Página 1 dos resultados de 3421 itens digitais encontrados em 0.009 segundos

A fatal forensic intoxication with fenarimol: analysis by HPLC/DAD/MSD

Proença, P.; Marques, E. Pinho; Teixeira, H.; Castanheira, F.; Barroso, M.; Ávila, S.; Vieira, D. N.
Fonte: Universidade de Coimbra Publicador: Universidade de Coimbra
Tipo: Artigo de Revista Científica Formato: aplication/PDF
ENG
Relevância na Pesquisa
36.74%
Fenarimol (Rubigan®) is a pyrimidine ergosterol biosynthesis inhibitor used as a systemic fungicide. The authors present a fatal fenarimol intoxication case analysed in the Forensic Toxicology Service of the National Institute of Legal Medicine. The results were used to compare two different HPLC techniques, regarding selectivity and sensitivity: an HPLC system with a diode array detector (DAD) and an HPLC system with a DAD and a mass spectrometry detector (MSD) with an electrospray interface. All biological samples were submitted to a solid-phase extraction procedure. The detection and quantification limits of fenarimol, linearity, precision and accuracy were evaluated. The fenarimol concentration levels determined were of 89.0 mg/ml in gastric contents, 1.9 mg/g in liver and 0.4 mg/g in kidney. Blood was not available at autopsy. No published data related to fenarimol self-poisoning were found, so it was not possible to interpret the results obtained by comparison with toxic/lethal levels.; http://www.sciencedirect.com/science/article/B6T6W-488NYVD-R/1/712bf23bb727a7110f22a36460ab32fb

Desenvolvimento e aplicação das análises toxicológicas no diagnóstico e prognóstico da intoxicação aguda por paraquat e diquat; Development and application of toxicological analysis in the diagnosis and prognosis of acute intoxication by paraquat and diquat

Almeida, Rafael Menck de
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 18/12/2007 PT
Relevância na Pesquisa
36.97%
Uma das classes químicas de herbicidas que merece particular atenção é a dos bipiridílicos, representada pelo paraquat e diquat. Atualmente, muitos países têm banido ou restringido o uso destes herbicidas devido à grande quantidade de casos de intoxicação acidental, suicídio e envenenamento (tentativa de homicídio) ocorridos no passado. Em contrapartida, o paraquat ainda é bastante utilizado em cerca de 130 nações, com prevalência em países subdesenvolvidos ou em vias de desenvolvimento. O presente trabalho tem por objetivo o estudo e o desenvolvimento de métodos analíticos semi-quantitativo e quantitativo em amostras biológicas (plasma e urina) e aplicação no diagnóstico e investigação da intoxicação aguda por paraquat e diquat. Análises semi-quantitativas de triagem foram realizadas pela técnica enzimática-colorimétrica. Análises confirmatórias foram realizadas pela técnica de cromatografia em fase gasosa acoplada à espectrometria de massa (GC-MS). Após o desenvolvimento e validação dos métodos, as análises foram aplicadas em amostras de pacientes suspeitos de intoxicação aguda por paraquat/diquat atendidos no Hospital Regional do Vale do Ribeira (Pariquera-Açu) e no Hospital de Clínicas da Universidade Estadual de Campinas (SP). Foram avaliadas a efetividade do teste rápido semi-quantitativo e a correlação das concentrações plasmáticas e urinárias do paraquat/diquat obtidas com o método por GC-MS com o grau de intoxicação e o prognóstico de sobrevida dos pacientes após o diagnóstico e tratamento.; One of the chemical classes of herbicides that deserve particular attention is that of bipyridyl...

