Página 1 dos resultados de 63 itens digitais encontrados em 0.000 segundos

Fragmentação e ruptura: formas de duplicação em 'I giganti della montagna' de Luigi Pirandello; Fragmentation and rupture: duplication forms in 'I giganti della montagna' by Luigi Pirandello

Salatini, Erica Aparecida
Fonte: Biblioteca Digitais de Teses e Dissertações da USP Publicador: Biblioteca Digitais de Teses e Dissertações da USP
Tipo: Dissertação de Mestrado Formato: application/pdf
Publicado em 16/03/2007 PT
Relevância na Pesquisa
27.84%
O presente trabalho busca uma análise e interpretação da obra teatral I giganti della montagna de Luigi Pirandello, discutindo a questão da fragmentação e da ruptura do sujeito consigo mesmo, considerando-as formas de duplicação temática e estrutural no texto dramático. Além disso, tenta mostrar as relações estabelecidas entre a narrativa e o drama, por intermédio da concepção de mito, colocada pelo autor.; This work aims at analyzing and interpreting Luigi Pirandello's play I giganti della montagna, discussing the problem of the subject's fragmentation and rupture, regarding these as forms of the play's thematic and structural duplication. In addition, the work attempts to illustrate the existing connections between narrative and drama, taking into account the author's conception of myth.

A novel 4 S [3H]beta-naphthoflavone-binding protein in liver cytosol of female Sprague-Dawley rats treated with aryl hydrocarbon receptor agonists.

Brauze, D; Malejka-Giganti, D
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 01/05/2000 EN
Relevância na Pesquisa
16.68%
beta-Naphthoflavone (beta-NF) is a widely used inducer of phase-I and phase-II enzymes controlled by aryl hydrocarbon receptor (AhR). Studies of competitive binding with (3)H-labelled 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD), 3-methylcholanthrene (3-MC) and benzo[a]pyrene (B[a]P) have shown that beta-NF is a high-affinity ligand for AhR and also for polycyclic aromatic hydrocarbon (PAH)-binding protein, both soluble proteins of rat liver in 8 S and 4 S fractions, respectively, of sucrose gradients. This study examined binding of [(3)H]beta-NF to liver cytosolic proteins of female Sprague-Dawley rats. Treatment of rats with beta-NF, 3-MC, TCDD or alpha-naphthoflavone (alpha-NF) increased the specific [(3)H]beta-NF binding to liver cytosol up to 125-fold that of vehicle (corn oil)-treated rats (<100 fmol/mg of protein). Sucrose gradients revealed a large 4 S and a small 8 S peak of radioactivity from [(3)H]beta-NF binding to cytosols of beta-NF-, 3-MC-, TCDD- or alpha-NF-treated rats. Whereas co-incubation with the unlabelled beta-NF eliminated both peaks, co-incubation with 2,3, 7,8-tetrachlorodibenzofuran (TCDF) eliminated only the 8 S peak. The sucrose density gradient from [(3)H]TCDD binding to cytosol of beta-NF- or TCDD-treated rats yielded a small 4 S and a larger 8 S peak; only the latter was abolished by co-incubation with TCDF. Thus...

Modulations of hepatic gamma-glutamyltranspeptidase and N-hydroxy-N-2-fluorenylacetamide sulfotransferase activities following treatment of rats with a hepatocarcinogenic regimen: effect of partial hepatectomy.

Vijayaraghavan, P; Malejka-Giganti, D
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /10/1994 EN
Relevância na Pesquisa
16.68%
The feasibility of using biochemical assays of gamma-glutamyltranspeptidase (gamma-GTP) and N-hydroxy-N-2-fluorenylacetamide sulfotransferase (N-OH-2-FAA ST) activities to monitor the effects of treatment of male Sprague-Dawley rats with a two-stage hepatocarcinogenic regimen was investigated. One week after initiation with diethylnitrosamine (200 mg/kg of bw), the rats were treated with 10 oral doses within 2 weeks of N-2-fluorenylacetamide (2-FAA) at 0.05 mmole/kg or vehicle (corn oil) at 5 ml/kg of body weight. After five doses of 2-FAA or corn oil, half of the rats in each group underwent partial (70%) hepatectomy (PH). Three days after completion of 2-FAA treatment, gamma-GTP activity increased approximately 8-fold in the livers of both the nonhepatectomized (-PH) and hepatectomized (+PH) groups. After 17 days, the enzyme activity decreased to the control level in the -PH group but increased 3.1-fold above the control level in the +PH group. After 31, 66, and 87 days, gamma-GTP activity increased only 1.4- to 2.6-fold in the -PH group, whereas that of +PH group increased 15- to 32-fold. N-OH-2-FAA ST activity, determined 3 days after completion of 2-FAA treatment, decreased by approximately 60% in the -PH and +PH groups. After 17 days...

