatment) into 2 low-quality pastures with reduced forage availability. However, PB cows individually received, on average, 3 kg/cow per day (as-fed) of a concentrate during the study. All cows had an intravaginal progesterone releasing device inserted on d -14, which remained in cows until the end of the study. Cow BW and BCS were assessed again on d 0. on d 0, cows within nutritional treatment were randomly assigned to receive, in a crossover design containing 2 periods of 24 h each, 1) intravenous glucose infusion (GLU; 0.5 g of glucose/kg of BW, as a 5% glucose solution administered, on average, at 32 mL/min over a 3-h period)...

Improving the vacuum-infusion process to manufacture high quality structural composite for the aeronautic market

Oliveira, Luís; Nunes, J. P.; Ferreira, F.
Fonte: Universidade do Minho Publicador: Universidade do Minho
Tipo: Conferência ou Objeto de Conferência
Publicado em //2014 ENG
Relevância na Pesquisa
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In last years, the vacuum-infusion processing method is being replacing successfully autoclave technologies to manufacture advanced composite structures, namely, the carbon-fibre reinforced plastic (CFRP) ones, for aeronautical and aerospace applications. The high investment associated with autoclave “prepreg” manufacturing has prompted interest in the use of alternative vacuum-infusion technologies that proven to be much more cost-effective processing methods. The present work presents, describes and discusses improvements and developments made on an existing vacuum-infusion process to obtained high quality and reliable CRFP structural components to the aircraft industry. The first aim is to use the developed technology to produce wing elevators for an unmanned aerial vehicle (UAV), commonly known as “drone”, expected to be used in firefighting and policing civilian operations. An additional heating stage was enhanced to the initial standard vacuum process to increase the quality and reliability of the final manufactured composite parts, namely in terms of void reduction and control of fibre content and orientation. A prototype part was manufactured by using this improved vacuum-infusion process to be tested and validate the developed technology. This paper will present and discuss the results obtained in the manufacturing and characterization tests made on the produced prototypes.; FCT projeto UID/CTM/50025/2013

Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags

Adams,Andréa I.H.; Morimoto,Lucia N.; Meneghini,Leonardo Z.; Bergold,Ana M.
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2008 EN
Relevância na Pesquisa
36.6%
Voriconazole is a novel broad-spectrum antifungal drug, employed in the treatment of invasive fungal infections, and represents an alternative to amphotericin B treatment. The manufacturer recommends that any unused reconstituted product should be stored at 2ºC to 8ºC, for no more than 24 h, but no recommendations about i.v. infusion solutions are given. Previous works have reported on the stability of voriconazole in polyolefin bags and just one in 5% dextrose polyvinyl chloride (PVC) bags, at a 4 mg.mL-1 concentration. In this work, the stability of voriconazole as an i.v. infusion solution in 0.9% sodium chloride and in 5% dextrose, in PVC bags, at 0.5 mg.mL-1, stored at 4 ºC and at room temperature, protected from light, was evaluated. These infusion solutions were analyzed for a 21-day period. Chemical stability was evaluated by HPLC assay. Visual inspection was performed and pH of the solutions was measured. No color change or precipitation in the solutions was observed. The drug content remained above 90% for 11 days in 0.9% sodium chloride and for 9 days in 5% dextrose solutions. The i.v. infusion solutions stored at room temperature were not stable. At room temperature, the voriconazole content dropped down to 88.3 and 86.6%...

Metabolic and hematologic changes occurring after rapid intravenous infusion of gammaglobulin in patients with antibody deficiency syndromes

Costa-Carvalho,Beatriz Tavares; Lin,Marisa; Solé,Dirceu; Carneiro-Sampaio,Magda Maria Sales; Sorensen,Ricardo Uhr; Naspitz,Charles Kirov
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/1998 EN
Relevância na Pesquisa
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OBJECTIVE: We wished to investigate whether increased IgG infusion rates are associated with metabolic and hematologic changes in pediatric patients with antibody deficiency syndromes. METHODS: We studied 7 patients (2-16 years old) with primary antibody deficiencies who had been on regular IgG replacement treatment, 350-600 mg/kg/dose every 3 weeks with a 3% IVIG preparation, for periods ranging from 6 months to 4 years. Initially, the IgG concentration of IVIG preparations was increased to 6, 9 and 12% in consecutive infusions at a constant IgG infusion rate of 4 mg/kg/min. Subsequently, the infusion rates were increased to 8, 12, and 16 mg/kg/min using the IVIG 12% preparation. RESULTS: Clinically, all patients tolerated increases in IVIG concentrations while the infusion rate was 4 mg/kg/min. However, 3 patients presented side effects when the infusion rate was increased to 8 and 16 mg/kg/min. CONCLUSION: We conclude that metabolic and hematologic sides effects occur with rapid infusion of IVIG even in patients who tolerate the increased infusion rate clinically. The advantages of using high infusion rates have to be re-evaluated.