Acute 2,4-dichlorophenoxyacetic acid intoxication in broiler chicks

Morgulis, M. S. F. A.; Oliveira, G. H.; Dagli, M. L. Z.; Palermo-Neto, J.
Fonte: Poultry Science Assoc Inc Publicador: Poultry Science Assoc Inc
Tipo: Artigo de Revista Científica Formato: 509-515
ENG
Relevância na Pesquisa
36.74%
The acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D), a herbicide, was studied in chicks dosed with 100, 300, 500, or 600 mg 2,4-D/kg BW, by the oral route. Clinical, laboratory, and histopathological methods were used as indicators of toxicity. After acute exposure, the herbicide decreased motor activity and induced muscular weakness and motor incoordination; decreased weight gain; increased serum creatine kinase (CK) and alkaline phosphatase (AP) activities and serum uric acid (UA), creatinine (CR), and total proteins (TP) levels; and did not change serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) activities. These changes were time-and dose-dependent and reversible. The LD50 (lethal dose 50%) calculated for oral 2,4-D in chicks was 420 mg/kg BW (385 to 483). Chromatographic analysis of the serum of the intoxicated chicks showed the presence of the herbicide; the amount found was dose-and time-dependent, increasing from 2 to 8 h after exposure and decreasing afterwards. Histopathological post-mortem studies conducted on intoxicated chicks showed hepatic (vacuolar degeneration of the hepatocytes), renal (tubular nephrosis), and intestinal (hemorragic) lesions. Taken together, the observed alterations mainly reflected kidney and muscle tissue damage...

Hematological and biochemical profiles and histopathological evaluation of experimental intoxication by sodium fluoroacetate in cats

Collicchio-Zuanaze, R. C.; Sakate, M.; Langrafe, L.; Takahira, R. K.; Burini, C.
Fonte: Sage Publications Ltd Publicador: Sage Publications Ltd
Tipo: Artigo de Revista Científica Formato: 903-913
ENG
Relevância na Pesquisa
37.03%
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Sodium fluoroacetate (SFAC) is a potent rodenticide, largely used for rodent and domestic pest control. The toxic effects of SFAC are caused by fluoroacetate, a toxic metabolite, whose toxic action blocks the Krebs cycle and also induces the accumulation of citrate in the body, which is a serum calcium chelator. The most common clinical signs of this intoxication are the cardiac and neurological effects. However, the hematological, biochemical and histopathological findings occurring in intoxication are still unknown in different species. In the present study, 16 domestic cats were experimentally intoxicated with oral doses of fluoroacetate (0.45 mg/kg). The hematological and biochemical profiles and histopathological findings were made to look for auxiliary diagnosis methods in SFAC intoxications. The hematological profile showed transitory leucopenia and thrombocytopenia; in the biochemical profiles were detected hyperglycemia, increase of creatinequinase enzyme (CK) and creatinequinase cardiac isoenzyme (CK-MB), hypokalemia and hypophosfatemia. In the macroscopic and histopathological findings were observed lesions characteristic of degenerative and ischemic processes in heart...

Effects of experimental amitraz intoxication in cats

Andrade, S.F.; Sakate, M.; Laposy, C.B.; Valente, S.F.; Bettanim, V.M.; Rodrigues, L.T.; Marcicano, J.
Fonte: Universidade Federal de Minas Gerais (UFMG), Escola de Veterinária Publicador: Universidade Federal de Minas Gerais (UFMG), Escola de Veterinária
Tipo: Artigo de Revista Científica Formato: 1236-1244
ENG
Relevância na Pesquisa
36.97%
Este trabalho estudou os efeitos da intoxicação experimental por amitraz em 16 gatos, distribuídos, aleatoriamente, em dois grupos: grupo amitraz - animais receberam amitraz a 1,5% na dose de 1,0 mg/kg IV; e grupo controle - animais sem amitraz. Parâmetros fisiológicos sangüíneos, do sistema cardiorespiratório e de sedação foram aferidos até 360min. Perfil sangüíneo, uréia, creatinina, alanina aminotransferase e aspartato aminotransferase não foram afetados pelo amitraz. Sedação, perda de reflexos, hipotermia, bradicardia, bradiarritmias, hipotensão, bradipnéia, midríase, além de transitória hiperglicemia, hipoinsulinemia e diminuição dos níveis de cortisol, foram observados nos gatos experimentalmente expostos ao amitraz. Os efeitos alfa 2-adrenérgicos induzidos pela intoxicação por amitraz em gatos são muito similares aos mesmos efeitos relatados em outras espécies, contribuindo com mais informações dessa intoxicação para a toxicologia veterinária.; This work studied the effects of experimental amitraz intoxication in cats. Sixteen cats were randomly divided equally into two groups: amitraz group - animals received 1.5% amitraz at 1mg/kg IV; and the control group - animals without amitraz. Physiological parameters from blood...

