Página 1 dos resultados de 69 itens digitais encontrados em 0.001 segundos

Acute Bivalvular Left-Sided Methicillin-Resistant Staphylococcus Aureus Endocarditis with Cardiac, Cerebral, Renal and Septic Complications

Póvoas, D; Figueiredo, M; Murinello, A; Damásio, H; Ramos, A; Rodrigues, N; Sousa, J; Carvalho, F; Peres, H; Gomes, P
Fonte: Sociedade Portuguesa de Cardiologia Publicador: Sociedade Portuguesa de Cardiologia
Tipo: Artigo de Revista Científica
Publicado em //2011 ENG
Relevância na Pesquisa
26.39%
Infective endocarditis (IE) is now rare in developed countries, but its prevalence is higher in elderly patients with prosthetic valves, diabetes, renal impairment, or heart failure. An increase in health-care associated IE (HCAIE) has been observed due to invasive maneuvers (30% of cases). Methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus are the most common agents in HCAIE, causing high mortality and morbidity. We review complications of IE and its therapy, based on a patient with acute bivalvular left-sided MRSA IE and a prosthetic aortic valve, aggravated by congestive heart failure, stroke, acute immune complex glomerulonephritis, Candida parapsilosis fungémia and death probably due to Serratia marcescens sepsis. The HCAIE was assumed to be related to three temporally associated in-hospital interventions considered as possible initial etiological mechanisms: overcrowding in the hospital environment,iv quinolone therapy and red blood cell transfusion. Later in the clinical course,C. parapsilosis and S. marcescens septicemia were considered to be possible secondary etiological mechanisms of HCAIE.

Cardiac Angiosarcoma. A Review

Murinello, A; Mendonça, P; Abreu, A; Santos, AL; Roquette, J; Pinto, E; Alpendra, J; Semedo, J; Rodrigues, A; Cunha, D; Coelho, JF; Lourenço, S; Miranda, S
Fonte: Sociedade Portuguesa de Cardiologia Publicador: Sociedade Portuguesa de Cardiologia
Tipo: Artigo de Revista Científica
Publicado em //2007 ENG
Relevância na Pesquisa
26.22%
Based on a case of a patient with angiosarcoma (AS) of the right atrium with superior vena cava syndrome associated with urticaria and polyarthralgias, who died soon after surgery, the authors present a brief review of the subject of cardiac AS, an extremely rare pathology, usually diagnosed late due to its non-specific symptomatology. Several topics are discussed, including mechanisms of clinical manifestations caused by blood flow obstruction and valve dysfunction, local invasion with arrhythmias and pericardial effusion, embolic phenomena and constitutional symptoms. Imaging and histopathologic methods of diagnosis are considered, as well as references to cytogenetic analysis. Surgery is the first treatment choice, but heart AS are frequently not completely resectable and concomitant metastases at the time of surgery are common, both usually leading to a dismal prognosis. Chemotherapy, radiotherapy and even heart transplantation do not substantially improve the survival of these patients. Urticaria is not generally assumed by most authors to be associated with malignancy, but there are rare reports of its association with some malignant tumors.

Pneumonia por Pneumocystis e Citomegalovírus no Doente VIH. A Propósito de Dois Casos Clínicos

Lourenço, S; Amaral, M; Almeida, R; Marcelino, P; Marum, S; Milheiro, MA; Oliveira, J; Mourão, L
Fonte: Sociedade Portuguesa de Pneumologia Publicador: Sociedade Portuguesa de Pneumologia
Tipo: Artigo de Revista Científica
Publicado em //2008 POR
Relevância na Pesquisa
26.32%
Nos doentes com infecção pelo vírus da imunodeficiência humana (VIH) o citomegalovírus torna-se um agente de doença importante quando existe imunossupressão avançada. O seu papel como agente de doença pulmonar neste contexto tem sido amplamente debatido. Nos doentes com pneumocistose, a presença do citomegalovírus no pulmão não parece conferir pior prognóstico, excepto nos que recebem terapêutica adjuvante com corticóides. Os autores apresentam dois casos de doentes com infecção VIH e imunossupressão avançada, admitidos na unidade de cuidados intensivos por insuficiência respiratória. Em ambos houve isolamento de Pneumocystis jirovecii no lavado broncoalveolar. Apesar da terapêutica instituída ambos vieram a falecer. A biópsia pulmonar post mortem mostrou, nos dois casos, a presença de Pneumocystis e inclusões por citomegalovírus. Perante este achado tecem-se algumas considerações sobre o papel do citomegalovírus como agente de pneumonia na SIDA e sobre o seu significado como co-infectante na pneumocistose, sobretudo nos casos de falência terapêutica.