Is glycosuria a reliable indicator of adequacy of glucose infusion rate in preterm infants?

Falcão,Mário Cícero; Leone,Cléa Rodrigues; Ramos,José Lauro Araújo
Fonte: Associação Paulista de Medicina - APM Publicador: Associação Paulista de Medicina - APM
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/1999 EN
Relevância na Pesquisa
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CONTEXT: Adequacy of glucose infusion may be monitored via the glycosuria levels, as there is a relationship between glycemia and glycosuria regulated by the renal glucose threshold. In the neonatal period, however, this relationship is not so clear. OBJECTIVE: To evaluate the occurrence of glycosuria in preterm infants submitted to glucose infusion and to verify the relationship between glycosuria and blood glucose level. DESIGN: Accuracy study. SETTING: Neonatal intensive care unit of General Maternity Hospital. PATIENTS: 40 preterm newborns receiving glucose infusion. PROCEDURES: 511 concomitant determinations of glycemia and glycosuria were performed. These 511 pairs were divided into stable and unstable, according to the clinical status of the newborn at the time of data collection, and they were studied in relation to the gestational age, birth weight and glucose infusion rate. RESULTS: The results revealed a greater frequency of glycosuria in gestational age £ 30 weeks, birth weight <1500 g and glucose infusion rate > 6 mg/kg/min. Eight (25.8%) episodes of positive glycosuria occurred in the absence of hyperglycemia, indicating only a moderate concordance between them. CONCLUSION: Glycosuria alone is an unreliable marker of blood glucose concentration and adequacy of glucose infusion rate. It is therefore necessary to monitor blood glucose levels in infants submitted to continuous glucose infusion.

A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval

Coskun,Demet; Gunaydin,Berrin; Tas,Ayca; Inan,Gozde; Celebi,Hulya; Kaya,Kadir
Fonte: Faculdade de Medicina / USP Publicador: Faculdade de Medicina / USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2011 EN
Relevância na Pesquisa
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OBJECTIVE: To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. METHODS: Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effectsite concentration of 1.5 μg/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site concentration of either 1.5 (group I, n = 23), 2 (group II, n = 23) or 2.5 ng/mL (group III, n = 23). Hemodynamic variables, sedation, pain, the Aldrete recovery score, and side effects were recorded. RESULTS: Hemodynamic variables, sedation and pain scores and the number of patients with the maximum Aldrete recovery score 10 min after the procedure were comparable among the groups. The number of patients in group III with the maximum Aldrete recovery score 5 min after the procedure was significantly lower than that in groups I and II. One patient in group II and one patient in group III suffered from nausea. CONCLUSION: Similar pain-free conscious sedation conditions without significant changes in hemodynamic parameters were provided by all three protocols. However, target controlled infusion of remifentanil at 1.5 or 2 ng/mL proved superior at providing early recovery compared to 2.5 ng/mL.

Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers

Jensen, M.; Foster, D.; Upton, R.; Kristensen, K.; Hansen, S.; Jensen, N.; Nielsen, B.; Skram, U.; Villesen, H.; Christrup, L.
Fonte: Springer Publicador: Springer
Tipo: Artigo de Revista Científica
Publicado em //2007 EN
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Objective: The aim of this investigation was to characterize the pharmacokinetics of buprenorphine following administration of an intravenous (i.v.) infusion. To date, the population kinetics of buprenorphine has been described for bolus administration only. Methods: Twenty-three healthy male volunteers aged 21–40 years received 0.6 mg buprenorphine by means of an i.v. infusion over a 150-min period. The plasma concentration–time profiles up to 24 h post-administration of the infusion were subjected to population pharmacokinetic modelling using NONMEM software. Results: A three-compartment model best described the plasma concentration–time course. Body weight was found to be a significant covariate for elimination clearance in a linear fashion. Inter-individual variability (coefficient of variation) was estimable for apparent clearance (CL, 23.5%), central distribution volume (V₁, 81.8%), peripheral distribution volume 1 (V₂, 23.7%) and inter-compartmental clearances between V₁ and V₂ (Q₂, 34.8%). Models using parameters derived from previous published data obtained after an i.v. bolus of buprenorphine were found to overestimate the measured buprenorphine concentrations during the course of the i.v. infusion and to underpredict those following the end of the infusion. Conclusion: Most parameters describing the disposition of buprenorphine in the volunteers showed only moderate inter-subject variability. However...