The comparative efficacy of yohimbine and atipamezole to treat amitraz intoxication in dogs

Andrade, Silvia Franco; Sakate, Michiko
Fonte: Universidade Estadual Paulista Publicador: Universidade Estadual Paulista
Tipo: Artigo de Revista Científica Formato: 124-127
ENG
Relevância na Pesquisa
36.87%
This study compared the efficacy of yohimbine with atipamezole, a new α2-adrenergic antagonist, to treat canine amitraz intoxication. Thirty dogs were divided equally into 3 groups (A, AY, and AA). Group A received 2.5% amitraz iv at 1 mg/kg; Group AY received the same dose of amitraz followed 30 min later by 0.1 mg/kg (2 mg/mL) yohimbine iv; and Group AA received the same dose of amitraz followed 30 min later by 0.2 mg/kg (5 mg/mL) atipamezole iv. Temperature, heart rate, respiratory frequency, mean arterial pressure, degree of sedation, mean time of tranquilization and diameter of pupils were monitored for 360 min. Sedation, logs of reflexes, hypothermia bradycardia, hypotension, bradypnea and mydriasis were observed in Group A, with 3rd eyelid prolapse, increased diuresis and vomiting in some animals. Yohimbine reversed all alterations induced by amitraz, but induced significant cardiorespiratory effects such as tachycardia and tachypnea. Atipamezole was a useful antagonist for amitraz, with less cardiorespiratory effects, suggesting its potential role as an alternative treatment of amitraz intoxication in dogs.

Clinical and laboratory parameters in dapsone acute intoxication

Carrazza,Maria Zilda N; Carrazza,Francisco R; Oga,Seizi
Fonte: Faculdade de Saúde Pública da Universidade de São Paulo Publicador: Faculdade de Saúde Pública da Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2000 EN
Relevância na Pesquisa
37.12%
OBJECTIVE: To determine the severity of dapsone (DDS) acute intoxication – an uncommon medical event – using clinical and laboratory parameters. METHODS: Two hundred and seventy four patients with acute DDS intoxication, aged 1 month to 50 years old, were studied and classified into four age groups. Clinical evaluation was assessed through a protocol and correlated with laboratory parameters. Spectrophotometric methods were used to analyze methemoglobinemia (MHbp) and dapsonemia (DDSp). RESULTS: The most prevalent clinical sign of intoxication was cyanosis, seen in 65.7% of the patients and in 100% of children less than 5 years of age. According to laboratory criteria, MHbp-related severe clinical intoxication was seen in 56.2% and DDSp-related occurred in 58% of the patients. Regarding DDSp, intoxication was considered severe when 20 tablets (100 mg each) were ingested, a median of 29 mug/ml. Regarding MHbp, intoxication was severe when 7.5 tablets were ingested, a median of 38% of the total Hb. The correlation between MHbp and DDSp was statistically significant (n=144, r=0.32, p<0.05). Negative correlation was observed between MHbp and the time elapsed since DDS intake (n=124, r=-0.34, p<0.001). There was also a negative correlation between DDSp and the time elapsed since DDS intake (n=63...

