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A cross-sectional study on the clinical and immunological spectrum of human Leishmania (L.) infantum chagasi infection in the Brazilian Amazon region
Procalcitonina (PCT) como indicador de infecção grave em adultos neutropênicos febris; Procalcitonin (PCT) as a marker of severe systemic infection in febrile neutropenia
Estudo seccional sobre o espectro clínico e imunológico da infecção humana por Leishmania (L.) i. chagasi na Amazônia brasileira; A cross study on the clinical and immunological spectrum of human Leishmania (L.) i. chagasi infection in the Brazilian amazon
Incidência e fatores de risco de remoção por suspeita de infecção de corrente sanguínea associada ao cateter central de inserção periférica em uma coorte de neonatos; Incidence and risk factors of removal due to suspected catheter-associated bloodstream infection of Peripherally Inserted Central Catheter in a cohort of neonates.
Diagnostico molecular da infecção ativa por citomegalovirus humano (HCMV) em pacientes submetidos a transplante pela reação em cadeia da polimerase (tipo "Nested PCR") : comparação entre leucocitos do sangue periferico e soro; Molecular diagnostic of active human cytomegalovirus infection in patient urdergoing transplanation by nested polymerase chain reaction : comparison between peripheral blood leucocytes and serum
Peristomal infection after percutaneous endoscopic gastrostomy: a 7-year surveillance of 297 patients.
Additional Risk factors for infection by multidrug-resistant pathogens in healthcare associated infection: a large cohort study
Peristomal infection after percutaneous endoscopic gastrostomy: a 7-year surveillance of 297 patients
Peristomal infection after percutaneous endoscopic gastrostomy: a 7-year surveillance of 297 patients
Prevalence rates of infection in intensive care units of a tertiary teaching hospital
Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution
Differential Response of Respiratory Dendritic Cell Subsets to Influenza Virus Infection▿
Blocking of integrins inhibits HIV-1 infection of human cervical mucosa immune cells with free and complement-opsonized virions
Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure
Systematic Review of Emergency Department Central Venous and Arterial Catheter Infection
Prevalence of early-onset neonatal infection among newborns of mothers with bacterial infection or colonization: a systematic review and meta-analysis
Characterizing InternetWorm Spatial-Temporal Infection Structures
Characterisation of the events involved in the resolution of acute duck hepatitis B virus infection.
Morbidade materna grave por infecção e influenza H1N1 na Rede Brasileira de Vigilância de Morbidade Materna Grave=Severe maternal morbidity due to infection in the Brazilian Network for the Surveillance of Severe Maternal Morbidity; Severe maternal morbidity due to infection in the Brazilian Network for the Surveillance of Severe Maternal Morbidity
Host Responses to Infection of the Upper and Lower Urinary Tract
Urinary tract infections (UTIs) are the second most common type of infection identified in the clinical setting and disproportionately afflict women. UTIs most frequently manifest in the form of infection of the lower urinary tract, involving the bladder. Uropathogens, particularly uropathogenic E. coli, progressively colonize the urethra and ascend to the bladder, where they initiate cystitis. In some cases, infection further ascends through the ureters and reaches the kidneys, where it causes pyelonephritis. Infection of both the upper and lower urinary tract can have serious ramifications for the host, and this is in large part due not to infection itself but to host-directed responses to bacterial insults.
In this thesis, I will describe and discuss two distinct aspects of UTIs. In the first study, in vivo work in a mouse model of urinary tract infection revealed a novel role for mast cells, which are tissue-resident granulated innate immune cells, in directing the detachment and death of epithelial cells during cystitis, facilitating the clearance of bacteria from the bladder. An ex vivo porcine bladder infection model suggested a specific role for mast cell granules and the proteases contained therein, which was corroborated with in vitro experiments utlizing isolated mast cell granules and human epithelial cells to demonstrate granule-induced exfoliation and cell death. From this work...