Abcessos Renais - Revisão

Murinello, A; Mendonça, P; Correia, R; Rocha Mendes; Albergaria, M; Neta, J; Coelho, J; Lourenço, S
Fonte: Associação Portuguesa de Urologia Publicador: Associação Portuguesa de Urologia
Tipo: Artigo de Revista Científica
Publicado em //2007 POR
Relevância na Pesquisa
26.32%
Baseados num caso de associação de abcessos renal, perirrenal e de quisto renal infectado, ocorrendo após biopsia prostática, os autores fazem revisão bibliográfica dos abcessos renais, classificados segundo características anatómicas perinéfrico, cortical e cortico- -medular (nefrite bacteriana aguda focal/multifocal, pielonefrite enfisematosa e pielonefrite xantogranulomatosa). Os abcessos renais são mais frequentes em diabéticos, menos vezes em alcoólicos, desnutridos e imunodeprimidos, estando associados geralmente a pielonefrites recorrentes, refluxo vesicoureteral, litíase urinária, ou resultam de êmbolos sépticos hematogéneos originados em focos extra-renais de infecção. A Escherichia coli é responsável pela maioria dos casos, e menos vezes a Klebsiella Proteus, Enterobacter, Pseudomonas, e Estafilococo aureus. Descrevem-se a expressão clínica, complicações evolutivas e diagnóstico radiológico, enfatizando-se as infecções acompanhadas de formação de gás. Referem-se opções terapêuticas médico-cirúrgicas, cujas indicações dependem do diagnóstico precoce, complicações e factores predisponentes.

Atypical Case of Mediterranean Spotted Fever

Figueira-Coelho, J; Martins, T; Machado, J; Maltez, F
Fonte: Brazilian Society of Infectious Diseases Publicador: Brazilian Society of Infectious Diseases
Tipo: Outros
Publicado em //2010 ENG
Relevância na Pesquisa
26.22%
The authors present a case of atypical severe (malignant) Mediterranean spotted fever, with a brief review on the subject. Although not previously described in Brazil, the possibility of imported cases, especially from Portuguese tourists, is real. This case report highlights the severe form of the disease and the possibility of atypical presentation with confounding differential diagnosis. A brief review of classical presentation is also done. The authors believe it is a valid paper and a good contribution to your Journal of Infectious Diseases. The content of the manuscript represents the views of the coauthors, and neither the corresponding author nor the coauthors have submitted duplicate or overlapping manuscripts elsewhere.

Pielonefrite Enfisematosa

Rosado, J; Fernandes, AP; Aleluia, C; Neto, AP; Garção Nunes; Riso, N; Soromenho, F
Fonte: Centro Editor e Livreiro da Ordem dos Médicos Publicador: Centro Editor e Livreiro da Ordem dos Médicos
Tipo: Artigo de Revista Científica
Publicado em //1993 POR
Relevância na Pesquisa
26.32%
Os autores apresentam um caso de pielonefrite enfisematosa a E. coli, numa doente diabética de 63 anos. Os exames imagiológicos(Rx simples do abdómen, ultrassonografia e tomografia computorizada) permitiram estabelecer o diagnóstico. A nefrostomia percutânea, combinada com o tratamento médico, contribuiu para a favorável evolução clínica.