Impact of alcohol intoxication and withdrawal syndrome on social phobia and panic disorder in alcoholic inpatients

Terra,Mauro Barbosa; Figueira,Ivan; Barros,Helena Maria Tannhauser
Fonte: Faculdade de Medicina / Universidade de São Paulo - FM/USP Publicador: Faculdade de Medicina / Universidade de São Paulo - FM/USP
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2004 EN
Relevância na Pesquisa
37.15%
PURPOSE: To investigate the impact of alcohol intoxication and withdrawal on the course of social phobia and panic disorder. METHOD: A group of 41 alcoholic inpatients undergoing detoxification therapy were interviewed using the SCID-I (DSM-IV) and questions to detect fluctuations in the course of social phobia and panic disorder as a function of the different phases in alcohol dependence (intoxication, withdrawal, and lucid interval). RESULTS: Only 1 (2.4%) patient presented panic disorder throughout life, and 9 (21.9%) had panic attacks during alcohol intoxication or during the withdrawal syndrome. Sixteen (39%) alcoholic patients showed social phobia with onset prior to drug use. However, drinking eventually became unable to alleviate social phobia symptoms or worsened such symptoms in 31.2% of social-phobic patients. While patients with social phobia reported a significant improvement in psychiatric symptoms during alcohol intoxication, patients experiencing panic attacks worsened significantly during intoxication. In the withdrawal phase, patients with social phobia tended to have more and more intense phobic symptoms. CONCLUSION: Our findings indicate that the impact of alcohol intoxication is different for social phobia as compared to panic disorder...

Effects of experimental amitraz intoxication in cats

Andrade,S.F.; Sakate,M.; Laposy,C.B.; Valente,S.F.; Bettanim,V.M.; Rodrigues,L.T.; Marcicano,J.
Fonte: Universidade Federal de Minas Gerais, Escola de Veterinária Publicador: Universidade Federal de Minas Gerais, Escola de Veterinária
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/10/2007 EN
Relevância na Pesquisa
36.97%
This work studied the effects of experimental amitraz intoxication in cats. Sixteen cats were randomly divided equally into two groups: amitraz group - animals received 1.5% amitraz at 1mg/kg IV; and the control group - animals without amitraz. Physiological parameters from blood, cardiorespiratory system, and sedation indicators were quantified over time up to 360 minutes. Blood profile, urea, creatinine, alananine aminotransferase and aspartate aminotransferase were not affected by amitraz. Sedation, loss of reflexes, hypothermia, bradycardia, bradyarrhythmia, hypotension, bradypnea, mydriasis, besides transitory hyperglycemia, hypoinsulinemia and decrease of cortisol levels were observed in cats experimentally exposed to amitraz. The alpha2-adrenergic effects induced by amitraz intoxication in cats are very similar to the same effects reported in others species, contributing with more information about this type of intoxication to veterinary toxicology.

Crisis management during anaesthesia: water intoxication

Kluger, M.; Szekely, S.; Singleton, R.; Helps, S.
Fonte: British Med Journal Publ Group Publicador: British Med Journal Publ Group
Tipo: Artigo de Revista Científica
Publicado em //2005 EN
Relevância na Pesquisa
37.08%
Background: Irrigation of closed body spaces may lead to substantial perioperative fluid and electrolyte shifts. A syndrome occurring during transurethral resection of prostate (TURP), and a similar syndrome described in women undergoing transcervical endometrial ablation (TCEA) are both characterised by a spectrum of symptoms which may range from asymptomatic hyponatraemia to convulsions, coma, and death. Such potentially serious consequences require prompt recognition and appropriate management of this "water intoxication" syndrome. Objectives: To examine the role of a previously described core algorithm "COVER ABCD–A SWIFT CHECK", supplemented by a specific sub-algorithm for water intoxication, in the management of this syndrome occurring in association with anaesthesia. Methods: The potential performance of this structured approach for each of the relevant incidents among the first 4000 reported to the Australian Incident Monitoring Study (AIMS) was compared with the actual management as reported by the anaesthetists involved. Results: From the first 4000 incidents reported to AIMS, 10 reports of water intoxication were identified, two from endometrial ablations under general anaesthesia and eight from male urological procedures under spinal anaesthesia. The "core" crisis management algorithm detected a problem in seven cases; however...