Peroxidative metabolism of carcinogenic N-arylhydroxamic acids: implications for tumorigenesis.

Malejka-Giganti, D; Ritter, C L
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /10/1994 EN
Relevância na Pesquisa
16.68%
Peroxidative oxidations of chemical carcinogens including N-substituted aryl compounds could result in their metabolic activation because the products react with cellular molecules and lead to cytotoxicity, mutagenicity, and carcinogenicity. In vivo, peroxidative activities are chiefly of neutrophilic leukocyte origin. Neutrophils may be attracted to the site(s) of exposure to carcinogen and, via phagocytosis and respiratory burst, release oxidants that catalyze carcinogen activation and/or cause DNA damage. Our studies, presented herein, concern oxidations of carcinogenic N-arylhydroxamic acids, N-hydroxy-N-2-fluorenylacetamide (N-OH-2-FAA), and N-hydroxy-N-2-fluorenylbenzamide (N-OH-2-FBA), by enzymatic and chemical systems simulating those of neutrophils, myeloperoxidase and hydrogen peroxide (H2O2) +/- halide, and hypohalous acid and halide at the physiologic concentrations (0.1 M Cl- and/or 0.1 mM Br-) and the pH (4-6.5) of phagocytosis. Studies also concern oxidations of the hydroxamic acids by rat peritoneal neutrophils stimulated to undergo respiratory burst and release myeloperoxidase in medium-containing 0.14 M Cl- +/- 0.1 mM Br-. The metabolites formed in the presence of exogenous H2O2 are consistent with two peroxidative mechanisms: one electron-oxidation to a radical that dismutates to equimolar 2-nitrosofluorene (2-NOF) and the ester of the respective hydroxamic acid and halide-dependent oxidative cleavage...

Pathobiologic and metabolic aspects of mammary gland tumorigenesis by N-substituted aryl compounds

Malejka-Giganti, D.; Ritter, C. L.; Ryzewski, C. N.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /03/1983 EN
Relevância na Pesquisa
16.68%
Metabolic or synthetic N-hydroxylation of N-arylamides yields N-arylacylhydroxamic acids considerably more carcinogenic for the rat mammary gland than the parent amides both by systemic and topical administration. The size of the aryl moiety, the position of the nitrogen relative to the aryl moiety and the type of acyl group are determinants of the carcinogenic potency of N-arylacylhydroxamic acids. Induction of mammary tumors required ovarian hormones. Receptors for estrogen, androgen and progesterone were shown in the N-hydroxy-N-2-fluorenylacetamide (N-OH-2-FAA)-induced mammary carcinoma. This tumor involved epithelial and stromal components of the mammary gland that were separated in culture and produced tumors of their respective origin in the isologous host. Both mammary epithelial cells and fibroblasts are capable of metabolism of carcinogens. The enzymes potentially involved in metabolic activation of N-arylamides and N-arylacylhydroxamic acids in the mammary gland include: a cytochrome P-450(P1-450) system, UDP-glucuronyltransferase, N,O-acyltransferases and peroxidases. Mammary microsomes in which cytochrome P1-450 was induced generated small amounts of N-OH-2-FAA from 2-FAA. N-OH-2-FAA and its carcinogenic isomer, N-OH-3-FAA...