Síndrome Hemolítico-Urémico

Rodrigues, P; Machado, J; Cardoso, O; Cruz, J; Carvalho, F; Marques da Costa; Proença, R
Fonte: Centro Editor e Livreiro da Ordem dos Médicos Publicador: Centro Editor e Livreiro da Ordem dos Médicos
Tipo: Artigo de Revista Científica
Publicado em //1999 POR
Relevância na Pesquisa
26.22%
Os síndromes de mieroangiopatia trombótica - Púrpura Trombótica Trombocitopénica (PTT) e Síndrome Hemolftico Urémico (SHU) - são caracterizados por anemia hemolftica microan giopática, trombocitopénia, alterações da função renal, febre e anomalias do sistema nervoso central. Actualmente são considerados como dois extremos de um espectro contínuo designado PTT- SHU. São doenças raras com uma taxa de mortalidade elevada, apesar dos avanços na terapêutica. Os autores descrevem um caso de síndrome hemolítico urémico num adulto jovem em que o curso inicial e a primeira biópsia sugeriam bom prognóstico. Contudo a recaída precoce e o aparecimento de hipertensão arterial grave implicaram um desfecho fatal em 6 meses. A este propósito os autores fazem uma revisão de alguns dos aspectos mais recentes da patogénese e tratamento deste síndrome.

Neuropsychiatric Features of a Cohort of Patients with Systemic Lupus Erythematosus

Moraes-Fontes, MF; Lúcio, I; Santos, C; Campos, MM; Riso, N; Vaz Riscado, M
Fonte: Hindawi Publishing Corporation Publicador: Hindawi Publishing Corporation
Tipo: Artigo de Revista Científica
Publicado em //2012 ENG
Relevância na Pesquisa
26.22%
In order to establish if neuropsychiatric systemic lupus erythematosus (NPSLE) can be identified by any characteristic other than those used to diagnose the neuropsychiatric (NP) disease itself, we retrospectively reviewed 98 systemic lupus erythematosus (SLE) patients followed over a mean period of 10 years. NPSLE was identified in 22 patients. Stroke and generalized seizures were the most frequent NP manifestations. The NPSLE and non-NPSLE groups were similar with regard to demographic characteristics, ACR criteria, serum autoantibodies, and frequency of hypertension and hypercholesterolemia. Of note, compared to the non-NPSLE group, NPSLE was associated with a higher frequency of smoking (78 versus 26%), organ damage (73 versus 34%), and cumulative mortality rate (14 versus 7%). The series of patients was further analysed according to the presence of antiphospholipid syndrome (APS). Significantly, the interval between the onset of NP disease and SLE diagnosis was shorter in the APS(-) (0.3 ± 1 years) than in the APS(+) (5 ± 7 years) groups. Recurrence and/or persistence of NP events were only documented in the APS(-) group. Overall cumulative mortality was highest in NPSLE and in APS(+) patients with inadequate anticoagulation control...

Acute Bivalvular Left-Sided Methicillin-Resistant Staphylococcus Aureus Endocarditis with Cardiac, Cerebral, Renal and Septic Complications

Póvoas, D; Figueiredo, M; Murinello, A; Damásio, H; Ramos, A; Rodrigues, N; Sousa, J; Carvalho, F; Peres, H; Gomes, P
Fonte: Sociedade Portuguesa de Cardiologia Publicador: Sociedade Portuguesa de Cardiologia
Tipo: Artigo de Revista Científica
Publicado em //2011 ENG
Relevância na Pesquisa
26.39%
Infective endocarditis (IE) is now rare in developed countries, but its prevalence is higher in elderly patients with prosthetic valves, diabetes, renal impairment, or heart failure. An increase in health-care associated IE (HCAIE) has been observed due to invasive maneuvers (30% of cases). Methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus are the most common agents in HCAIE, causing high mortality and morbidity. We review complications of IE and its therapy, based on a patient with acute bivalvular left-sided MRSA IE and a prosthetic aortic valve, aggravated by congestive heart failure, stroke, acute immune complex glomerulonephritis, Candida parapsilosis fungémia and death probably due to Serratia marcescens sepsis. The HCAIE was assumed to be related to three temporally associated in-hospital interventions considered as possible initial etiological mechanisms: overcrowding in the hospital environment,iv quinolone therapy and red blood cell transfusion. Later in the clinical course,C. parapsilosis and S. marcescens septicemia were considered to be possible secondary etiological mechanisms of HCAIE.