Alcohol intoxication may exacerbate the effects of blunt cranial trauma through changes in brain free magnesium levels

Vink, R.; Byard, R.
Fonte: Amer Soc Testing Materials Publicador: Amer Soc Testing Materials
Tipo: Artigo de Revista Científica
Publicado em //2012 EN
Relevância na Pesquisa
36.74%
Moderate to high levels of alcohol decrease brain intracellular free magnesium concentration, a factor known to be critical in brain injury. Phosphorus magnetic resonance spectroscopy was used to examine changes to brain free magnesium concentration after blunt cranial trauma in alcohol-intoxicated rats. Rats exposed acutely or chronically to alcohol sufficient to increase blood alcohol levels to between 150 and 350 mg/dL demonstrated a brain free magnesium level that was 20-50% less than in nonintoxicated animals (p < 0.01). After injury, brain free magnesium levels declined more rapidly and to a greater extent in alcohol-affected animals than in nonintoxicated control animals (p < 0.001). As both preinjury depletion of magnesium and degree of magnesium decline after brain injury have been associated with poor recovery, these findings suggest that moderate to severe alcohol intoxication may predispose the brain to a worse outcome by reducing brain free magnesium levels, both before and after injury.; Robert Vink and Roger W. Byard

The separate effects of self-estimated and actual alcohol intoxication on risk-taking: a field experiment

Cort??s Aguilar, Alexandra; Esp??n, Antonio M.; Exadaktylos, Filippos; Oyediran, Olusegun A.; Palacio Garc??a, Luis Alejandro; Proestakis, Antonios
Fonte: Universidad de Granada. Departamento de Teor??a e Historia Econ??mica Publicador: Universidad de Granada. Departamento de Teor??a e Historia Econ??mica
Tipo: Relatório
ENG
Relevância na Pesquisa
36.97%
First??? Version???(???Alcohol??? Consumption ???and ???Risk ???Attitude???):??? October ???2008.; Many risky actions are carried out under the influence of alcohol. However, the effect of alcoholic intoxication over the willingness to take risks is complex and still remains unclear. We conduct an economic field experiment in a natural, drinking and risk-taking environment to analyze how both actual and self-estimated blood alcohol concentration (BAC) levels influence subjects??? choices over monetary lotteries. Our results reveal a negative impact of both actual and self-estimated BAC levels on risk-taking. However, for male and young subjects, we find a positive relationship between BAC underestimation (a pattern of estimation error which mainly occurs at high BAC levels) and the willingness to choose riskier lotteries. Our findings suggest that a risk compensation mechanism is activated only when individuals??? own intoxication level is consciously self-perceived to be high. We conclude therefore that human propensity to engage in risky activities under the influence of alcohol is not due to an enhanced preference for risky choices. In addition to the suggestion in the existing literature that such propensity is due to a weakened ability to perceive risks...

Variabilidade clínica na determinação da dose tóxica oral em intoxicação experimental por fluoroacetato de sódio em gatos; Clinical variability in the determination of oral toxic dosis in the experimental intoxication with sodium fluoroacetate in cats

Collicchio-Zuanaze, Rita de Cássia; Sakate, Michiko; Crocci, Adalberto José
Fonte: Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia Publicador: Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2006 POR
Relevância na Pesquisa
36.74%
O fluoroacetato de sódio (FAS) ou composto 1080 é um potente rodenticida utilizado no controle de roedores e predadores mamíferos. Sua utilização está proibida por lei em diversos países devido à sua alta toxicidade, mas no Brasil há evidências do uso ilegal e sem critérios causando intoxicações, principalmente em crianças e animais domésticos. O FAS age por meio do seu metabólito tóxico, o fluorocitrato, no bloqueio do ciclo de Krebs com conseqënte diminuição da produção de energia do organismo, provocando principalmente manifestações clínicas neurológicas e cardíacas. No presente estudo compararam quatro doses orais tóxicas do fluoroacetato de sódio, descritas em gatos, na literatura, observando-se o aparecimento dos sinais clínicos predominantes da intoxicação, as diferenças entre as doses quanto a variabilidade clínica em relação ao período de latência para o aparecimento dos sinais clínicos e sua respectiva intensidade. A dose oral tóxica que melhor caracterizou o quadro clínico da intoxicação por FAS em gatos, sem causar a letalidade aguda, foi de 0,45mg/kg. As diferenças entre as manifestações clínicas foram dose-dependentes e em ordem crescente de intensidade, caracterizando-se como sinais leves (dose 1: 0...