Quantitative analysis of the oxidative DNA lesion, 2,2-diamino-4-(2-deoxy-β-d-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), in vitro and in vivo by isotope dilution-capillary HPLC-ESI-MS/MS

Matter, Brock; Malejka-Giganti, Danuta; Csallany, A. Saari; Tretyakova, Natalia
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.68%
A major DNA oxidation product, 2,2-diamino-4-[(2-deoxy-β-d-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), can be generated either directly by oxidation of dG or as a secondary oxidation product with an intermediate of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG). Site-specific mutagenesis studies indicate that oxazolone is a strongly mispairing lesion, inducing ∼10-fold more mutations than 8-oxo-dG. While 8-oxo-dG undergoes facile further oxidation, oxazolone appears to be a stable final product of guanine oxidation, and, if formed in vivo, can potentially serve as a biomarker of DNA damage induced by oxidative stress. In this study, capillary liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) methods were developed to enable quantitative analysis of both 8-oxo-dG and oxazolone in DNA from biological sources. Sensitive and specific detection of 8-oxo-dG and oxazolone in enzymatic DNA hydrolysates was achieved by isotope dilution with the corresponding 15N-labeled internal standards. Both nucleobase adducts were formed in a dose-dependent manner in calf thymus DNA subjected to photooxidation in the presence of riboflavin. While the amounts of oxazolone continued to increase with the duration of irradiation...

CD4+ response and subsequent risk of death among patients on antiretroviral therapy in Lusaka, Zambia

Chi, Benjamin H.; Giganti, Mark; Mulenga, Priscilla L.; Limbada, Mohammed; Reid, Stewart E.; Mutale, Wilbroad; Stringer, Jeffrey S. A.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 01/09/2009 EN
Relevância na Pesquisa
16.68%

Substrate-induced Conformational Changes in the Essential Peripheral Membrane-associated Mannosyltransferase PimA from Mycobacteria: IMPLICATIONS FOR CATALYSIS*

Guerin, Marcelo E.; Schaeffer, Francis; Chaffotte, Alain; Gest, Petra; Giganti, David; Korduláková, Jana; van der Woerd, Mark; Jackson, Mary; Alzari, Pedro M.
Fonte: American Society for Biochemistry and Molecular Biology Publicador: American Society for Biochemistry and Molecular Biology
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.68%
Phosphatidyl-myo-inositol mannosyltransferase A (PimA) is an essential glycosyltransferase (GT) involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs), which are key components of the mycobacterial cell envelope. PimA is the paradigm of a large family of peripheral membrane-binding GTs for which the molecular mechanism of substrate/membrane recognition and catalysis is still unknown. Strong evidence is provided showing that PimA undergoes significant conformational changes upon substrate binding. Specifically, the binding of the donor GDP-Man triggered an important interdomain rearrangement that stabilized the enzyme and generated the binding site for the acceptor substrate, phosphatidyl-myo-inositol (PI). The interaction of PimA with the β-phosphate of GDP-Man was essential for this conformational change to occur. In contrast, binding of PI had the opposite effect, inducing the formation of a more relaxed complex with PimA. Interestingly, GDP-Man stabilized and PI destabilized PimA by a similar enthalpic amount, suggesting that they formed or disrupted an equivalent number of interactions within the PimA complexes. Furthermore, molecular docking and site-directed mutagenesis experiments provided novel insights into the architecture of the myo-inositol 1-phosphate binding site and the involvement of an essential amphiphatic α-helix in membrane binding. Altogether...

Methods and Baseline Results of a Repeated Cross-Sectional Survey to Assess the Public Health Impact of Antiretroviral Therapy in Lusaka, Zambia

Giganti, Mark J.; Levy, Jens W.; Banda, Yolan; Kusanthan, Thankian; Sinkala, Moses; Stringer, Jeffrey S. A.; Chi, Benjamin H.
Fonte: The American Society of Tropical Medicine and Hygiene Publicador: The American Society of Tropical Medicine and Hygiene
Tipo: Artigo de Revista Científica
Publicado em /05/2010 EN
Relevância na Pesquisa
16.68%
Although the individual-level impact of antiretroviral therapy (ART) is well documented, there are few available data describing the public health impact of services for persons infected with human immunodeficiency virus in resource-constrained settings. We describe the methods and baseline results of a household survey that assessed the population-level impact of the national program for HIV care in Zambia and treatment in the city of Lusaka. The survey was timed with the staggered expansion of services and repeated cross-sectional surveys planned for pre-implementation and post-implementation comparisons made by community. In the initial survey round, which was performed during the early phases of the program (November–December 2004), 18,110 persons were enumerated from 3,600 households surveyed. Respondents were asked questions designed to evaluate community-level mortality and respondent knowledge and attitudes towards HIV. These findings will serve as a reliable reference in the future analysis of the population-level impact of this HIV treatment and care program in Zambia.