Pneumonia por Pneumocystis e Citomegalovírus no Doente VIH. A Propósito de Dois Casos Clínicos

Lourenço, S; Amaral, M; Almeida, R; Marcelino, P; Marum, S; Milheiro, MA; Oliveira, J; Mourão, L
Fonte: Sociedade Portuguesa de Pneumologia Publicador: Sociedade Portuguesa de Pneumologia
Tipo: Artigo de Revista Científica
Publicado em //2008 POR
Relevância na Pesquisa
26.32%
Nos doentes com infecção pelo vírus da imunodeficiência humana (VIH) o citomegalovírus torna-se um agente de doença importante quando existe imunossupressão avançada. O seu papel como agente de doença pulmonar neste contexto tem sido amplamente debatido. Nos doentes com pneumocistose, a presença do citomegalovírus no pulmão não parece conferir pior prognóstico, excepto nos que recebem terapêutica adjuvante com corticóides. Os autores apresentam dois casos de doentes com infecção VIH e imunossupressão avançada, admitidos na unidade de cuidados intensivos por insuficiência respiratória. Em ambos houve isolamento de Pneumocystis jirovecii no lavado broncoalveolar. Apesar da terapêutica instituída ambos vieram a falecer. A biópsia pulmonar post mortem mostrou, nos dois casos, a presença de Pneumocystis e inclusões por citomegalovírus. Perante este achado tecem-se algumas considerações sobre o papel do citomegalovírus como agente de pneumonia na SIDA e sobre o seu significado como co-infectante na pneumocistose, sobretudo nos casos de falência terapêutica.

Abcessos Renais - Revisão

Murinello, A; Mendonça, P; Correia, R; Rocha Mendes; Albergaria, M; Neta, J; Coelho, J; Lourenço, S
Fonte: Associação Portuguesa de Urologia Publicador: Associação Portuguesa de Urologia
Tipo: Artigo de Revista Científica
Publicado em //2007 POR
Relevância na Pesquisa
26.32%
Baseados num caso de associação de abcessos renal, perirrenal e de quisto renal infectado, ocorrendo após biopsia prostática, os autores fazem revisão bibliográfica dos abcessos renais, classificados segundo características anatómicas perinéfrico, cortical e cortico- -medular (nefrite bacteriana aguda focal/multifocal, pielonefrite enfisematosa e pielonefrite xantogranulomatosa). Os abcessos renais são mais frequentes em diabéticos, menos vezes em alcoólicos, desnutridos e imunodeprimidos, estando associados geralmente a pielonefrites recorrentes, refluxo vesicoureteral, litíase urinária, ou resultam de êmbolos sépticos hematogéneos originados em focos extra-renais de infecção. A Escherichia coli é responsável pela maioria dos casos, e menos vezes a Klebsiella Proteus, Enterobacter, Pseudomonas, e Estafilococo aureus. Descrevem-se a expressão clínica, complicações evolutivas e diagnóstico radiológico, enfatizando-se as infecções acompanhadas de formação de gás. Referem-se opções terapêuticas médico-cirúrgicas, cujas indicações dependem do diagnóstico precoce, complicações e factores predisponentes.

Pielonefrite Enfisematosa

Rosado, J; Fernandes, AP; Aleluia, C; Neto, AP; Garção Nunes; Riso, N; Soromenho, F
Fonte: Centro Editor e Livreiro da Ordem dos Médicos Publicador: Centro Editor e Livreiro da Ordem dos Médicos
Tipo: Artigo de Revista Científica
Publicado em //1993 POR
Relevância na Pesquisa
26.32%
Os autores apresentam um caso de pielonefrite enfisematosa a E. coli, numa doente diabética de 63 anos. Os exames imagiológicos(Rx simples do abdómen, ultrassonografia e tomografia computorizada) permitiram estabelecer o diagnóstico. A nefrostomia percutânea, combinada com o tratamento médico, contribuiu para a favorável evolução clínica.