Estudo comparativo da intoxicação experimental por amitraz entre cães e gatos; Comparative study of experimental amitraz intoxication between dogs and cats

Andrade, Silvia Franco; Laposy, Cecília Braga; Rodrigues, Luciana Teramossi; Marcicano, Jacqueline; Andrade Jr, Carlos Vianna de; Appel, Thiago Luiz
Fonte: Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia Publicador: Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2008 POR
Relevância na Pesquisa
36.87%
O objetivo do presente trabalho foi estudar as características em comum e as diferenças observadas na intoxicação induzida por 1 mg/kg de amitraz, IV, em cães e gatos. Os principais sinais clínicos observados em comum foram sedação, hipotermia, bradicardia, bradiarritmias, hipotensão, bradipnéia, midríase e hiperglicemia transitória, porém a intensidade destes sinais foi diferente entre as espécies. A hipotermia foi mais acentuada em gatos. Os cães foram mais sensíveis às alterações cardiorespiratórias apresentando diminuição mais significativa na freqüência cardíaca e respiratória, além de ocorrência de maior número de bradiarritmias. Os gatos apresentaram midríase mais prolongada do que os cães. Observou-se hiperglicemia e hipoinsulinemia transitórias e diminuição transitória dos níveis plasmáticos de cortisol em ambas espécies, porém os gatos apresentaram um pico de hiperglicemia maior e mais precoce do que os cães, e com relação aos níveis plasmáticos de cortisol, os cães apresentaram uma diminuição mais acentuada do que os gatos. O tempo médio de retorno da sedação foi mais prolongado em gatos. Estes resultados mostraram que a intoxicação por amitraz entre cães e gatos é muito similar...

Neuropsychology in experimental research: Mercury intoxication as an example of application; La neuropsychologie en recherche experimental: l'intoxication par mercure comme un exemple d'application; A aplicação da neuropsicologia na pesquisa experimental: o exemplo da intoxicação por vapor de mercúrio

Taub, Anita; Zachi, Elaine Cristina; Teixeira, Rosani Aparecida Antunes; Faria, Marcília da Araújo Medrado; Ventura, Dora Fix
Fonte: Universidade de São Paulo. Instituto de Psicologia Publicador: Universidade de São Paulo. Instituto de Psicologia
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; Formato: application/pdf
Publicado em 01/01/2006 POR
Relevância na Pesquisa
36.74%
Le dévelopment de la neuropsychologie a accompagné l'étude du cerveau dès ces plus anciens régistres. La science neuropsychologique s'utilise des mésures quantitatives de performance et des téchnologies pour la production de neuroimage, qui permettent l'observation des relations cerveau-comportement. Sur le champ experimental, la neuropsychologie a revelé des résultats dans les investigations des alterations cognitives, psychomotrices, ou comportamentales associés aux patologies génétiques ou acquises. Dans cet article on abordera les aspects historiques de la neuropsychologie experimental. Aussi on presentera les principaux résultats d'un étude référant aux altérations neuropsychologiques des pacients avec une histoire d'intoxication de vapeur de mercure présent après des années d'exposition au même.; O desenvolvimento da neuropsicologia acompanhou a evolução do estudo do cérebro desde os registros mais antigos. A ciência neuropsicológica faz uso de medidas quantitativas de desempenho e tecnologias para produção de neuroimagem que, em conjunto, permitem a observação das relações cérebro-comportamento. No âmbito experimental, a neuropsicologia tem revelado novos conhecimentos na investigação de alterações cognitivas...