Early clinical and programmatic outcomes with tenofovir-based antiretroviral therapy in Zambia

Chi, Benjamin H.; Mwango, Albert; Giganti, Mark; Mulenga, Lloyd B.; Tambatamba-Chapula, Bushimbwa; Reid, Stewart E.; Bolton-Moore, Carolyn; Chintu, Namwinga; Mulenga, Priscilla L.; Stringer, Elizabeth M.; Sheneberger, Robert; Mwaba, Peter; Stringer, Jeffr
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 01/05/2010 EN
Relevância na Pesquisa
16.68%

Strengthening Health Systems at Facility-Level: Feasibility of Integrating Antiretroviral Therapy into Primary Health Care Services in Lusaka, Zambia

Topp, Stephanie M.; Chipukuma, Julien M.; Giganti, Mark; Mwango, Linah K.; Chiko, Like M.; Tambatamba-Chapula, Bushimbwa; Wamulume, Chibesa S.; Reid, Stewart
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 13/07/2010 EN
Relevância na Pesquisa
16.68%

EARLY IMMUNOLOGIC RESPONSE AND SUBSEQUENT SURVIVAL AMONG MALNOURISHED ADULTS RECEIVING ANTIRETROVIRAL THERAPY IN URBAN ZAMBIA

KOETHE, John R.; LIMBADA, Mohammed I.; GIGANTI, Mark J.; NYIRENDA, Christopher K.; MULENGA, Lloyd; WESTER, C. William; CHI, Benjamin H.; STRINGER, Jeffrey S.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 24/08/2010 EN
Relevância na Pesquisa
16.68%

Peripartum nevirapine exposure and subsequent clinical outcomes among HIV-infected women receiving antiretroviral therapy for at least 12 months

Chintu, Namwinga; Giganti, Mark J.; Putta, Nande B.; Sinkala, Moses; Sadoki, Ebedy; Stringer, Elizabeth M.; Stringer, Jeffrey S. A.; Chi, Benjamin H.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.68%

Implementation of the Zambia Electronic Perinatal Record System for comprehensive prenatal and delivery care

Chi, Benjamin H.; Vwalika, Bellington; Killam, William P.; Wamalume, Chibesa; Giganti, Mark J.; Mbewe, Reuben; Stringer, Elizabeth M.; Chintu, Namwinga T.; Putta, Nande B.; Liu, Katherine C.; Chibwesha, Carla J.; Rouse, Dwight J.; Stringer, Jeffrey S.A.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em /05/2011 EN
Relevância na Pesquisa
16.68%

Predictors of CD4 Eligibility for Antiretroviral Therapy Initiation Among HIV-Infected Pregnant Women in Lusaka, Zambia

Liu, Katherine C.; Mulindwa, Jessica; Giganti, Mark J.; Putta, Nande B.; Chintu, Namwinga; Chi, Benjamin H.; Stringer, Jeffrey S. A.; Stringer, Elizabeth M.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 15/08/2011 EN
Relevância na Pesquisa
16.68%
In resource-limited settings, CD4 testing is a barrier to antiretroviral therapy initiation in pregnancy. We used logistic regression to identify predictors of CD4+ cell count ≤ 350 cells/uL in 20,233 pregnant women. The best-performing model included any 3 of: age ≥ 28 years old, hemoglobin ≤ 9.8 g/dL, gestational age ≤ 30 weeks, weight ≤ 64kg, history of tuberculosis or previous death of an infant prior to one year old. Sensitivity was 45.7% (95% CI: 44.5-47.0), specificity 70.7% (95% CI: 69.6-71.8), and misclassification rate 41.4% (95% CI: 40.5-42.2). CD4 triage remains a critical element of maternal HIV care and PMTCT.