MRI in detection of hepatocellular carcinoma (HCC)

Digumarthy, Subba R; Sahani, Dushyant V; Saini, Sanjay
Fonte: e-MED Publicador: e-MED
Tipo: Artigo de Revista Científica
Publicado em 13/04/2005 EN
Relevância na Pesquisa
36.39%
Hepatocellular carcinoma (HCC) is the commonest malignancy of the liver and is usually due to cirrhosis. Early detection of HCC and the premalignant dysplastic nodules has implications on the management options of tumor ablation, liver resection and transplantation. Magnetic resonance imaging is useful for the detection and characterization of lesions, in the identification of dysplastic nodules and their malignant transformation into HCC.

Thermal ablation of hepatocellular carcinoma

Crocetti, Laura; Lencioni, Riccardo
Fonte: e-Med Publicador: e-Med
Tipo: Artigo de Revista Científica
Publicado em 27/02/2008 EN
Relevância na Pesquisa
26.46%
Hepatocellular carcinoma (HCC) is the fifth most common cause of cancer, and its incidence is increasing worldwide because of the dissemination of hepatitis B and C virus infection. Patients with cirrhosis are at the highest risk of developing HCC and should be monitored every 6 months to diagnose the tumour at an early, asymptomatic stage. Patients with early-stage HCC should be considered for any of the available curative therapies, including surgical resection, liver transplantation and percutaneous image-guided ablation. Liver transplantation is the only option that provides cure of both the tumour and the underlying chronic liver disease. However, the lack of sufficient liver donation greatly limits its applicability. Resection is the treatment of choice for HCC in non-cirrhotic patients, who account for about 5% of the cases in western countries. However, in patients with cirrhosis, candidates for resection have to be carefully selected to reduce the risk of postoperative liver failure. It has been shown that a normal bilirubin concentration and the absence of clinically significant portal hypertension are the best predictors of excellent outcomes after surgery. However, less than 5% of cirrhotic patients with HCC fit these criteria. Image-guided percutaneous ablation is the best therapeutic choice for non-surgical patients with early-stage HCC. While ethanol injection has been the seminal percutaneous technique...

Gadoxetate acid-enhanced MRI of hepatocellular carcinoma in a c-myc/TGFα transgenic mouse model including signal intensity and fat content: initial experience

Korkusuz, Huedayi; Knau, Lea; Kromen, Wolfgang; Huebner, Frank; Hammerstingl, Renate; Lindemayr, Sebastian; Bihrer, Verena; Piiper, Albrecht; Vogl, Thomas J
Fonte: e-Med Publicador: e-Med
Tipo: Artigo de Revista Científica
Publicado em 07/03/2012 EN
Relevância na Pesquisa
26.54%
Genetically engineered mouse models, such as double transgenic c-myc/TGFα mice, with specific pathway abnormalities might be more successful at predicting the clinical response of hepatocellular carcinoma (HCC) treatment. But a major drawback of the tumour models is the difficulty of visualizing endogenously formed tumours. The optimal imaging procedure should be brief and minimally invasive. Magnetic resonance imaging (MRI) satisfies these criteria and gadoxetate acid-enhanced MRI improves the detection of HCC. Fat content is stated to be an additional tool to help assess tumour responses, for example, in cases of radiofrequency ablation. Therefore the aim of this study was to investigate if gadoxetate acid-enhanced MRI could be used to detect HCC in c-myc/TGFα transgenic mice by determining the relation between the signal intensity of HCC and normal liver parenchyma and the corresponding fat content as a diagnostic marker of HCC. In our study, 20 HCC in c-myc/TGFα transgenic male mice aged 20–34 weeks were analyzed. On gadoxetate acid-enhanced MRI, the signal intensity was 752.4 for liver parenchyma and 924.5 for HCC. The contrast to noise ratio was 20.4, the percentage enhancement was 267.1% for normal liver parenchyma and 353.9% for HCC. The fat content was 11.2% for liver parenchyma and 16.2% for HCC. There was a correlation between fat content and signal intensity with r = 0.7791. All parameters were statistically significant with P < 0.05. Our data indicate that gadoxetate acid contrast enhancement allows sensitive detection of HCC in c-myc/TGFα transgenic mice and determination of the fat content seems to be an additional useful parameter for HCC.