Parâmetros clínicos e laboratoriais na intoxicação aguda pela dapsona; Clinical and laboratory parameters in dapsone acute intoxication

Carrazza, Maria Zilda N; Carrazza, Francisco R; Oga, Seizi
Fonte: Universidade de São Paulo. Faculdade de Saúde Pública Publicador: Universidade de São Paulo. Faculdade de Saúde Pública
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; Formato: application/pdf
Publicado em 01/08/2000 ENG
Relevância na Pesquisa
37.12%
OBJETIVO: Definir a gravidade da intoxicação aguda por dapsona (DDS) – uma ocorrência médica não usual – usando parâmetros clínicos e laboratoriais. MÉTODOS: Foram estudados 274 pacientes intoxicados por DDS, divididos em quatro grupos etários; as idades variaram de um mês a 50 anos. A avaliação clínica foi efetuada por meio de um questionário e correlacionada com parâmetros laboratoriais. A metemoglobinemia (MHbp) e a dapsonemia (DDSp) foram analisadas por métodos espectrofotométricos. RESULTADOS: O sinal clínico mais prevalente da intoxicação foi a cianose, presente em 65,7% dos pacientes e em 100% das crianças menores de 5 anos. A intoxicação grave, definida laboratorialmente, de acordo com a MHb ocorreu em 56,2% dos pacientes e, de acordo com a DDSp, em 58%. A intoxicação foi grave, de acordo com a DDSp, quando houve a ingestão mediana de 20 comprimidos (100mg cada) e, de acordo com a MHbp, quando a ingestão foi de 7,5 comprimidos. A mediana de MHbp foi de 38% da Hb total. A correlação entre MHbp e a DDSp foi significativa (n=144, r=0,32, p; OBJECTIVE: To determine the severity of dapsone (DDS) acute intoxication – an uncommon medical event – using clinical and laboratory parameters. METHODS: Two hundred and seventy four patients with acute DDS intoxication...

Impacto das fases de intoxicação e de abstinência de álcool sobre a fobia social e o transtorno de pânico em pacientes alcoolistas hospitalizados; Impact of alcohol intoxication and withdrawal syndrome on social phobia and panic disorder in alcoholic inpatients

Terra, Mauro Barbosa; Figueira, Ivan; Barros, Helena Maria Tannhauser
Fonte: Universidade de São Paulo. Faculdade de Medicina Publicador: Universidade de São Paulo. Faculdade de Medicina
Tipo: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion; ; ; ; ; Formato: application/pdf
Publicado em 01/01/2004 ENG
Relevância na Pesquisa
37.15%
OBJETIVO: Estudar o impacto das fases de intoxicação e de abstinência do uso de álcool sobre o curso da fobia social e do transtorno de pânico. MÉTODO: Um grupo de 41 pacientes hospitalizados por dependência de álcool foi entrevistado com o SCID-I (DSM-IV), adicionado de perguntas para detectar as flutuações no curso da fobia social e do transtorno do pânico em função das diferentes fases do uso da droga (intoxicação, abstinência e intervalo lúcido). RESULTADOS: Apenas um (2,4%) paciente, apresentou transtorno de pânico ao longo da vida e nove (21.9%) tiveram ataques de pânico na intoxicação ou na síndrome de abstinência. Dezesseis (39%) pacientes dependentes de álcool apresentavam fobia social, que iniciava-se antes de começar o uso de bebidas alcoólicas. No entanto, com o tempo, o álcool perdeu o efeito de aliviar os sintomas da fobia social ou piorou estes sintomas em 31.2% dos pacientes fóbicos sociais. Enquanto os pacientes com fobia social relataram uma melhora significativa dos sintomas psiquiátricos na fase de intoxicação, os pacientes com pânico pioraram significativamente na fase de intoxicação. Na fase de abstinência, os pacientes com fobia social tenderam a piorar com maior freqüência. CONCLUSÃO: Nossos achados indicam que o impacto do álcool...