Comparative outcomes of tenofovir- and zidovudine-based antiretroviral therapy regimens in Lusaka, Zambia

Chi, Benjamin H.; Mwango, Albert; Giganti, Mark J.; Sikazwe, Izukanji; Moyo, Crispin; Schuttner, Linnaea; Mulenga, Lloyd B.; Bolton-Moore, Carolyn; Chintu, Namwinga T.; Sheneberger, Robert; Stringer, Elizabeth M.; Stringer, Jeffrey S. A.
Fonte: PubMed Publicador: PubMed
Tipo: Artigo de Revista Científica
Publicado em 15/12/2011 EN
Relevância na Pesquisa
16.68%

Effectiveness of generic and proprietary first-line anti-retroviral regimens in a primary health care setting in Lusaka, Zambia: a cohort study

Stringer, Jeffrey SA; Mwango, Albert J; Giganti, Mark J; Mulenga, Lloyd; Levy, Jens W; Stringer, Elizabeth M; Mulenga, Priscilla; Saag, Michael S; Musonda, Patrick; Williams, Frank B; Reid, Stewart E; Chi, Benjamin H
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: Artigo de Revista Científica
EN
Relevância na Pesquisa
16.68%
Background Although generic anti-retroviral drugs are in common use throughout the developing world, studies comparing their clinical effectiveness with that of proprietary formulations are lacking.

Taking ART to Scale: Determinants of the Cost and Cost-Effectiveness of Antiretroviral Therapy in 45 Clinical Sites in Zambia

Marseille, Elliot; Giganti, Mark J.; Mwango, Albert; Chisembele-Taylor, Angela; Mulenga, Lloyd; Over, Mead; Kahn, James G.; Stringer, Jeffrey S. A.
Fonte: Public Library of Science Publicador: Public Library of Science
Tipo: Artigo de Revista Científica
Publicado em 20/12/2012 EN
Relevância na Pesquisa
16.68%

El impuesto a la transmisión gratuita de bienes en la República Argentina

Giganti, José Hugo
Fonte: Facultad de Ciencias Económicas, UBA. Buenos Aires Publicador: Facultad de Ciencias Económicas, UBA. Buenos Aires
Tipo: info:eu-repo/semantics/doctoralThesis; info:ar-repo/semantics/tesis doctoral; info:eu-repo/semantics/publishedVersion Formato: application/pdf
Publicado em //1942 SPA
Relevância na Pesquisa
27.31%
Fil: Giganti, José Hugo. .

Centauri e Giganti nell'artigianato artistico di ambiente etrusco

LANDI, ALICE
Fonte: La Sapienza Universidade de Roma Publicador: La Sapienza Universidade de Roma
Tipo: Tese de Doutorado
IT
Relevância na Pesquisa
38.26%
La presente tesi di dottorato affronta l’analisi delle iconografie di Centauri e Giganti nell’artigianato artistico in Etruria seguendone il percorso evolutivo a partire dalla loro prima comparsa (primo quarto del VII secolo a.C. per i Centauri, seconda metà del VI per i Giganti) fino alle più recenti rappresentazioni di II e I secolo a.C. Il lavoro, concentrandosi su quanto finora edito, ha innanzitutto l’obiettivo di costituire un catalogo aggiornato che, suddiviso per classi di materiali, possa costituire la base per un’indagine sistematica dei soggetti iconografici in esame. Allo spoglio della bibliografia sono stati affiancati, ove possibile, la visione diretta dei materiali e il recupero della documentazione fotografica inedita, in particolare presso il Louvre, il Musée des Monnaies, Médailles et Antiques della Bibliothèque Nationale de France e il British Museum. I documenti raccolti, che costituiscono un Catalogo di circa 470 pezzi, interessano molte classi di materiali, dalla coroplastica architettonica alle diverse produzioni ceramiche (impasto ‒ white-on-red, impasti orientalizzanti con decorazione incisa e a stampo, produzione ceretana stampigliata in impasto rosso ‒, bucchero, ceramica dipinta tardo-orientalizzante...