Evaluation of the safety and feasibility of rapid rituximab infusion

Lang, S.; Prouse, J.; Barry, F.; Catherwood, A.; Chaplin, K.; Elliott, L.; Greco, K.; McGahey, W.; Nilsen, J.; Singhal, N.
Fonte: Blackwell Publishing Ltd. Publicador: Blackwell Publishing Ltd.
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
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AIM: To assess safety of rapid infusion by measuring infusion-related side effects and toxicities. METHODS: Participants received the first rituximab infusion according to the manufacturers’ recommendations. If well-tolerated, they then received the second and subsequent infusions at a rate of 20% of the dose over the first 30 min and the remaining 80% over the next hour. Premedication was administered for all the infusions. RESULTS: A total of 243 infusions in 65 consecutive participants were evaluated. Six experienced a grade 1 reaction and one a grade 3 transfusion-related adverse event. Three of these participants were withdrawn from the rapid infusion study. The other four participants (grade 1 only participants) were re-challenged. The same premedication was used as in the first rapid infusion. On experiencing a grade 1 reaction, promethazine 12.5 mg i.v. was administered and infusion recommenced at 50% of the previous rate upon the resolution of symptoms. Three patients developed a grade 1 adverse event and one patient experienced no adverse reaction. The three patients who did not tolerate the second rapid infusion were withdrawn from this study. CONCLUSION: A rituximab infusion over 90-min was safe and feasible for participants who seek treatment at ambulatory cancer centre. The new regimen has been adopted as a standard practice with better resource utilization.; Dora Lang...

Effects of taurocholic acid on glycemic, glucagon-like peptide-1, and insulin responses to small intestinal glucose infusion in healthy humans

Wu, T.; Bound, M.; Standfield, S.; Jones, K.; Horowitz, M.; Rayner, C.
Fonte: Endocrine Society Publicador: Endocrine Society
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
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CONTEXT: In vitro and animal studies suggest that bile acids have the capacity to reduce blood glucose by stimulating glucagon-like peptide-1 (GLP-1) and, thereby, insulin. OBJECTIVE: This study evaluated the effects of intrajejunal taurocholic acid (TCA) on blood glucose, GLP-1, and insulin responses to jejunal glucose infusion in healthy men. PARTICIPANTS AND DESIGN: Ten healthy men were each studied on 2 days in a double-blind, randomized order. After the subjects fasted overnight, a jejunal catheter was positioned and a balloon inflated 30 cm beyond the pylorus with aspiration of endogenous bile. Two grams TCA in saline, or saline control, was infused beyond the balloon over 30 minutes, followed by 2 g TCA or control, together with 60 g glucose, over the next 120 minutes. Blood was sampled frequently for the measurements of blood glucose, total GLP-1, insulin, C-peptide, and glucagon. RESULTS: Intrajejunal infusion of TCA alone (t = −30 to 0 minutes) had no effect on blood glucose, GLP-1, insulin, C-peptide, or glucagon concentrations. During intrajejunal glucose infusion (t = 0 to 120 minutes), blood glucose concentrations were lower (P < .001), and plasma GLP-1 (P < .001) and the C-peptide/glucose ratio (P = .008) were both greater...

Predictors of acute adverse events from rapid rituximab infusion

Lang, S.; Keefe, D.; Schultz, T.; Pearson, A.
Fonte: Springer-Verlag Publicador: Springer-Verlag
Tipo: Artigo de Revista Científica
Publicado em //2013 EN
Relevância na Pesquisa
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PURPOSE: This study aimed to identify the predictors of acute adverse events resulting from rapid rituximab infusion over 90 min. METHOD: It was a retrospective cohort study using medical record review based on a convenience sampling from 2007 till May 2011 in both in-patient and ambulatory setting in Royal Adelaide Hospital. RESULTS: There were a total of 294 patients who received 376 courses and 1,571 cycles of rapid rituximab infusion. Forty-three (14.6 %) patients experienced acute adverse events of hypotension being the most commonly occurring events followed by patients feeling hot and face-flushed. There were 11 predictors analysed, namely age, gender, diagnosis, stage of disease, presence of cardiac or lung morbidities, type of treatment, number of course and cycles, total white blood cells count, lymphocyte counts and lactate dehydrogenase using log generalised estimating equation for univariate and multivariate analysis. The findings successfully demonstrated that high lymphocyte counts were the independent predictor of acute adverse event from rapid rituximab infusion (p = 0.0009). Patient with high lymphocyte counts were 6.9382 times the odd to experience an adverse event as compared to those with normal lymphocyte counts. CONCLUSION: There are no specific patient characteristics to preclude prescribing rapid rituximab infusion following a 90-min regimen for non-Hodgkin lymphoma except a potential for adverse events to occur when patients have abnormally high lymphocyte counts.; Dora S. P. Lang...