Imaging of hepatocellular carcinoma: diagnosis, staging and treatment monitoring

Hennedige, Tiffany; Kundapur Venkatesh, Sudhakar
Fonte: e-Med Publicador: e-Med
Tipo: Artigo de Revista Científica
Publicado em 08/02/2013 EN
Relevância na Pesquisa
26.5%
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Imaging is important for establishing a diagnosis of HCC. Several imaging modalities including ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) and angiography are used in evaluating patients with chronic liver disease and suspected HCC. CT, MRI and contrast-enhanced US have replaced biopsy for diagnosis of HCC. Dynamic multiphase contrast-enhanced CT or MRI is the current standard for imaging diagnosis of HCC. Functional imaging techniques such as perfusion CT and diffusion-weighted MRI provide additional information about tumor angiogenesis that may be useful for treatment. Techniques evaluating tissue mechanical properties such as magnetic resonance elastography, and acoustic radiation force impulse imaging are being explored for characterizing liver lesions. The role of PET in the evaluation of HCC is evolving with promise seen especially with the use of a hepatocyte-specific PET tracer. Imaging is also critical for assessment of treatment response and detection of recurrence following locoregional treatment. Knowledge of the post-treatment appearance of HCC is essential for correct interpretation. This review article provides an overview of the role of imaging in the diagnosis...

Softwaregestützte Bildsynchronisation zur automatisierten Charakterisierung solider Leberläsionen mittels der dynamischen MRT; Software-supported image synchronisation to automatically characterize solide liver lesions using dynamic MRI

Plathow, Daniela Maren
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
Relevância na Pesquisa
26.32%
Moderne MR-Techniken der Leber sind in der Lage neben einem hervorragenden Weichteilkontrast theoretisch durch eine Quantifizierung der Kontrastmittelanflutung und –charakteristik Aussagen zu Dignität und Therapieverlauf zu liefern. Dem Problem der Organmobilität und damit nicht identischen Schichtposition während unterschiedlicher Atem- und damit Kontrastmittelanflutungsphasen versucht man praktisch bisher durch Atemtriggerungstechniken zu begegnen. Trotzdem ist das Problem nicht identischer Schichtpositionen bei dynamischen MR Untersuchungen in der Klinik ungelöst. Manuelle Schichtkorrekturen und –synchronisationen sind aufgrund der hohen Zeiterfordernis und Untersucherabhängigkeit in der klinischen Praxis kaum praktikabel. Automatisierte unterstützende Bearbeitungssoftware zur Schichtkorrektur und –synchronisation liegen bislang nicht vor. Eine inadäquate Bildgebung mit nur eingeschränkter Beurteilbarkeit ist häufig die Folge. Ziel der vorliegenden Doktorarbeit war es in einem direkten und systematischen Vergleich der herkömmlichen Auswertetechnik mit einer neu entwickelten softwaregestützten Auswertetechnik das Potenzial und mögliche Limitationen einer solchen Technik im Rahmen einer Workflowoptimierung bei der Auswertung von dynamischen Datensätzen der Leberperfusion quantitativ und qualitativ auszuwerten. Die Bearbeitungssoftware ermöglicht dabei sowohl eine automatische Bildsynchronisation und -korrektur wie auch Bildsubtraktion. Es wurden hierzu 55 Läsionen bei 17 Patienten mit HCC...

Adenovirus vermittelte in vitro Suizidgentherapie des humanen Hepatoblastoms mittels Cytosindesaminase/5-Fluorcytosin; Adenovirus-mediated cytosine deaminase/5-fluorocytosine suicide gene therapy of human hepatoblastoma in vitro