Alcoholic intoxication in the emergency department – evidenced based nursing practice

Aragão, José Helder Alves; UFF, RJ; Cruz, Isabel CF da; Professional Nursing Master Program/Fluminense Federal University
Fonte: Universidade Federal Fluminense Publicador: Universidade Federal Fluminense
Tipo: Peer-reviewed Article; literature review Formato: text/html
Publicado em 07/07/2008 PT
Relevância na Pesquisa
36.87%
Worldwide scientific literature and the secular press emphasize that alcohol abuse frequently associates itself to the occurrences of diverse forms of trauma. Currently alcohol is a problem of Public Health. This study characterizes itself as a essay of a bibliographical revision and has as its objective to identify the scientific output of nursing, from the period of 2002 to 2007, concerning alcoholic intoxication, analyzing its application to the practice of nursing. Ten scientific articles were gathered together, being six in Portuguese and four in English. The results reveal a great variety of themes being that these favor a discreet tendency by giving evidence to the lack of preparation of nurses in caring for alcoholic patients and seeking to strengthen the knowledge of these professionals about the theme. The bibliography revealed a single source that proclaims “brief interventions” in caring for patients, although signaling toward a registered structure of medical care, making necessary, still, greater investigations to be annexed to the body of knowledge of nursing and utilized by its professionals.

Acute lead intoxication in a pregnant mare

Kruger,K; Saulez,M N; Neser,J A; Solberg,K
Fonte: Journal of the South African Veterinary Association Publicador: Journal of the South African Veterinary Association
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/01/2008 EN
Relevância na Pesquisa
36.87%
Lead (Pb) intoxication in horses is usually a chronic phenomenon with clinical signs associated with central nervous dysfunction. This report gives details of a case of acute Pb intoxication in a 9-year-old American Saddlebred mare with severe, progressive and ultimately fatal neurological deterioration. During the 4 days of hospitalisation, clinical signs progressed from intermittent headshaking and depression to severe, continuous, uncontrollable manic behaviour. At autopsy, three grey-coloured, hard metal particles were present in the gastrointestinal tract and subsequently found to contain 2614 ppm Pb. Lead concentrations in the brain, liver, stomach and kidney were 29, 4, 6 and 2 ppm wet weight, respectively.

Clinical and laboratory parameters in dapsone acute intoxication

Carrazza,Maria Zilda N; Carrazza,Francisco R; Oga,Seizi
Fonte: Faculdade de Saúde Pública da Universidade de São Paulo Publicador: Faculdade de Saúde Pública da Universidade de São Paulo
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/08/2000 EN
Relevância na Pesquisa
37.12%
OBJECTIVE: To determine the severity of dapsone (DDS) acute intoxication – an uncommon medical event – using clinical and laboratory parameters. METHODS: Two hundred and seventy four patients with acute DDS intoxication, aged 1 month to 50 years old, were studied and classified into four age groups. Clinical evaluation was assessed through a protocol and correlated with laboratory parameters. Spectrophotometric methods were used to analyze methemoglobinemia (MHbp) and dapsonemia (DDSp). RESULTS: The most prevalent clinical sign of intoxication was cyanosis, seen in 65.7% of the patients and in 100% of children less than 5 years of age. According to laboratory criteria, MHbp-related severe clinical intoxication was seen in 56.2% and DDSp-related occurred in 58% of the patients. Regarding DDSp, intoxication was considered severe when 20 tablets (100 mg each) were ingested, a median of 29 mug/ml. Regarding MHbp, intoxication was severe when 7.5 tablets were ingested, a median of 38% of the total Hb. The correlation between MHbp and DDSp was statistically significant (n=144, r=0.32, p<0.05). Negative correlation was observed between MHbp and the time elapsed since DDS intake (n=124, r=-0.34, p<0.001). There was also a negative correlation between DDSp and the time elapsed since DDS intake (n=63...