The safe administration of rapid rituximab infusion : an evidence-based approach.

Lang, Siew Ping
Fonte: Universidade de Adelaide Publicador: Universidade de Adelaide
Tipo: Tese de Doutorado
Publicado em //2012
Relevância na Pesquisa
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The goal of this study was to approach a global clinical issue that is imperative using an evidence-based approach to the investigation of the rapid administration of rituximab infusions for non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL). This study focused on an evidence-based approach to improving patient safety, drawing on the Joanna Briggs Institute‟s model of evidence-based health care with its particular emphasis on evidence synthesis, evidence generation and evidence transfer. The study consists of two central phases. The first phase is a comprehensive systematic review (CSR), which informed the design of a subsequent primary study that constitutes the second phase. The specific systematic review question was: “How safe is it to administer rituximab rapidly for NHL and CLL patients?” The objective was to identify and synthesise the existing published and unpublished literature on the use of rapid rituximab infusion as an alternative infusion rate and its safety. The systematic review found that rapid rituximab infusion is not safe for chronic lymphocytic leukemia (CLL) patients yet it is safe for non-Hodgkin Lymphoma (NHL) patients. However, there was insufficient evidence to address other aspects of clinical concern related to the safe administration of the rapid infusion of rituximab. Therefore...

Antibiotika-Konzentration im Serum und in Bronchialepithel-Flüssigkeit unter kontinuierlicher Infusion; Serum and alveolar concentrations of continuous infused antibiotics in critical ill patients

Peiffer, Manou
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
Relevância na Pesquisa
36.75%
Betalaktam Antibiotika, Glykopeptide und das neue Oxazolidinon Linezolid werden zur Therapie schwerer Infektionen eingesetzt und weisen ein zeitabhängiges pharmakodynamisches Wirkprofil auf. Eine optimale antibakterielle Wirkung von Betalaktamen wird erzielt, wenn die Wirkspiegel möglichst lange oberhalb der minimalen Hemmkonzentration (MHK) der Erreger liegen. Dieses zeitabhängige pharmakodynamische Wirkprofil trifft höchstwahrscheinlich auch für Glykopeptide und das Oxazolidinon Linezolid zu. Kritisch kranke Patienten weisen jedoch eine Reihe von pathophysiologischen Besonderheiten auf, die zu einer veränderten Pharmakokinetik der verabreichten Medikamente führen. Das ausreichend lange Überschreiten der MHK der Infektionserreger unter standardisierter Dosierung ist in dieser Patienten-Gruppe nicht mehr gewährleistet. Aufgrund experimenteller und zunehmend auch klinischer Daten wird daher für Antibiotika mit zeitabhängigem pharmakodynamischem Profil die kontinuierliche Infusion favorisiert. Gerade bei diesen schwer kranken Patienten sollen durch die kontinuierliche Infusion zuverlässig hohe Antibiotika-Wirkspiegel über der MHK erreicht und somit bessere Therapieerfolge erzielt werden. Ziel dieser Studie ist es, bei kritisch kranken Patienten Steady-state-Wirkspiegel von kontinuierlich verabreichten Antibiotika (Piperacillin/Tazobactam...

Diseño y construcción de un prototipo de una jeringa de infusión para neonatología

Escobar Restrepo, Juliana
Fonte: Ingeniería de Diseño de Producto; Escuela de Ingeniería. Departamento de Ingeniería de Diseño de Producto Publicador: Ingeniería de Diseño de Producto; Escuela de Ingeniería. Departamento de Ingeniería de Diseño de Producto
Tipo: bachelorThesis; Trabajo de grado; acceptedVersion
SPA
Relevância na Pesquisa
36.67%
Este proyecto es una iniciativa del Centro de Ciencia y Tecnología de Antioquia (CTA) para el desarrollo de equipos biomédicos, cuyo objetivo es fortalecer el cluster de servicios médicos de Medellín. Esta propuesta fue llevada al departamento de Ingeniería de Diseño de Producto de la Universidad EAFIT, para que se llevara a cabo por medio de un proyecto de investigación del semillero HECAS- ID (Herramientas de Cálculo y Simulación) el desarrollo de un prototipo de una jeringa de infusión para Neonatología en conjunto con un grupo de investigadores que conformaron un equipo interdisciplinario.; 120 p., + presentación (45 diapositivas); Contenido parcial: Bombas de uso general -- Bombas de micro infusión -- Bombas de infusión tipo jeringa (jeringa de infusión) -- Descripción del por qué de una jeringa de infusión -- Desarrollo de modelos y pruebas iniciales.