Heigoldt, Heike geb. Buck
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE_DE
Relevância na Pesquisa
26.43%
Hintergrund: Das Hepatoblastom (HB) ist der häufigste Lebertumor im Kindesalter und hat bei den malignen Erkrankungen im Kindesalter einen Anteil von 0,8-1,0%. Die Prognose und das Langzeitüberleben für Kinder mit einem HB im Stadium III oder IV bzw. bei Rezidiven ist aufgrund der sich entwickelnden Chemotherapieresistenz nicht ausreichend zu verbessern. Daher ist es von großer Bedeutung neue Therapiealternativen zu entwickeln und zu untersuchen. In der Therapie solider Tumoren u.a. Ovarial-CA, Colon-CA, Mamma-CA u d HCC, spielt die Gentherapie derzeit eine wichtige Rolle. Aus diesem Grunde wurde in dieser Arbeit zum ersten Mal in der Therapie des HB eine viral-vermittelte Gentherapie (Suizidgentherapie) untersucht. Material/Methode: Die Suizidgentherapie beruht auf dem Konzept Tumorzellen selektiv durch Erzeugung toxischer Metabolite aus einer nicht toxischen Substanz, sogenanntes Prodrug, wie z.B. 5-Fluorcytosin (5-FC) in die zytotoxische Substanz, hier 5-Fluorouracil (5-FU), umzuwandeln. Das dafür notwendige Enzym wird durch einen viralen Vektor (hier Adenovirus) in die Zelle als sogenanntes Suizidgen transduziert und dort exprimiert. In dieser Arbeit war das Suizidgen ein Fusionsgen aus der Cytosindesaminase aus Saccharomyces cerevisae (YCD = Yeast CD) und der nachgeschalteten Yeast Uracilphosphoribosyltransferase (YUPRT). Dieses Fusionsgen wird Super-Cytosindesaminase (SCD = SuperCD) genannt. Zu Anfang der Untersuchung wurde für alle drei HB-Zelllinien HepT1...

Einfluss der Magnetfeldstärke bei präoperativer Planung und postoperativer Erfolgskontrolle der magnetresonanzgesteuerten perkutanen Radiofrequenzablation von hepatozellulären Karzinomen und kolorektalen Metastasen; Influence of magnetic field strength on preoperative planning and postoperative controlling in MRI-guided percutaneous radiofrequency ablation of hepatocellular carcinoma and colorectal liver metastases

Benmalek, Tarik
Fonte: Universidade de Tubinga Publicador: Universidade de Tubinga
Tipo: Dissertação
DE
Relevância na Pesquisa
26.39%
Die MRT-gesteuerte Radiofrequenzablation hat sich in den letzten Jahren als ein sicheres und ideales Verfahren bei der Behandlung von primären und sekundären Lebermalignomen etabliert. Die in dieser Arbeit verwendete Software soll dem Radiologen helfen, die MR-gesteuerte Ablation noch sicherer zu gestalten. Es wurde der Einfluss der Magnetfeldstärke - 0,2T versus 1,5T – auf die Effektivität der Software untersucht. Für die Evaluation der beschriebenen Software wurden mittels Segmentierung, Registrierung und Ergebniskontrolle/ Beurteilung 0,2T und 1,5T MRT-Bilddatensätze analysiert und mit der konventionellen Vorgehensweise verglichen. Retrospektiv wurden jeweils 20 Patienten ausgewählt, die sich auf die beiden Hauptgruppen 1,5T und 0,2T gleich verteilen. Jede Hauptgruppe umfasste vier Kategorien (HCC, HCC + TACE, Rezidiv, Metastasen) à fünf Patientenfälle. Alle Daten wurden über PACS im standardisierten DICOM-Format bezogen. Für beide Hauptgruppen (0,2T und 1,5T) wurden präinterventionelle mit postinterventionellen Bildern verglichen (beide in der gleichen Gewichtung). Dieses Vorgehen geschah einmal für die Hauptintervention und einmal für die Nachuntersuchung (MR-Follow-up nach 4 Monaten). Unter der Voraussetzung T1w Bilder und fehlender Bewegungsartefakte ermöglichte die softwaregestützte 1...

Hansen's Disease in an HIV Patient Complicated by Deep Vein Thrombosis: a Rare Complication of Thalidomide Therapy

Medeiros, S; Fernandes, C; Martins, N; Machado, J; Kutzner, H; Afonso, A; Vieira, R; Maltez, F; Cardoso, J
Fonte: John Libbey Eurotext Publicador: John Libbey Eurotext
Tipo: Artigo de Revista Científica
Publicado em //2009 ENG
Relevância na Pesquisa
26.39%