Efecto hemodinamico del uso de remifentanilo en infusion a bajas dosis hasta la extubacion estudio descriptivo

Silva Gómez, Oscar Alberto
Fonte: Facultad de Medicina Publicador: Facultad de Medicina
Tipo: info:eu-repo/semantics/bachelorThesis; info:eu-repo/semantics/acceptedVersion Formato: application/pdf
Publicado em 09/08/2011 SPA
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36.63%
INTRODUCCION: El despertar de la anestesia general se ha asociado con tos, agitación y cambios hemodinámicos, con los consiguientes efectos deletéreos para los pacientes, el uso de medicamentes opioides como el remifentanilo pueden atenuar estos efectos. METODOS: Estudio observacional descriptivo, de 166 pacientes a los que se les realizo procedimientos quirúrgicos bajo anestesia general balanceada, 53 pacientes recibieron remifentanil en infusión continua hasta la extubación y 113 pacientes en los que la infusión se suspendió 10 minutos antes de la extubación en el Hospital de Kennedy ESE. RESULTADOS: La media de la presión arterial sistólica de los pacientes que recibieron remifentanilo hasta la extubación y la media de la presión arterial sistólica de los que no recibieron remifentanilo hasta la extubación presentaron diferencias estadísticamente significativas al 95% (p= 0.034) siendo un 20% mayor en los pacientes que no recibieron la infusión de remifentanil hasta la extubación, un resultado similar se observó respecto a la presión arterial distolica (p= 0.010). CONCLUSIONES: El uso de remifentanil en infusión continua a bajas dosis hasta la extubación, tiene un efecto hemodinámico benefico en los pacientes y puede disminuir la incidencia de efectos secundarios

Assessment of non-invasive ICP during CSF infusion test: an approach with Transcranial Doppler

Cardim, D.; Czosnyka, M.; Donnelly, J.; Robba, C.; Cabella, B. C.; Liu, X.; Cabeleira, M. T.; Smielewsky, P.; Haubrich, C.; Garnett, M. R.; Pickard, J. D.; Czosnyka, Z.
Fonte: Springer Publicador: Springer
Tipo: Article; accepted version
EN
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This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Springer.; Objectives. This study aimed to compare four non-invasive intracranial pressure (nICP) methods in a prospective cohort of hydrocephalus patients whose CSF dynamics was investigated using infusion tests involving controllable test-rise of ICP. Material & Methods. Cerebral blood flow velocity (FV), ICP and non-invasive arterial blood pressure (ABP) were recorded in 53 patients diagnosed for hydrocephalus. nICP methods were based on: I) interaction between FV and ABP using black-box model (nICP_BB); II) diastolic FV (nICP_FVd); III) critical closing pressure (nICP_CrCP) and IV) TCD-derived pulsatility index (nICP_PI). Correlation between rise in ICP (?ICP) and ?nICP and averaged correlations for changes in time between ICP and nICP during infusion test were investigated. Results. All nICP formulas overestimated ICP at. At plateau of ICP during infusion test, only nICP_BB and nICP_PI presented significant difference from ICP. From baseline to plateau, all nICPs estimators increased significantly. Correlations between ?ICP and ?nICP were better represented by nICP_PI and nICP_BB: 0.45 and 0.30 (p<0.05). nICP_FVd and nICP_CrCP presented non-significant correlations: -0.17 (p=0.21)...

A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval

Coskun, Demet; Gunaydin, Berrin; Tas, Ayca; Inan, Gozde; Celebi, Hulya; Kaya, Kadir
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2011 ENG
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OBJECTIVE: To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. METHODS: Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effectsite concentration of 1.5 μg/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site concentration of either 1.5 (group I, n = 23), 2 (group II, n = 23) or 2.5 ng/mL (group III, n = 23). Hemodynamic variables, sedation, pain, the Aldrete recovery score, and side effects were recorded. RESULTS: Hemodynamic variables, sedation and pain scores and the number of patients with the maximum Aldrete recovery score 10 min after the procedure were comparable among the groups. The number of patients in group III with the maximum Aldrete recovery score 5 min after the procedure was significantly lower than that in groups I and II. One patient in group II and one patient in group III suffered from nausea. CONCLUSION: Similar pain-free conscious sedation conditions without significant changes in hemodynamic parameters were provided by all three protocols. However, target controlled infusion of remifentanil at 1.5 or 2 ng/mL proved superior at providing early recovery compared to 2.5 ng/mL.